Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DGAT2 Gene

protein-coding GIFtS: 61
GCID: GC11P075479

Diacylglycerol O-Acyltransferase 2

(Previous name: diacylglycerol O-acyltransferase homolog 2 (mouse))

Microbiology & Infectious Diseases Congress

6 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Diacylglycerol O-Acyltransferase 2¹ ²		Diacylglycerol O-Acyltransferase Homolog 2 (Mouse)¹
Acyl-CoA Retinol O-Fatty-Acyltransferase² ³		GS1999FULL²
Diglyceride Acyltransferase 2² ³		Diacylglycerol O-Acyltransferase Homolog 2²
Retinol O-Fatty-Acyltransferase² ³		Diacylglycerol O-Acyltransferase-Like Protein 2²
ARAT² ³		EC 2.3.1.76³
EC 2.3.1.20³ ⁸		EC 2.3.1⁸

External Ids:	HGNC: 16940¹	Entrez Gene: 84649²	Ensembl: ENSG00000062282⁷	OMIM: 606983⁵	UniProtKB: Q96PD7³

Export aliases for DGAT2 gene to outside databases

Previous GC identifers: GC11P077806 GC11P077018 GC11P075693 GC11P075206 GC11P075157 GC11P071776

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGAT2 Gene:

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which

diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low

concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium

chloride. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,

Dec 2011)

GeneCards Summary for DGAT2 Gene:

DGAT2 (diacylglycerol O-acyltransferase 2) is a protein-coding gene. Diseases associated with DGAT2 include fatty liver disease, and hepatoblastoma, and among its related super-pathways are Metabolic pathways and triacylglycerol biosynthesis. GO annotations related to this gene include diacylglycerol O-acyltransferase activity and protein homodimerization activity. An important paralog of this gene is MOGAT3.

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by

using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular

triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for

incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA

retinol acyltransferase (ARAT)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.2 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DGAT2 gene promoter:
C/EBPbeta PPAR-gamma1 GATA-6 E2F-1 E2F HOXA5 PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DGAT2 promoter sequence

Search SABiosciences Chromatin IP Primers for DGAT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGAT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.3

DGAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGAT2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P075479: view genomic region (about GC identifiers)

Start:	75,470,557 bp from pter	End:	75,512,579 bp from pter
Size:	42,023 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7 (See protein sequence)

Recommended Name: Diacylglycerol O-acyltransferase 2

Size: 388 amino acids; 43831 Da

Subunit: Forms multimeric complexes consisting of several DGAT2 subunits (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet (By similarity)

Sequence caution: Sequence=BAD38635.1; Type=Erroneous initiation; Sequence=CAD38961.1; Type=Erroneous initiation;

Secondary accessions: A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5

Alternative splicing: 2 isoforms: Q96PD7-1 Q96PD7-2

Explore the universe of human proteins at neXtProt for DGAT2: NX_Q96PD7

Explore proteomics data for DGAT2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96PD7

4/9 DME Specific Peptides for DGAT2 (Q96PD7) (see all 9)

GGAAESL

PITTVVG

QKKFQKY

VSKKFPGI

DGAT2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001240820.1 NP_115953.2

ENSEMBL proteins:

ENSP00000474015 ENSP00000474887 ENSP00000228027 ENSP00000474668 ENSP00000475066

ENSP00000365438

Reactome Protein details: Q96PD7
Human Recombinant Protein Products for DGAT2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for DGAT2 OriGene Custom MassSpec OriGene Custom Protein Services for DGAT2
	GenScript Custom Purified and Recombinant Proteins Services for DGAT2
	Novus Biologicals DGAT2 Proteins Novus Biologicals DGAT2 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for DGAT2

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	colocalizes with mitochondrion	ISS	--
GO:0005783	endoplasmic reticulum	IDA	14521909
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005811	colocalizes with lipid particle	ISS	--
GO:0016020	membrane	--	--

DGAT2 for ontologies About GeneDecksing

DGAT2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for DGAT2
	OriGene Antibodies for DGAT2 OriGene Custom Antibody Services for DGAT2
	GenScript Custom Superior Antibodies Services for DGAT2
	Novus Biologicals DGAT2 Antibodies
	Abcam antibodies for DGAT2
	Cloud-Clone Corp. Antibodies for DGAT2
	ThermoFisher Antibody for DGAT2
	LSBio Antibodies in human, mouse, rat for DGAT2

Assay Products for DGAT2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for DGAT2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DGAT2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DGAT2 Cloud-Clone Corp. CLIAs for DGAT2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR007130 DAGAT

