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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DGAT2 Gene

protein-coding GIFtS: 59
GCID: GC11P075479

diacylglycerol O-acyltransferase 2

(Previous name: diacylglycerol O-acyltransferase homolog 2 (mouse) )

Explore 7 diseases affiliated with
DGAT2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Diacylglycerol O-Acyltransferase 2¹ ²		Diacylglycerol O-Acyltransferase Homolog 2 (Mouse)¹
Acyl-CoA Retinol O-Fatty-Acyltransferase² ³		GS1999FULL²
Diglyceride Acyltransferase 2² ³		Diacylglycerol O-Acyltransferase Homolog 2²
Retinol O-Fatty-Acyltransferase² ³		Diacylglycerol O-Acyltransferase-Like Protein 2²
ARAT² ³		EC 2.3.1.76³
EC 2.3.1.20³ ⁸		EC 2.3.1⁸

External Ids:	HGNC: 16940¹	Entrez Gene: 84649²	Ensembl: ENSG00000062282⁷	OMIM: 606983⁵	UniProtKB: Q96PD7³

Export aliases for DGAT2 gene to outside databases

Previous GC identifers: GC11P077806 GC11P077018 GC11P075693 GC11P075206 GC11P075157 GC11P071776

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGAT2:

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which

diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low

concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium

chloride. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,

Dec 2011)

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by

using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular

triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for

incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA

retinol acyltransferase (ARAT)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DGAT2 gene promoter:
C/EBPbeta PPAR-gamma1 GATA-6 E2F-1 E2F HOXA5 PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DGAT2 promoter sequence

Search SABiosciences Chromatin IP Primers for DGAT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGAT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.3

DGAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGAT2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P075479: view genomic region (about GC identifiers)

Start:	75,479,778 bp from pter	End:	75,512,579 bp from pter
Size:	32,802 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7 (See protein sequence)

Recommended Name: Diacylglycerol O-acyltransferase 2

Size: 388 amino acids; 43831 Da

Subunit: Forms multimeric complexes consisting of several DGAT2 subunits (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet (By similarity)

Sequence caution: Sequence=BAD38635.1; Type=Erroneous initiation; Sequence=CAD38961.1; Type=Erroneous initiation;

Secondary accessions: A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5

Alternative splicing: 2 isoforms: Q96PD7-1 Q96PD7-2

Explore the universe of human proteins at neXtProt for DGAT2: NX_Q96PD7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96PD7

4/9 DME Specific Peptides for DGAT2 (Q96PD7) (see all 9)

GGAAESL

PITTVVG

QKKFQKY

VSKKFPGI

DGAT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001240820.1 NP_115953.2

ENSEMBL proteins:

ENSP00000228027 ENSP00000365438

Reactome Protein details: Q96PD7
Human Recombinant Protein Products:

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	Uscn Proteins for DGAT2

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	colocalizes with mitochondrion	ISS	--
GO:0005783	endoplasmic reticulum	IDA	14521909
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0005811	colocalizes with lipid particle	ISS	--

DGAT2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DGAT2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DGAT2 for domains About GeneDecksing

1 InterPro domain/family:

IPR007130 DAGAT

Graphical View of Domain Structure for InterPro Entry Q96PD7

ProtoNet protein and cluster: Q96PD7

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Similarity: Belongs to the diacylglycerol acyltransferase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by

using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular

triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for

incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA

retinol acyltransferase (ARAT)

Catalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol

Catalytic activity: Acyl-CoA + retinol = CoA + retinyl ester

Enzyme regulation: Inhibited by niacin (By similarity)

Enzyme Numbers (IUBMB): EC 2.3.1.20¹ ² EC 2.3.1² EC 2.3.1.76¹

miRNA Products:		OriGene 3'-UTR Clone: DGAT2 Browse MicroRNA Expression Plasmids
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		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DGAT2 (see all 11):
		hsa-miR-299-5p hsa-miR-374b hsa-miR-1179 hsa-miR-374a hsa-miR-4316 hsa-miR-1273d hsa-miR-124 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: DGAT2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGAT2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003846	2-acylglycerol O-acyltransferase activity	IEA	--
GO:0004144	diacylglycerol O-acyltransferase activity	IDA	11481335
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	--	--
GO:0042803	protein homodimerization activity	ISS	--
GO:0050252	retinol O-fatty-acyltransferase activity	IEA	--

DGAT2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DGAT2:

Decreased viability of wild-ty

Animal Models:
Mouse knock-outs for DGAT2: Dgat2^tm1Lex Dgat2^tm1Far Dgat2^tm2Lex
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dgat2):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	integument
limbs/digits/tail	mortality/aging

