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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGAT1 Gene

protein-coding   GIFtS: 62
GCID: GC08M145510

Diacylglycerol O-Acyltransferase 1

(Previous name: diacylglycerol O-acyltransferase homolog 1 (mouse))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Diacylglycerol O-Acyltransferase 11 2     Diacylglycerol O-Acyltransferase Homolog 1 (Mouse)1
Acyl-CoA Retinol O-Fatty-Acyltransferase2 3     ACAT Related Gene Product 12
Diglyceride Acyltransferase2 3     Acyl Coenzyme A:Cholesterol Acyltransferase Related Gene 12
Retinol O-Fatty-Acyltransferase2 3     Acyl-CoA:Diacylglycerol Acyltransferase2
ARAT2 3     AGRP13
DGAT2 3     EC 2.3.1.763
EC 2.3.1.203 8     ACAT-Related Gene Product 13
ARGP12 5     EC 2.3.18

External Ids:    HGNC: 28431   Entrez Gene: 86942   Ensembl: ENSG000001850007   OMIM: 6049005   UniProtKB: O759073   

Export aliases for DGAT1 gene to outside databases

Previous GC identifers: GC08M143202 GC08U900023 GC08M145142 GC08M145544 GC08M140652


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGAT1 Gene:
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein
catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer
acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases.
(provided by RefSeq, Jul 2013)

GeneCards Summary for DGAT1 Gene: 
DGAT1 (diacylglycerol O-acyltransferase 1) is a protein-coding gene. Diseases associated with DGAT1 include congenital chronic diarrhea with protein-losing enteropathy, and fatty liver disease, and among its related super-pathways are Metabolic pathways and Statin Pathway. GO annotations related to this gene include retinol O-fatty-acyltransferase activity and transferase activity, transferring acyl groups. An important paralog of this gene is SOAT1.

UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907
Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and
fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL
(very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol.
Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid
homeostasis and prevent retinoid toxicity leading to skin and hair disorders

summary for DGAT1 Gene:
Acyl-CoA:diacylglycerol acyltransferase (DGAT) catalyzes the generation of triglycerides from diacylglycerol
(DAG) and Acyl-CoA.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_037704.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DGAT1 gene promoter:
         PPAR-alpha   CREB   PPAR-gamma1   deltaCREB   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDGAT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DGAT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

DGAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGAT1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145510:  view genomic region     (about GC identifiers)

Start:
145,538,247 bp from pter      End:
145,550,573 bp from pter
Size:
12,327 bases      Orientation:
minus strand

1 alternative location:
Chr8-,NW_003315924 83,843-96,163     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907 (See protein sequence)
Recommended Name: Diacylglycerol O-acyltransferase 1  
Size: 488 amino acids; 55278 Da
Subunit: Homodimer or homotetramer (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: B2RWQ2 D3DWL6 Q96BB8

Explore the universe of human proteins at neXtProt for DGAT1: NX_O75907

Explore proteomics data for DGAT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75907

  • 4/8 DME Specific Peptides for DGAT1 (O75907) (see all 8)
     WNIPVHK  ESITPVGS  PLRMFRLWAFT  FHSCLNAVAEL 

    DGAT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DGAT1 Protein Expression
    REFSEQ proteins: NP_036211.2  
    ENSEMBL proteins: 
     ENSP00000332258   ENSP00000432795  
    Reactome Protein details: O75907
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane ISS--
    GO:0043231intracellular membrane-bounded organelle ----

    DGAT1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR014371 Oat_ACAT_DAG_ARE
     IPR027251 Diacylglycerol_acylTrfase1
     IPR004299 MBOAT_fam

    Graphical View of Domain Structure for InterPro Entry O75907

    ProtoNet protein and cluster: O75907

    1 Blocks protein domain: IPB004299 Membrane bound O-acyl transferase

    UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907
    Similarity: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily


    DGAT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGAT1_HUMAN, O75907
    Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and
    fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL
    (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol.
    Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid
    homeostasis and prevent retinoid toxicity leading to skin and hair disorders
    Catalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol
    Catalytic activity: Acyl-CoA + retinol = CoA + retinyl ester
    Enzyme regulation: XP620 is a selective DGAT1 inhibitor
    Biophysicochemical properties: Kinetic parameters: KM=25.9 uM for retinol; KM=13.9 uM for palmitoyl coenzyme A;

         Enzyme Numbers (IUBMB): EC 2.3.1.201 2 EC 2.3.12 EC 2.3.1.761

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038462-acylglycerol O-acyltransferase activity IEA--
    GO:0004144diacylglycerol O-acyltransferase activity EXP--
    GO:0008374O-acyltransferase activity ----
    GO:0016746transferase activity, transferring acyl groups TAS9756920
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    DGAT1 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dgat1):
     adipose tissue  behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  integument  liver/biliary system 

    DGAT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DGAT1: Dgat1tm1Far Dgat1tm1Ryyo

