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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DFNA5 Gene

protein-coding   GIFtS: 55
GCID: GC07M024704

deafness, autosomal dominant 5
 Explore 8 diseases affiliated with
DFNA5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DFNA5    

Aliases
for DFNA5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Deafness, Autosomal Dominant 51 2
ICERE-11 2 3
Inversely Correlated With Estrogen Receptor Expression 12 3
Non-Syndromic Hearing Impairment Protein 52
Nonsyndromic Hearing Impairment Protein2
ICERE13

External Ids:    HGNC: 28101   Entrez Gene: 16872   Ensembl: ENSG000001059287   OMIM: 6087985   UniProtKB: O604433   

Export aliases for DFNA5 gene to outside databases

Previous GC identifers: GC07M024380 GC07M024480 GC07M024511


Summaries
for DFNA5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DFNA5:
Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is
expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a
mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DFNA5_HUMAN, O60443
Function: Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage
probably by cooperating with TP53

Gene Wiki entry for DFNA5


Genomic Views
for DFNA5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DFNA5 gene promoter:
         S8   CP2   p53   LUN-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): DFNA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DFNA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DFNA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15

DFNA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DFNA5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M024704:  view genomic region     (about GC identifiers)

Start:
 24,737,972 bp from pter      End:
 24,809,244 bp from pter
Size:
 71,273 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 24,789,534-24,849,193     

Proteins
for DFNA5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DFNA5_HUMAN, O60443 (See protein sequence)
Recommended Name: Non-syndromic hearing impairment protein 5  
Size: 496 amino acids; 54555 Da
Sequence caution: Sequence=AAB83938.1; Type=Erroneous gene model prediction; Sequence=AAC39635.2; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: A4D156 B2RAX9 B3KT05 O14590 Q08AQ8 Q9UBV3
Alternative splicing: 3 isoforms:  O60443-1   O60443-2   O60443-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DFNA5: NX_O60443

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60443

    • DFNA5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001120925.1  NP_001120926.1  NP_004394.1  

    ENSEMBL proteins: 
     ENSP00000339587   ENSP00000387119   ENSP00000386670   ENSP00000395540   ENSP00000389874  
     ENSP00000398445   ENSP00000414090   ENSP00000413963   ENSP00000401332   ENSP00000442661  

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    Novus Biologicals DFNA5 Proteins
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DFNA5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--


    DFNA5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DFNA5

    Protein Domains /
    Families
    for DFNA5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DFNA5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007677 Gasdermin

    Graphical View of Domain Structure for InterPro Entry O60443

    ProtoNet protein and cluster: O60443

    1 Blocks protein family: IPB007677 DFNA5 protein

    UniProtKB/Swiss-Prot: DFNA5_HUMAN, O60443
    Similarity: Belongs to the gasdermin family


    Function
    for DFNA5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DFNA5_HUMAN, O60443
    Function: Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage
    probably by cooperating with TP53

         Genatlas biochemistry entry for DFNA5:
    gene expressed in the cochlea,mutated in neurosensory dominant deafness 3,likely same as ICERE1 (inversely correlated
    with estrogen receptor expression gene 1)

    miRNA
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    hsa-miR-188-3p hsa-miR-539 hsa-miR-1179
    SwitchGear 3'UTR luciferase reporter plasmid: DFNA5 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: DFNA5
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DFNA5

    Clone
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    Search LifeMap BioReagents cell lines for DFNA5

    In Situ Assay
    Products:       
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    Animal Models:
         Mouse knock-out Dfna5tm1Ant for DFNA5
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dfna5):
     hearing/vestibular/ear  nervous system 

    DFNA5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DFNA5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DFNA5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/740 Interacting proteins for DFNA5 (O604432, 3 ENSP000003395874) via UniProtKB, MINT, STRING, and/or I2D (see all 740)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTNP212462, 3MINT-63175 I2D: score=5 
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    ABCF3Q9NUQ82MINT-7945693 MINT-7947479
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IDA--
    GO:0006917induction of apoptosis IDA--
    GO:0007605sensory perception of sound TAS9771715
    GO:0008285negative regulation of cell proliferation IDA18223688
    GO:0060113inner ear receptor cell differentiation IEA--


