Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DGCR2 Gene

protein-coding   GIFtS: 61
GCID: GC22M019023

DiGeorge Syndrome Critical Region Gene 2

  See DGCR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
DiGeorge Syndrome Critical Region Gene 21 2     SEZ-122
IDD2 3 5     DiGeorge Syndrome Critical Region Protein 22
Integral Membrane Protein DGCR21     Integral Membrane Protein Deleted In DiGeorge Syndrome2
DGS-C2     Integral Membrane Protein DGCR2/IDD2
LAN2     KIAA01633

External Ids:    HGNC: 28451   Entrez Gene: 99932   Ensembl: ENSG000000704137   OMIM: 6005945   UniProtKB: P981533   

Export aliases for DGCR2 gene to outside databases

Previous GC identifers: GC22M015964 GC22M017398 GC22M002645


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DGCR2 Gene:
Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge
syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects)
classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which
could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge
syndrome. Alternative splicing results in multiple transcript variants.(provided by RefSeq, May 2010)

GeneCards Summary for DGCR2 Gene:
DGCR2 (DiGeorge syndrome critical region gene 2) is a protein-coding gene. Diseases associated with DGCR2 include digeorge syndrome/velocardiofacial syndrome complex-2, and velocardiofacial syndrome. GO annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot: IDD_HUMAN, P98153
Function: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for
normal cell differentiation and migration

Gene Wiki entry for DGCR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DGCR2 gene promoter:
         CREB   NF-1/L   NF-1   AML1a   HTF   NCX/Ncx   deltaCREB   IRF-1   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DGCR2 promoter sequence
   Search Chromatin IP Primers for DGCR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DGCR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

DGCR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGCR2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M019023:  view genomic region     (about GC identifiers)

Start:
19,023,795 bp from pter      End:
19,109,967 bp from pter
Size:
86,173 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DGCR2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IDD_HUMAN, P98153 (See protein sequence)
Recommended Name: Integral membrane protein DGCR2/IDD precursor  
Size: 550 amino acids; 60811 Da
Secondary accessions: A6NIB5 A8K6K5 B7Z935
Alternative splicing: 2 isoforms:  P98153-1   P98153-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DGCR2: NX_P98153

Explore proteomics data for DGCR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn149, Asn196
  • Modification sites at PhosphoSitePlus

  • See DGCR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001167004.1  NP_001167005.1  NP_001171710.1  NP_005128.1  

    ENSEMBL proteins: 
     ENSP00000373914   ENSP00000263196   ENSP00000440062   ENSP00000445069  

    DGCR2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DGCR2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DGCR2
    GenScript Custom Purified and Recombinant Proteins Services for DGCR2
    Novus Biologicals DGCR2 Protein
    Novus Biologicals DGCR2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DGCR2

     
    Search eBioscience for Proteins for DGCR2 

     
    antibodies-online proteins for DGCR2 (4 products) 

     
    antibodies-online peptides for DGCR2

    DGCR2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DGCR2
    Novus Biologicals DGCR2 Antibodies
    Abcam antibodies for DGCR2
    Cloud-Clone Corp. Antibodies for DGCR2
    ThermoFisher Antibodies for DGCR2
    antibodies-online antibodies for DGCR2 (34 products) 

    DGCR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DGCR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DGCR2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DGCR2
    Cloud-Clone Corp. CLIAs for DGCR2
    Search eBioscience for ELISAs for DGCR2 
    antibodies-online kits for DGCR2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR023415 LDLR_class-A_CS
     IPR002172 LDrepeatLR_classA_rpt
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P98153

    ProtoNet protein and cluster: P98153

    2 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: IDD_HUMAN, P98153
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 LDL-receptor class A domain
    Similarity: Contains 1 VWFC domain


    Find genes that share domains with DGCR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IDD_HUMAN, P98153
    Function: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for
    normal cell differentiation and migration

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with DGCR2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DGCR2:
     Increased Salmonella enterica  

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Dgcr2):
     no phenotypic analysis 

