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Aliases for DGAT2 Gene

Aliases for DGAT2 Gene

  • Diacylglycerol O-Acyltransferase 2 2 3
  • Acyl-CoA Retinol O-Fatty-Acyltransferase 3 4
  • Retinol O-Fatty-Acyltransferase 3 4
  • Diglyceride Acyltransferase 2 3 4
  • EC 2.3.1.20 4 64
  • ARAT 3 4
  • Diacylglycerol O-Acyltransferase Homolog 2 (Mouse) 2
  • Diacylglycerol O-Acyltransferase-Like Protein 2 3
  • Diacylglycerol O-Acyltransferase Homolog 2 3
  • EC 2.3.1.76 4
  • GS1999FULL 3
  • HMFN1045 3
  • EC 2.3.1 64

External Ids for DGAT2 Gene

Summaries for DGAT2 Gene

Entrez Gene Summary for DGAT2 Gene

  • This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for DGAT2 Gene

DGAT2 (Diacylglycerol O-Acyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and diacylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for DGAT2 Gene

  • Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGAT2 Gene

Genomics for DGAT2 Gene

Genomic Location for DGAT2 Gene

Start:
75,759,512 bp from pter
End:
75,801,536 bp from pter
Size:
42,025 bases
Orientation:
Plus strand

Genomic View for DGAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGAT2 Gene

Regulatory Elements for DGAT2 Gene

Proteins for DGAT2 Gene

  • Protein details for DGAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PD7-DGAT2_HUMAN
    Recommended name:
    Diacylglycerol O-acyltransferase 2
    Protein Accession:
    Q96PD7
    Secondary Accessions:
    • A6ND76
    • Q5U810
    • Q68CL3
    • Q68DJ0
    • Q8NDB7
    • Q96BS0
    • Q9BYE5

    Protein attributes for DGAT2 Gene

    Size:
    388 amino acids
    Molecular mass:
    43831 Da
    Quaternary structure:
    • Forms multimeric complexes consisting of several DGAT2 subunits.
    SequenceCaution:
    • Sequence=BAD38635.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38961.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DGAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGAT2 Gene

Proteomics data for DGAT2 Gene at MOPED

Post-translational modifications for DGAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGAT2 Gene

Domains for DGAT2 Gene

Protein Domains for DGAT2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DGAT2_HUMAN
Family:
  • Belongs to the diacylglycerol acyltransferase family.:
    • Q96PD7
genes like me logo Genes that share domains with DGAT2: view

No data available for Gene Families for DGAT2 Gene

Function for DGAT2 Gene

Molecular function for DGAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + retinol = CoA + retinyl ester.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by niacin.
UniProtKB/Swiss-Prot Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).

Enzyme Numbers (IUBMB) for DGAT2 Gene

Gene Ontology (GO) - Molecular Function for DGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity IEA --
GO:0004144 diacylglycerol O-acyltransferase activity IDA 11481335
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:0042803 protein homodimerization activity ISS --
GO:0050252 retinol O-fatty-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with DGAT2: view
genes like me logo Genes that share phenotypes with DGAT2: view

Animal Models for DGAT2 Gene

MGI Knock Outs for DGAT2:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for DGAT2 Gene

Localization for DGAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGAT2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGAT2 Gene COMPARTMENTS Subcellular localization image for DGAT2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
mitochondrion 2
cytosol 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 colocalizes_with mitochondrion ISS --
GO:0005783 endoplasmic reticulum IDA 14521909
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005811 colocalizes_with lipid particle ISS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with DGAT2: view

Pathways for DGAT2 Gene

genes like me logo Genes that share pathways with DGAT2: view

UniProtKB/Swiss-Prot Q96PD7-DGAT2_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis

Interacting Proteins for DGAT2 Gene

Gene Ontology (GO) - Biological Process for DGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0008152 metabolic process --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0019915 lipid storage ISS --
genes like me logo Genes that share ontologies with DGAT2: view

Compounds for DGAT2 Gene

(1165) HMDB Compounds for DGAT2 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(4) Novoseek inferred chemical compound relationships for DGAT2 Gene

Compound -log(P) Hits PubMed IDs
triacylglycerol 75.9 1
niacin 62.5 7
lipid 15.2 2
cholesterol 5.46 1
genes like me logo Genes that share compounds with DGAT2: view

