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DGAT2 Gene(Protein Coding)

Diacylglycerol O-Acyltransferase 2

GCID:
GC11P075759
GIFtS:
62
Genes Participants
UDN Logo

Aliases for DGAT2 Gene

Aliases for DGAT2 Gene

  • Diacylglycerol O-Acyltransferase 2 2 3 5
  • Acyl-CoA Retinol O-Fatty-Acyltransferase 3 4
  • Diglyceride Acyltransferase 2 3 4
  • EC 2.3.1.20 4 63
  • ARAT 3 4
  • Diacylglycerol O-Acyltransferase Homolog 2 (Mouse) 2
  • Diacylglycerol O-Acyltransferase-Like Protein 2 3
  • Diacylglycerol O-Acyltransferase Homolog 2 3
  • Retinol O-Fatty-Acyltransferase 4
  • EC 2.3.1.76 4
  • GS1999FULL 3
  • HMFN1045 3
  • EC 2.3.1 63

External Ids for DGAT2 Gene

Previous GeneCards Identifiers for DGAT2 Gene

  • GC11P077806
  • GC11P077018
  • GC11P075693
  • GC11P075206
  • GC11P075157
  • GC11P075479
  • GC11P071776

Summaries for DGAT2 Gene

Entrez Gene Summary for DGAT2 Gene

  • This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for DGAT2 Gene

DGAT2 (Diacylglycerol O-Acyltransferase 2) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and triacylglycerol biosynthesis. GO annotations related to this gene include protein homodimerization activity and 2-acylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for DGAT2 Gene

  • Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).

Tocris Summary for DGAT2 Gene

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGAT2 Gene

Genomics for DGAT2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DGAT2 Gene

Enhancers for DGAT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DGAT2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DGAT2 gene promoter:

Genomic Location for DGAT2 Gene

Chromosome:
11
Start:
75,759,512 bp from pter
End:
75,801,536 bp from pter
Size:
42,025 bases
Orientation:
Plus strand

Genomic View for DGAT2 Gene

Genes around DGAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGAT2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DGAT2 Gene

Proteins for DGAT2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DGAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PD7-DGAT2_HUMAN
    Recommended name:
    Diacylglycerol O-acyltransferase 2
    Protein Accession:
    Q96PD7
    Secondary Accessions:
    • A6ND76
    • Q5U810
    • Q68CL3
    • Q68DJ0
    • Q8NDB7
    • Q96BS0
    • Q9BYE5

    Protein attributes for DGAT2 Gene

    Size:
    388 amino acids
    Molecular mass:
    43831 Da
    Quaternary structure:
    • Forms multimeric complexes consisting of several DGAT2 subunits.
    SequenceCaution:
    • Sequence=BAD38635.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38961.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DGAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGAT2 Gene

Proteomics data for DGAT2 Gene at MOPED

Protein Expression for DGAT2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for DGAT2 Gene

Q96PD7:

Post-translational modifications for DGAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for DGAT2 Gene

Gene Families for DGAT2 Gene

HGNC:

Protein Domains for DGAT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DGAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PD7

UniProtKB/Swiss-Prot:

DGAT2_HUMAN :
  • Belongs to the diacylglycerol acyltransferase family.
Family:
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with DGAT2: view

Function for DGAT2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DGAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + retinol = CoA + retinyl ester.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by niacin.
UniProtKB/Swiss-Prot Function:
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).

Enzyme Numbers (IUBMB) for DGAT2 Gene

Gene Ontology (GO) - Molecular Function for DGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004144 diacylglycerol O-acyltransferase activity IDA,TAS --
genes like me logo Genes that share ontologies with DGAT2: view

Phenotypes for DGAT2 Gene

MGI mutant phenotypes for DGAT2:
inferred from 2 alleles
GenomeRNAi human phenotypes for DGAT2:
genes like me logo Genes that share phenotypes with DGAT2: view

Animal Models for DGAT2 Gene

MGI Knock Outs for DGAT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for DGAT2

miRNA for DGAT2 Gene

miRTarBase miRNAs that target DGAT2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGAT2 Gene

Localization for DGAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGAT2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGAT2 Gene COMPARTMENTS Subcellular localization image for DGAT2 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 4
cytosol 2
extracellular 2
peroxisome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DGAT2: view

Pathways & Interactions for DGAT2 Gene

genes like me logo Genes that share pathways with DGAT2: view

UniProtKB/Swiss-Prot Q96PD7-DGAT2_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.

