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DGAT2 Gene

protein-coding GIFtS: 60
GCID: GC11P075479

Diacylglycerol O-Acyltransferase 2

(Previous name: diacylglycerol O-acyltransferase homolog 2 (mouse))

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MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Diacylglycerol O-Acyltransferase 2¹ ²		Diacylglycerol O-Acyltransferase Homolog 2 (Mouse)¹
Acyl-CoA Retinol O-Fatty-Acyltransferase² ³		GS1999FULL²
Diglyceride Acyltransferase 2² ³		Diacylglycerol O-Acyltransferase Homolog 2²
Retinol O-Fatty-Acyltransferase² ³		Diacylglycerol O-Acyltransferase-Like Protein 2²
ARAT² ³		EC 2.3.1.76³
EC 2.3.1.20³ ⁸		EC 2.3.1⁸

External Ids:	HGNC: 16940¹	Entrez Gene: 84649²	Ensembl: ENSG00000062282⁷	OMIM: 606983⁵	UniProtKB: Q96PD7³

Export aliases for DGAT2 gene to outside databases

Previous GC identifers: GC11P077806 GC11P077018 GC11P075693 GC11P075206 GC11P075157 GC11P071776

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGAT2 Gene:

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which

diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at

low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of

magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, Dec 2011)

GeneCards Summary for DGAT2 Gene:

DGAT2 (diacylglycerol O-acyltransferase 2) is a protein-coding gene. GO annotations related to this gene include diacylglycerol O-acyltransferase activity and protein homodimerization activity. An important paralog of this gene is MOGAT3.

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol

synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of

intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is

primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity).

Functions also as an acyl-CoA retinol acyltransferase (ARAT)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000011.9 NC_018922.2 NT_167190.2

Regulatory elements:

Regulatory transcription factor binding sites in the DGAT2 gene promoter:
C/EBPbeta PPAR-gamma1 GATA-6 E2F-1 E2F HOXA5 PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DGAT2 promoter sequence

Search Chromatin IP Primers for DGAT2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DGAT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.3

DGAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGAT2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P075479: view genomic region (about GC identifiers)

Start:	75,470,557 bp from pter	End:	75,512,579 bp from pter
Size:	42,023 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7 (See protein sequence)

Recommended Name: Diacylglycerol O-acyltransferase 2

Size: 388 amino acids; 43831 Da

Subunit: Forms multimeric complexes consisting of several DGAT2 subunits (By similarity)

Sequence caution: Sequence=BAD38635.1; Type=Erroneous initiation; Sequence=CAD38961.1; Type=Erroneous initiation;

Secondary accessions: A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5

Alternative splicing: 2 isoforms: Q96PD7-1 Q96PD7-2

Explore the universe of human proteins at neXtProt for DGAT2: NX_Q96PD7

Explore proteomics data for DGAT2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for DGAT2 (Q96PD7) (see all 9)

GGAAESL

PITTVVG

QKKFQKY

VSKKFPGI

See DGAT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001240820.1 NP_115953.2

ENSEMBL proteins:

ENSP00000474015 ENSP00000474887 ENSP00000228027 ENSP00000474668 ENSP00000475066

ENSP00000365438

Reactome Protein details: Q96PD7

DGAT2 Human Recombinant Protein Products:

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	Cloud-Clone Corp. Proteins for DGAT2
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	Search GeneTex for Proteins for DGAT2
	antibodies-online proteins for DGAT2 (4 products)
	antibodies-online peptides for DGAT2

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	antibodies-online antibodies for DGAT2 (33 products)

DGAT2 Assay Products:

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	Cloud-Clone Corp. ELISAs for DGAT2 Cloud-Clone Corp. CLIAs for DGAT2
	Search eBioscience for ELISAs for DGAT2
	antibodies-online kits for DGAT2 (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

1 InterPro protein domain:

IPR007130 DAGAT

Graphical View of Domain Structure for InterPro Entry Q96PD7

ProtoNet protein and cluster: Q96PD7

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Similarity: Belongs to the diacylglycerol acyltransferase family

Find genes that share domains with DGAT2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DGAT2_HUMAN, Q96PD7

Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol

synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of

intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is

primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity).