Transcripts for DGAT2 Gene

Unigene Clusters for DGAT2 Gene

Diacylglycerol O-acyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGAT2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - - - - -
SP5:
SP6:

Relevant External Links for DGAT2 Gene

GeneLoc Exon Structure for
DGAT2
ECgene alternative splicing isoforms for
DGAT2

Expression for DGAT2 Gene

mRNA expression in normal human tissues for DGAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGAT2 Gene

This gene is overexpressed in Whole Blood (12.3), Adipose - Visceral (Omentum) (8.6), Liver (5.2), Adipose - Subcutaneous (4.9), Breast - Mammary Tissue (4.4), and Skin - Sun Exposed (Lower leg) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DGAT2 Gene

SOURCE GeneReport for Unigene cluster for DGAT2 Gene Hs.129798

mRNA Expression by UniProt/SwissProt for DGAT2 Gene

Q96PD7-DGAT2_HUMAN
Tissue specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.
genes like me logo Genes that share expressions with DGAT2: view

Orthologs for DGAT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DGAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGAT2 36
  • 99.66 (n)
  • 100 (a)
DGAT2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DGAT2 36
  • 92.43 (n)
  • 96.95 (a)
DGAT2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGAT2 36
  • 90.56 (n)
  • 95.28 (a)
DGAT2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgat2 36
  • 89.69 (n)
  • 95.1 (a)
Dgat2 16
Dgat2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DGAT2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 75 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dgat2 36
  • 90.29 (n)
  • 94.85 (a)
chicken
(Gallus gallus)
Aves DGAT2 36
  • 79.24 (n)
  • 86.31 (a)
DGAT2 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGAT2 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68683 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dgat2 36
  • 73.06 (n)
  • 77.5 (a)
MGC76066 36
zebrafish
(Danio rerio)
Actinopterygii dgat2 36
  • 69.07 (n)
  • 69.25 (a)
dgat2 37
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1942 38
  • 38 (a)
CG1946 38
  • 34 (a)
CG1941 38
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea F59A1.10 38
  • 44 (a)
Y53G8B.2 38
  • 47 (a)
W01A11.2 38
  • 45 (a)
Species with no ortholog for DGAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGAT2 Gene

ENSEMBL:
Gene Tree for DGAT2 (if available)
TreeFam:
Gene Tree for DGAT2 (if available)

Paralogs for DGAT2 Gene

Paralogs for DGAT2 Gene

Selected SIMAP similar genes for DGAT2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DGAT2: view

Variants for DGAT2 Gene

Sequence variations from dbSNP and Humsavar for DGAT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3060 -- 75,800,527(-) AGGGA(A/G)TTGGC utr-variant-3-prime
rs1010716 -- 75,778,284(+) AGTGC(A/G)CACTT intron-variant
rs1017713 -- 75,788,407(-) ATCGC(A/G)GAAGG intron-variant
rs1043349 -- 75,801,344(+) GCCTT(C/T)TGAGC utr-variant-3-prime
rs1944438 -- 75,772,578(-) CTAGA(C/T)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGAT2 Gene

Variant ID Type Subtype PubMed ID
nsv897924 CNV Gain 21882294
nsv897925 CNV Gain 21882294

Relevant External Links for DGAT2 Gene

HapMap Linkage Disequilibrium report
DGAT2

Disorders for DGAT2 Gene

(1) University of Copenhagen DISEASES for DGAT2 Gene

Relevant External Links for DGAT2

Genetic Association Database (GAD)
DGAT2
Human Genome Epidemiology (HuGE) Navigator
DGAT2
genes like me logo Genes that share disorders with DGAT2: view

No data available for UniProtKB/Swiss-Prot for DGAT2 Gene

Publications for DGAT2 Gene

  1. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PMID: 11481335) Cases S. … Farese R.V. Jr. (J. Biol. Chem. 2001) 2 3 4 23
  2. A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. (PMID: 14521909) Wakimoto K. … Imai Y. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  3. Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. (PMID: 17477860) Friedel S. … Hebebrand J. (BMC Genet. 2007) 3 23 49
  4. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3
  5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4

Products for DGAT2 Gene

Sources for DGAT2 Gene

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