    Find genes that share phenotypes with DGCR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dgcr2tm1Ais for DGCR2

       genOway: Develop your customized and physiologically relevant rodent model for DGCR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DGCR2:
    hsa-mir-23b-3p (MIRT046368), hsa-mir-346 (MIRT004236), hsa-mir-484 (MIRT042326)

    Block miRNA regulation of human, mouse, rat DGCR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DGCR2 (see all 34):
    hsa-miR-1224-3p hsa-miR-4272 hsa-let-7a-2* hsa-miR-3653 hsa-miR-342-3p hsa-miR-3658 hsa-miR-181b hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidDGCR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DGCR2
    Predesigned siRNA for gene silencing in human, mouse, rat DGCR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DGCR2

    Clone
    Products:
         
    OriGene clones in human, mouse for DGCR2 (see all 20)
    OriGene ORF clones in mouse, rat for DGCR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): DGCR2 (NM_005137)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGCR2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DGCR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for DGCR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGCR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IDD_HUMAN, P98153: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DGCR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DGCR2
    Interactions:

        Search GeneGlobe Interaction Network for DGCR2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for DGCR2 (P981532, 3 ENSP000002631964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF2Q9HAU42, 3MINT-61797 I2D: score=3 
    DDIT3ENSP000003406714STRING: ENSP00000340671
    CRKENSP000003005744STRING: ENSP00000300574
    CRKLENSP000003463004STRING: ENSP00000346300
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0009887organ morphogenesis TAS7655455

    Find genes that share ontologies with DGCR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DGCR2 (IDD)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DGCR2 gene (4 alternative transcripts): 
    NM_001173533.1  NM_001173534.1  NM_001184781.1  NM_005137.2  

    Unigene Cluster for DGCR2:

    DiGeorge syndrome critical region gene 2
    Hs.517357  [show with all ESTs]
    Unigene Representative Sequence: CR936871
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389262(uc002zor.1) ENST00000263196(uc002zoq.1 uc021wkx.1)
    ENST00000467659 ENST00000608548 ENST00000473832 ENST00000537045(uc021wky.1 uc021wkz.1 uc011agr.1)
    ENST00000545799
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DGCR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DGCR2 (see all 34):
    hsa-miR-1224-3p hsa-miR-4272 hsa-let-7a-2* hsa-miR-3653 hsa-miR-342-3p hsa-miR-3658 hsa-miR-181b hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidDGCR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DGCR2
    Predesigned siRNA for gene silencing in human, mouse, rat DGCR2
    Clone
    Products:
         
    OriGene clones in human, mouse for DGCR2 (see all 20)
    OriGene ORF clones in mouse, rat for DGCR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): DGCR2 (NM_005137)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGCR2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DGCR2
    OriGene qSTAR qPCR primer pairs in human, mouse for DGCR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DGCR2
      QuantiTect SYBR Green Assays in human, mouse, rat DGCR2
      QuantiFast Probe-based Assays in human, mouse, rat DGCR2

    Additional mRNA sequence: 

    AK291670.1 AK295697.1 AK296337.1 AK303130.1 AK304382.1 BC020339.1 BC032430.1 BC035425.1 
    BC040500.1 CR456433.1 CR936871.1 D79985.1 FJ032369.1 L46352.1 L77560.1 NR_033674.1 
    X83545.1 X84076.1 

    Selected DOTS entries (see all 35):

    DT.100708084  DT.452296  DT.100886491  DT.97815665  DT.100886493  DT.95170492  DT.100886496  DT.100647981 
    DT.100038708  DT.101974655  DT.100696733  DT.100832006  DT.100038706  DT.91816984  DT.92057718  DT.102836515 
    DT.91876522  DT.100038705  DT.100038707  DT.100763071  DT.100830002  DT.120640000  DT.97824109  DT.100644960 

    Selected AceView cDNA sequences (see all 587):

    BE646373 CA487955 AI867171 CA776444 BM998754 BG324963 AU132368 AI923812 
    CA943371 BQ068206 AI970228 CA944629 CR607605 BU077964 CR456433 BM910534 
    BI767328 AA037429 T33049 AK098432 BM787523 BU078211 CA775293 BP381773 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DGCR2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b ^ 14a ·
    SP1:                                -     -                 -                             -                                               -           -         
    SP2:                                -     -                 -     -                       -                                                                     
    SP3:                                                                                      -                                                           -         
    SP4:                    -     -     -     -                 -     -                       -                                                                     
    SP5:                                -     -           -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16
    SP1:              -                           
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:              -                           