    DFNA5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DFNA5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DFNA5
    Search CenterWatch for drugs/clinical trials and news about DFNA5 

    Transcripts
    for DFNA5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DFNA5 gene (3 alternative transcripts): 
    NM_001127453.1  NM_001127454.1  NM_004403.2  

    Unigene Cluster for DFNA5:

    Deafness, autosomal dominant 5
    Hs.520708  [show with all ESTs]
    Unigene Representative Sequence: AK094714
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342947(uc010kus.1 uc003sxa.1) ENST00000479636 ENST00000409970
    ENST00000409775 ENST00000430096 ENST00000415480 ENST00000446822 ENST00000469133
    ENST00000411476 ENST00000559637 ENST00000493723 ENST00000414428 ENST00000473990
    ENST00000419307(uc010kut.1) ENST00000545231

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DFNA5
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate DFNA5:
    hsa-miR-188-3p hsa-miR-539 hsa-miR-1179
    SwitchGear 3'UTR luciferase reporter plasmid: DFNA5 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DFNA5

    Additional cDNA sequence: 

    AF007790.2 AF073308.1 AF075171.1 AF131765.1 AJ270686.1 AK094714.1 AK290775.1 AK314402.1 
    BC019689.1 BC099911.1 BC125065.1 BC125066.1 

    18 DOTS entries:

    DT.100779351  DT.95078370  DT.213599  DT.101968548  DT.100779343  DT.92431635  DT.100774085  DT.95193035 
    DT.100779353  DT.121046523  DT.92431651  DT.121046516  DT.121046546  DT.75182197  DT.95078352  DT.100803962 
    DT.91762954  DT.95101917 

    24/182 AceView cDNA sequences (see all 182):

    AF075171 N22722 CR595348 AF073308 BG748140 AI918194 CN484767 N20315 
    BX089347 CB161015 BQ011285 N31196 CR608176 BF569626 BQ953531 AL134863 
    BU631672 AI478454 CD107188 BM051295 BQ948367 NM_004403 CR605051 AI745270 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DFNA5 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
    SP1:              -     -                                               -     -                                         -               
    SP2:                    -                                               -     -                                                         
    SP3:                    -     -                                   -     -     -     -     -                                             
    SP4:                                                                    -                                                               
    SP5:              -     -     -                                         -     -                                                         


    ECgene alternative splicing isoforms for DFNA5

    Expression
    for DFNA5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DFNA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGATTTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DFNA5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DFNA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DFNA5

    SOURCE GeneReport for Unigene cluster: Hs.520708

    UniProtKB/Swiss-Prot: DFNA5_HUMAN, O60443
    Tissue specificity: Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal
    muscle, kidney and pancreas, with highest expression in placenta

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    In Situ
    Assay Products:     
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    Orthologs
    for DFNA5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DFNA5 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DFNA51 deafness, autosomal dominant 5 59.78(n)
    52.97(a)    		   420623  NM_001006361.1  NP_001006361.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DFNA56
    		 --
    		 49(a)
    		 1 ↔ 1
    		 6(31094430-31119581)
    zebrafish
    (Danio rerio)    		 Actinopterygii dfna51 deafness, autosomal dominant 5 48.24(n)
    37.42(a)    		   335722  NM_001001947.1  NP_001001947.1 


    ENSEMBL Gene Tree for DFNA5 (if available)
    TreeFam Gene Tree for DFNA5 (if available) 

    Paralogs
    for DFNA5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DFNA5 gene
    DFNB592  