Graphical View of Domain Structure for InterPro Entry Q96PD7

ProtoNet protein and cluster: Q96PD7

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Similarity: Belongs to the diacylglycerol acyltransferase family

DGAT2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DGAT2_HUMAN, Q96PD7

Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by

using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular

triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for

incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA

retinol acyltransferase (ARAT)

Catalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol

Catalytic activity: Acyl-CoA + retinol = CoA + retinyl ester

Enzyme regulation: Inhibited by niacin (By similarity)

Enzyme Numbers (IUBMB): EC 2.3.1.20¹ ² EC 2.3.1² EC 2.3.1.76¹

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003846	2-acylglycerol O-acyltransferase activity	IEA	--
GO:0004144	diacylglycerol O-acyltransferase activity	IDA	11481335
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	--	--
GO:0042803	protein homodimerization activity	ISS	--
GO:0050252	retinol O-fatty-acyltransferase activity	IEA	--

DGAT2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DGAT2:

Decreased viability of wild-ty

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dgat2):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	integument
limbs/digits/tail	mortality/aging

DGAT2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for DGAT2: Dgat2^tm1Lex Dgat2^tm1Far

inGenious Targeting Laboratory - Custom generated mouse model solutions for DGAT2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DGAT2

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DGAT2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DGAT2 (see all 11):
		hsa-miR-299-5p hsa-miR-374b hsa-miR-1179 hsa-miR-374a hsa-miR-4316 hsa-miR-1273d hsa-miR-124 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: DGAT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for DGAT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DGAT2
		Sirion Biotech Custom design and validation of potent shRNA sequences against DGAT2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DGAT2
			Sirion Biotech Customized adenovirus for overexpression of DGAT2 Customized adenovirus for potent knockdown of DGAT2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for DGAT2 (see all 8) OriGene ORF clones in mouse, rat for DGAT2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DGAT2 (NM_032564)
		Sino Biological Human cDNA Clone for DGAT2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGAT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGAT2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DGAT2
		Search LifeMap BioReagents cell lines for DGAT2
		Sirion Biotech Customized stable knockdown cell line services for DGAT2 Customized inducible knockdown cell line services for DGAT2 Customized stable overexpressing cell line services for DGAT2 Customized inducible overexpressing cell line services for DGAT2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGAT2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for DGAT2 About (see all 8)

See pathways by source

SuperPath

Contained pathways About

Metabolism

	Metabolism	0.40			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.40

CDP-diacylglycerol biosynthesis I

triacylglycerol biosynthesis

0.50

Triacylglyceride Synthesis

0.36

Glycerophospholipid biosynthesis

Glycerophospholipid biosynthesis

0.64

Phospholipid metabolism

0.64

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Fatty acid, triacylglycerol, and ketone body metabolism

0.52

Fatty Acyl-CoA Biosynthesis

Triglyceride Biosynthesis

0.47

Pathways by source See SuperPaths
Show all pathways

2 BioSystems Pathways for DGAT2

	Triacylglyceride Synthesis
	triacylglycerol biosynthesis

5/7 Reactome Pathways for DGAT2 (see all 7)

	Glycerophospholipid biosynthesis
	Metabolism
	Phospholipid metabolism
	Triglyceride Biosynthesis
	Acyl chain remodeling of DAG and TAG

3 Kegg Pathways (Kegg details for DGAT2):

	Glycerolipid metabolism
	Metabolic pathways
	Fat digestion and absorption

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis

DGAT2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DGAT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for DGAT2 (ENSP00000228027⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEL	ENSP00000361151⁴	STRING: ENSP00000361151
DGKZ	ENSP00000320340⁴	STRING: ENSP00000320340
LIPC	ENSP00000299022⁴	STRING: ENSP00000299022
LIPG	ENSP00000261292⁴	STRING: ENSP00000261292
LPIN1	ENSP00000256720⁴	STRING: ENSP00000256720

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006071	glycerol metabolic process	IEA	--
GO:0006644	phospholipid metabolic process	TAS	--
GO:0019432	triglyceride biosynthetic process	TAS	--
GO:0019915	lipid storage	ISS	--
GO:0034383	low-density lipoprotein particle clearance	ISS	--

DGAT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DGAT2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DGAT2

10/1165 HMDB Compounds for DGAT2 (see all 1165) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--

4 Novoseek inferred chemical compound relationships for DGAT2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
triacylglycerol	75.9	7	18331995 (1)
niacin	62.5	7	15258194 (5), 18047854 (2)
lipid	15.2	3	20105310 (1), 20374941 (1)
cholesterol	5.46	1	20227438 (1)

