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Aliases for DGAT1 Gene

Aliases for DGAT1 Gene

  • Diacylglycerol O-Acyltransferase 1 2 3 5
  • Acyl-CoA Retinol O-Fatty-Acyltransferase 3 4
  • Diglyceride Acyltransferase 3 4
  • EC 2.3.1.20 4 61
  • ARAT 3 4
  • DGAT 3 4
  • Acyl Coenzyme A:Cholesterol Acyltransferase Related Gene 1 3
  • Diacylglycerol O-Acyltransferase Homolog 1 (Mouse) 2
  • Acyl-CoA:Diacylglycerol Acyltransferase 3
  • Retinol O-Fatty-Acyltransferase 4
  • ACAT Related Gene Product 1 3
  • ACAT-Related Gene Product 1 4
  • EC 2.3.1.76 4
  • EC 2.3.1 61
  • ARGP1 3
  • DIAR7 3
  • AGRP1 4

External Ids for DGAT1 Gene

Previous GeneCards Identifiers for DGAT1 Gene

  • GC08M143202
  • GC08U900023
  • GC08M145142
  • GC08M145544
  • GC08M145510
  • GC08M140652
  • GC08M145539
  • GC08M144315

Summaries for DGAT1 Gene

Entrez Gene Summary for DGAT1 Gene

  • This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]

GeneCards Summary for DGAT1 Gene

DGAT1 (Diacylglycerol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with DGAT1 include Diarrhea 7 and Obesity. Among its related pathways are triacylglycerol biosynthesis and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and 2-acylglycerol O-acyltransferase activity. An important paralog of this gene is SOAT1.

UniProtKB/Swiss-Prot for DGAT1 Gene

  • Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

Tocris Summary for DGAT1 Gene

  • Diacylglycerol O-Acyltransferases (DGATs), EC 2.3.1.20, are enzymes that catalyze the final step of triglyceride (TG) synthesis, the covalent attachment of fatty acyl-CoA and diacylglycerol (DAG). There have been two DGAT isoforms identified to date, DGAT1 and DGAT2.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGAT1 Gene

Genomics for DGAT1 Gene

Regulatory Elements for DGAT1 Gene

Enhancers for DGAT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DGAT1 on UCSC Golden Path with GeneCards custom track

Promoters for DGAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DGAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DGAT1 Gene

Chromosome:
8
Start:
144,314,583 bp from pter
End:
144,326,919 bp from pter
Size:
12,337 bases
Orientation:
Minus strand

Genomic View for DGAT1 Gene

Genes around DGAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGAT1 Gene

Proteins for DGAT1 Gene

  • Protein details for DGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75907-DGAT1_HUMAN
    Recommended name:
    Diacylglycerol O-acyltransferase 1
    Protein Accession:
    O75907
    Secondary Accessions:
    • B2RWQ2
    • D3DWL6
    • Q96BB8

    Protein attributes for DGAT1 Gene

    Size:
    488 amino acids
    Molecular mass:
    55278 Da
    Quaternary structure:
    • Homodimer or homotetramer.
    • Homodimer or homotetramer.

neXtProt entry for DGAT1 Gene

Post-translational modifications for DGAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DGAT1 Gene

Protein Domains for DGAT1 Gene

Suggested Antigen Peptide Sequences for DGAT1 Gene

Graphical View of Domain Structure for InterPro Entry

O75907

UniProtKB/Swiss-Prot:

DGAT1_HUMAN :
  • Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Family:
  • Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
genes like me logo Genes that share domains with DGAT1: view

No data available for Gene Families for DGAT1 Gene

Function for DGAT1 Gene

Molecular function for DGAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=25.9 uM for retinol {ECO:0000269 PubMed:16214399}; KM=13.9 uM for palmitoyl coenzyme A {ECO:0000269 PubMed:16214399};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + retinol = CoA + retinyl ester.
UniProtKB/Swiss-Prot EnzymeRegulation:
XP620 is a selective DGAT1 inhibitor.
UniProtKB/Swiss-Prot Function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