Interacting Proteins for DGAT2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000228027%0d%0a9606.ENSP00000223114%0d%0a9606.ENSP00000198801%0d%0a9606.ENSP00000216180%0d%0a9606.ENSP00000412178%0d%0a9606.ENSP00000273814%0d%0a
Selected Interacting proteins: ENSP00000228027 for DGAT2 Gene via STRING

Gene Ontology (GO) - Biological Process for DGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0008152 metabolic process IEA --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0019915 lipid storage ISS --
GO:0034383 low-density lipoprotein particle clearance ISS --
genes like me logo Genes that share ontologies with DGAT2: view

No data available for SIGNOR curated interactions for DGAT2 Gene

Drugs & Compounds for DGAT2 Gene

Products:

  1. Drug

(5) Drugs for DGAT2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved Nutra 438
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(42) Additional Compounds for DGAT2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
 10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
 1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
 4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
 10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
 38795-33-4
genes like me logo Genes that share compounds with DGAT2: view

Transcripts for DGAT2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DGAT2 Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(183) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DGAT2 Gene

Diacylglycerol O-acyltransferase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGAT2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - - - - -
SP5:
SP6:

Relevant External Links for DGAT2 Gene

GeneLoc Exon Structure for
DGAT2
ECgene alternative splicing isoforms for
DGAT2

Expression for DGAT2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for DGAT2 Gene

mRNA expression in normal human tissues for DGAT2 Gene
mRNA expression by BioGPS for DGAT2 GenemRNA expression by GTEx for DGAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGAT2 Gene

This gene is overexpressed in Whole Blood (x12.3), Adipose - Visceral (Omentum) (x8.6), Liver (x5.2), Adipose - Subcutaneous (x4.9), Breast - Mammary Tissue (x4.4), and Skin - Sun Exposed (Lower leg) (x4.3).

Protein differential expression in normal tissues from HIPED for DGAT2 Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DGAT2 Gene



SOURCE GeneReport for Unigene cluster for DGAT2 Gene Hs.129798

mRNA Expression by UniProt/SwissProt for DGAT2 Gene

Q96PD7-DGAT2_HUMAN
Tissue specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.
genes like me logo Genes that share expression patterns with DGAT2: view

Protein tissue co-expression partners for DGAT2 Gene

Primer Products

Orthologs for DGAT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DGAT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia DGAT2 35
  • 92.43 (n)
  • 96.95 (a)
DGAT2 36
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia DGAT2 35
  • 90.56 (n)
  • 95.28 (a)
DGAT2 36
  • 95 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dgat2 35
  • 89.69 (n)
  • 95.1 (a)
Dgat2 16
Dgat2 36
  • 95 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia DGAT2 35
  • 99.66 (n)
  • 100 (a)
DGAT2 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Dgat2 35
  • 90.29 (n)
  • 94.85 (a)
oppossum
(Monodelphis domestica)
 Mammalia DGAT2 36
  • 93 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 75 (a)
 OneToMany
-- 36
  • 88 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves DGAT2 35
  • 79.24 (n)
  • 86.31 (a)
DGAT2 36
  • 86 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DGAT2 36
  • 82 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dgat2 35
  • 73.06 (n)
  • 77.5 (a)
MGC76066 35
African clawed frog
(Xenopus laevis)
 Amphibia MGC68683 35
zebrafish
(Danio rerio)
 Actinopterygii dgat2 35
  • 69.07 (n)
  • 69.25 (a)
dgat2 36
  • 68 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG1941 37
  • 39 (a)
CG1942 37
  • 38 (a)
CG1946 37
  • 34 (a)
worm
(Caenorhabditis elegans)
 Secernentea F59A1.10 37
  • 44 (a)
W01A11.2 37
  • 45 (a)
Y53G8B.2 37
  • 47 (a)
Species with no ortholog for DGAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGAT2 Gene

ENSEMBL:
Gene Tree for DGAT2 (if available)
TreeFam:
Gene Tree for DGAT2 (if available)

Paralogs for DGAT2 Gene

Paralogs for DGAT2 Gene

(6) SIMAP similar genes for DGAT2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DGAT2: view

Variants for DGAT2 Gene

Sequence variations from dbSNP and Humsavar for DGAT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs34421064 - 75,798,366(+) ATGGT(C/G/T)GAGGC reference, missense, stop-gained
VAR_033865 -
rs1010716 -- 75,778,284(+) AGTGC(A/G)CACTT intron-variant
rs1017713 -- 75,788,407(-) ATCGC(A/G)GAAGG intron-variant
rs1944438 -- 75,772,578(-) CTAGA(C/T)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGAT2 Gene

Variant ID Type Subtype PubMed ID
nsv897924 CNV Gain 21882294
nsv897925 CNV Gain 21882294

Variation tolerance for DGAT2 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DGAT2 Gene

Disorders for DGAT2 Gene

Relevant External Links for DGAT2

Genetic Association Database (GAD)
DGAT2
Human Genome Epidemiology (HuGE) Navigator
DGAT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGAT2

No disorders were found for DGAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGAT2 Gene

Publications for DGAT2 Gene

  1. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PMID: 11481335) Cases S. … Farese R.V. Jr. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. (PMID: 18757836) Yen C.L. … Farese R.V. (J. Lipid Res. 2008) 3 23
  3. Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. (PMID: 17477860) Friedel S. … Hebebrand J. (BMC Genet. 2007) 3 23
  4. Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. (PMID: 15258194) Ganji S.H. … Kashyap M.L. (J. Lipid Res. 2004) 3 23
  5. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3

Products for DGAT2 Gene

Sources for DGAT2 Gene

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