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Aliases for DGAT2L6 Gene

Aliases for DGAT2L6 Gene

  • Diacylglycerol O-Acyltransferase 2 Like 6 2 3
  • Diacylglycerol O-Acyltransferase Candidate 3 3 4
  • Diacylglycerol O-Acyltransferase 2-Like 6 3 5
  • DC3 3 4
  • EC 2.3.1.- 4
  • HDC3 4

External Ids for DGAT2L6 Gene

Previous GeneCards Identifiers for DGAT2L6 Gene

  • GC0XP069181
  • GC0XP069314
  • GC0XP069397
  • GC0XP063218

Summaries for DGAT2L6 Gene

Entrez Gene Summary for DGAT2L6 Gene

  • This gene is a member of the diacylglycerol acyltransferase 2 family. The encoded protein is a putative acyltransferase and is most likely involved in the synthesis of di- or triacylglycerol, however its substrate specificity is currently unknown. [provided by RefSeq, Feb 2015]

GeneCards Summary for DGAT2L6 Gene

DGAT2L6 (Diacylglycerol O-Acyltransferase 2 Like 6) is a Protein Coding gene. Diseases associated with DGAT2L6 include Tropical Sprue. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for DGAT2L6 Gene

  • Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to produce wax esters.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGAT2L6 Gene

Genomics for DGAT2L6 Gene

Regulatory Elements for DGAT2L6 Gene

Enhancers for DGAT2L6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DGAT2L6 on UCSC Golden Path with GeneCards custom track

Genomic Location for DGAT2L6 Gene

70,177,483 bp from pter
70,205,705 bp from pter
28,223 bases
Plus strand

Genomic View for DGAT2L6 Gene

Genes around DGAT2L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGAT2L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGAT2L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGAT2L6 Gene

Proteins for DGAT2L6 Gene

  • Protein details for DGAT2L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Diacylglycerol O-acyltransferase 2-like protein 6
    Protein Accession:
    Secondary Accessions:
    • Q6IEE2

    Protein attributes for DGAT2L6 Gene

    337 amino acids
    Molecular mass:
    38593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DGAT2L6 Gene

Proteomics data for DGAT2L6 Gene at MOPED

Post-translational modifications for DGAT2L6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGAT2L6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DGAT2L6 Gene

Domains & Families for DGAT2L6 Gene

Gene Families for DGAT2L6 Gene

Protein Domains for DGAT2L6 Gene


Suggested Antigen Peptide Sequences for DGAT2L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the diacylglycerol acyltransferase family.
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with DGAT2L6: view

Function for DGAT2L6 Gene

Molecular function for DGAT2L6 Gene

UniProtKB/Swiss-Prot Function:
Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to produce wax esters.

Enzyme Numbers (IUBMB) for DGAT2L6 Gene

genes like me logo Genes that share phenotypes with DGAT2L6: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DGAT2L6 Gene

Localization for DGAT2L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGAT2L6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DGAT2L6 Gene COMPARTMENTS Subcellular localization image for DGAT2L6 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for DGAT2L6 Gene

Pathways & Interactions for DGAT2L6 Gene

genes like me logo Genes that share pathways with DGAT2L6: view

Interacting Proteins for DGAT2L6 Gene

Gene Ontology (GO) - Biological Process for DGAT2L6 Gene


No data available for SIGNOR curated interactions for DGAT2L6 Gene

Drugs & Compounds for DGAT2L6 Gene

(1) Drugs for DGAT2L6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(35) Additional Compounds for DGAT2L6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with DGAT2L6: view

Transcripts for DGAT2L6 Gene

mRNA/cDNA for DGAT2L6 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DGAT2L6 Gene

Diacylglycerol O-acyltransferase 2-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGAT2L6 Gene

No ASD Table

Relevant External Links for DGAT2L6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGAT2L6 Gene

mRNA expression in normal human tissues for DGAT2L6 Gene

mRNA differential expression in normal tissues according to GTEx for DGAT2L6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x33.3) and Skin - Sun Exposed (Lower leg) (x14.6).

SOURCE GeneReport for Unigene cluster for DGAT2L6 Gene Hs.454355

mRNA Expression by UniProt/SwissProt for DGAT2L6 Gene

Tissue specificity: Expressed in all tissues tested except pancreas.
genes like me logo Genes that share expression patterns with DGAT2L6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DGAT2L6 Gene

Orthologs for DGAT2L6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DGAT2L6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DGAT2L6 35
  • 86.9 (n)
  • 81.55 (a)
DGAT2L6 36
  • 81 (a)
(Canis familiaris)
Mammalia DGAT2L6 35
  • 88 (n)
  • 86.9 (a)
DGAT2L6 36
  • 87 (a)
(Mus musculus)
Mammalia Dgat2l6 35
  • 79.66 (n)
  • 72.32 (a)
Dgat2l6 16
Dgat2l6 36
  • 72 (a)
(Pan troglodytes)
Mammalia DGAT2L6 35
  • 99.4 (n)
  • 98.51 (a)
DGAT2L6 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dgat2l6 35
  • 80.65 (n)
  • 77.68 (a)
(Monodelphis domestica)
Mammalia DGAT2L6 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1941 36
  • 35 (a)
CG1942 36
  • 35 (a)
CG1946 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea dgat-2 36
  • 34 (a)
dgtr-1 36
  • 35 (a)
K07B1.4 36
  • 40 (a)
Y53G8B.2 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for DGAT2L6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DGAT2L6 Gene

Gene Tree for DGAT2L6 (if available)
Gene Tree for DGAT2L6 (if available)

Paralogs for DGAT2L6 Gene

Paralogs for DGAT2L6 Gene

(6) SIMAP similar genes for DGAT2L6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DGAT2L6: view

Variants for DGAT2L6 Gene

Sequence variations from dbSNP and Humsavar for DGAT2L6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747678692 -- 70,178,841(+) TACCT(A/G)TGAGT intron-variant
rs747704684 -- 70,200,783(+) AATCC(A/G)GGGAA intron-variant
rs747756799 -- 70,200,579(+) ACACC(C/G)TGGGC intron-variant
rs747805188 -- 70,184,466(+) CTTTC(-/T)TTTTT intron-variant
rs747825132 -- 70,179,557(+) TCTGA(G/T)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGAT2L6 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv519741 CNV Gain 19592680
nsv520416 CNV Loss 19592680

Variation tolerance for DGAT2L6 Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGAT2L6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGAT2L6 Gene

Disorders for DGAT2L6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DGAT2L6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tropical sprue
  • sprue - tropical
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DGAT2L6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DGAT2L6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGAT2L6 Gene

Publications for DGAT2L6 Gene

  1. Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. (PMID: 15671038) Turkish A.R. … Sturley S.L. (J. Biol. Chem. 2005) 2 3 4 67
  2. Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT). (PMID: 20374941) Holmes R.S. (Comp. Biochem. Physiol. Part D Genomics Proteomics 2010) 3
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 3

Products for DGAT2L6 Gene

Sources for DGAT2L6 Gene