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Aliases for DGAT2L6 Gene

Aliases for DGAT2L6 Gene

  • Diacylglycerol O-Acyltransferase 2-Like 6 2 3
  • Diacylglycerol O-Acyltransferase Candidate 3 3 4
  • DC3 3 4
  • Diacylglycerol O-Acyltransferase 2-Like Protein 6 3
  • EC 2.3.1.- 4
  • HDC3 4

External Ids for DGAT2L6 Gene

Previous GeneCards Identifiers for DGAT2L6 Gene

  • GC0XP069181
  • GC0XP069314
  • GC0XP069397
  • GC0XP063218

Summaries for DGAT2L6 Gene

Entrez Gene Summary for DGAT2L6 Gene

  • This gene is a member of the diacylglycerol acyltransferase 2 family. The encoded protein is a putative acyltransferase and is most likely involved in the synthesis of di- or triacylglycerol, however its substrate specificity is currently unknown. [provided by RefSeq, Feb 2015]

GeneCards Summary for DGAT2L6 Gene

DGAT2L6 (Diacylglycerol O-Acyltransferase 2-Like 6) is a Protein Coding gene. Diseases associated with DGAT2L6 include tropical sprue. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for DGAT2L6 Gene

  • Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to produce wax esters.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGAT2L6 Gene

Genomics for DGAT2L6 Gene

Regulatory Elements for DGAT2L6 Gene

Genomic Location for DGAT2L6 Gene

Start:
70,177,483 bp from pter
End:
70,205,703 bp from pter
Size:
28,221 bases
Orientation:
Plus strand

Genomic View for DGAT2L6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGAT2L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGAT2L6 Gene

Proteins for DGAT2L6 Gene

  • Protein details for DGAT2L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZPD8-DG2L6_HUMAN
    Recommended name:
    Diacylglycerol O-acyltransferase 2-like protein 6
    Protein Accession:
    Q6ZPD8
    Secondary Accessions:
    • Q6IEE2

    Protein attributes for DGAT2L6 Gene

    Size:
    337 amino acids
    Molecular mass:
    38593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DGAT2L6 Gene

Proteomics data for DGAT2L6 Gene at MOPED

Post-translational modifications for DGAT2L6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGAT2L6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DGAT2L6 Gene

Domains for DGAT2L6 Gene

Protein Domains for DGAT2L6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DGAT2L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZPD8

UniProtKB/Swiss-Prot:

DG2L6_HUMAN :
  • Q6ZPD8
Family:
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with DGAT2L6: view

No data available for Gene Families for DGAT2L6 Gene

Function for DGAT2L6 Gene

Molecular function for DGAT2L6 Gene

UniProtKB/Swiss-Prot Function: Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to produce wax esters.

Enzyme Numbers (IUBMB) for DGAT2L6 Gene

Gene Ontology (GO) - Molecular Function for DGAT2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA --
genes like me logo Genes that share ontologies with DGAT2L6: view

Phenotypes for DGAT2L6 Gene

GenomeRNAi human phenotypes for DGAT2L6:
genes like me logo Genes that share phenotypes with DGAT2L6: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DGAT2L6 Gene

Localization for DGAT2L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGAT2L6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGAT2L6 Gene COMPARTMENTS Subcellular localization image for DGAT2L6 gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DGAT2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DGAT2L6: view

Pathways for DGAT2L6 Gene

SuperPathways for DGAT2L6 Gene

No Data Available

Interacting Proteins for DGAT2L6 Gene

Gene Ontology (GO) - Biological Process for DGAT2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with DGAT2L6: view

No data available for Pathways by source for DGAT2L6 Gene

Compounds for DGAT2L6 Gene

(875) HMDB Compounds for DGAT2L6 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with DGAT2L6: view

Transcripts for DGAT2L6 Gene

mRNA/cDNA for DGAT2L6 Gene

(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DGAT2L6 Gene

Diacylglycerol O-acyltransferase 2-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGAT2L6 Gene

No ASD Table

Relevant External Links for DGAT2L6 Gene

GeneLoc Exon Structure for
DGAT2L6
ECgene alternative splicing isoforms for
DGAT2L6

Expression for DGAT2L6 Gene

mRNA expression in normal human tissues for DGAT2L6 Gene

mRNA differential expression in normal tissues according to GTEx for DGAT2L6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (33.3) and Skin - Sun Exposed (Lower leg) (14.6).

SOURCE GeneReport for Unigene cluster for DGAT2L6 Gene Hs.454355

mRNA Expression by UniProt/SwissProt for DGAT2L6 Gene

Q6ZPD8-DG2L6_HUMAN
Tissue specificity: Expressed in all tissues tested except pancreas.
genes like me logo Genes that share expressions with DGAT2L6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for DGAT2L6 Gene

Orthologs for DGAT2L6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DGAT2L6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGAT2L6 35
  • 99.4 (n)
  • 98.51 (a)
DGAT2L6 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DGAT2L6 35
  • 86.9 (n)
  • 81.55 (a)
DGAT2L6 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGAT2L6 35
  • 88 (n)
  • 86.9 (a)
DGAT2L6 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgat2l6 35
  • 79.66 (n)
  • 72.32 (a)
Dgat2l6 16
Dgat2l6 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DGAT2L6 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Dgat2l6 35
  • 80.65 (n)
  • 77.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1941 36
  • 35 (a)
ManyToMany
CG1942 36
  • 35 (a)
ManyToMany
CG1946 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dgat-2 36
  • 34 (a)
ManyToMany
dgtr-1 36
  • 35 (a)
ManyToMany
K07B1.4 36
  • 40 (a)
ManyToMany
Y53G8B.2 36
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for DGAT2L6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DGAT2L6 Gene

ENSEMBL:
Gene Tree for DGAT2L6 (if available)
TreeFam:
Gene Tree for DGAT2L6 (if available)

Paralogs for DGAT2L6 Gene

Paralogs for DGAT2L6 Gene

Selected SIMAP similar genes for DGAT2L6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DGAT2L6: view

Variants for DGAT2L6 Gene

Sequence variations from dbSNP and Humsavar for DGAT2L6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1152182 -- 70,203,871(-) GCCTC(A/G)TACTC intron-variant
rs1152183 -- 70,201,146(-) CTCCA(C/G)AGAAA intron-variant
rs1199502 -- 70,183,692(+) CCTTT(C/T)TGGGT intron-variant
rs1199503 -- 70,183,789(+) ATTTT(G/T)GGAGG intron-variant
rs1199504 -- 70,186,529(+) GGAAT(A/G)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGAT2L6 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv519741 CNV Gain 19592680
nsv520416 CNV Loss 19592680

Relevant External Links for DGAT2L6 Gene

HapMap Linkage Disequilibrium report
DGAT2L6
Human Gene Mutation Database (HGMD)
DGAT2L6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGAT2L6 Gene

Disorders for DGAT2L6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DGAT2L6 Gene including...

Search for DGAT2L6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DGAT2L6 Gene

genes like me logo Genes that share disorders with DGAT2L6: view

No data available for UniProtKB/Swiss-Prot for DGAT2L6 Gene

Publications for DGAT2L6 Gene

  1. Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. (PMID: 15671038) Turkish A.R. … Sturley S.L. (J. Biol. Chem. 2005) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 3 4
  5. Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT). (PMID: 20374941) Holmes R.S. (Comp. Biochem. Physiol. Part D Genomics Proteomics 2010) 3

Products for DGAT2L6 Gene

Sources for DGAT2L6 Gene

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