Search CenterWatch for drugs/clinical trials and news about DGAT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DGAT2 gene (2 alternative transcripts):

NM_001253891.1 NM_032564.4

Unigene Cluster for DGAT2:

Diacylglycerol O-acyltransferase 2

Hs.129798 [show with all ESTs]

Unigene Representative Sequence: AK091870

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000603276 ENST00000604935 ENST00000228027(uc001oxa.3 uc001oxb.3)

ENST00000605608 ENST00000604733 ENST00000605099 ENST00000603363 ENST00000603865

ENST00000376262

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DGAT2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DGAT2 (see all 11):
		hsa-miR-299-5p hsa-miR-374b hsa-miR-1179 hsa-miR-374a hsa-miR-4316 hsa-miR-1273d hsa-miR-124 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: DGAT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for DGAT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DGAT2
		Sirion Biotech Custom design and validation of potent shRNA sequences against DGAT2

Clone Products:		OriGene clones in human, mouse for DGAT2 (see all 8) OriGene ORF clones in mouse, rat for DGAT2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DGAT2 (NM_032564)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGAT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGAT2

Primer Products:		OriGene qPCR primer pairs and template standards for DGAT2 OriGene qSTAR qPCR primer pairs in human, mouse for DGAT2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DGAT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DGAT2
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGAT2

Additional mRNA sequence:

AB048286.2 AB073384.1 AF384161.2 AK074203.1 AK091870.1 AL834287.1 AY358532.1 AY780646.1

AY780647.1 BC015234.1

6 DOTS entries:

DT.454450 DT.100027002 DT.100702689 DT.100665769 DT.92431250 DT.99929287

24/183 AceView cDNA sequences (see all 183):

AI126704 AA541264 BX325114 AI201835 BU541989 BG696693 BM851596 AB073384

AW469669 BQ932479 AK091870 BC015234 BG674952 BU502475 BQ957657 BM455645

CB157015 BM922281 AI347956 AL834287 AF384161 CD515287 BQ649756 BI908609

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DGAT2 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11
SP1:									-		-								-
SP2:									-		-		-						-
SP3:																			-
SP4:			-		-		-		-		-								-
SP5:

ECgene alternative splicing isoforms for DGAT2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DGAT2 expression in normal human tissues (normalized intensities) DGAT2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCAGACTTTT

About this image

DGAT2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/9 selected tissues (see all 9) fully expand


Lower Urinary Tract (Urinary System) fully expand to see all 3 entries
visceral organ

Limb (Muscoskeletal System) fully expand to see all 2 entries
limb/hindlimb

Liver (Hepatobiliary System)
Liver Lobule

Gut Tube (Gastrointestinal Tract)
Foregut

Nose (Sensory Organs)
sensory organ/nose/nasal cavity

See DGAT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DGAT2

SOURCE GeneReport for Unigene cluster: Hs.129798

UniProtKB/Swiss-Prot: DGAT2_HUMAN, Q96PD7

Tissue specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary

gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic

skin

SABiosciences Expression via Pathway-Focused PCR Arrays including DGAT2:

Polycomb & Trithorax Target Genes in human mouse rat

Fatty Liver in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for DGAT2 OriGene qSTAR qPCR primer pairs in human, mouse for DGAT2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DGAT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DGAT2
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGAT2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGAT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGAT2 gene from 10/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dgat2^{1 , 5}	diacylglycerol O-acyltransferase 2^{1, 5}	89.69(n)¹ 95.1(a)¹		7 (54.01 cM)⁵ 67800¹ NM_026384.3¹ NP_080660.1¹ 99153663⁵
chicken (Gallus gallus)	Aves	DGAT2¹	diacylglycerol O-acyltransferase homolog 2 (mouse)	79.24(n) 86.31(a)		421309 XM_419374.3 XP_419374.3
lizard (Anolis carolinensis)	Reptilia	DGAT2⁶ --	Uncharacterized protein	82(a) 44(a)	1 ↔ 1 possible ortholog	GL343298.1(1305951-1327254) GL344027.1(35241-39997)
African clawed frog (Xenopus laevis)	Amphibia	MGC68683²	hypothetical protein MGC68683	76.13(n)		BC059991.1
zebrafish (Danio rerio)	Actinopterygii	dgat2¹	diacylglycerol O-acyltransferase 2	69.07(n) 69.25(a)		565316 NM_001030196.1 NP_001025367.1
fruit fly (Drosophila melanogaster)	Insecta	CG1941³	--	39(a) (best of 3)		43E12 --
worm (Caenorhabditis elegans)	Secernentea	Y53G8B.2³	--	47(a) (best of 3)		III(3173221-3175757) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	DGA1⁶	Diacylglycerol acyltransferase, catalyzes the term...	29(a)	1 → many	XV(794076-795332)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G51520¹	diacylglycerol O-acyltransferase 2	44.12(n) 34.91(a)		824315 NM_115011.3 NP_566952.1
rice (Oryza sativa)	Liliopsida	Os02g0714100¹	hypothetical protein	45.68(n) 38.43(a)		4330511 NM_001054452.1 NP_001047917.1