DGAT2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Glycerophospholipid biosynthesis

Glycerophospholipid biosynthesis

1.00

Phospholipid metabolism

0.64

CDP-diacylglycerol biosynthesis I

triacylglycerol biosynthesis

0.50

Triacylglyceride Synthesis

0.17

Acyl chain remodeling of DAG and TAG

Acyl chain remodeling of DAG and TAG

1.00

Glycerolipid metabolism

Glycerolipid metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for DGAT2

	Triacylglyceride Synthesis
	triacylglycerol biosynthesis

5/7 Reactome Pathways for DGAT2 (see all 7)

	Glycerophospholipid biosynthesis
	Metabolism
	Phospholipid metabolism
	Triglyceride Biosynthesis
	Acyl chain remodeling of DAG and TAG

3 Kegg Pathways (Kegg details for DGAT2):

	Glycerolipid metabolism
	Metabolic pathways
	Fat digestion and absorption

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis

DGAT2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DGAT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for DGAT2 (ENSP00000228027⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEL	ENSP00000361151⁴	STRING: ENSP00000361151
DGKZ	ENSP00000320340⁴	STRING: ENSP00000320340
LIPC	ENSP00000299022⁴	STRING: ENSP00000299022
LIPG	ENSP00000261292⁴	STRING: ENSP00000261292
LPIN1	ENSP00000256720⁴	STRING: ENSP00000256720

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006071	glycerol metabolic process	IEA	--
GO:0006644	phospholipid metabolic process	TAS	--
GO:0019432	triglyceride biosynthetic process	TAS	--
GO:0019915	lipid storage	ISS	--
GO:0034383	low-density lipoprotein particle clearance	ISS	--

DGAT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DGAT2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DGAT2

10/1165 HMDB Compounds for DGAT2 (see all 1165) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--

4 Novoseek chemical compound relationships for DGAT2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
triacylglycerol	75.9	7	18331995 (1)
niacin	62.5	7	15258194 (5), 18047854 (2)
lipid	15.2	3	20105310 (1), 20374941 (1)
cholesterol	5.46	1	20227438 (1)

Search CenterWatch for drugs/clinical trials and news about DGAT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DGAT2 gene (2 alternative transcripts):

NM_001253891.1 NM_032564.4

Unigene Cluster for DGAT2:

Diacylglycerol O-acyltransferase 2

Hs.129798 [show with all ESTs]

Unigene Representative Sequence: AK091870

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000228027(uc001oxa.3 uc001oxb.3) ENST00000376262

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		hsa-miR-299-5p hsa-miR-374b hsa-miR-1179 hsa-miR-374a hsa-miR-4316 hsa-miR-1273d hsa-miR-124 hsa-miR-3613-3p

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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGAT2

Additional cDNA sequence:

AB048286.2 AB073384.1 AF384161.2 AK074203.1 AK091870.1 AL834287.1 AY358532.1 AY780646.1

AY780647.1 BC015234.1

6 DOTS entries:

DT.454450 DT.100027002 DT.100702689 DT.100665769 DT.92431250 DT.99929287

24/183 AceView cDNA sequences (see all 183):

CR616126 AX747231 BG741469 BC015234 BG674952 BM455645 BU502475 BQ957657

CB157015 AL834287 AI347956 BM922281 CD515287 AI624506 BQ932479 AI126704

BM851596 BG468762 BG696965 AB048286 BG696693 BI908609 BX325114 BQ649756

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DGAT2 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11
SP1:									-		-								-
SP2:									-		-		-						-
SP3:																			-
SP4:			-		-		-		-		-								-
SP5:

ECgene alternative splicing isoforms for DGAT2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DGAT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGACTTTT

About this image

DGAT2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DGAT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DGAT2

SOURCE GeneReport for Unigene cluster: Hs.129798

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Tissue specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary

gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic

skin

SABiosciences Expression via Pathway-Focused PCR Arrays including DGAT2:

