Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DEXI Gene

Aliases for DEXI Gene

  • Dexi Homolog 2 3
  • Dexamethasone-Induced Transcript 2 3
  • Dexi Homolog (Mouse) 2 5
  • MYLE 3 4
  • Protein MYLE 4

External Ids for DEXI Gene

Previous GeneCards Identifiers for DEXI Gene

  • GC16M010989
  • GC16M010930
  • GC16M011024

Summaries for DEXI Gene

GeneCards Summary for DEXI Gene

DEXI (Dexi Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEXI Gene

Genomics for DEXI Gene

Regulatory Elements for DEXI Gene

Promoters for DEXI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DEXI on UCSC Golden Path with GeneCards custom track

Genomic Location for DEXI Gene

Chromosome:
16
Start:
10,928,891 bp from pter
End:
10,942,460 bp from pter
Size:
13,570 bases
Orientation:
Minus strand

Genomic View for DEXI Gene

Genes around DEXI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEXI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEXI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEXI Gene

Proteins for DEXI Gene

  • Protein details for DEXI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95424-DEXI_HUMAN
    Recommended name:
    Dexamethasone-induced protein
    Protein Accession:
    O95424
    Secondary Accessions:
    • B2RAA7

    Protein attributes for DEXI Gene

    Size:
    95 amino acids
    Molecular mass:
    10429 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEXI Gene

Proteomics data for DEXI Gene at MOPED

Post-translational modifications for DEXI Gene

No Post-translational modifications

Other Protein References for DEXI Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEXI Gene

Domains & Families for DEXI Gene

Protein Domains for DEXI Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEXI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95424

UniProtKB/Swiss-Prot:

DEXI_HUMAN :
  • Belongs to the DEXI family.
Family:
  • Belongs to the DEXI family.
genes like me logo Genes that share domains with DEXI: view

No data available for Gene Families for DEXI Gene

Function for DEXI Gene

Molecular function for DEXI Gene

UniProtKB/Swiss-Prot Induction:
By dexamethasone.

Phenotypes for DEXI Gene

GenomeRNAi human phenotypes for DEXI:
genes like me logo Genes that share phenotypes with DEXI: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DEXI

miRNA for DEXI Gene

miRTarBase miRNAs that target DEXI

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEXI Gene

Localization for DEXI Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEXI Gene COMPARTMENTS Subcellular localization image for DEXI gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEXI Gene

Pathways & Interactions for DEXI Gene

SuperPathways for DEXI Gene

No Data Available

Interacting Proteins for DEXI Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330509%0d%0a9606.ENSP00000347719%0d%0a
Selected Interacting proteins: O95424-DEXI_HUMAN ENSP00000330509 for DEXI Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for DEXI Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DEXI Gene

Drugs & Compounds for DEXI Gene

No Compound Related Data Available

Transcripts for DEXI Gene

Unigene Clusters for DEXI Gene

Dexi homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEXI Gene

No ASD Table

Relevant External Links for DEXI Gene

GeneLoc Exon Structure for
DEXI
ECgene alternative splicing isoforms for
DEXI

Expression for DEXI Gene

mRNA expression in normal human tissues for DEXI Gene

SOURCE GeneReport for Unigene cluster for DEXI Gene Hs.592051

mRNA Expression by UniProt/SwissProt for DEXI Gene

O95424-DEXI_HUMAN
Tissue specificity: Highest levels in heart. Also expressed in brain, liver, pancreas, placenta and lung. Up-regulated in emphysematous lung compared to normal lung.
genes like me logo Genes that share expression patterns with DEXI: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DEXI Gene

Orthologs for DEXI Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEXI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEXI 36
  • 100 (a)
OneToOne
DEXI 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia DEXI 36
  • 97 (a)
OneToOne
DEXI 35
  • 95.79 (n)
  • 96.84 (a)
dog
(Canis familiaris)
Mammalia DEXI 35
  • 96.14 (n)
  • 96.84 (a)
DEXI 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dexi 16
Dexi 36
  • 95 (a)
OneToOne
Dexi 35
  • 90.88 (n)
  • 94.74 (a)
oppossum
(Monodelphis domestica)
Mammalia DEXI 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dexi 35
  • 90.53 (n)
  • 94.74 (a)
chicken
(Gallus gallus)
Aves DEXI 35
  • 81.36 (n)
  • 76.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16631 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dexi 35
  • 75.98 (n)
  • 85.29 (a)
zebrafish
(Danio rerio)
Actinopterygii dexi 36
  • 72 (a)
OneToOne
dexi 35
  • 71.57 (n)
  • 85.29 (a)
Species with no ortholog for DEXI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEXI Gene

ENSEMBL:
Gene Tree for DEXI (if available)
TreeFam:
Gene Tree for DEXI (if available)

Paralogs for DEXI Gene

No data available for Paralogs for DEXI Gene

Variants for DEXI Gene

Sequence variations from dbSNP and Humsavar for DEXI Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs186057737 -- 10,942,460(+) TCCCG(G/T)TGGCG upstream-variant-2KB
rs529197150 -- 10,942,361(+) GTCCC(C/G)GCAGC upstream-variant-2KB, utr-variant-5-prime
rs537605356 -- 10,942,462(+) CCGGT(G/T)GCGCT upstream-variant-2KB
rs548942723 -- 10,942,374(+) TCTCT(A/C)CCGCC upstream-variant-2KB, utr-variant-5-prime
rs551447362 -- 10,942,451(+) GCGTA(C/G)CCCTC upstream-variant-2KB

Variation tolerance for DEXI Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEXI Gene

HapMap Linkage Disequilibrium report
DEXI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DEXI Gene

Disorders for DEXI Gene

Relevant External Links for DEXI

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEXI

No disorders were found for DEXI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEXI Gene

Publications for DEXI Gene

  1. Cloning of dexamethasone-induced transcript: a novel glucocorticoid- induced gene that is upregulated in emphysema. (PMID: 11472984) Edgar A.J. … Polak J.M. (Am. J. Respir. Cell Mol. Biol. 2001) 2 3 4 23 67
  2. Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11-->q13 imprinting clusters. (PMID: 11306815) Kelly M. … Wevrick R. (Cytogenet. Cell Genet. 2001) 2 3
  3. Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13. (PMID: 25008175) Tomlinson M.J. … Onengut-Gumuscu S. (Diabetes 2014) 3
  4. Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus. (PMID: 23151489) Leikfoss I.S. … Berge T. (Genes Immun. 2013) 3
  5. Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. (PMID: 21989056) Davison L.J. … Wallace C. (Hum. Mol. Genet. 2012) 3

Products for DEXI Gene

Sources for DEXI Gene

Back to Top

Content