Enzyme Numbers (IUBMB) for DGAT1 Gene

Gene Ontology (GO) - Molecular Function for DGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity IEA --
GO:0004144 diacylglycerol O-acyltransferase activity IEA,TAS --
GO:0005515 protein binding IPI 23420847
GO:0016746 transferase activity, transferring acyl groups TAS 9756920
GO:0050252 retinol O-fatty-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with DGAT1: view
genes like me logo Genes that share phenotypes with DGAT1: view

Human Phenotype Ontology for DGAT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DGAT1 Gene

MGI Knock Outs for DGAT1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DGAT1 Gene

Localization for DGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGAT1 Gene COMPARTMENTS Subcellular localization image for DGAT1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
plasma membrane 3
cytosol 2
extracellular 2
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for DGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,ISS --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with DGAT1: view

Pathways & Interactions for DGAT1 Gene

genes like me logo Genes that share pathways with DGAT1: view

UniProtKB/Swiss-Prot O75907-DGAT1_HUMAN

  • Pathway: Lipid metabolism; glycerolipid metabolism.

Gene Ontology (GO) - Biological Process for DGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006641 triglyceride metabolic process TAS 9756920
GO:0019432 triglyceride biosynthetic process IEA,TAS --
GO:0019915 lipid storage IEA,ISS --
GO:0034379 very-low-density lipoprotein particle assembly IMP 15308631
GO:0035336 long-chain fatty-acyl-CoA metabolic process IEA,ISS --
genes like me logo Genes that share ontologies with DGAT1: view

No data available for SIGNOR curated interactions for DGAT1 Gene

Drugs & Compounds for DGAT1 Gene

(21) Drugs for DGAT1 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra 450
Propionyl-CoA Experimental Pharma 0
AZD7687 Pharma inhibitor DGAT inhibitor,potent and selective 0
PF-04620110 Pharma inhibitor DGAT-1 inhibitor,potent and selective 0
A922500 Pharma DGAT-1 inhibitor, Potent DGAT-1 inhibitor 0

(54) Additional Compounds for DGAT1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7

(3) Tocris Compounds for DGAT1 Gene

Compound Action Cas Number
A 922500 Potent DGAT-1 inhibitor 959122-11-3
AZD 3988 Potent and selective DGAT-1 inhibitor 892489-52-0
JNJ DGAT2-A DGAT2 inhibitor

(9) ApexBio Compounds for DGAT1 Gene

Compound Action Cas Number
A922500 DGAT-1 inhibitor 959122-11-3
ABT-046 DGAT-1 inhibitor,potent and selective 1031336-60-3
AZD 3988 892489-52-0
AZD7687 DGAT inhibitor,potent and selective 1166827-44-6
DGAT-1 inhibitor Diacylglycerol acyltransferase (DGAT1) inhibitor 701232-20-4
DGAT-1 inhibitor 2 Antiobesity agents 942999-61-3
DGAT1-IN-1 1449779-49-0
LCQ-908 DGAT1 inhibitor 956136-95-1
PF-04620110 DGAT-1 inhibitor,potent and selective 1109276-89-2
genes like me logo Genes that share compounds with DGAT1: view

Transcripts for DGAT1 Gene

Unigene Clusters for DGAT1 Gene

Diacylglycerol O-acyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGAT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17
SP1: - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for DGAT1 Gene

GeneLoc Exon Structure for
DGAT1
ECgene alternative splicing isoforms for
DGAT1

Expression for DGAT1 Gene

mRNA expression in normal human tissues for DGAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGAT1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.9).

Protein differential expression in normal tissues from HIPED for DGAT1 Gene

This gene is overexpressed in Nasal epithelium (60.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DGAT1 Gene



Protein tissue co-expression partners for DGAT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DGAT1 Gene:

DGAT1

SOURCE GeneReport for Unigene cluster for DGAT1 Gene:

Hs.521954
genes like me logo Genes that share expression patterns with DGAT1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DGAT1 Gene