Polycomb & Trithorax Target Genes in human mouse rat

Fatty Liver in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGAT2 gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DGAT2¹	diacylglycerol O-acyltransferase homolog 2 (mouse)	79.24(n) 86.31(a)		421309 XM_419374.3 XP_419374.3
lizard (Anolis carolinensis)	Reptilia	DGAT2⁶	--	82(a)	1 ↔ 1	GL343298.1(1305987-1323982)
African clawed frog (Xenopus laevis)	Amphibia	MGC68683²	hypothetical protein MGC68683	76.13(n)		BC059991.1
zebrafish (Danio rerio)	Actinopterygii	dgat2¹	diacylglycerol O-acyltransferase 2	69.07(n) 69.25(a)		565316 NM_001030196.1 NP_001025367.1
fruit fly (Drosophila melanogaster)	Insecta	CG1941³	--	39(a) (best of 3)		43E12 --
worm (Caenorhabditis elegans)	Secernentea	Y53G8B.2³	--	47(a) (best of 3)		III(3173221-3175757) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G51520¹	diacylglycerol O-acyltransferase 2	44.12(n) 34.91(a)		824315 NM_115011.3 NP_566952.1
rice (Oryza sativa)	Liliopsida	Os02g0714100¹	hypothetical protein	45.68(n) 38.43(a)		4330511 NM_001054452.1 NP_001047917.1

ENSEMBL Gene Tree for DGAT2 (if available)
TreeFam Gene Tree for DGAT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DGAT2 gene

MOGAT3² DGAT2L7P² MOGAT1² DGAT2L6² AWAT2² AWAT1² MOGAT2²

6 SIMAP similar genes for DGAT2 using alignment to 1 protein entry: DGAT2_HUMAN:

MOGAT3 AWAT1 AWAT2 DGAT2L6 MOGAT1 MOGAT2

DGAT2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73504542^1,2	C,	--	75477937(+)	`AAAAAC/TAAACC`	3	--	int¹ us2k¹		4		WA CSA EA	241
rs149681004^1,2		--	75477996(+)	`CCCCCC/GATCCC`	3	--	int¹ us2k¹		0	--	--	--	--
rs73504544^1,2	C,	--	75478126(+)	`GGCCAA/GTTCGG`	3	--	us2k¹ int¹		3		WA CSA	121
rs185420818^1,2		--	75478240(+)	`GCTGCC/TCTGTG`	3	--	us2k¹ int¹		0	--	--	--	--
rs145524646^1,2		--	75478303(+)	`CAAAGG/TCAGGG`	3	--	int¹ us2k¹		0	--	--	--	--
rs73504545^1,2	C,	--	75478344(+)	`AGCTAT/GCTCGC`	3	--	int¹ us2k¹		4		WA CSA EA	241
rs148867646^1,2		--	75478347(+)	`TATCTC/TGCTCC`	3	--	us2k¹ int¹		0	--	--	--	--
rs142609424^1,2		--	75478548(+)	`TCCCCC/TGCCCC`	3	--	us2k¹ int¹		0	--	--	--	--
rs190044733^1,2		--	75478549(+)	`CCCCCA/GCCCCT`	3	--	us2k¹ int¹		0	--	--	--	--
rs147622726^1,2		--	75478682(+)	`TCCCCA/CCCAAT`	3	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DGAT2 (75479778 - 75512579 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DGAT2: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DGAT2 for disorders           About GeneDecksing

OMIM gene information: 606983    OMIM disorders: --

7 diseases for DGAT2:    About MalaCards

fatty liver disease insulin resistance liver disease hepatoblastoma

obesity cholesterol alcoholism

1 disease from the University of Copenhagen DISEASES database for DGAT2:

Fatty liver disease

Human Genome Epidemiology (HuGE) Navigator: DGAT2 (8 documents)

Export disorders for DGAT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DGAT2 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with DGAT2)

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Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PubMed id 11481335)^{1, 2, 3, 9} Cases S.... Farese R.V. Jr. (2001)
A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. (PubMed id 14521909)^{1, 2, 9} Wakimoto K.... Imai Y. (2003)
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)^{1, 2} Yamada S....Nakagawara A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677)^{1, 3} Winter A....Fries R. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. (PubMed id 17477860)^{1, 9} Friedel S....Hebebrand J. (2007)
Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. (PubMed id 15258194)^{1, 9} Ganji S.H....Kashyap M.L. (2004)
Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. (PubMed id 18757836)^{1, 9} Yen C.L....Farese R.V. (2008)
Diacylglycerol acyltransferase 2 acts upstream of diac ylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synth esized fatty acids in HepG2 cells. (PubMed id 22748069)¹ Wurie H.R....Zammit V.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84649	HGNC: 16940	AceView: DGAT2	Ensembl:ENSG00000062282	euGenes: HUgn84649
ECgene: DGAT2	Kegg: 84649	H-InvDB: DGAT2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DGAT2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DGAT2 gene
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Patent Information for DGAT2 gene:
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GeneCards and IP:
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diacylglycerol O-acyltransferase 2

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DGAT2 Gene

diacylglycerol O-acyltransferase 2

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