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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DGAT1 Gene

protein-coding GIFtS: 61
GCID: GC08M145510

diacylglycerol O-acyltransferase 1

(Previous name: diacylglycerol O-acyltransferase homolog 1 (mouse) )

Explore 12 diseases affiliated with
DGAT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Diacylglycerol O-Acyltransferase 1¹ ²		EC 2.3.1.20³ ⁸
DGAT¹ ² ³		Diacylglycerol O-Acyltransferase Homolog 1 (Mouse)¹
ARGP1¹ ² ⁵		ACAT Related Gene Product 1²
Acyl-CoA Retinol O-Fatty-Acyltransferase² ³		Acyl Coenzyme A:Cholesterol Acyltransferase Related Gene 1²
Diglyceride Acyltransferase² ³		Diacylglycerol O-Acyltransferase Homolog 1²
Retinol O-Fatty-Acyltransferase² ³		AGRP1³
ARAT² ³		EC 2.3.1.76³
ACAT-Related Gene Product 1² ³		EC 2.3.1⁸

External Ids:	HGNC: 2843¹	Entrez Gene: 8694²	Ensembl: ENSG00000185000⁷	OMIM: 604900⁵	UniProtKB: O75907³

Export aliases for DGAT1 gene to outside databases

Previous GC identifers: GC08M143202 GC08U900023 GC08M145142 GC08M145544 GC08M140652

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGAT1:

The enzyme encoded by this gene utilizes diacylglycerol and fatty acyl CoA as substrates in order to catalyze the final

stage of triacylglycerol synthesis. It is also involved in cellular as well as physiological metabolic processes.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907

Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty

acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low

density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as

the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and

prevent retinoid toxicity leading to skin and hair disorders

summary for DGAT1:

Acyl-CoA:diacylglycerol acyltransferase (DGAT) catalyzes the generation of triglycerides from diacylglycerol

(DAG) and Acyl-CoA.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_037704.5

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DGAT1 gene promoter:
PPAR-alpha CREB PPAR-gamma1 deltaCREB PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DGAT1 promoter sequence

Search SABiosciences Chromatin IP Primers for DGAT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGAT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3

DGAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGAT1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M145510: view genomic region (about GC identifiers)

Start:	145,538,247 bp from pter	End:	145,550,573 bp from pter
Size:	12,327 bases	Orientation:	minus strand

1 alternative location:

Chr8-,PATCHES 145,454,727-145,467,047

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907 (See protein sequence)

Recommended Name: Diacylglycerol O-acyltransferase 1

Size: 488 amino acids; 55278 Da

Subunit: Homodimer or homotetramer (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: B2RWQ2 D3DWL6 Q96BB8

Explore the universe of human proteins at neXtProt for DGAT1: NX_O75907

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75907

4/8 DME Specific Peptides for DGAT1 (O75907) (see all 8)

WNIPVHK

ESITPVGS

PLRMFRLWAFT

FHSCLNAVAEL

DGAT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036211.2

ENSEMBL proteins:

ENSP00000332258 ENSP00000435883 ENSP00000432795

Reactome Protein details: O75907
Human Recombinant Protein Products for DGAT1:

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	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for DGAT1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0016021	integral to membrane	ISS	--

DGAT1 for ontologies About GeneDecksing

DGAT1 Antibody Products:

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	ThermoFisher Antibodies for DGAT1

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	Uscn ELISAs and CLIAs for DGAT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DGAT1 for domains About GeneDecksing

3 InterPro domains/families:

IPR014371 Oat_ACAT_DAG_ARE

IPR027251 Diacylglycerol_acylTrfase1

IPR004299 MBOAT_fam

Graphical View of Domain Structure for InterPro Entry O75907

ProtoNet protein and cluster: O75907

1 Blocks protein family: IPB004299 Membrane bound O-acyl transferase

UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907

Similarity: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DGAT1_HUMAN, O75907

Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty

acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low

density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as

the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and

prevent retinoid toxicity leading to skin and hair disorders

Catalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol

Catalytic activity: Acyl-CoA + retinol = CoA + retinyl ester

Enzyme regulation: XP620 is a selective DGAT1 inhibitor

Biophysicochemical properties: Kinetic parameters: KM=25.9 uM for retinol; KM=13.9 uM for palmitoyl coenzyme A;

Enzyme Numbers (IUBMB): EC 2.3.1.20¹ ² EC 2.3.1² EC 2.3.1.76¹

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003846	2-acylglycerol O-acyltransferase activity	IEA	--
GO:0004144	diacylglycerol O-acyltransferase activity	EXP	--
GO:0005504	fatty acid binding	--	--
GO:0008374	O-acyltransferase activity	--	--
GO:0016746	transferase activity, transferring acyl groups	TAS	9756920

DGAT1 for ontologies About GeneDecksing

Phenotypes:
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dgat1):

adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	integument	liver/biliary system

DGAT1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for DGAT1: Dgat1^tm1Far Dgat1^tm1Ryyo

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DGAT1

miRNA Products:		OriGene 3'-UTR Clone: DGAT1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DGAT1
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DGAT1 (see all 11):
		hsa-miR-1290 hsa-miR-1206 hsa-miR-125a-5p hsa-miR-876-5p hsa-miR-486-3p hsa-miR-3167 hsa-miR-125b hsa-miR-514

		SwitchGear 3'UTR luciferase reporter plasmid: DGAT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against DGAT1

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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DGAT1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DGAT1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DGAT1 (NM_012079)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGAT1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Glycerophospholipid biosynthesis

Glycerophospholipid biosynthesis

1.00

Phospholipid metabolism

0.64

Statin Pathway, Pharmacodynamics

Statin Pathway, Pharmacodynamics

1.00

Statin Pathway

0.80

CDP-diacylglycerol biosynthesis I

triacylglycerol biosynthesis

0.50

Triacylglyceride Synthesis

0.17

Retinol metabolism

Retinol metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for DGAT1

Retinol metabolism

3 BioSystems Pathways for DGAT1

	Statin Pathway
	Triacylglyceride Synthesis
	triacylglycerol biosynthesis

5/7 Reactome Pathways for DGAT1 (see all 7)

	Glycerophospholipid biosynthesis
	Metabolism
	Phospholipid metabolism
	Triglyceride Biosynthesis
	Acyl chain remodeling of DAG and TAG

1 PharmGKB Pathway for DGAT1

Statin Pathway, Pharmacodynamics

4 Kegg Pathways (Kegg details for DGAT1):

	Glycerolipid metabolism
	Retinol metabolism
	Metabolic pathways
	Fat digestion and absorption

UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907

Pathway: Lipid metabolism; glycerolipid metabolism

DGAT1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DGAT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for DGAT1 (ENSP00000332258⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEL	ENSP00000361151⁴	STRING: ENSP00000361151
CYP26A1	ENSP00000224356⁴	STRING: ENSP00000224356
DGKD	ENSP00000264057⁴	STRING: ENSP00000264057
DGKQ	ENSP00000273814⁴	STRING: ENSP00000273814
DHRS3	ENSP00000365397⁴	STRING: ENSP00000365397

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006641	triglyceride metabolic process	TAS	9756920
GO:0006644	phospholipid metabolic process	TAS	--
GO:0019432	triglyceride biosynthetic process	TAS	--
GO:0019915	lipid storage	ISS	--
GO:0030073	insulin secretion	--	--

DGAT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DGAT1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for DGAT1 available from Tocris Bioscience About this table

Compound	Action	CAS #
A 922500	Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor	[959122-11-3]

10/1165 HMDB Compounds for DGAT1 (see all 1165) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Acrylyl-CoA	Acryloyl coenzyme A (see all 14)	5776-58-9	--

