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Aliases for DEXI Gene

Aliases for DEXI Gene

  • Dexi Homolog 2 3 5
  • Dexamethasone-Induced Transcript 2 3
  • MYLE 3 4
  • Dexamethasone-Induced Protein 3
  • Dexi Homolog (Mouse) 2
  • Protein MYLE 4

External Ids for DEXI Gene

Previous GeneCards Identifiers for DEXI Gene

  • GC16M010989
  • GC16M010930
  • GC16M011024

Summaries for DEXI Gene

GeneCards Summary for DEXI Gene

DEXI (Dexi Homolog) is a Protein Coding gene. Diseases associated with DEXI include Angelman Syndrome.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEXI Gene

Genomics for DEXI Gene

Regulatory Elements for DEXI Gene

Enhancers for DEXI Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F010772 0.6 Ensembl 10.9 +170.0 169960 0.2 CIITA DEXI CLEC16A ENSG00000256013 PIR44837 TVP23A
GH16F010770 0.8 Ensembl ENCODE 10.9 +171.3 171260 1.6 POLR2A CEBPB ZNF264 HNRNPCP4 CIITA SOCS1 CLEC16A DEXI NUBP1 TXNDC11 ENSG00000256013 TVP23A TEKT5
GH16F011038 0.6 ENCODE 10.8 -96.5 -96517 1.3 HDAC1 ATF1 PKNOX1 ARNT SIN3A ZNF766 ETV6 FOS CREM EGR2 CLEC16A DEXI ENSG00000212228 PRM2 RPL7P46 ENSG00000274038
GH16F011161 0.8 Ensembl ENCODE 10.7 -219.7 -219741 2.0 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 KLF13 NUBP1 RMI2 GSPT1 TNP2 ENSG00000212228 PRM3 CLEC16A DEXI COX6CP1 LOC400499
GH16F011031 1 Ensembl ENCODE 10.7 -90.7 -90716 3.9 HDAC1 ATF1 PKNOX1 TBL1XR1 ARNT ZNF121 ZNF766 GATA2 CREM EGR2 CLEC16A DEXI ENSG00000212228 PRM2 TNP2 PRM3 ENSG00000263013 RPL7P46 ENSG00000274038
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DEXI on UCSC Golden Path with GeneCards custom track

Promoters for DEXI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001631665 560 2601 HDGF ZNF133 ARID4B ZNF48 ZNF121 SLC30A9 GLIS2 ZNF143 ZNF207 FOS

Genomic Location for DEXI Gene

Chromosome:
16
Start:
10,928,891 bp from pter
End:
10,942,460 bp from pter
Size:
13,570 bases
Orientation:
Minus strand

Genomic View for DEXI Gene

Genes around DEXI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEXI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEXI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEXI Gene

Proteins for DEXI Gene

  • Protein details for DEXI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95424-DEXI_HUMAN
    Recommended name:
    Dexamethasone-induced protein
    Protein Accession:
    O95424
    Secondary Accessions:
    • B2RAA7

    Protein attributes for DEXI Gene

    Size:
    95 amino acids
    Molecular mass:
    10429 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEXI Gene

Post-translational modifications for DEXI Gene

No Post-translational modifications

Other Protein References for DEXI Gene

No data available for DME Specific Peptides for DEXI Gene

Domains & Families for DEXI Gene

Protein Domains for DEXI Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEXI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95424

UniProtKB/Swiss-Prot:

DEXI_HUMAN :
  • Belongs to the DEXI family.
Family:
  • Belongs to the DEXI family.
genes like me logo Genes that share domains with DEXI: view

No data available for Gene Families for DEXI Gene

Function for DEXI Gene

Molecular function for DEXI Gene

UniProtKB/Swiss-Prot Induction:
By dexamethasone.