ENSEMBL Gene Tree for DGAT2 (if available)
TreeFam Gene Tree for DGAT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DGAT2 gene

MOGAT3² MOGAT1² DGAT2L6² AWAT2² AWAT1² MOGAT2²

6 SIMAP similar genes for DGAT2 using alignment to 1 protein entry: DGAT2_HUMAN:

MOGAT3 AWAT1 AWAT2 DGAT2L6 MOGAT1 MOGAT2

DGAT2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58622855^1,2	C	--	75481845(+)	`AAAAC-/TTTTTT`	2	--	int¹		0	--	--	--	--
rs142069473^1,2		--	75482042(+)	`TTGAAA/GATACT`	2	--	int¹		0	--	--	--	--
rs150727912^1,2		--	75482070(+)	`GCCTCA/TGTGGG`	2	--	int¹		0	--	--	--	--
rs139081549^1,2		--	75482098(+)	`GAGCTA/GGTGAA`	2	--	int¹		0	--	--	--	--
rs144874742^1,2	C	--	75482210(+)	`TGGCC-/AAAAAA`	2	--	int¹		0	--	--	--	--
rs145172768^1,2		--	75482265(+)	`GGAAGC/TGGGAG`	2	--	int¹		0	--	--	--	--
rs76046281^1,2	C,F	--	75482266(+)	`GAAGCG/AGGAGT`	2	--	int¹		1		NA	120
rs147603949^1,2	C	--	75482294(+)	`AATCCC/TTGGAG`	2	--	int¹		0	--	--	--	--
rs183093195^1,2		--	75482476(+)	`CCCAGG/TAAAAT`	2	--	int¹		0	--	--	--	--
rs142170279^1,2		--	75482611(+)	`GGGGTA/GGGTGA`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DGAT2 (75470557 - 75512579 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for DGAT2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv897924	CNV	Gain	21882294
nsv897925	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DGAT2

DNA2.0 Custom Variant and Variant Library Synthesis for DGAT2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DGAT2 for disorders           About GeneDecksing

OMIM gene information: 606983    OMIM disorders: --

6 diseases for DGAT2:    About MalaCards

fatty liver disease hepatoblastoma liver disease insulin resistance

obesity alcoholism

1 disease from the University of Copenhagen DISEASES database for DGAT2:

Fatty liver disease

Genetic Association Database (GAD): DGAT2
Human Genome Epidemiology (HuGE) Navigator: DGAT2 (8 documents)

Export disorders for DGAT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DGAT2 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with DGAT2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PubMed id 11481335)^{1, 2, 3, 9} Cases S.... Farese R.V. Jr. (2001)
A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. (PubMed id 14521909)^{1, 2, 9} Wakimoto K.... Imai Y. (2003)
Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. (PubMed id 17477860)^{1, 4, 9} Friedel S....Hebebrand J. (2007)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
The DGAT2 gene is a candidate for dissociation between fatty liver and insulin resistance in humans. (PubMed id 18980578)^{1, 4} Kantartzis K....Stefan N. (2008)
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)^{1, 2} Yamada S....Nakagawara A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677)^{1, 3} Winter A....Fries R. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84649	HGNC: 16940	AceView: DGAT2	Ensembl:ENSG00000062282	euGenes: HUgn84649
ECgene: DGAT2	Kegg: 84649	H-InvDB: DGAT2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DGAT2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DGAT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DGAT2 gene:
Search GeneIP for patents involving DGAT2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for DGAT2 (DGAT2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for DGAT2		OriGene RNAi products in human, mouse, rat for DGAT2
	OriGene qPCR primer pairs and template standards for DGAT2		OriGene Protein Over-expression Lysate for DGAT2
	OriGene Custom Mass Spec		OriGene clones in human, mouse for DGAT2
	OriGene qSTAR qPCR primer pairs in human, mouse for DGAT2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for DGAT2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DGAT2		OriGene Custom Protein Services for DGAT2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DGAT2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DGAT2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGAT2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DGAT2
	Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGAT2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DGAT2

