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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGAT2L6 Gene

protein-coding   GIFtS: 43
GCID: GC0XP069397

diacylglycerol O-acyltransferase 2-like 6
 Explore 2 diseases affiliated with
DGAT2L6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DGAT2L6    

Aliases
for DGAT2L6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Diacylglycerol O-Acyltransferase 2-Like 61 2     FLJ259891
DC31 2 3     Diacylglycerol O-Acyltransferase 2 Like 62
Diacylglycerol O-Acyltransferase Candidate 32 3     Diacylglycerol O-Acyltransferase 2-Like Protein 62
HDC31     EC 2.3.1.-3

External Ids:    HGNC: 232501   Entrez Gene: 3475162   Ensembl: ENSG000001842107   UniProtKB: Q6ZPD83   

Export aliases for DGAT2L6 gene to outside databases

Previous GC identifers: GC0XP069181 GC0XP069314 GC0XP063218


Summaries
for DGAT2L6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DG2L6_HUMAN, Q6ZPD8
Function: Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to
produce wax esters




Genomic Views
for DGAT2L6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011669.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DGAT2L6 gene promoter:
         c-Fos   C/EBPbeta   AP-1   JunB   FosB   Fra-1   C/EBPalpha   SRY   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DGAT2L6 promoter sequence
   Search SABiosciences Chromatin IP Primers for DGAT2L6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGAT2L6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

DGAT2L6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGAT2L6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP069397:  view genomic region     (about GC identifiers)

Start:
 69,397,333 bp from pter      End:
 69,425,553 bp from pter
Size:
 28,221 bases      Orientation:
 plus strand

Proteins
for DGAT2L6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DG2L6_HUMAN, Q6ZPD8 (See protein sequence)
Recommended Name: Diacylglycerol O-acyltransferase 2-like protein 6  
Size: 337 amino acids; 38593 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q6IEE2

Explore the universe of human proteins at neXtProt for DGAT2L6: NX_Q6ZPD8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZPD8

    • DGAT2L6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_940914.1  
    ENSEMBL proteins: 
     ENSP00000328036  

    Human Recombinant Protein Products: 
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    Uscn Proteins for DGAT2L6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    DGAT2L6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DGAT2L6

    Protein Domains /
    Families
    for DGAT2L6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DGAT2L6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007130 DAGAT

    Graphical View of Domain Structure for InterPro Entry Q6ZPD8

    ProtoNet protein and cluster: Q6ZPD8

    UniProtKB/Swiss-Prot: DG2L6_HUMAN, Q6ZPD8
    Similarity: Belongs to the diacylglycerol acyltransferase family


    Function
    for DGAT2L6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DG2L6_HUMAN, Q6ZPD8
    Function: Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to
    produce wax esters

    Enzyme Number (IUBMB): EC 2.3.1.-1

    miRNA
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    hsa-miR-299-5p hsa-miR-4261 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: DGAT2L6 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups IEA--


    DGAT2L6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DGAT2L6:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for DGAT2L6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGAT2L6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for DGAT2L6 (ENSP000003280364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process IEA--
    GO:0008610lipid biosynthetic process ----


    DGAT2L6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DGAT2L6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DGAT2L6

    10/875 HMDB Compounds for DGAT2L6 (see all 875)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Search CenterWatch for drugs/clinical trials and news about DGAT2L6 / DG2L6 

    Transcripts
    for DGAT2L6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DGAT2L6 gene: 
    NM_198512.1  

    Unigene Cluster for DGAT2L6:

    Diacylglycerol O-acyltransferase 2-like 6
    Hs.454355  [show with all ESTs]
    Unigene Representative Sequence: AK129500
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000333026(uc004dxx.1)

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    hsa-miR-299-5p hsa-miR-4261 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: DGAT2L6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DGAT2L6 (see all 7)
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DGAT2L6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGAT2L6

    Additional cDNA sequence: AK129500.1 

    1 DOTS entry:

    DT.95094689 

    5 AceView cDNA sequences:

    NM_198512 AK129500 BG696880 BG743707 BG739793 

    GeneLoc Exon Structure


    Expression
    for DGAT2L6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DGAT2L6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGATCCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DGAT2L6 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.454355