Orthologs for DGAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DGAT1 34
  • 88.17 (n)
  • 89.39 (a)
DGAT1 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGAT1 34
  • 86.85 (n)
  • 86.42 (a)
DGAT1 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgat1 34
  • 83.19 (n)
  • 85.47 (a)
Dgat1 16
Dgat1 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DGAT1 34
  • 99.64 (n)
  • 100 (a)
DGAT1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgat1 34
  • 82.12 (n)
  • 84.62 (a)
oppossum
(Monodelphis domestica)
Mammalia DGAT1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGAT1 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGAT1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgat1 34
  • 70.43 (n)
  • 72.87 (a)
zebrafish
(Danio rerio)
Actinopterygii dgat1b 34
  • 66.75 (n)
  • 70.1 (a)
wufd36g11 34
dgat1a 35
  • 61 (a)
OneToMany
dgat1b 35
  • 59 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4684 34
fruit fly
(Drosophila melanogaster)
Insecta mdy 36
  • 44 (a)
mdy 34
  • 51.69 (n)
  • 46.14 (a)
mdy 35
  • 30 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007843 34
  • 56.2 (n)
  • 49.03 (a)
worm
(Caenorhabditis elegans)
Secernentea mboa-2 34
  • 50.99 (n)
  • 48.39 (a)
mboa-2 35
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARE1 35
  • 15 (a)
ManyToMany
ARE2 35
  • 14 (a)
ManyToMany
ARE2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons TAG1 34
  • 47.89 (n)
  • 40.69 (a)
rice
(Oryza sativa)
Liliopsida Os05g0196800 34
  • 47.33 (n)
  • 39.69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14600 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToOne
Species where no ortholog for DGAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGAT1 Gene

ENSEMBL:
Gene Tree for DGAT1 (if available)
TreeFam:
Gene Tree for DGAT1 (if available)

Paralogs for DGAT1 Gene

Paralogs for DGAT1 Gene

genes like me logo Genes that share paralogs with DGAT1: view

Variants for DGAT1 Gene

Sequence variations from dbSNP and Humsavar for DGAT1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1061430 -- 144,316,516(-) CCTCA(A/C/T)ACCCG utr-variant-3-prime
rs3757968 -- 144,327,537(-) CAGGC(A/C/G)GGGAG upstream-variant-2KB
rs3757969 -- 144,327,536(-) AGGCG(C/G)GGAGG upstream-variant-2KB
rs3757970 -- 144,322,373(-) CCTCT(C/T)ACAAA intron-variant
rs3757971 -- 144,322,286(-) TGTAT(A/G)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGAT1 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
esv2759652 CNV gain+loss 17122850
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612919 CNV gain 21841781
nsv612920 CNV loss 21841781
nsv824804 CNV gain 20364138

Variation tolerance for DGAT1 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGAT1 Gene

Human Gene Mutation Database (HGMD)
DGAT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGAT1 Gene

Disorders for DGAT1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DGAT1 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diarrhea 7
  • congenital chronic diarrhea with protein-losing enteropathy
obesity
  • obesity, association with
hepatitis c virus
  • hepatitic c virus
diabetes mellitus, noninsulin-dependent
  • diabetes, type 2
- elite association - COSMIC cancer census association via MalaCards
Search DGAT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DGAT1_HUMAN
  • Diarrhea 7 (DIAR7) [MIM:615863]: A life-threatening disease characterized by severe, intractable, watery diarrhea. {ECO:0000269 PubMed:23114594}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DGAT1

Genetic Association Database (GAD)
DGAT1
Human Genome Epidemiology (HuGE) Navigator
DGAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGAT1
genes like me logo Genes that share disorders with DGAT1: view

No data available for Genatlas for DGAT1 Gene

Publications for DGAT1 Gene

  1. Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. (PMID: 16214399) Orland M.D. … Cheng D. (Biochim. Biophys. Acta 2005) 3 4 22 65
  2. Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects. (PMID: 14569040) Coudreau S.K. … ClAcment K. (Obes. Res. 2003) 3 22 46 65
  3. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. (PMID: 9756920) Oelkers P. … Sturley S.L. (J. Biol. Chem. 1998) 2 3 4 65
  4. DGAT1 mutation is linked to a congenital diarrheal disorder. (PMID: 23114594) Haas J.T. … Farese R.V. (J. Clin. Invest. 2012) 3 4 65
  5. DGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins. (PMID: 20167659) Krapivner S. … van't Hooft F.M. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 22 65

Products for DGAT1 Gene

Sources for DGAT1 Gene

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