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Aliases for DEUP1 Gene

Aliases for DEUP1 Gene

  • Deuterosome Assembly Protein 1 2 3 5
  • Coiled-Coil Domain-Containing Protein 67 3 4
  • Coiled-Coil Domain Containing 67 2 3
  • CCDC67 3 4
  • Deuterosome Protein 1 3

External Ids for DEUP1 Gene

Previous HGNC Symbols for DEUP1 Gene

  • CCDC67

Summaries for DEUP1 Gene

GeneCards Summary for DEUP1 Gene

DEUP1 (Deuterosome Assembly Protein 1) is a Protein Coding gene. An important paralog of this gene is CEP63.

UniProtKB/Swiss-Prot for DEUP1 Gene

  • Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEUP1 Gene

Genomics for DEUP1 Gene

Regulatory Elements for DEUP1 Gene

Enhancers for DEUP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G093523 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.2 +195.3 195258 4.4 HDGF PKNOX1 FOXA2 WRNIP1 RAD21 RARA RFX5 YY1 RELB IKZF2 SMCO4 SLC36A4 GPR83 DEUP1 MED17 ENSG00000234106 GC11M093401
GH11G092915 0.3 FANTOM5 3.9 -414.3 -414280 0.1 ENSG00000255127 DEUP1 ENSG00000282940 LOC105369431
GH11G093330 0.8 ENCODE 0.7 +0.6 638 0.2 RB1 CREB3L1 BMI1 ZNF766 CREM HCFC1 REST ZNF592 TFDP1 NFIC DEUP1 GC11M093402
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DEUP1 on UCSC Golden Path with GeneCards custom track

Promoters for DEUP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000043366 648 401 RB1 CREB3L1 BMI1 ZNF766 CREM HCFC1 REST ZNF592 TFDP1 NFIC

Genomic Location for DEUP1 Gene

Chromosome:
11
Start:
93,329,952 bp from pter
End:
93,438,487 bp from pter
Size:
108,536 bases
Orientation:
Plus strand

Genomic View for DEUP1 Gene

Genes around DEUP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEUP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEUP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEUP1 Gene

Proteins for DEUP1 Gene

  • Protein details for DEUP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05D60-DEUP1_HUMAN
    Recommended name:
    Deuterosome assembly protein 1
    Protein Accession:
    Q05D60
    Secondary Accessions:
    • Q8NEF1
    • Q96LL7

    Protein attributes for DEUP1 Gene

    Size:
    604 amino acids
    Molecular mass:
    70977 Da
    Quaternary structure:
    • Interacts with CEP152; the interaction is mutually exclusive with CEP63.
    Miscellaneous:
    • CEP63 and DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, DEUP1 mediates de novo centriole amplification in multiciliated cells.

    Alternative splice isoforms for DEUP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEUP1 Gene

Post-translational modifications for DEUP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DEUP1 Gene

Domains & Families for DEUP1 Gene

Protein Domains for DEUP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEUP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05D60

UniProtKB/Swiss-Prot:

DEUP1_HUMAN :
  • Belongs to the CEP63 family.
Family:
  • Belongs to the CEP63 family.
genes like me logo Genes that share domains with DEUP1: view

No data available for Gene Families for DEUP1 Gene

Function for DEUP1 Gene

Molecular function for DEUP1 Gene

UniProtKB/Swiss-Prot Function:
Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for DEUP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DEUP1: view

Phenotypes for DEUP1 Gene

genes like me logo Genes that share phenotypes with DEUP1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DEUP1 Gene

Localization for DEUP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEUP1 Gene

Cytoplasm. Note=Localizes to the deuterosome. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEUP1 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DEUP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0098536 deuterosome ISS,IBA --
genes like me logo Genes that share ontologies with DEUP1: view

Pathways & Interactions for DEUP1 Gene

SuperPathways for DEUP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DEUP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007099 centriole replication IBA --
GO:0030030 cell projection organization IEA --
GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA,ISS --
GO:1903251 multi-ciliated epithelial cell differentiation ISS,IEA --
genes like me logo Genes that share ontologies with DEUP1: view