	GenScript Custom Purified and Recombinant Proteins Services for DGAT2		GenScript cDNA clones with any tag delivered in your preferred vector for DGAT2
	GenScript Custom Assay Services for DGAT2		GenScript Custom Superior Antibodies Services for DGAT2
	GenScript Custom overexpressing Cell Line Services for DGAT2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DGAT2 promoter
	Search Chromatin IP Primers for DGAT2
	RT² qPCR Primer Assay in human, mouse, rat DGAT2
	Search GNC Networks for DGAT2
	SABiosciences PCR Arrays including human, mouse, rat DGAT2

Search Tocris compounds for DGAT2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	cDNA Clones for DGAT2
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DGAT2 antibodies
	DGAT2 proteins
	DGAT2 lysates

	Antibodies for DGAT2
	See all of Abcam's Antibodies, Kits and Proteins for DGAT2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for DGAT2
	Antibodies for DGAT2
	ELISAs for DGAT2
	CLIAs for DGAT2

Search LifeMap BioReagents cell lines for DGAT2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGAT2

	SwitchGear 3'UTR luciferase reporter plasmids for DGAT2
	SwitchGear Promoter luciferase reporter plasmids for DGAT2

ThermoFisher Antibody for DGAT2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGAT2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for DGAT2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DGAT2

Customized:

	stable knockdown cell line services for DGAT2
	inducible knockdown cell line services for DGAT2
	design and validation of potent shRNA sequences against DGAT2
	adenovirus for potent knockdown of DGAT2
	stable overexpressing cell line services for DGAT2
	inducible overexpressing cell line services for DGAT2
	adenovirus for overexpression of DGAT2

LSBio Antibodies in human, mouse, rat for DGAT2

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DGAT2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

DGAT2 Gene

Diacylglycerol O-Acyltransferase 2

Aliases
for DGAT2 gene

Summaries
for DGAT2 gene

Genomic Views
for DGAT2 gene

Proteins
for DGAT2 gene

Protein Domains /
Families
for DGAT2 gene

Function
for DGAT2 gene

Pathways & Interactions
for DGAT2 gene

Drugs & Compounds
for DGAT2 gene

Transcripts
for DGAT2 gene

Expression
for DGAT2 gene

Orthologs
for DGAT2 gene

Paralogs
for DGAT2 gene

Genomic Variants
for DGAT2 gene

Disorders / Diseases
for DGAT2 gene

Publications
for DGAT2 gene

External Searches for DGAT2 gene

Genome Databases showing DGAT2 gene

Other Databases showing DGAT2 gene

Specialized Databases showing DGAT2 gene

Intellectual Property
for DGAT2 gene

Products
for DGAT2 gene

View Random Gene

Advanced Search

Export list of displayed genes

DGAT2 Gene

Diacylglycerol O-Acyltransferase 2

Aliasesfor DGAT2 gene

Summariesfor DGAT2 gene

Genomic Viewsfor DGAT2 gene

Proteinsfor DGAT2 gene

Protein Domains /Familiesfor DGAT2 gene

Functionfor DGAT2 gene

Pathways & Interactionsfor DGAT2 gene

Drugs & Compoundsfor DGAT2 gene

Transcriptsfor DGAT2 gene

Expression for DGAT2 gene

Orthologsfor DGAT2 gene

Paralogsfor DGAT2 gene

Genomic Variantsfor DGAT2 gene

Disorders / Diseasesfor DGAT2 gene

Publicationsfor DGAT2 gene

External Searches for DGAT2 gene

Genome Databases showing DGAT2 gene

Other Databases showing DGAT2 gene

Specialized Databases showing DGAT2 gene

Intellectual Propertyfor DGAT2 gene

Productsfor DGAT2 gene

View Random Gene

Aliases
for DGAT2 gene

Summaries
for DGAT2 gene

Genomic Views
for DGAT2 gene

Proteins
for DGAT2 gene

Protein Domains /
Families
for DGAT2 gene

Function
for DGAT2 gene

Pathways & Interactions
for DGAT2 gene

Drugs & Compounds
for DGAT2 gene

Transcripts
for DGAT2 gene

Expression
for DGAT2 gene

Orthologs
for DGAT2 gene

Paralogs
for DGAT2 gene

Genomic Variants
for DGAT2 gene

Disorders / Diseases
for DGAT2 gene

Publications
for DGAT2 gene

Intellectual Property
for DGAT2 gene

Products
for DGAT2 gene