Aliases for DGAT1 Gene
External Ids for DGAT1 Gene
Previous GeneCards Identifiers for DGAT1 Gene
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]
GeneCards Summary for DGAT1 Gene
DGAT1 (Diacylglycerol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with DGAT1 include diarrhea 7 and congenital chronic diarrhea with protein-losing enteropathy. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include transferase activity, transferring acyl groups and retinol O-fatty-acyltransferase activity. An important paralog of this gene is SOAT2.
UniProtKB/Swiss-Prot for DGAT1 Gene
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.
Acyl-CoA:diacylglycerol acyltransferase (DGAT) catalyzes the generation of triglycerides from diacylglycerol (DAG) and Acyl-CoA.