Functions also as an acyl-CoA retinol acyltransferase (ARAT)

Catalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol

Catalytic activity: Acyl-CoA + retinol = CoA + retinyl ester

Enzyme regulation: Inhibited by niacin (By similarity)

Enzyme Numbers (IUBMB): EC 2.3.1.20¹ ² EC 2.3.1² EC 2.3.1.76¹

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003846	2-acylglycerol O-acyltransferase activity	IEA	--
GO:0004144	diacylglycerol O-acyltransferase activity	IDA	11481335
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	--	--
GO:0042803	protein homodimerization activity	ISS	--
GO:0050252	retinol O-fatty-acyltransferase activity	IEA	--

Find genes that share ontologies with DGAT2 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for DGAT2:

Decreased viability of wild-ty

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dgat2):

adipose tissue	behavior/neurological	growth/size/body	homeostasis/metabolism	integument
limbs/digits/tail	mortality/aging

Find genes that share phenotypes with DGAT2 About GenesLikeMe

Animal Models:
MGI mouse knock-outs for DGAT2: Dgat2^tm1Lex Dgat2^tm1Far

genOway: Develop your customized and physiologically relevant rodent model for DGAT2

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		Selected qRT-PCR Assays for microRNAs that regulate DGAT2 (see all 11):
		hsa-miR-299-5p hsa-miR-374b hsa-miR-1179 hsa-miR-374a hsa-miR-4316 hsa-miR-1273d hsa-miR-124 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: DGAT2 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat DGAT2

Gene Editing
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DNA2.0 Custom Protein Engineering Service for DGAT2

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		GenScript: all cDNA clones in your preferred vector: DGAT2 (NM_032564)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGAT2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

DGAT2_HUMAN, Q96PD7: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
extracellular	2
mitochondrion	2
cytosol	1
golgi apparatus	1
peroxisome	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	colocalizes with mitochondrion	ISS	--
GO:0005783	endoplasmic reticulum	IDA	14521909
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005811	colocalizes with lipid particle	ISS	--
GO:0016020	membrane	--	--

Find genes that share ontologies with DGAT2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for DGAT2 About (see all 7)

See pathways by source

Powered
by

SuperPath

Contained pathways About

Metabolism

	Metabolism	0.38			Metabolism of lipids and lipoproteins	0.37
	Metabolic pathways	0.38

triacylglycerol biosynthesis

triacylglycerol biosynthesis

0.48

Triacylglyceride Synthesis

0.36

Glycerolipid metabolism

Glycerolipid metabolism

Acyl chain remodeling of DAG and TAG

0.00

Glycerophospholipid biosynthesis

Glycerophospholipid biosynthesis

0.64

Phospholipid metabolism

0.64

Fatty acid, triacylglycerol, and ketone body metabolism

Fatty acid, triacylglycerol, and ketone body metabolism

0.65

Find genes that share SuperPaths with DGAT2 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

2 BioSystems Pathways for DGAT2

	Triacylglyceride Synthesis
	triacylglycerol biosynthesis

2 Reactome Pathways for DGAT2

	Triglyceride Biosynthesis
	Acyl chain remodeling of DAG and TAG

3 Kegg Pathways (Kegg details for DGAT2):

	Glycerolipid metabolism
	Metabolic pathways
	Fat digestion and absorption

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis

Pathway & Disease-focused RT² Profiler PCR Arrays including DGAT2:

Polycomb & Trithorax Target Genes in human mouse rat

Fatty Liver in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for DGAT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DGAT2 (ENSP00000228027⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEL	ENSP00000361151⁴	STRING: ENSP00000361151
DGKD	ENSP00000264057⁴	STRING: ENSP00000264057
DGKH	ENSP00000337572⁴	STRING: ENSP00000337572
DGKQ	ENSP00000273814⁴	STRING: ENSP00000273814
DGKZ	ENSP00000320340⁴	STRING: ENSP00000320340