    UniProtKB/Swiss-Prot: DG2L6_HUMAN, Q6ZPD8
    Tissue specificity: Expressed in all tissues tested except pancreas

        SABiosciences Custom PCR Arrays for DGAT2L6
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    In Situ
    Assay Products:     
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    Orthologs
    for DGAT2L6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGAT2L6 gene from 4/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG19416
    CG19426
    (see all 3)    		 --
    		 35(a)
    34(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 2R(3597379-3599494)
    2R(3600128-3601695)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y53G8B.26
    K07B1.46
    (see all 4)    		 Protein K07B1.4, isoform a
    (see all 4)    		 39(a)
    39(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 III(3101222-3103949)
    V(9328946-9331496)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G515206
    		 diacylglycerol O-acyltransferase 2
    		 26(a)
    		 possible ortholog
    		 3(19110596-19112760)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 diacylglycerol O-acyltransferase, putative, expres...
    diacylglycerol O-acyltransferase, putative, expres...
    		 23(a)
    22(a)
    		 possible ortholog
    possible ortholog
    		 2(29593105-29595977)
    6(12808567-12811496)


    ENSEMBL Gene Tree for DGAT2L6 (if available)
    TreeFam Gene Tree for DGAT2L6 (if available) 

    Paralogs
    for DGAT2L6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DGAT2L6 gene
    MOGAT32  DGAT2L7P2  MOGAT12  DGAT22  AWAT22  AWAT12  MOGAT22  
    6 SIMAP similar genes for DGAT2L6 using alignment to 1 protein entry:     DG2L6_HUMAN:
    AWAT1    AWAT2    DGAT2    MOGAT3    MOGAT1    MOGAT2

    DGAT2L6 for paralogs           About GeneDecksing



    Genomic Variants
    for DGAT2L6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/361 NCBI SNPs in DGAT2L6 are shown (see all 361)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1852798321,2
    		--69395355(+) CTCCTC/GCCGTG 1 -- us2k10--------
    rs1390340741,2
    		--69395358(+) CTCCCA/GTGCAA 1 -- us2k10--------
    rs1138231991,2
    		C,--69395379(+) GATACA/GCTCTG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1885319641,2
    		--69395579(+) GTCACA/GTTGGT 1 -- us2k10--------
    rs1932361781,2
    		--69395672(+) GCCCCA/CTTGCA 1 -- us2k10--------
    rs1458165371,2
    		--69395696(+) TGATAC/TCATTT 1 -- us2k10--------
    rs1379107631,2
    		--69395763(+) ACCTTC/GTATAT 1 -- us2k10--------
    rs1494857801,2
    		--69395897(+) ATCTCA/GTTATG 1 -- us2k10--------
    rs1856557531,2
    		--69395943(+) AACCCC/TCCCGC 1 -- us2k10--------
    rs1893992851,2
    		--69396078(+) AATCAC/TGTCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DGAT2L6 (69397333 - 69425553 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DGAT2L6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DGAT2L6
    DNA2.0 Custom Variant and Variant Library Synthesis for DGAT2L6

    Disorders / Diseases
    for DGAT2L6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DGAT2L6 for disorders           About GeneDecksing

    2 diseases for DGAT2L6:    About MalaCards
    tropical sprue    alcoholism

    1 disease from the University of Copenhagen DISEASES database for DGAT2L6:
    Tropical sprue

    Export disorders for DGAT2L6 gene to outside databases

    Publications
    for DGAT2L6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DGAT2L6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DGAT2L6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. (PubMed id 15671038)1, 2, 3 Turkish A.R.... Sturley S.L. (2005)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677)1, 2 Winter A....Fries R. (2003)
    5. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)6 Kurz M....Kramer W. (2003)

    External Searches for DGAT2L6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DGAT2L6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 347516 HGNC: 23250 AceView: FLJ25989 Ensembl:ENSG00000184210 euGenes: HUgn347516
    ECgene: DGAT2L6 H-InvDB: DGAT2L6

    Other Databases showing DGAT2L6 gene

    (According to HUGE)
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    		   --

    Specialized Databases showing DGAT2L6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DGAT2L6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DGAT2L6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DGAT2L6 gene:
    Search GeneIP for patents involving DGAT2L6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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