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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGAT2L7P Gene

protein-coding   GIFtS: 23
GCID: GC07M100852          (predicted)

diacylglycerol O-acyltransferase 2-like 7, pseudogene

  Search for DGAT2L7P
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Diacylglycerol O-Acyltransferase 2-Like 7, Pseudogene1 2     Putative Diacylglycerol O-Acyltransferase 2-Like Protein 72
Diacylglycerol O-Acyltransferase 2-Like 7 Pseudogene2 3     Putative Diacylglycerol O-Acyltransferase 2-Like Protein DGAT2L7P2
DGAT2L72     EC 2.3.1.-3
Diacylglycerol O-Acyltransferase 2 Like Protein 72     

External Ids:    HGNC: 443671   Entrez Gene: 6464092   Ensembl: ENSG000002052677   UniProtKB: Q6IED93   

Export aliases for DGAT2L7P gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DG2L7_HUMAN, Q6IED9
Function: Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DGAT2L7P
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DGAT2L7P

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGAT2L7P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

DGAT2L7P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGAT2L7P gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100852:  view genomic region     (about GC identifiers)

Start:
100,845,043 bp from pter      End:
100,846,804 bp from pter
Size:
1,762 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,203,430-100,205,191     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DG2L7_HUMAN, Q6IED9 (See protein sequence)
Recommended Name: Putative diacylglycerol O-acyltransferase 2-like protein DGAT2L7P precursor  
Size: 249 amino acids; 27571 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for DGAT2L7P: NX_Q6IED9

DGAT2L7P Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000368732  

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DGAT2L7P for domains           About GeneDecksing

1 InterPro domain/family:
 IPR007130 DAGAT

Graphical View of Domain Structure for InterPro Entry Q6IED9

ProtoNet protein and cluster: Q6IED9

UniProtKB/Swiss-Prot: DG2L7_HUMAN, Q6IED9
Similarity: Belongs to the diacylglycerol acyltransferase family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: DG2L7_HUMAN, Q6IED9
Function: Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity)

Enzyme Number (IUBMB): EC 2.3.1.-1

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups IEA--


DGAT2L7P for ontologies           About GeneDecksing



(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGAT2L7P

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5 Interacting proteins for DGAT2L7P (Q6IED93 ENSP000003687324) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
GABARAPO951663I2D: score=1 
GABARAPL1Q9H0R83I2D: score=1 
MAP1LC3AQ9H4923I2D: score=1 
--Q6FG913I2D: score=1 
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006629lipid metabolic process IEA--
GO:0008610lipid biosynthetic process ----


DGAT2L7P for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DGAT2L7P
Search CenterWatch for drugs/clinical trials and news about DGAT2L7P / DG2L7 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000379421

miRNA
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Inhib. RNA
Products:
     
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

See DGAT2L7P Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for DGAT2L7P
Primer
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGAT2L7P gene from 5/16 species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
zebrafish
(Danio rerio)
Actinopterygii mogat3a6
monoacylglycerol O-acyltransferase 3a
36(a)
1 ↔ 1
23(45618635-45625827)
fruit fly
(Drosophila melanogaster)
Insecta CG19426
CG19466
(see all 3)
--
18(a)
17(a)
(see all 3)
possible ortholog
possible ortholog
(see all 3)
2R(3600128-3601695)
2R(3602445-3604286)
worm
(Caenorhabditis elegans)
Secernentea Y53G8B.26
F59A1.106
(see all 4)
Protein F59A1.10
(see all 4)
24(a)
22(a)
(see all 4)
possible ortholog
possible ortholog
(see all 4)
III(3101222-3103949)
V(17660278-17661785)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G515206
diacylglycerol O-acyltransferase 2
16(a)
possible ortholog
3(19110596-19112760)
rice
(Oryza sativa)
Liliopsida --
--
diacylglycerol O-acyltransferase, putative, expres...
diacylglycerol O-acyltransferase, putative, expres...
13(a)
12(a)
possible ortholog
possible ortholog
2(29593105-29595977)
6(12808567-12811496)


ENSEMBL Gene Tree for DGAT2L7P (if available)
TreeFam Gene Tree for DGAT2L7P (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for DGAT2L7P gene
MOGAT32  MOGAT12  DGAT22  DGAT2L62  AWAT22  AWAT12  MOGAT22  
2 SIMAP similar genes for DGAT2L7P using alignment to 2 protein entries:     DG2L7_HUMAN (see all proteins):
MOGAT2    MOGAT1

DGAT2L7P for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/45 NCBI SNPs in DGAT2L7P are shown (see all 45    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs734084511,2
C,--100203438(+) CCCAGC/TGGACA 2 T A mis15Minor allele frequency- T:0.23WA CSA NA EA 361
rs1134355741,2
C,--100203920(+) CTGCAC/TCCACG 2 M V mis12Minor allele frequency- T:0.07CSA WA 120
rs1148602251,2
C,F,--100204806(+) TGTGGC/TGGGAG 2 P syn11Minor allele frequency- T:0.03WA 118
rs1156968591,2
C,F,--100204871(+) TCCCAC/TGACCA 2 M V mis11Minor allele frequency- T:0.04WA 118
rs102463011,2
C,F,H,--100204929(+) AACTTT/CGCAGT 2 /A syn16Minor allele frequency- C:0.03NS EA CSA WA 538
rs562453941,2
C--100205332(+) GGGAGC/TTGCAG 1 -- us2k10--------
rs561967361,2
C--100205775(+) GCTGAC/TCAGCC 1 -- us2k10--------
rs595495941,2
--100205906(+) AGCACA/GGCCCT 1 -- us2k10--------
rs556334401,2
C--100206224(+) CCTCTA/GTGGGT 1 -- us2k10--------
rs286219211,2
--100206274(+) GACGAT/AGTCTT 1 -- us2k11Minor allele frequency- A:0.50CSA 2

HapMap Linkage Disequilibrium report for DGAT2L7P (100845043 - 100846804 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for DGAT2L7P: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for DGAT2L7P gene integrated from 9 sources:
(articles sorted by number of sources associating them with DGAT2L7P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677)1, 2, 3 Winter A....Fries R. (2003)
  2. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 646409 HGNC: 44367 Ensembl:ENSG00000205267 euGenes: HUgn646409 ECgene: DGAT2L7P
H-InvDB: DGAT2L7P

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for DGAT2L7P gene:
Search GeneIP for patents involving DGAT2L7P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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