DEXI Gene
protein-coding GIFtS: 43
GCID: GC16M011024
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Dexi homolog (mouse)
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Aliases
for DEXI gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dexi Homolog (Mouse)1 2 | | MYLE1 2 3 | | Dexamethasone-Induced Protein2 | | Dexamethasone-Induced Transcript2 | | Protein MYLE3 |
Export aliases for DEXI gene to outside databasesPrevious GC identifers: GC16M010989 GC16M010930 |
Summaries
for DEXI gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DEXI gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DEXI gene promoter:
Pax-5 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) LCR-F1 POU3F2 Egr-4 AREB6 POU2F1 Ik-2 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DEXI
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEXI |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.13 Ensembl cytogenetic band: 16p13.13 HGNC cytogenetic band: 16p13.13DEXI Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M011024: view genomic region
(about GC identifiers)
Start:
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11,022,748 bp from pter |
End:
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11,036,317 bp from pter |
Size:
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13,570 bases |
Orientation:
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minus strand |
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Proteins
for DEXI gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DEXI_HUMAN, O95424 (See
protein sequence)Recommended Name: Dexamethasone-induced protein Size: 95 amino acids; 10429 Da
Secondary accessions: B2RAA7Explore the universe of human proteins at neXtProt for DEXI: NX_O95424
DEXI Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054734.2
ENSEMBL proteins: ENSP00000330509
Human Recombinant Protein Products:
DEXI Antibody Products:
Assay Products for DEXI: |
Protein
Domains /
Families
for DEXI gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DEXI for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95424ProtoNet protein and cluster: O95424 UniProtKB/Swiss-Prot: DEXI_HUMAN, O95424Similarity: Belongs to the DEXI family |
Function
for DEXI gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DEXI_HUMAN, O95424Induction: By dexamethasone
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEXI (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEXI
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DEXI (NM_014015) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEXI | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEXI |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEXI |
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Pathways & Interactions
for DEXI gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEXI
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for DEXI (O954242, 3 ENSP000003305094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for DEXI gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DEXI
Search CenterWatch for drugs/clinical trials and news about DEXI
|
Transcripts
for DEXI gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DEXI gene: NM_014015.3 Unigene Cluster for DEXI: Dexi homolog (mouse) Hs.592051 [show with all ESTs]Unigene Representative Sequence: AK1240333 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000469379 ENST00000331808(uc002dal.3) ENST00000570992
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEXI (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEXI
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DEXI (NM_014015) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEXI | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEXI |
Additional cDNA sequence: AF108145.2 AF129929.1 AK124033.1 BC001083.2 BC037569.1 BC052989.1 BC071683.1 6 DOTS entries: DT.316036 DT.95147840 DT.99985212 DT.101980122 DT.316035 DT.121053900 24/177 AceView cDNA sequences (see all 177): NM_014015 CD625100 CR611608 AI936896 BF940080 AW172306 AW073158 AW182862 CR607364 BG776006 AI247181 AA251975 BI712543 BU726287 CA428607 CB158508 BC037569 BI712785 AA974063 AA907187 AF129929 CR599313 CR590912 AI279614
GeneLoc Exon Structure
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Expression
for DEXI gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DEXI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGTGAGTG
About this image
See DEXI Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DEXI
SOURCE GeneReport for Unigene cluster: Hs.592051
UniProtKB/Swiss-Prot: DEXI_HUMAN, O95424Tissue specificity: Highest levels in heart. Also expressed in brain, liver, pancreas, placenta and lung. Up-regulatedin emphysematous lung compared to normal lung
SABiosciences Custom PCR Arrays for DEXI
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEXI
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DEXI | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEXI | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEXI | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEXI |
Orthologs
for DEXI gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for DEXI gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for DEXI (if available)
TreeFam Gene Tree for DEXI (if available) |
Paralogs
for DEXI gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DEXI gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for DEXI (11022748 - 11036317 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DEXI: --
Human Gene Mutation Database (HGMD): DEXI
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEXI |
|
Disorders
/ Diseases
for DEXI gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DEXI for disorders About GeneDecksing
3  diseases for DEXI: About MalaCardsangelman syndrome emphysema colon cancer
Export disorders for DEXI gene to outside databases
|
Publications
for DEXI gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DEXI gene integrated from 9 sources:
(articles sorted by number of sources associating them with DEXI) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of dexamethasone-induced transcript: a novel glucocorticoid- induced gene that is upregulated in emphysema. (PubMed id 11472984)1, 2, 3, 9 Edgar A.J.... Polak J.M. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11-->q13 imprinting clusters. (PubMed id 11306815)1, 3 Kelly M....Wevrick R. (2001)
- Long-range DNA looping and gene expression analyses id entify DEXI as an autoimmune disease candidate gene. (PubMed id 21989056)1 Davison L.J....Wallace C. (2012)
- Identification of a potent epigenetic biomarker for r esistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer. (PubMed id 21901246)1 Miyaki Y....Konishi F. (2012)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Large genomic duplicons map to sites of instability in the Prader-Willi/Angelman syndrome chromosome region (15q11-q13). (PubMed id 10332034)1 Christian S.L....Ledbetter D.H. (1999)
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External Searches for DEXI gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DEXI gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing DEXI gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEXI gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DEXI | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DEXI gene:
Search GeneIP for patents involving DEXI
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DEXI gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DEXI | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEXI | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEXI | | | OriGene Protein Over-expression Lysate for DEXI | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DEXI | | OriGene 3'-UTR Clone for DEXI | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEXI | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEXI | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DEXI | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DEXI | | OriGene Custom Protein Services for DEXI | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DEXI | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEXI | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEXI | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEXI | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEXI | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEXI |
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 |  |  |  | |
| | | | Search Tocris compounds for DEXI |
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 | | | DEXI Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEXI |
|  |  |  | | | | Search ThermoFisher Antibodies for DEXI |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEXI |
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