No data available for Pathways by source and SIGNOR curated interactions for DEUP1 Gene

Transcripts for DEUP1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for DEUP1 Gene

No ASD Table

Relevant External Links for DEUP1 Gene

GeneLoc Exon Structure for
DEUP1
ECgene alternative splicing isoforms for
DEUP1

Expression for DEUP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of DEUP1 Gene:

DEUP1

Evidence on tissue expression from TISSUES for DEUP1 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with DEUP1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEUP1 Gene

Orthologs for DEUP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEUP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC67 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia CCDC67 34 35
  • 90.84 (n)
cow
(Bos Taurus)
Mammalia CCDC67 34 35
  • 89.25 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc67 34
  • 79.53 (n)
mouse
(Mus musculus)
Mammalia Ccdc67 34 35
  • 77.11 (n)
Deup1 16
oppossum
(Monodelphis domestica)
Mammalia CCDC67 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC67 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC67 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC67 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc67 34
  • 53.76 (n)
zebrafish
(Danio rerio)
Actinopterygii cep63 35
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5362 35
  • 42 (a)
OneToMany
Species where no ortholog for DEUP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEUP1 Gene

ENSEMBL:
Gene Tree for DEUP1 (if available)
TreeFam:
Gene Tree for DEUP1 (if available)

Paralogs for DEUP1 Gene

Paralogs for DEUP1 Gene

genes like me logo Genes that share paralogs with DEUP1: view

Variants for DEUP1 Gene

Sequence variations from dbSNP and Humsavar for DEUP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000013205 -- 93,434,589(+) AGGAG(C/T)CCAAA intron-variant
rs1000023917 -- 93,378,979(+) TGATC(C/T)ATACA intron-variant
rs1000056719 -- 93,347,906(+) GCTAA(-/T)TTTTT intron-variant
rs1000057269 -- 93,332,885(+) AGCCA(A/G)CTGAC intron-variant
rs1000073142 -- 93,393,855(+) GGGTG(A/G)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEUP1 Gene

Variant ID Type Subtype PubMed ID
dgv38n16 CNV deletion 17901297
dgv694n106 CNV deletion 24896259
esv1003032 CNV deletion 20482838
esv1004124 CNV deletion 20482838
esv1079371 CNV deletion 17803354
esv1760867 CNV deletion 17803354
esv2316215 CNV deletion 18987734
esv2478418 CNV deletion 19546169
esv2744921 CNV deletion 23290073
esv3167 CNV loss 18987735
esv3396412 CNV duplication 20981092
esv3548165 CNV deletion 23714750
esv3548167 CNV deletion 23714750
esv3627290 CNV loss 21293372
esv3627292 CNV loss 21293372
esv5775 CNV loss 19470904
nsv1035530 CNV loss 25217958
nsv1039134 CNV loss 25217958
nsv1070064 CNV deletion 25765185
nsv1148425 CNV deletion 26484159
nsv438 CNV deletion 18451855
nsv439 CNV deletion 18451855
nsv468793 CNV loss 19166990
nsv498766 CNV loss 21111241
nsv507609 OTHER sequence alteration 20534489
nsv508649 CNV deletion 20534489
nsv555941 CNV loss 21841781
nsv958625 CNV deletion 24416366

Variation tolerance for DEUP1 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEUP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEUP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEUP1 Gene

Disorders for DEUP1 Gene

Relevant External Links for DEUP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEUP1

No disorders were found for DEUP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEUP1 Gene

Publications for DEUP1 Gene

  1. The Cep63 paralogue Deup1 enables massive deA novo centriole biogenesis for vertebrate multiciliogenesis. (PMID: 24240477) Zhao H. … Zhu X. (Nat. Cell Biol. 2013) 2 3 64
  2. Characterization of the novel tumor-suppressor gene CCDC67 in papillary thyroid carcinoma. (PMID: 26716505) Yin d.e. .T. … Xing M. (Oncotarget 2016) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3 64
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64

Products for DEUP1 Gene

Sources for DEUP1 Gene

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