10/16 Novoseek chemical compound relationships for DGAT1 gene (see all 16) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
triacylglycerol	85.4	47	14557275 (4), 18768481 (3), 16864897 (2), 15500922 (2) (see all 20)
monoacylglycerol	60.6	14	18768481 (5), 20374941 (1)
fatty acid	59.6	18	16130466 (2), 12923227 (2), 15500922 (1), 20126314 (1) (see all 12)
acyl-coa	58.8	4	20374941 (2), 11672446 (1)
lipid	52.8	25	15669762 (2), 16459663 (1), 19028692 (1), 15500922 (1) (see all 17)
palmitate	45.7	4	10070036 (2), 15500922 (1)
glycerol 3-phosphate	45.2	1	16864897 (1)
oleic acid	42.6	4	18278045 (1), 15308631 (1)
acetyl-coa	35.9	1	12888629 (1)
phosphatidylcholine	26.3	4	14557275 (2)

Search CenterWatch for drugs/clinical trials and news about DGAT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DGAT1 gene:

NM_012079.4

Unigene Cluster for DGAT1:

Diacylglycerol O-acyltransferase 1

Hs.521954 [show with all ESTs]

Unigene Representative Sequence: NM_012079

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000527438 ENST00000332324(uc003zbv.3) ENST00000524965 ENST00000528718

ENST00000526479 ENST00000527885 ENST00000524844 ENST00000531896 ENST00000525371

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		hsa-miR-1290 hsa-miR-1206 hsa-miR-125a-5p hsa-miR-876-5p hsa-miR-486-3p hsa-miR-3167 hsa-miR-125b hsa-miR-514

		SwitchGear 3'UTR luciferase reporter plasmid: DGAT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against DGAT1

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		GenScript: all cDNA clones in your preferred vector: DGAT1 (NM_012079)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DGAT1
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGAT1

Additional cDNA sequence:

AB057815.1 AF059202.1 BC006263.2 BC015762.1 BC023565.1 BC106084.1 BC150649.1

12 DOTS entries:

DT.415463 DT.100780987 DT.121492236 DT.86840605 DT.411156 DT.97848211 DT.100688235 DT.100780988

DT.40291106 DT.100028131 DT.95195890 DT.100812890

24/208 AceView cDNA sequences (see all 208):

BE271571 CR619886 BC006263 AW015835 BC015762 AI370656 BM743182 BU680970

BU682526 AI367529 BM739263 AB057815 CK825344 BM857224 BF345504 BM450197

BM851470 AA769695 BM476315 CR625143 CB161855 AI366194 AA430536 BG152560

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DGAT1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17
SP1:																																			-		-
SP2:					-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DGAT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DGAT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACGTCCACG

About this image
See DGAT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DGAT1

SOURCE GeneReport for Unigene cluster: Hs.521954
SABiosciences Expression via Pathway-Focused PCR Array including DGAT1:

PPAR Targets in human mouse rat

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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGAT1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGAT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGAT1 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dgat1^{1 , 5}	diacylglycerol O-acyltransferase 1^{1, 5}	83.75(n)¹ 87.19(a)¹		15 (35.99 cM)⁵ 13350¹ NM_010046.2¹ NP_034176.1¹ 76502015⁵
lizard (Anolis carolinensis)	Reptilia	DGAT1⁶	--	77(a)	1 ↔ 1	1(259580488-259602552)
zebrafish (Danio rerio)	Actinopterygii	wufd36g11²	wufd36g11	77.43(n)		325875 BC063970.1
fruit fly (Drosophila melanogaster)	Insecta	mdy^{1 , 3}	triacylglycerol biosynthesis sterol O-acyltransferase³ midway¹	44(a)³ 52.01(n)¹ 46.38(a)¹		44887¹ NM_206002.1¹ NP_995724.1¹
worm (Caenorhabditis elegans)	Secernentea	mboa-2¹	Protein MBOA-2	51.88(n) 49.53(a)		179540 NM_073427.5 NP_505828.3
thale cress (Arabidopsis thaliana)	eudicotyledons	TAG1¹	diacylglycerol O-acyltransferase 1	46.93(n) 42.57(a)		816464 NM_127503.2 NP_179535.1
rice (Oryza sativa)	Liliopsida	Os05g0196800¹	hypothetical protein	46.58(n) 37.99(a)		4338045 NM_001061404.2 NP_001054869.2