    DFNA5 for paralogs           About GeneDecksing



    Genomic Variants
    for DFNA5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1277 NCBI SNPs in DFNA5 are shown (see all 1277)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1499699471,2
    		C,--24737480(+) TATAC-/ATCT  
                ATCTA     		3 -- int1 ds50010--------
    rs1390687071,2
    		--24737545(+) TTTTAC/TTTATT 3 -- int1 ds50010--------
    rs1175845121,2
    		--24738108(+) CAGGGG/ATGTGT 3 -- ut311Minor allele frequency- A:0.01NA 120
    rs772767591,2
    		C,--24738140(+) TTTAA-/TTTTGT 3 -- ut310--------
    rs2014560601,2
    		--24738159(+) GAATA-/TACTC 
                TACTC     		3 -- ut310--------
    rs1922899651,2
    		--24738167(+) CTCTAG/TGAGCA 3 -- ut310--------
    rs1440612921,2
    		--24738197(+) CATCAA/GATAAC 3 -- ut310--------
    rs1181108601,2
    		--24738221(+) AAAACG/ATAGCC 3 -- ut311Minor allele frequency- A:0.01EA 120
    rs1449285301,2
    		--24738299(+) TCAGAC/GTCTTT 3 -- ut310--------
    rs171498881,2
    		C,F,H,--24738372(+) TGAATG/ATATGC 3 -- ut3120Minor allele frequency- A:0.21NA NS EA WA 2434

    HapMap Linkage Disequilibrium report for DFNA5 (24737972 - 24809244 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DFNA5: --
    Human Gene Mutation Database (HGMD): DFNA5

    Locus Specific Mutation Databases (LSDB): DFNA5

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DFNA5
    DNA2.0 Custom Variant and Variant Library Synthesis for DFNA5

    Disorders / Diseases
    for DFNA5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DFNA5 for disorders           About GeneDecksing

    OMIM gene information: 608798   
    OMIM disorders: 600994  
    UniProtKB/Swiss-Prot: DFNA5_HUMAN, O60443
  • Defects in DFNA5 are the cause of deafness autosomal dominant type 5 (DFNA5) [MIM:600994]. DFNA5 is a form of
    • sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the
    nerve pathways to the brain, or the area of the brain that receives sound information
  • Note=Is a tumor suppressor gene with an important role in major types of tumors. Could be a valuable molecular
    • marker in cancer

    8 diseases for DFNA5:    About MalaCards
    deafness, autosomal dominant 5    sensorineural hearing loss    hearing loss    breast carcinoma
    colorectal cancer    melanoma    breast cancer    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for DFNA5:
    Nonsyndromic deafness     Sensorineural hearing loss

    1 Novoseek disease relationship for DFNA5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 21 3 11297734 (2), 16735241 (1)

    Genatlas disease: DFNA5
    neurosensory dominant deafness,5,non syndromic,postlingual,progressive,starting in the high tones

    Human Genome Epidemiology (HuGE) Navigator: DFNA5 (2 documents)

    Export disorders for DFNA5 gene to outside databases

    Publications
    for DFNA5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DFNA5 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with DFNA5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DFNA5 gene, responsible for hearing loss and invo lved in cancer, encodes a novel apoptosis-inducing protein. (PubMed id 21522185)1, 2 Op de Beeck K....Van Laer L. (2011)
    2. Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma. (PubMed id 18223688)1, 2 Kim M.S....Sidransky D. (2008)
    3. The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage. (PubMed id 16897187)1, 2 Masuda Y....Arakawa H. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Nonsyndromic hearing impairment is associated with a mutation in DFNA5. (PubMed id 9771715)1, 2 Van Laer L.... Van Camp G. (1998)
    8. Characterization of a gene that is inversely correlated with estrogen receptor expression (ICERE-1) in breast carcinomas. (PubMed id 9523727)1, 2 Thompson D.A. and Weigel R.J. (1998)
    9. Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea. (PubMed id 9450185)1, 3 Van Laer L....Willems P. (1997)
    10. Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15. (PubMed id 8589696)1, 3 van Camp G....Frants R.R. (1995)

    External Searches for DFNA5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing DFNA5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1687 HGNC: 2810 AceView: DFNA5 Ensembl:ENSG00000105928 euGenes: HUgn1687
    ECgene: DFNA5 H-InvDB: DFNA5

    Other Databases showing DFNA5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DFNA5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DFNA5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DFNA5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DFNA5 gene:
    Search GeneIP for patents involving DFNA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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