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DGAT1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DGAT1 
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    SwitchGear 3'UTR luciferase reporter plasmidDGAT1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DGAT1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    2Statin Pathway, Pharmacodynamics
    Statin Pathway0.73
    Statin Pathway, Pharmacodynamics0.73
    3CDP-diacylglycerol biosynthesis I
    triacylglycerol biosynthesis0.50
    Triacylglyceride Synthesis0.36
    4Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Phospholipid metabolism0.64
    5Retinol metabolism
    Retinol metabolism0.95

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for DGAT1
        Retinol metabolism

    3 BioSystems Pathways for DGAT1
        Statin Pathway
    Triacylglyceride Synthesis
    triacylglycerol biosynthesis

    5/7        Reactome Pathways for DGAT1 (see all 7)
        Glycerophospholipid biosynthesis
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis
    Acyl chain remodeling of DAG and TAG

    1 PharmGKB Pathway for DGAT1
        Statin Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for DGAT1):
        Glycerolipid metabolism
    Retinol metabolism
    Metabolic pathways
    Fat digestion and absorption

    UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907
    Pathway: Lipid metabolism; glycerolipid metabolism


    DGAT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for DGAT1 (ENSP000003322584) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CELENSP000003611514STRING: ENSP00000361151
    CYP26A1ENSP000002243564STRING: ENSP00000224356
    DGKDENSP000002640574STRING: ENSP00000264057
    DGKQENSP000002738144STRING: ENSP00000273814
    DHRS3ENSP000003653974STRING: ENSP00000365397
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006641triglyceride metabolic process TAS9756920
    GO:0006644phospholipid metabolic process TAS--
    GO:0016310phosphorylation ----
    GO:0019432triglyceride biosynthetic process TAS--
    GO:0019915lipid storage ISS--

    DGAT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DGAT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Compounds for DGAT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    YM 750Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor[138046-43-2]
    VULM 1457Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor[228544-65-8]
    N1,N11-Diethylnorspermine tetrahydrochloride Spermine and spermidine acetyltransferase potentiator[121749-39-1]
    (R)-(+)-Etomoxir sodium saltCarnitine palmitoyltransferase I (CPT1) inhibitor[828934-41-4]
    A 922500Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor[959122-11-3]

    10/1165 HMDB Compounds for DGAT1 (see all 1165)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    10/16 Novoseek inferred chemical compound relationships for DGAT1 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    triacylglycerol 85.4 47 14557275 (4), 18768481 (3), 16864897 (2), 15500922 (2) (see all 20)
    monoacylglycerol 60.6 14 18768481 (5), 20374941 (1)
    fatty acid 59.6 18 16130466 (2), 12923227 (2), 15500922 (1), 20126314 (1) (see all 12)
    acyl-coa 58.8 4 20374941 (2), 11672446 (1)
    lipid 52.8 25 15669762 (2), 16459663 (1), 19028692 (1), 15500922 (1) (see all 17)
    palmitate 45.7 4 10070036 (2), 15500922 (1)
    glycerol 3-phosphate 45.2 1 16864897 (1)
    oleic acid 42.6 4 18278045 (1), 15308631 (1)
    acetyl-coa 35.9 1 12888629 (1)
    phosphatidylcholine 26.3 4 14557275 (2)

    Search CenterWatch for drugs/clinical trials and news about DGAT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for DGAT1 gene: 
    NM_012079.5  

    Unigene Cluster for DGAT1:

    Diacylglycerol O-acyltransferase 1
    Hs.521954  [show with all ESTs]
    Unigene Representative Sequence: NM_012079
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527438 ENST00000526479 ENST00000332324(uc003zbv.3) ENST00000524965
    ENST00000528718 ENST00000527885 ENST00000524844 ENST00000531896 ENST00000525371

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB057815.1 AF059202.1 BC006263.2 BC015762.1 BC023565.1 BC106084.1 BC150649.1 

    12 DOTS entries:

    DT.415463  DT.100780987  DT.121492236  DT.86840605  DT.411156  DT.97848211  DT.100688235  DT.100780988 
    DT.40291106  DT.100028131  DT.95195890  DT.100812890 

    24/208 AceView cDNA sequences (see all 208):

    BU070233 BX420014 CR622706 BF345504 AI472888 BI907285 CK825343 AW015835 
    CR619886 BM857224 BC015762 BF345707 CR625143 BQ058342 BM014458 BM743182 
    BX099763 BU680970 BU682526 AI370656 AI367529 BM739011 BM739263 CB161855 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DGAT1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                                                                        -     -                     
    SP2:              -                                                                                                                     
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for DGAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DGAT1 expression in normal human tissues (normalized intensities)      DGAT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACGTCCACG
    DGAT1 Expression
    About this image


    DGAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine   
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See DGAT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DGAT1