About this table

Gene Ontology (GO): Selected biological process terms (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006071	glycerol metabolic process	IEA	--
GO:0006644	phospholipid metabolic process	TAS	--
GO:0019432	triglyceride biosynthetic process	TAS	--
GO:0019915	lipid storage	ISS	--
GO:0034383	low-density lipoprotein particle clearance	ISS	--

Find genes that share ontologies with DGAT2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DGAT2

Selected HMDB Compounds for DGAT2 (see all 1165) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--

4 Novoseek inferred chemical compound relationships for DGAT2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
triacylglycerol	75.9	7	18331995 (1)
niacin	62.5	7	15258194 (5), 18047854 (2)
lipid	15.2	3	20105310 (1), 20374941 (1)
cholesterol	5.46	1	20227438 (1)

Find genes that share compounds with DGAT2 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for DGAT2 gene (2 alternative transcripts):

NM_001253891.1 NM_032564.4

Unigene Cluster for DGAT2:

Diacylglycerol O-acyltransferase 2

Hs.129798 [show with all ESTs]

Unigene Representative Sequence: AK091870

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000603276 ENST00000604935 ENST00000228027(uc001oxa.3 uc001oxb.3)

ENST00000605608 ENST00000604733 ENST00000605099 ENST00000603363 ENST00000603865

ENST00000376262

miRNA Products:		Block miRNA regulation of human, mouse, rat DGAT2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate DGAT2 (see all 11):
		hsa-miR-299-5p hsa-miR-374b hsa-miR-1179 hsa-miR-374a hsa-miR-4316 hsa-miR-1273d hsa-miR-124 hsa-miR-3613-3p

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		GenScript: all cDNA clones in your preferred vector: DGAT2 (NM_032564)
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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DGAT2
		QuantiTect SYBR Green Assays in human, mouse, rat DGAT2
		Search QuantiFast Probe-based Assays in human, mouse, rat DGAT2

Additional mRNA sequence:

AB048286.2 AB073384.1 AF384161.2 AK074203.1 AK091870.1 AL834287.1 AY358532.1 AY780646.1

AY780647.1 BC015234.1

6 DOTS entries:

DT.454450 DT.100027002 DT.100702689 DT.100665769 DT.92431250 DT.99929287

Selected AceView cDNA sequences (see all 183):

BG681732 AI126704 BQ958365 AB073384 BQ932479 AB048286 AL834287 CD515287

AI624506 AI201835 BX325114 AY358532 BI908609 AF384161 AI273729 BQ649756

BM851596 AW469669 BG696693 BU172571 AA541264 AK091870 BG468762 BG696965

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DGAT2 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11
SP1:									-		-								-
SP2:									-		-		-						-
SP3:																			-
SP4:			-		-		-		-		-								-
SP5:

ECgene alternative splicing isoforms for DGAT2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DGAT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCAGACTTTT

About this image

DGAT2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Adipose (Muscoskeletal System)
White adipocyte-like cells

Gut Tube (Gastrointestinal Tract)
Foregut

Liver (Hepatobiliary System)
Liver Lobule

Blood (Hematopoietic System)
Granulocytes Peripheral Blood

DGAT2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DGAT2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.129798

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Tissue specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary

gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased

psoriatic skin

Pathway & Disease-focused RT² Profiler PCR Arrays including DGAT2:

Polycomb & Trithorax Target Genes in human mouse rat

Fatty Liver in human mouse rat

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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DGAT2
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		Search QuantiFast Probe-based Assays in human, mouse, rat DGAT2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGAT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DGAT2 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dgat2^{1 , 5}	diacylglycerol O-acyltransferase 2^{1, 5}	89.69(n)¹ 95.1(a)¹		7 (54.01 cM)⁵ 67800¹ NM_026384.3¹ NP_080660.1¹ 99153663⁵
chicken (Gallus gallus)	Aves	DGAT2¹	diacylglycerol O-acyltransferase homolog 2 (mouse)	79.24(n) 86.31(a)		421309 XM_419374.4 XP_419374.3
lizard (Anolis carolinensis)	Reptilia	DGAT2⁶	diacylglycerol O-acyltransferase 2	82(a)	1 ↔ 1	GL343298.1(1305951-1327254)
African clawed frog (Xenopus laevis)	Amphibia	MGC68683²	hypothetical protein MGC68683	76.13(n)		BC059991.1
zebrafish (Danio rerio)	Actinopterygii	dgat2¹	diacylglycerol O-acyltransferase 2	69.07(n) 69.25(a)		565316 NM_001030196.1 NP_001025367.1

