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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGAT2 Gene

protein-coding   GIFtS: 61
GCID: GC11P075479

Diacylglycerol O-Acyltransferase 2

(Previous name: diacylglycerol O-acyltransferase homolog 2 (mouse))
Microbiology & Infectious Diseases Congress
  6 related diseases
at
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Aliases
for DGAT2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Diacylglycerol O-Acyltransferase 21 2     Diacylglycerol O-Acyltransferase Homolog 2 (Mouse)1
Acyl-CoA Retinol O-Fatty-Acyltransferase2 3     GS1999FULL2
Diglyceride Acyltransferase 22 3     Diacylglycerol O-Acyltransferase Homolog 22
Retinol O-Fatty-Acyltransferase2 3     Diacylglycerol O-Acyltransferase-Like Protein 22
ARAT2 3     EC 2.3.1.763
EC 2.3.1.203 8     EC 2.3.18

External Ids:    HGNC: 169401   Entrez Gene: 846492   Ensembl: ENSG000000622827   OMIM: 6069835   UniProtKB: Q96PD73   

Export aliases for DGAT2 gene to outside databases

Previous GC identifers: GC11P077806 GC11P077018 GC11P075693 GC11P075206 GC11P075157 GC11P071776


Summaries
for DGAT2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DGAT2 Gene:
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which
diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at
low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of
magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Dec 2011)

GeneCards Summary for DGAT2 Gene: 
DGAT2 (diacylglycerol O-acyltransferase 2) is a protein-coding gene. Diseases associated with DGAT2 include fatty liver disease, and hepatoblastoma, and among its related super-pathways are Metabolic pathways and triacylglycerol biosynthesis. GO annotations related to this gene include diacylglycerol O-acyltransferase activity and protein homodimerization activity. An important paralog of this gene is MOGAT3.

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7
Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol
synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of
intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is
primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity).
Functions also as an acyl-CoA retinol acyltransferase (ARAT)




Genomic Views
for DGAT2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DGAT2 gene promoter:
         C/EBPbeta   PPAR-gamma1   GATA-6   E2F-1   E2F   HOXA5   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DGAT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DGAT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.3

DGAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGAT2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P075479:  view genomic region     (about GC identifiers)

Start:
 75,470,557 bp from pter      End:
 75,512,579 bp from pter
Size:
 42,023 bases      Orientation:
 plus strand

Proteins
for DGAT2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7 (See protein sequence)
Recommended Name: Diacylglycerol O-acyltransferase 2  
Size: 388 amino acids; 43831 Da
Subunit: Forms multimeric complexes consisting of several DGAT2 subunits (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet (By similarity)
Sequence caution: Sequence=BAD38635.1; Type=Erroneous initiation; Sequence=CAD38961.1; Type=Erroneous initiation;
Secondary accessions: A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5
Alternative splicing: 2 isoforms:  Q96PD7-1   Q96PD7-2   

Explore the universe of human proteins at neXtProt for DGAT2: NX_Q96PD7

Explore proteomics data for DGAT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PD7

    • 4/9 DME Specific Peptides for DGAT2 (Q96PD7) (see all 9)
     GGAAESL  PITTVVG  QKKFQKY  VSKKFPGI 

    DGAT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DGAT2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001240820.1  NP_115953.2  

    ENSEMBL proteins: 
     ENSP00000474015   ENSP00000474887   ENSP00000228027   ENSP00000474668   ENSP00000475066  
     ENSP00000365438  
    Reactome Protein details: Q96PD7
    Human Recombinant Protein Products for DGAT2: 
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    Novus Biologicals DGAT2 Lysate
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for DGAT2 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739colocalizes with mitochondrion ISS--
    GO:0005783endoplasmic reticulum IDA14521909
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005811colocalizes with lipid particle ISS--
    GO:0016020membrane ----

    DGAT2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for DGAT2 
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    Protein Domains /
    Families
    for DGAT2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 1 InterPro protein domain:
     IPR007130 DAGAT

    Graphical View of Domain Structure for InterPro Entry Q96PD7

    ProtoNet protein and cluster: Q96PD7

    UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7
    Similarity: Belongs to the diacylglycerol acyltransferase family


    DGAT2 for domains           About GeneDecksing


    Function
    for DGAT2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGAT2_HUMAN, Q96PD7
    Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol
    synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of
    intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is
    primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity).
    Functions also as an acyl-CoA retinol acyltransferase (ARAT)
    Catalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol
    Catalytic activity: Acyl-CoA + retinol = CoA + retinyl ester
    Enzyme regulation: Inhibited by niacin (By similarity)

         Enzyme Numbers (IUBMB): EC 2.3.1.201 2 EC 2.3.12 EC 2.3.1.761

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038462-acylglycerol O-acyltransferase activity IEA--
    GO:0004144diacylglycerol O-acyltransferase activity IDA11481335
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
    GO:0042803protein homodimerization activity ISS--
    GO:0050252retinol O-fatty-acyltransferase activity IEA--
         
