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Aliases for DGAT2 Gene

Aliases for DGAT2 Gene

  • Diacylglycerol O-Acyltransferase 2 2 3 5
  • Acyl-CoA Retinol O-Fatty-Acyltransferase 3 4
  • Diglyceride Acyltransferase 2 3 4
  • EC 2.3.1.20 4 61
  • ARAT 3 4
  • Diacylglycerol O-Acyltransferase Homolog 2 (Mouse) 2
  • Diacylglycerol O-Acyltransferase-Like Protein 2 3
  • Diacylglycerol O-Acyltransferase Homolog 2 3
  • Retinol O-Fatty-Acyltransferase 4
  • EC 2.3.1.76 4
  • GS1999FULL 3
  • HMFN1045 3
  • EC 2.3.1 61

External Ids for DGAT2 Gene

Previous GeneCards Identifiers for DGAT2 Gene

  • GC11P077806
  • GC11P077018
  • GC11P075693
  • GC11P075206
  • GC11P075157
  • GC11P075479
  • GC11P071776

Summaries for DGAT2 Gene

Entrez Gene Summary for DGAT2 Gene

  • This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for DGAT2 Gene

DGAT2 (Diacylglycerol O-Acyltransferase 2) is a Protein Coding gene. Diseases associated with DGAT2 include Pellagra. Among its related pathways are triacylglycerol biosynthesis and Fat digestion and absorption. GO annotations related to this gene include protein homodimerization activity and 2-acylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT3.

UniProtKB/Swiss-Prot for DGAT2 Gene

  • Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).

Tocris Summary for DGAT2 Gene

  • Diacylglycerol O-Acyltransferases (DGATs), EC 2.3.1.20, are enzymes that catalyze the final step of triglyceride (TG) synthesis, the covalent attachment of fatty acyl-CoA and diacylglycerol (DAG). There have been two DGAT isoforms identified to date, DGAT1 and DGAT2.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGAT2 Gene

Genomics for DGAT2 Gene

Regulatory Elements for DGAT2 Gene

Enhancers for DGAT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G075820 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.8 +64.8 64766 7.8 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF143 ZNF207 FOS DEK JUNB DGAT2 ENSG00000254814 MOGAT2 THAP12 UVRAG ARRB1 LOC100506113 ENSG00000200256 GC11M075836
GH11G075785 1.1 ENCODE dbSUPER 21.1 +27.0 27005 2.2 BCOR HDGF CTCF ZNF792 SAP130 ZMYM3 ARID4B THRB ZNF48 RAD21 DGAT2 ENSG00000255421 MOGAT2 ENSG00000254826 ENSG00000254814
GH11G075273 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -483.1 -483106 5.3 HDGF AGO1 ARID4B SIN3A DMAP1 YY1 ZNF121 ZNF263 SP3 SP5 ARRB1 MIR326 DGAT2 ENSG00000254963 GC11M075326
GH11G075771 1.3 FANTOM5 ENCODE dbSUPER 14.2 +12.3 12312 0.5 ZNF639 JUND NFIA SAP130 ZBTB11 MAX ARID4B HNF4A RAD21 DGAT2 ENSG00000254814 MOGAT2 UVRAG ENSG00000254826 LOC283214
GH11G075781 1 dbSUPER 17.7 +23.4 23396 2.9 HDGF FOXA2 PKNOX1 ZFP64 ARID4B ZNF48 FOS SP5 MIER2 PPARG DGAT2 MOGAT2 SERPINH1 ENSG00000254826 ENSG00000254814
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DGAT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DGAT2 Gene

Chromosome:
11
Start:
75,759,512 bp from pter
End:
75,801,536 bp from pter
Size:
42,025 bases
Orientation:
Plus strand

Genomic View for DGAT2 Gene

Genes around DGAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGAT2 Gene

Proteins for DGAT2 Gene

  • Protein details for DGAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PD7-DGAT2_HUMAN
    Recommended name:
    Diacylglycerol O-acyltransferase 2
    Protein Accession:
    Q96PD7
    Secondary Accessions:
    • A6ND76
    • Q5U810
    • Q68CL3
    • Q68DJ0
    • Q8NDB7
    • Q96BS0
    • Q9BYE5

    Protein attributes for DGAT2 Gene

    Size:
    388 amino acids
    Molecular mass:
    43831 Da
    Quaternary structure:
    • Forms multimeric complexes consisting of several DGAT2 subunits.
    SequenceCaution:
    • Sequence=BAD38635.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38961.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DGAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGAT2 Gene

Selected DME Specific Peptides for DGAT2 Gene

Q96PD7:
  • QKKFQKY
  • LQVISVLQ
  • VSKKFPGI
  • GGAAESL
  • YSFGENEVYKQ
  • VLQWVLSFL
  • LATLAGNFR
  • WVRNWAVWRYFRDYFP
  • PITTVVG

Post-translational modifications for DGAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DGAT2

Domains & Families for DGAT2 Gene

Gene Families for DGAT2 Gene

Protein Domains for DGAT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DGAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PD7

UniProtKB/Swiss-Prot:

DGAT2_HUMAN :
  • Belongs to the diacylglycerol acyltransferase family.
Family:
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with DGAT2: view

Function for DGAT2 Gene

Molecular function for DGAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + retinol = CoA + retinyl ester.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by niacin.
UniProtKB/Swiss-Prot Function:
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).