ENSEMBL Gene Tree for DGAT1 (if available)
TreeFam Gene Tree for DGAT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DGAT1 gene

SOAT1² SOAT2²

DGAT1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7817003^1,2	C,F,A	--	145538917(+)	`CCCATC/TCCCCC`	1	--	ut3¹		5		NA WA	244
rs189616608^1,2		--	145539028(+)	`CAAGGG/TAGCCC`	1	--	ut3¹		0	--	--	--	--
rs182306190^1,2		--	145539102(+)	`CCTGTA/GCAGGG`	1	--	ut3¹		0	--	--	--	--
rs187720117^1,2		--	145539155(+)	`GGGGAC/TACCAG`	1	--	ut3¹		0	--	--	--	--
rs147899518^1,2		--	145539249(+)	`CCTCCC/TGCTAC`	1	--	ut3¹		0	--	--	--	--
rs140520886^1,2		--	145539267(+)	`GGGGGC/GCCCAT`	1	--	ut3¹		0	--	--	--	--
rs150809228^1,2		--	145539410(+)	`AACCTC/TGTGGA`	1	--	ut3¹		0	--	--	--	--
rs145568026^1,2		--	145539515(+)	`TGGACA/GTAGCC`	1	--	ut3¹		0	--	--	--	--
rs192686518^1,2		--	145539531(+)	`GTACCA/GTAGCC`	1	--	ut3¹		0	--	--	--	--
rs148893049^1,2		--	145539674(+)	`GTTGAC/TCATCC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DGAT1 (145538247 - 145550573 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DGAT1
3 CNVs: 3752 31457 30306
Human Gene Mutation Database (HGMD): DGAT1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DGAT1 for disorders           About GeneDecksing

OMIM gene information: 604900    OMIM disorders: --

12 diseases for DGAT1:    About MalaCards

cholesterol insulin resistance fatty liver disease liver disease

hepatitis c obesity hepatoblastoma obesity, resistance to

atherosclerosis hepatitis malaria alcoholism

4 Novoseek disease relationships for DGAT1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	54.8	20	16595853 (3), 11956242 (2), 15569818 (2), 17907060 (2) (see all 9)
fatty liver	46.8	1	16595853 (1)
insulin resistance	33.6	3	11956242 (2), 16595853 (1)
insulin sensitivity	16.6	2	15224651 (1), 16595853 (1)

Genetic Association Database (GAD): DGAT1
Human Genome Epidemiology (HuGE) Navigator: DGAT1 (4 documents)

Export disorders for DGAT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DGAT1 gene, integrated from 9 sources (see all 107):
(articles sorted by number of sources associating them with DGAT1)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. (PubMed id 9756920)^{1, 2, 3} Oelkers P.... Sturley S.L. (1998)
Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects. (PubMed id 14569040)^{1, 4, 9} Coudreau S.K....Clement K. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. (PubMed id 12123490)^{1, 4} Ludwig E.H....Farese R.V. (2002)
Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. (PubMed id 18768481)^{1, 9} Cheng D....Hussain M.M. (2008)
Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts. (PubMed id 14557275)^{1, 9} Bagnato C. and Igal R.A. (2003)
DGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins. (PubMed id 20167659)^{1, 9} Krapivner S....van't Hooft F.M. (2010)
Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. (PubMed id 15258194)^{1, 9} Ganji S.H....Kashyap M.L. (2004)
Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein. (PubMed id 11672446)^{1, 9} Cheng D....Young P.R. (2001)
Visceral and subcutaneous adipose tissue diacylglycer ol acyltransferase activity in humans. (PubMed id 19197254)^{1, 9} Hou X.G....Jensen M.D. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8694	HGNC: 2843	AceView: DGAT1	Ensembl:ENSG00000185000	euGenes: HUgn8694
ECgene: DGAT1	Kegg: 8694	H-InvDB: DGAT1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DGAT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DGAT1 gene
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Patent Information for DGAT1 gene:
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GeneCards and IP:
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diacylglycerol O-acyltransferase 1

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DGAT1 Gene

diacylglycerol O-acyltransferase 1

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