    SOURCE GeneReport for Unigene cluster: Hs.521954
        SABiosciences Expression via Pathway-Focused PCR Array including DGAT1: 
              PPAR Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGAT1 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dgat11 , 5 diacylglycerol O-acyltransferase 11, 5 83.75(n)1
    87.19(a)1
      15 (35.99 cM)5
    133501  NM_010046.21  NP_034176.11 
     765020155 
    lizard
    (Anolis carolinensis)
    Reptilia DGAT16
    Uncharacterized protein
    77(a)
    1 ↔ 1
    1(259580488-259602614)
    zebrafish
    (Danio rerio)
    Actinopterygii wufd36g112 wufd36g11 77.43(n)   325875  BC063970.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mdy1 , 3 triacylglycerol biosynthesis sterol
    O-acyltransferase3
    midway1
    44(a)3
    52.01(n)1
    46.38(a)1
      448871  NM_206002.11  NP_995724.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mboa-21 Protein MBOA-2 51.88(n)
    49.53(a)
      179540  NM_073427.5  NP_505828.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARE2(YNR019W)4 Acyl-CoA:sterol acyltransferase, isozyme of Are1p; more   --   14(665339-667267) 855753  NP_014416.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TAG11 diacylglycerol O-acyltransferase 1 46.93(n)
    42.57(a)
      816464  NM_127503.2  NP_179535.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01968001 hypothetical protein 46.58(n)
    37.99(a)
      4338045  NM_001061404.2  NP_001054869.2 


    ENSEMBL Gene Tree for DGAT1 (if available)
    TreeFam Gene Tree for DGAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DGAT1 gene
    SOAT12  SOAT22  

    DGAT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/332 SNPs in DGAT1 are shown (see all 332)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78170031,2
    C,F,A--145538917(+) CCCATC/TCCCCC 1 -- ut315Minor allele frequency- T:0.30NA WA 244
    rs1896166081,2
    --145539028(+) CAAGGG/TAGCCC 1 -- ut310--------
    rs1823061901,2
    --145539102(+) CCTGTA/GCAGGG 1 -- ut310--------
    rs1877201171,2
    --145539155(+) GGGGAC/TACCAG 1 -- ut310--------
    rs1478995181,2
    --145539249(+) CCTCCC/TGCTAC 1 -- ut310--------
    rs1405208861,2
    C--145539267(+) GGGGGC/GCCCAT 1 -- ut310--------
    rs1508092281,2
    C--145539410(+) AACCTC/TGTGGA 1 -- ut310--------
    rs1455680261,2
    --145539515(+) TGGACA/GTAGCC 1 -- ut310--------
    rs1926865181,2
    --145539531(+) GTACCA/GTAGCC 1 -- ut310--------
    rs1488930491,2
    --145539674(+) GTTGAC/TCATCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DGAT1 (145538247 - 145550573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for DGAT1 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv7962n71CNV Loss21882294
    nsv891841CNV Loss21882294
    dgv7960n71CNV Loss21882294
    nsv891846CNV Loss21882294
    dgv7955n71CNV Loss21882294
    nsv891817CNV Loss21882294
    dgv7957n71CNV Loss21882294
    nsv891807CNV Loss21882294
    dgv7958n71CNV Loss21882294
    dgv7940n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): DGAT1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DGAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for DGAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604900    OMIM disorders: --

    10 diseases for DGAT1:    About MalaCards
    congenital chronic diarrhea with protein-losing enteropathy    fatty liver disease    insulin resistance    hepatoblastoma
    obesity    liver disease    hepatitis c    atherosclerosis
    alcoholism    hepatitis


    DGAT1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for DGAT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 54.8 20 16595853 (3), 11956242 (2), 15569818 (2), 17907060 (2) (see all 9)
    fatty liver 46.8 1 16595853 (1)
    insulin resistance 33.6 3 11956242 (2), 16595853 (1)
    insulin sensitivity 16.6 2 15224651 (1), 16595853 (1)

    Genetic Association Database (GAD): DGAT1
    Human Genome Epidemiology (HuGE) Navigator: DGAT1 (4 documents)

    Export disorders for DGAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DGAT1 gene, integrated from 9 sources (see all 114):
    (articles sorted by number of sources associating them with DGAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. (PubMed id 9756920)1, 2, 3 Oelkers P.... Sturley S.L. (1998)
    2. Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. (PubMed id 16214399)1, 2, 9 Orland M.D....Cheng D. (2005)
    3. Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects. (PubMed id 14569040)1, 4, 9 Coudreau S.K....Clement K. (2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. (PubMed id 12123490)1, 4 Ludwig E.H....Farese R.V. (2002)
    6. Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. (PubMed id 18768481)1, 9 Cheng D....Hussain M.M. (2008)
    7. Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts. (PubMed id 14557275)1, 9 Bagnato C. and Igal R.A. (2003)
    8. DGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins. (PubMed id 20167659)1, 9 Krapivner S....van't Hooft F.M. (2010)
    9. Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. (PubMed id 15258194)1, 9 Ganji S.H....Kashyap M.L. (2004)
    10. Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein. (PubMed id 11672446)1, 9 Cheng D....Young P.R. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8694 HGNC: 2843 AceView: DGAT1 Ensembl:ENSG00000185000 euGenes: HUgn8694
    ECgene: DGAT1 Kegg: 8694 H-InvDB: DGAT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DGAT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DGAT1 gene:
    Search GeneIP for patents involving DGAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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