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Aliases for DGAT1 Gene

Aliases for DGAT1 Gene

  • Diacylglycerol O-Acyltransferase 1 2 3
  • Acyl-CoA Retinol O-Fatty-Acyltransferase 3 4
  • Diglyceride Acyltransferase 3 4
  • EC 2.3.1.20 4 64
  • ARGP1 3 6
  • ARAT 3 4
  • DGAT 3 4
  • Acyl Coenzyme A:Cholesterol Acyltransferase Related Gene 1 3
  • Diacylglycerol O-Acyltransferase Homolog 1 (Mouse) 2
  • Acyl-CoA:Diacylglycerol Acyltransferase 3
  • Retinol O-Fatty-Acyltransferase 4
  • ACAT Related Gene Product 1 3
  • ACAT-Related Gene Product 1 4
  • EC 2.3.1.76 4
  • EC 2.3.1 64
  • DIAR7 3
  • AGRP1 4

External Ids for DGAT1 Gene

Summaries for DGAT1 Gene

Entrez Gene Summary for DGAT1 Gene

  • This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]

GeneCards Summary for DGAT1 Gene

DGAT1 (Diacylglycerol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with DGAT1 include congenital chronic diarrhea with protein-losing enteropathy and diarrhea 7. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include transferase activity, transferring acyl groups and retinol O-fatty-acyltransferase activity. An important paralog of this gene is SOAT2.

UniProtKB/Swiss-Prot for DGAT1 Gene

  • Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

Tocris Summary for DGAT1 Gene

  • Acyl-CoA:diacylglycerol acyltransferase (DGAT) catalyzes the generation of triglycerides from diacylglycerol (DAG) and Acyl-CoA.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGAT1 Gene

Genomics for DGAT1 Gene

Genomic Location for DGAT1 Gene

Start:
144,314,583 bp from pter
End:
144,326,919 bp from pter
Size:
12,337 bases
Orientation:
Minus strand

Genomic View for DGAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGAT1 Gene

Regulatory Elements for DGAT1 Gene

Proteins for DGAT1 Gene

  • Protein details for DGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75907-DGAT1_HUMAN
    Recommended name:
    Diacylglycerol O-acyltransferase 1
    Protein Accession:
    O75907
    Secondary Accessions:
    • B2RWQ2
    • D3DWL6
    • Q96BB8

    Protein attributes for DGAT1 Gene

    Size:
    488 amino acids
    Molecular mass:
    55278 Da
    Quaternary structure:
    • Homodimer or homotetramer.

neXtProt entry for DGAT1 Gene

Proteomics data for DGAT1 Gene at MOPED

Post-translational modifications for DGAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGAT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for DGAT1 Gene

Protein Domains for DGAT1 Gene

UniProtKB/Swiss-Prot:

DGAT1_HUMAN
Family:
  • Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.:
    • O75907
genes like me logo Genes that share domains with DGAT1: view

No data available for Gene Families for DGAT1 Gene

Function for DGAT1 Gene

Molecular function for DGAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=25.9 uM for retinol {ECO:0000269 PubMed:16214399}; KM=13.9 uM for palmitoyl coenzyme A {ECO:0000269 PubMed:16214399};
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + retinol = CoA + retinyl ester.
UniProtKB/Swiss-Prot EnzymeRegulation: XP620 is a selective DGAT1 inhibitor.
UniProtKB/Swiss-Prot Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

Enzyme Numbers (IUBMB) for DGAT1 Gene

Gene Ontology (GO) - Molecular Function for DGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity IEA --
GO:0004144 diacylglycerol O-acyltransferase activity IDA 18458083
GO:0005515 protein binding IPI 23420847
GO:0016746 transferase activity, transferring acyl groups TAS 9756920
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with DGAT1: view
genes like me logo Genes that share phenotypes with DGAT1: view

Animal Models for DGAT1 Gene

MGI Knock Outs for DGAT1:

miRNA for DGAT1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for DGAT1 Gene

Localization for DGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGAT1 Gene COMPARTMENTS Subcellular localization image for DGAT1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
peroxisome 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane ISS --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with DGAT1: view

Pathways for DGAT1 Gene

genes like me logo Genes that share pathways with DGAT1: view

Pathways by source for DGAT1 Gene

UniProtKB/Swiss-Prot O75907-DGAT1_HUMAN

  • Pathway: Lipid metabolism; glycerolipid metabolism

Interacting Proteins for DGAT1 Gene

Gene Ontology (GO) - Biological Process for DGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006641 triglyceride metabolic process TAS 9756920
GO:0006644 phospholipid metabolic process TAS --
GO:0016310 phosphorylation --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0019915 lipid storage ISS --
genes like me logo Genes that share ontologies with DGAT1: view

Compounds for DGAT1 Gene

(5) Tocris Compounds for DGAT1 Gene

Compound Action Cas Number
(R)-(+)-Etomoxir sodium salt Carnitine palmitoyltransferase I (CPT1) inhibitor [828934-41-4]
A 922500 Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor [959122-11-3]
N1,N11-Diethylnorspermine tetrahydrochloride Spermine and spermidine acetyltransferase potentiator [121749-39-1]
VULM 1457 Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor [228544-65-8]
YM 750 Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor [138046-43-2]

(1165) HMDB Compounds for DGAT1 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(16) Novoseek inferred chemical compound relationships for DGAT1 Gene

Compound -log(P) Hits PubMed IDs
triacylglycerol 85.4 34
monoacylglycerol 60.6 6
fatty acid 59.6 14
acyl-coa 58.8 3
lipid 52.8 18
genes like me logo Genes that share compounds with DGAT1: view

