Aliases
for DGCR5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| DiGeorge Syndrome Critical Region Gene 5 (Non-Protein Coding)1 2 | | LINC000371 2 | | NCRNA000371 2 |
| External Ids: | HGNC: 167571 | Entrez Gene: 262202 | Ensembl: ENSG000002375177 | | ORGUL members: | |
|---|
| NONCODE:n384082 | |
Export aliases for DGCR5 gene to outside databasesPrevious GC identifers: GC22U990094 GC22P015899 GC22P017332 GC22P017347 GC22P002579
|---|
Summaries
for DGCR5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for DGCR5
|
Genomic Views
for DGCR5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011519.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DGCR5 gene promoter:
p53 Pax-5 AML1a Egr-1 Egr-4 HNF-4alpha1 CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for DGCR5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGCR5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11DGCR5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P018958: view genomic region
(about GC identifiers)
Start:
|
18,958,027 bp from pter |
End:
|
19,018,742 bp from pter |
Size:
|
60,716 bases |
Orientation:
|
plus strand |
|
Proteins
for DGCR5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for DGCR5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for DGCR5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for DGCR5 | |  | Search LifeMap BioReagents cell lines for DGCR5 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGCR5 |
Pathways & Interactions
for DGCR5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGCR5
|
Drugs & Compounds
for DGCR5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DGCR5
Search CenterWatch for drugs/clinical trials and news about DGCR5 
|
Transcripts
for DGCR5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for DGCR5: DiGeorge syndrome critical region gene 5 (non-protein coding) Hs.646438 [show with all ESTs]Unigene Representative Sequence: NR_0027337 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000440005(uc002zon.2) ENST00000438934(uc021wku.1 uc021wkv.1)
ENST00000424407 ENST00000421572 ENST00000399539 ENST00000537283 ENST00000540720
Additional cDNA sequence: AK124980.1 AK302666.1 BC035092.1 NR_002733.2 NR_045121.1 U84528.1 XR_109699.2 XR_133279.2 XR_172361.1 8 DOTS entries: DT.95264276 DT.100023122 DT.101964241 DT.40192859 DT.91757216 DT.95264275 DT.75173775 DT.99987654 24/80 AceView cDNA sequences (see all 80): CR606945 CR623368 AI027934 CA776305 BU585163 AW204048 AL041213 BC033112 AA757817 AW135056 BU584564 BU585177 BU585176 CK903475 BG163946 AI684378 BF317417 BU584349 AW418897 BM929395 BM041426 BV184327 BM040664 BQ067304
GeneLoc Exon Structure
|
Expression
for DGCR5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for DGCR5:none
DGCR5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for DGCR5
SOURCE GeneReport for Unigene cluster: Hs.646438
SABiosciences Custom PCR Arrays for DGCR5
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DGCR5
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DGCR5 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DGCR5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGCR5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGCR5 |
Orthologs
for DGCR5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DGCR5 (if available)
TreeFam Gene Tree for DGCR5 (if available) |
Paralogs
for DGCR5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DGCR5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DGCR5 (18958027 - 19018742 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 26 variations for DGCR5
15/25 CNVs (see all 25): 67835 3237 50803 34524 34485 50800 4116 50805 34650 50804 37722 53199 31070 50802 34618
1 Indel: 73712
Human Gene Mutation Database (HGMD): DGCR5
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DGCR5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DGCR5 for disorders About GeneDecksing
1  disease for DGCR5: About MalaCardsdigeorge syndrome
Export disorders for DGCR5 gene to outside databases
|
Publications
for DGCR5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DGCR5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DGCR5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel transcript disrupted by a balanced translocation associated with DiGeorge syndrome. (PubMed id 8659529)1, 3 Sutherland H.F....Scambler P.J. (1996)
- Human metabolic individuality in biomedical and pharma ceutical research. (PubMed id 21886157)1 Suhre K....Gieger C. (2011)
- Regulation of neural macroRNAs by the transcriptional repressor REST. (PubMed id 19050060)1 Johnson R....Lipovich L. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1 Hirosawa M....Ohara O. (2001)
|
External Searches for DGCR5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DGCR5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DGCR5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DGCR5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DGCR5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DGCR5 gene:
Search GeneIP for patents involving DGCR5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DGCR5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DGCR5 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DGCR5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGCR5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DGCR5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGCR5 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DGCR5 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DGCR5 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGCR5 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for DGCR5 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DGCR5 |
| |  | |
|
|
|
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