Enzyme Numbers (IUBMB) for DGAT2 Gene

Gene Ontology (GO) - Molecular Function for DGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity IEA --
GO:0004144 diacylglycerol O-acyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA --
genes like me logo Genes that share ontologies with DGAT2: view
genes like me logo Genes that share phenotypes with DGAT2: view

Animal Models for DGAT2 Gene

MGI Knock Outs for DGAT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for DGAT2

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGAT2 Gene

Localization for DGAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGAT2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGAT2 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 4
extracellular 2
peroxisome 2
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 colocalizes_with mitochondrion ISS --
GO:0005783 endoplasmic reticulum IDA 14521909
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005811 colocalizes_with lipid particle ISS,IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DGAT2: view

Pathways & Interactions for DGAT2 Gene

genes like me logo Genes that share pathways with DGAT2: view

UniProtKB/Swiss-Prot Q96PD7-DGAT2_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.

Gene Ontology (GO) - Biological Process for DGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0010867 positive regulation of triglyceride biosynthetic process IEA --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0019915 lipid storage ISS --
genes like me logo Genes that share ontologies with DGAT2: view

No data available for SIGNOR curated interactions for DGAT2 Gene

Drugs & Compounds for DGAT2 Gene

(5) Drugs for DGAT2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra 492
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(42) Additional Compounds for DGAT2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with DGAT2: view

Transcripts for DGAT2 Gene

Unigene Clusters for DGAT2 Gene

Diacylglycerol O-acyltransferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGAT2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - - - - -
SP5:
SP6:

Relevant External Links for DGAT2 Gene

GeneLoc Exon Structure for
DGAT2
ECgene alternative splicing isoforms for
DGAT2

Expression for DGAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGAT2 Gene

This gene is overexpressed in Whole Blood (x12.3), Adipose - Visceral (Omentum) (x8.6), Liver (x5.2), Adipose - Subcutaneous (x4.9), Breast - Mammary Tissue (x4.4), and Skin - Sun Exposed (Lower leg) (x4.3).

Protein differential expression in normal tissues from HIPED for DGAT2 Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DGAT2 Gene



Protein tissue co-expression partners for DGAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DGAT2 Gene:

DGAT2

SOURCE GeneReport for Unigene cluster for DGAT2 Gene:

Hs.129798

mRNA Expression by UniProt/SwissProt for DGAT2 Gene:

Q96PD7-DGAT2_HUMAN
Tissue specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.

Evidence on tissue expression from TISSUES for DGAT2 Gene

  • Lymph node(4.1)
  • Pancreas(4.1)
  • Liver(3.3)
  • Skin(2.8)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with DGAT2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DGAT2 Gene

Orthologs for DGAT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DGAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGAT2 34 35
  • 99.66 (n)
oppossum
(Monodelphis domestica)
Mammalia DGAT2 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DGAT2 34 35
  • 92.43 (n)
dog
(Canis familiaris)
Mammalia DGAT2 34 35
  • 90.56 (n)
rat
(Rattus norvegicus)
Mammalia Dgat2 34
  • 90.29 (n)
mouse
(Mus musculus)
Mammalia Dgat2 34 16 35
  • 89.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves DGAT2 34 35
  • 79.24 (n)
lizard
(Anolis carolinensis)
Reptilia DGAT2 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgat2 34
  • 73.06 (n)
MGC76066 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68683 34
zebrafish
(Danio rerio)
Actinopterygii dgat2 34 35
  • 69.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1941 36
  • 39 (a)
CG1942 36
  • 38 (a)
CG1946 36
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea Y53G8B.2 36
  • 47 (a)
W01A11.2 36
  • 45 (a)
F59A1.10 36
  • 44 (a)
Species where no ortholog for DGAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGAT2 Gene

ENSEMBL:
Gene Tree for DGAT2 (if available)
TreeFam:
Gene Tree for DGAT2 (if available)

Paralogs for DGAT2 Gene

Paralogs for DGAT2 Gene

(6) SIMAP similar genes for DGAT2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DGAT2: view

Variants for DGAT2 Gene

Sequence variations from dbSNP and Humsavar for DGAT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs869025595 Uncertain significance 75,797,190(+) TAGAC(C/T)ATTTG reference, missense
rs1000106737 -- 75,793,780(+) GTATT(A/G)GCTGC intron-variant
rs1000139436 -- 75,794,070(+) AGGGC(A/C)AAGCG intron-variant
rs1000272609 -- 75,799,939(+) TGTCA(C/T)ATTCC intron-variant
rs1000407142 -- 75,800,297(+) TCATG(A/G)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGAT2 Gene

Variant ID Type Subtype PubMed ID
nsv477609 CNV novel sequence insertion 20440878

Variation tolerance for DGAT2 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGAT2 Gene

Human Gene Mutation Database (HGMD)
DGAT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGAT2 Gene

Disorders for DGAT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DGAT2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pellagra
  • niacin deficiency
- elite association - COSMIC cancer census association via MalaCards
Search DGAT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DGAT2

Genetic Association Database (GAD)
DGAT2
Human Genome Epidemiology (HuGE) Navigator
DGAT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGAT2
genes like me logo Genes that share disorders with DGAT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGAT2 Gene

Publications for DGAT2 Gene

  1. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PMID: 11481335) Cases S. … Farese R.V. Jr. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. (PMID: 17477860) Friedel S. … Hebebrand J. (BMC Genet. 2007) 3 22 46 64
  3. A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. (PMID: 14521909) Wakimoto K. … Imai Y. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  4. DGAT2 mutation in a family with autosomal-dominant early-onset axonal Charcot-Marie-Tooth disease. (PMID: 26786738) Hong Y.B. … Chung K.W. (Hum. Mutat. 2016) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for DGAT2 Gene

Sources for DGAT2 Gene

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