Phenotypes for DEXI Gene

GenomeRNAi human phenotypes for DEXI:
genes like me logo Genes that share phenotypes with DEXI: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DEXI

miRNA for DEXI Gene

miRTarBase miRNAs that target DEXI

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEXI Gene

Localization for DEXI Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEXI Gene COMPARTMENTS Subcellular localization image for DEXI gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEXI Gene

Pathways & Interactions for DEXI Gene

SuperPathways for DEXI Gene

No Data Available

Interacting Proteins for DEXI Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330509%0d%0a9606.ENSP00000347719%0d%0a
Selected Interacting proteins: ENSP00000330509 O95424-DEXI_HUMAN for DEXI Gene via STRING IID

Gene Ontology (GO) - Biological Process for DEXI Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DEXI Gene

Transcripts for DEXI Gene

Unigene Clusters for DEXI Gene

Dexi homolog (mouse):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEXI Gene

No ASD Table

Relevant External Links for DEXI Gene

GeneLoc Exon Structure for
DEXI
ECgene alternative splicing isoforms for
DEXI

Expression for DEXI Gene

mRNA expression in normal human tissues for DEXI Gene

NURSA nuclear receptor signaling pathways regulating expression of DEXI Gene:

DEXI

SOURCE GeneReport for Unigene cluster for DEXI Gene:

Hs.592051

mRNA Expression by UniProt/SwissProt for DEXI Gene:

O95424-DEXI_HUMAN
Tissue specificity: Highest levels in heart. Also expressed in brain, liver, pancreas, placenta and lung. Up-regulated in emphysematous lung compared to normal lung.
genes like me logo Genes that share expression patterns with DEXI: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DEXI Gene

Orthologs for DEXI Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEXI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEXI 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia DEXI 34 35
  • 96.14 (n)
cow
(Bos Taurus)
Mammalia DEXI 34 35
  • 95.79 (n)
mouse
(Mus musculus)
Mammalia Dexi 34 16 35
  • 90.88 (n)
rat
(Rattus norvegicus)
Mammalia Dexi 34
  • 90.53 (n)
oppossum
(Monodelphis domestica)
Mammalia DEXI 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves DEXI 34
  • 81.36 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia dexi 34
  • 75.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16631 34
zebrafish
(Danio rerio)
Actinopterygii dexi 34 35
  • 71.57 (n)
Species where no ortholog for DEXI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEXI Gene

ENSEMBL:
Gene Tree for DEXI (if available)
TreeFam:
Gene Tree for DEXI (if available)

Paralogs for DEXI Gene

No data available for Paralogs for DEXI Gene

Variants for DEXI Gene

Sequence variations from dbSNP and Humsavar for DEXI Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111314000 -- 10,928,542(+) CGCCT(C/T)GGCCT intron-variant, downstream-variant-500B
rs111619866 -- 10,939,807(+) CTTCA(C/T)AGTTC intron-variant
rs111844241 -- 10,935,358(+) TCACC(C/T)GACAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111882238 -- 10,933,207(+) ACGTG(C/G)CTGGC intron-variant
rs112321748 -- 10,937,912(+) GCTGG(G/T)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEXI Gene

Variant ID Type Subtype PubMed ID
nsv1040428 CNV gain 25217958
nsv571452 CNV loss 21841781
nsv977902 CNV duplication 23825009

Variation tolerance for DEXI Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEXI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEXI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEXI Gene

Disorders for DEXI Gene

MalaCards: The human disease database

(1) MalaCards diseases for DEXI Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
angelman syndrome
  • as
- elite association - COSMIC cancer census association via MalaCards
Search DEXI in MalaCards View complete list of genes associated with diseases

Relevant External Links for DEXI

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEXI
genes like me logo Genes that share disorders with DEXI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DEXI Gene

Publications for DEXI Gene

  1. Cloning of dexamethasone-induced transcript: a novel glucocorticoid- induced gene that is upregulated in emphysema. (PMID: 11472984) Edgar A.J. … Polak J.M. (Am. J. Respir. Cell Mol. Biol. 2001) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11-->q13 imprinting clusters. (PMID: 11306815) Kelly M. … Wevrick R. (Cytogenet. Cell Genet. 2001) 2 3 64
  4. Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13. (PMID: 25008175) Tomlinson M.J. … Onengut-Gumuscu S. (Diabetes 2014) 3 64
  5. Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus. (PMID: 23151489) Leikfoss I.S. … Berge T. (Genes Immun. 2013) 3 64

Products for DEXI Gene

Sources for DEXI Gene

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