    ECgene alternative splicing isoforms for DGCR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DGCR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGAGGTGGG
    DGCR2 Expression
    About this image


    DGCR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    DGCR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DGCR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517357

    UniProtKB/Swiss-Prot: IDD_HUMAN, P98153
    Tissue specificity: Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult
    kidney

        Custom PCR Arrays for DGCR2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DGCR2
    OriGene qSTAR qPCR primer pairs in human, mouse for DGCR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DGCR2
    QuantiTect SYBR Green Assays in human, mouse, rat DGCR2
    QuantiFast Probe-based Assays in human, mouse, rat DGCR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGCR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DGCR2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dgcr21 , 5 DiGeorge syndrome critical region gene 21, 5 87.86(n)1
    93.44(a)1
      16 (11.05 cM)5
    133561  NM_010048.31  NP_034178.21 
     178394825 
    chicken
    (Gallus gallus)
    Aves DGCR21 DiGeorge syndrome critical region gene 2 75.06(n)
    79.44(a)
      416926  XM_003642212.2  XP_003642260.1 
    lizard
    (Anolis carolinensis)
    Reptilia DGCR26
    DiGeorge syndrome critical region gene 2
    77(a)
    1 ↔ 1
    GL343282.1(684960-728983)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16762 Xenopus laevis transcribed sequence with moderate similarity more 77.02(n)    BG364208.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dgcr21 DiGeorge syndrome critical region gene 2 67.72(n)
    67.46(a)
      436929  NM_001002656.2  NP_001002656.1 


    ENSEMBL Gene Tree for DGCR2 (if available)
    TreeFam Gene Tree for DGCR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DGCR2 gene
    1 SIMAP similar gene for DGCR2 using alignment to 4 protein entries:     IDD_HUMAN (see all proteins):
    DKFZp686I1730

    Find genes that share paralogs with DGCR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DGCR2 (see all 2203)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918223111,2
    Cuntested12999014(+) GAAGCA/GAACGG 9 R C mis10--------
    rs589960671,2
    C--2649499(+) CCACC-/ACTGTCGG 5 -- int10--------
    rs1452893341,2
    C--2651751(+) CCCCA-/CTGAGAT 5 -- int10--------
    rs58443691,2
    C--2652472(+) CAGGA-/CCCCTA 5 -- int11Minor allele frequency- C:0.00CSA 2
    rs58443701,2
    C--2654134(+) gtcttAAAC/-  
            
    aaaca
    5 -- int11Minor allele frequency- -:0.50CSA 2
    rs30798291,2
    C--2654146(+) ACAAA-/CAAA  
      
    /CAAAA
    AACAG
    5 -- int10--------
    rs760837291,2
    C--2658597(+) TCTCAC/AAAAAA 5 -- int11Minor allele frequency- A:0.50NA 2
    rs1455591171,2
    C--2661051(+) GTAGT-/GGCACA 5 -- int10--------
    rs1407639571,2
    C--2661183(+) TGTCT-/CACA  
     
    /CACACA
    CACAC
    9 -- int1 cds10--------
    rs1117246241,2
    C--2661381(+) TCTAC-/AAAAAA 5 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for DGCR2 (19023795 - 19109967 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DGCR2 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435744CNV Deletion17901297
    esv2678705CNV Deletion23128226
    nsv834122CNV Loss17160897
    nsv914244CNV Loss21882294
    nsv828932CNV Loss20364138
    esv2751935CNV Loss17911159
    dgv4822n71CNV Gain21882294
    nsv914263CNV Gain21882294
    nsv914268CNV Gain21882294
    dgv543n27CNV Gain19166990

    Human Gene Mutation Database (HGMD): DGCR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DGCR2
    DNA2.0 Custom Variant and Variant Library Synthesis for DGCR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600594    OMIM disorders: --

    3 diseases for DGCR2:    
    About MalaCards
    digeorge syndrome/velocardiofacial syndrome complex-2    velocardiofacial syndrome    digeorge syndrome