    DGAT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DGAT2:
     Decreased viability of wild-ty 

         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dgat2):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging 

    DGAT2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DGAT2: Dgat2tm1Lex Dgat2tm1Far

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DGAT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DGAT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DGAT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DGAT2 

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DGAT2 (see all 11):
    hsa-miR-299-5p hsa-miR-374b hsa-miR-1179 hsa-miR-374a hsa-miR-4316 hsa-miR-1273d hsa-miR-124 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DGAT2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DGAT2

    Clone
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    Sino Biological Human cDNA Clone for DGAT2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGAT2
    Sirion Biotech Customized lentivirus for stable overexpression of DGAT2 
                         Customized lentivirus expression plasmids for stable overexpression of DGAT2 

    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for DGAT2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DGAT2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    		Metabolism0.40
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.40
    2CDP-diacylglycerol biosynthesis I
    		triacylglycerol biosynthesis0.50
    		Triacylglyceride Synthesis0.36
    3Glycerophospholipid biosynthesis
    		Glycerophospholipid biosynthesis0.64
    		Phospholipid metabolism0.64
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    5Fatty Acyl-CoA Biosynthesis
    		Triglyceride Biosynthesis0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for DGAT2
        Triacylglyceride Synthesis
    triacylglycerol biosynthesis


    5/7        Reactome Pathways for DGAT2 (see all 7)
        Glycerophospholipid biosynthesis
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis
    Acyl chain remodeling of DAG and TAG


    3         Kegg Pathways  (Kegg details for DGAT2):
        Glycerolipid metabolism
    Metabolic pathways
    Fat digestion and absorption

    UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7
    Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis


    DGAT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for DGAT2 (ENSP000002280274) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CELENSP000003611514STRING: ENSP00000361151
    DGKZENSP000003203404STRING: ENSP00000320340
    LIPCENSP000002990224STRING: ENSP00000299022
    LIPGENSP000002612924STRING: ENSP00000261292
    LPIN1ENSP000002567204STRING: ENSP00000256720
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006071glycerol metabolic process IEA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0019432triglyceride biosynthetic process TAS--
    GO:0019915lipid storage ISS--
    GO:0034383low-density lipoprotein particle clearance ISS--

    DGAT2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DGAT2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DGAT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DGAT2

    10/1165 HMDB Compounds for DGAT2 (see all 1165)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--

    4 Novoseek inferred chemical compound relationships for DGAT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    triacylglycerol 75.9 7 18331995 (1)
    niacin 62.5 7 15258194 (5), 18047854 (2)
    lipid 15.2 3 20105310 (1), 20374941 (1)
    cholesterol 5.46 1 20227438 (1)

    Search CenterWatch for drugs/clinical trials and news about DGAT2

    Transcripts
    for DGAT2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for DGAT2 gene (2 alternative transcripts): 
    NM_001253891.1  NM_032564.4  

    Unigene Cluster for DGAT2:

    Diacylglycerol O-acyltransferase 2
    Hs.129798  [show with all ESTs]
    Unigene Representative Sequence: AK091870
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000603276 ENST00000604935 ENST00000228027(uc001oxa.3 uc001oxb.3)
    ENST00000605608 ENST00000604733 ENST00000605099 ENST00000603363 ENST00000603865
    ENST00000376262
    Congresses - knowledge worth sharing:  
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    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DGAT2 (see all 11):
    hsa-miR-299-5p hsa-miR-374b hsa-miR-1179 hsa-miR-374a hsa-miR-4316 hsa-miR-1273d hsa-miR-124 hsa-miR-3613-3p
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    Additional mRNA sequence: 

    AB048286.2 AB073384.1 AF384161.2 AK074203.1 AK091870.1 AL834287.1 AY358532.1 AY780646.1 
    AY780647.1 BC015234.1 

    6 DOTS entries:

    DT.454450  DT.100027002  DT.100702689  DT.100665769  DT.92431250  DT.99929287 

    24/183 AceView cDNA sequences (see all 183):

    AI126704 AA541264 BX325114 AI201835 BU541989 BG696693 BM851596 AB073384 
    AW469669 BQ932479 AK091870 BC015234 BG674952 BU502475 BQ957657 BM455645 
    CB157015 BM922281 AI347956 AL834287 AF384161 CD515287 BQ649756 BI908609 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DGAT2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
    SP1:                          -     -                       -                                 
    SP2:                          -     -     -                 -                                 
    SP3:                                                        -                                 
    SP4:        -     -     -     -     -                       -                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for DGAT2

    Expression
    for DGAT2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DGAT2 expression in normal human tissues (normalized intensities)      DGAT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGACTTTT
    DGAT2 Expression
    About this image


    DGAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             visceral organ   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See DGAT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DGAT2

    SOURCE GeneReport for Unigene cluster: Hs.129798

    UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7
    Tissue specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary
    gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased
    psoriatic skin

        SABiosciences Expression via Pathway-Focused PCR Arrays including DGAT2: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Fatty Liver in human mouse rat