ENSEMBL Gene Tree for DGAT2 (if available)
TreeFam Gene Tree for DGAT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for DGAT2 gene

MOGAT3² MOGAT1² DGAT2L6² AWAT2² AWAT1² MOGAT2²

6 SIMAP similar genes for DGAT2 using alignment to 5 protein entries: DGAT2_HUMAN (see all proteins):

MOGAT3 DGAT2L6 AWAT1 MOGAT1 AWAT2 MOGAT2

Find genes that share paralogs with DGAT2 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58622855^1,2	C	--	75481845(+)	`AAAAC-/TTTTTT`	2	--	int¹		0	--	--	--	--
rs142069473^1,2		--	75482042(+)	`TTGAAA/GATACT`	2	--	int¹		0	--	--	--	--
rs150727912^1,2		--	75482070(+)	`GCCTCA/TGTGGG`	2	--	int¹		0	--	--	--	--
rs139081549^1,2		--	75482098(+)	`GAGCTA/GGTGAA`	2	--	int¹		0	--	--	--	--
rs144874742^1,2	C	--	75482210(+)	`TGGCC-/AAAAAA`	2	--	int¹		0	--	--	--	--
rs145172768^1,2		--	75482265(+)	`GGAAGC/TGGGAG`	2	--	int¹		0	--	--	--	--
rs76046281^1,2	C,F	--	75482266(+)	`GAAGCG/AGGAGT`	2	--	int¹		1		NA	120
rs147603949^1,2	C	--	75482294(+)	`AATCCC/TTGGAG`	2	--	int¹		0	--	--	--	--
rs183093195^1,2		--	75482476(+)	`CCCAGG/TAAAAT`	2	--	int¹		0	--	--	--	--
rs142170279^1,2		--	75482611(+)	`GGGGTA/GGGTGA`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DGAT2 (75470557 - 75512579 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for DGAT2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv897924	CNV	Gain	21882294
nsv897925	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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OMIM gene information: 606983 OMIM disorders: --

1 inferred disease relationship from the University of Copenhagen DISEASES database for DGAT2:

Fatty liver disease

Find genes that share disorders with DGAT2 About GenesLikeMe

Genetic Association Database (GAD): DGAT2
Human Genome Epidemiology (HuGE) Navigator: DGAT2 (8 documents)

Export disorders for DGAT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DGAT2 gene, integrated from 10 sources (see all 49):
(articles sorted by number of sources associating them with DGAT2)

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PubMed id 11481335)^{1, 2, 3, 9} Cases S.... Farese R.V. Jr. (J. Biol. Chem. 2001)
A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. (PubMed id 14521909)^{1, 2, 9} Wakimoto K.... Imai Y. (Biochem. Biophys. Res. Commun. 2003)
Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. (PubMed id 17477860)^{1, 4, 9} Friedel S....Hebebrand J. (BMC Genet. 2007)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans. (PubMed id 18980578)^{1, 4} Kantartzis K....Stefan N. (Clin. Sci. 2009)
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)^{1, 2} Yamada S....Nakagawara A. (Oncogene 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677)^{1, 3} Winter A....Fries R. (Cytogenet. Genome Res. 2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84649	HGNC: 16940	AceView: DGAT2	Ensembl:ENSG00000062282	euGenes: HUgn84649
ECgene: DGAT2	Kegg: 84649	H-InvDB: DGAT2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DGAT2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DGAT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DGAT2 gene:
Search GeneIP for patents involving DGAT2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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DGAT2 Gene

Diacylglycerol O-Acyltransferase 2

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Diacylglycerol O-Acyltransferase 2

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