Transcripts for DGAT1 Gene

Unigene Clusters for DGAT1 Gene

Diacylglycerol O-acyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGAT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17
SP1: - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for DGAT1 Gene

GeneLoc Exon Structure for
DGAT1
ECgene alternative splicing isoforms for
DGAT1

Expression for DGAT1 Gene

mRNA expression in normal human tissues for DGAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGAT1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DGAT1 Gene

SOURCE GeneReport for Unigene cluster for DGAT1 Gene Hs.521954

genes like me logo Genes that share expressions with DGAT1: view

Orthologs for DGAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGAT1 36
  • 99.64 (n)
  • 100 (a)
DGAT1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DGAT1 36
  • 88.17 (n)
  • 89.39 (a)
DGAT1 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGAT1 36
  • 86.85 (n)
  • 86.42 (a)
DGAT1 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgat1 36
  • 83.19 (n)
  • 85.47 (a)
Dgat1 16
Dgat1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DGAT1 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGAT1 37
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgat1 36
  • 82.12 (n)
  • 84.62 (a)
lizard
(Anolis carolinensis)
Reptilia DGAT1 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgat1 36
  • 70.43 (n)
  • 72.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4684 36
zebrafish
(Danio rerio)
Actinopterygii dgat1a 37
  • 61 (a)
OneToMany
dgat1b 36
  • 66.75 (n)
  • 70.1 (a)
dgat1b 37
  • 59 (a)
OneToMany
wufd36g11 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007843 36
  • 56.2 (n)
  • 49.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta mdy 36
  • 51.69 (n)
  • 46.14 (a)
mdy 37
  • 30 (a)
OneToOne
mdy 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea mboa-2 36
  • 50.99 (n)
  • 48.39 (a)
mboa-2 37
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARE1 37
  • 15 (a)
ManyToMany
ARE2 37
  • 14 (a)
ManyToMany
ARE2 39
thale cress
(Arabidopsis thaliana)
eudicotyledons TAG1 36
  • 47.89 (n)
  • 40.69 (a)
rice
(Oryza sativa)
Liliopsida Os05g0196800 36
  • 47.33 (n)
  • 39.69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14600 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToOne
Species with no ortholog for DGAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGAT1 Gene

ENSEMBL:
Gene Tree for DGAT1 (if available)
TreeFam:
Gene Tree for DGAT1 (if available)

Paralogs for DGAT1 Gene

Paralogs for DGAT1 Gene

genes like me logo Genes that share paralogs with DGAT1: view

Variants for DGAT1 Gene

Sequence variations from dbSNP and Humsavar for DGAT1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3757968 -- 144,327,537(-) CAGGC(C/G)GGGAG upstream-variant-2KB
rs3757969 -- 144,327,536(-) AGGCG(C/G)GGAGG upstream-variant-2KB
rs3757970 -- 144,322,373(-) CCTCT(C/T)ACAAA intron-variant
rs3757971 -- 144,322,286(-) TGTAT(A/G)TGAGC intron-variant
rs3757972 -- 144,322,257(-) CGTGT(A/G)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGAT1 Gene

Variant ID Type Subtype PubMed ID
dgv7940n71 CNV Loss 21882294
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
dgv7955n71 CNV Loss 21882294
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7957n71 CNV Loss 21882294
dgv7958n71 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv8396 CNV Gain 18304495
dgv7960n71 CNV Loss 21882294
nsv891832 CNV Gain+Loss 21882294
nsv891838 CNV Gain 21882294
nsv891840 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv824804 CNV Gain 20364138
nsv891842 CNV Gain+Loss 21882294
nsv891843 CNV Loss 21882294
nsv891844 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
dgv7962n71 CNV Loss 21882294

Relevant External Links for DGAT1 Gene

HapMap Linkage Disequilibrium report
DGAT1
Human Gene Mutation Database (HGMD)
DGAT1

Disorders for DGAT1 Gene

UniProtKB/Swiss-Prot

DGAT1_HUMAN
  • Diarrhea 7 (DIAR7) [MIM:615863]: A life-threatening disease characterized by severe, intractable, watery diarrhea. {ECO:0000269 PubMed:23114594}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) Novoseek inferred disease relationships for DGAT1 Gene

Disease -log(P) Hits PubMed IDs
obesity 54.8 15
fatty liver 46.8 1
insulin resistance 33.6 3
insulin sensitivity 16.6 2

Relevant External Links for DGAT1

Genetic Association Database (GAD)
DGAT1
Human Genome Epidemiology (HuGE) Navigator
DGAT1
genes like me logo Genes that share disorders with DGAT1: view

Publications for DGAT1 Gene

  1. Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. (PMID: 16214399) Orland M.D. … Cheng D. (Biochim. Biophys. Acta 2005) 3 4 23
  2. Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects. (PMID: 14569040) Coudreau S.K. … ClAcment K. (Obes. Res. 2003) 3 23 49
  3. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. (PMID: 9756920) Oelkers P. … Sturley S.L. (J. Biol. Chem. 1998) 2 3 4
  4. Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts. (PMID: 14557275) Bagnato C. … Igal R.A. (J. Biol. Chem. 2003) 3 23
  5. DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. (PMID: 12123490) Ludwig E.H. … Farese R.V. (Clin. Genet. 2002) 3 49

Products for DGAT1 Gene

Sources for DGAT1 Gene

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