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    Orthologs
    for DGAT2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGAT2 gene from 10/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dgat21 , 5 diacylglycerol O-acyltransferase 21, 5 89.69(n)1
    95.1(a)1    		   7 (54.01 cM)5
    678001  NM_026384.31  NP_080660.11 
     991536635 
    chicken
    (Gallus gallus)    		 Aves DGAT21 diacylglycerol O-acyltransferase homolog 2 (mouse) 79.24(n)
    86.31(a)    		   421309  XM_419374.3  XP_419374.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DGAT26
    --
    		 Uncharacterized protein
    		 82(a)
    44(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343298.1(1305951-1327254)
    GL344027.1(35241-39997)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686832 hypothetical protein MGC68683 76.13(n)    BC059991.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dgat21 diacylglycerol O-acyltransferase 2 69.07(n)
    69.25(a)    		   565316  NM_001030196.1  NP_001025367.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG19413   -- 39(a)
    (best of 3)    		   43E12   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y53G8B.23   -- 47(a)
    (best of 3)    		   III(3173221-3175757)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes DGA16
    		 Diacylglycerol acyltransferase, catalyzes the term...
    		 29(a)
    		 1 → many
    		 XV(794076-795332)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G515201 diacylglycerol O-acyltransferase 2 44.12(n)
    34.91(a)    		   824315  NM_115011.3  NP_566952.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g07141001 hypothetical protein 45.68(n)
    38.43(a)    		   4330511  NM_001054452.1  NP_001047917.1 


    ENSEMBL Gene Tree for DGAT2 (if available)
    TreeFam Gene Tree for DGAT2 (if available)

    Paralogs
    for DGAT2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DGAT2 gene
    MOGAT32  MOGAT12  DGAT2L62  AWAT22  AWAT12  MOGAT22  
    6 SIMAP similar genes for DGAT2 using alignment to 1 protein entry:     DGAT2_HUMAN:
    MOGAT3    AWAT1    AWAT2    DGAT2L6    MOGAT1    MOGAT2

    DGAT2 for paralogs           About GeneDecksing



    Genomic Variants
    for DGAT2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/599 SNPs in DGAT2 are shown (see all 599)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs586228551,2
    		C--75481845(+) AAAAC-/TTTTTT 2 -- int10--------
    rs1420694731,2
    		--75482042(+) TTGAAA/GATACT 2 -- int10--------
    rs1507279121,2
    		--75482070(+) GCCTCA/TGTGGG 2 -- int10--------
    rs1390815491,2
    		--75482098(+) GAGCTA/GGTGAA 2 -- int10--------
    rs1448747421,2
    		C--75482210(+) TGGCC-/AAAAAA 2 -- int10--------
    rs1451727681,2
    		--75482265(+) GGAAGC/TGGGAG 2 -- int10--------
    rs760462811,2
    		C,F--75482266(+) GAAGCG/AGGAGT 2 -- int11Minor allele frequency- A:0.07NA 120
    rs1476039491,2
    		C--75482294(+) AATCCC/TTGGAG 2 -- int10--------
    rs1830931951,2
    		--75482476(+) CCCAGG/TAAAAT 2 -- int10--------
    rs1421702791,2
    		--75482611(+) GGGGTA/GGGTGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for DGAT2 (75470557 - 75512579 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DGAT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897924CNV Gain21882294
    nsv897925CNV Gain21882294

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    Disorders / Diseases
    for DGAT2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 606983    OMIM disorders: --

    6 diseases for DGAT2:    About MalaCards
    fatty liver disease    hepatoblastoma    liver disease    insulin resistance
    obesity    alcoholism

    1 disease from the University of Copenhagen DISEASES database for DGAT2:
    Fatty liver disease

    DGAT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DGAT2
    Human Genome Epidemiology (HuGE) Navigator: DGAT2 (8 documents)

    Export disorders for DGAT2 gene to outside databases

    Publications
    for DGAT2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DGAT2 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with DGAT2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PubMed id 11481335)1, 2, 3, 9 Cases S.... Farese R.V. Jr. (2001)
    2. A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. (PubMed id 14521909)1, 2, 9 Wakimoto K.... Imai Y. (2003)
    3. Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. (PubMed id 17477860)1, 4, 9 Friedel S....Hebebrand J. (2007)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. The DGAT2 gene is a candidate for dissociation between fatty liver and insulin resistance in humans. (PubMed id 18980578)1, 4 Kantartzis K....Stefan N. (2008)
    7. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677)1, 3 Winter A....Fries R. (2003)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    External Searches for DGAT2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DGAT2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84649 HGNC: 16940 AceView: DGAT2 Ensembl:ENSG00000062282 euGenes: HUgn84649
    ECgene: DGAT2 Kegg: 84649 H-InvDB: DGAT2

    Other Databases showing DGAT2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DGAT2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DGAT2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DGAT2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DGAT2 gene:
    Search GeneIP for patents involving DGAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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