    3 diseases from the University of Copenhagen DISEASES database for DGCR2:
    DiGeorge syndrome     Velocardiofacial syndrome     Hypoparathyroidism

    Find genes that share disorders with DGCR2           About GenesLikeMe

    Genetic Association Database (GAD): DGCR2
    Human Genome Epidemiology (HuGE) Navigator: DGCR2 (3 documents)

    Export disorders for DGCR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DGCR2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with DGCR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a gene encoding an integral membrane protein from the vicinity of a balanced translocation breakpoint associated with DiGeorge syndrome. (PubMed id 7655455)1, 2, 3 Wadey R.... Scambler P.J. (Hum. Mol. Genet. 1995)
    2. No association between genetic variants at the DGCR2 gene and schizophrenia in a German sample. (PubMed id 19668116)1, 4 Georgi A....Jamra R.A. (Psychiatr. Genet. 2009)
    3. Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia. (PubMed id 18797402)1, 4 Ishiguro H....Arinami T. (Psychiatr. Genet. 2008)
    4. A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia. (PubMed id 16783572)1, 4 Shifman S....Darvasi A. (Hum. Genet. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. Cloning of SEZ-12 encoding seizure-related and membrane-bound adhesion protein. (PubMed id 8630060)1, 3 Kajiwara K....Sugaya E. (Biochem. Biophys. Res. Commun. 1996)
    8. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    9. Cloning of a balanced translocation breakpoint in the DiGeorge syndrome critical region and isolation of a novel potential adhesion receptor gene in its vicinity. (PubMed id 7633403)1, 2 Demczuk S.... Aurias A. (Hum. Mol. Genet. 1995)
    10. Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates. (PubMed id 22465717)1 Lindskog C....Danielsson A. (J Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9993 HGNC: 2845 AceView: DGCR2 Ensembl:ENSG00000070413 euGenes: HUgn9993
    ECgene: DGCR2 H-InvDB: DGCR2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0163

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DGCR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DGCR2 gene:
    Search GeneIP for patents involving DGCR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DGCR2  
     OriGene qPCR primer pairs and template standards for DGCR2   OriGene Protein Over-expression Lysate for DGCR2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DGCR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for DGCR2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DGCR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DGCR2   OriGene Custom Protein Services for DGCR2  

     
     
     Block miRNA regulation of human, mouse, rat DGCR2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DGCR2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DGCR2 Predesigned siRNA for gene silencing in human, mouse, rat DGCR2
     QuantiFast Probe-based Assays in human, mouse, rat DGCR2 QuantiTect SYBR Green Assays in human, mouse, rat DGCR2
     Custom PCR Arrays for DGCR2 Search Chromatin IP Primers for DGCR2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DGCR2  Search GeneGlobe Interaction Network for DGCR2
     Regulatory tfbs in DGCR2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DGCR2 GenScript cDNA clones with any tag delivered in your preferred vector for DGCR2
     GenScript Custom Assay Services for DGCR2 GenScript Custom overexpressing Cell Line Services for DGCR2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DGCR2 (IDD)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DGCR2 antibodies
     DGCR2 proteins
     DGCR2 lysates
     Antibodies for DGCR2
     See all of Abcam's Antibodies, Kits and Proteins for DGCR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DGCR2
     Antibodies for DGCR2
     ELISAs for DGCR2
     CLIAs for DGCR2



     Browse ESI BIO Cell Lines and PureStem Progenitors for DGCR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGCR2
     SwitchGear 3'UTR luciferase reporter plasmids for DGCR2
     SwitchGear Promoter luciferase reporter plasmids for DGCR2
     ThermoFisher Antibodies for DGCR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGCR2
     Browse compounds at ApexBio
     Search Addgene for plasmids for DGCR2
      Search eBioscience for proteins for DGCR2
      Search eBioscience for elisas for DGCR2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DGCR2
     antibodies-online antibodies for DGCR2 (34 products)
     antibodies-online kits for DGCR2 (4 products)
     antibodies-online peptides for DGCR2
     antibodies-online proteins for DGCR2 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DGCR2 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4