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Aliases for DET1 Gene

Aliases for DET1 Gene

  • De-Etiolated Homolog 1 (Arabidopsis) 2 3
  • De-Etiolated-1 Homolog 4

External Ids for DET1 Gene

Previous GeneCards Identifiers for DET1 Gene

  • GC15M086786
  • GC15M086856
  • GC15M089055
  • GC15M065167

Summaries for DET1 Gene

GeneCards Summary for DET1 Gene

DET1 (De-Etiolated Homolog 1 (Arabidopsis)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for DET1 Gene

  • Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DET1 Gene

Genomics for DET1 Gene

Regulatory Elements for DET1 Gene

Genomic Location for DET1 Gene

Start:
88,493,218 bp from pter
End:
88,546,703 bp from pter
Size:
53,486 bases
Orientation:
Minus strand

Genomic View for DET1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DET1 Gene

Proteins for DET1 Gene

  • Protein details for DET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5Y6-DET1_HUMAN
    Recommended name:
    DET1 homolog
    Protein Accession:
    Q7L5Y6
    Secondary Accessions:
    • B3KNN6
    • Q2VPC0
    • Q9NWD5

    Protein attributes for DET1 Gene

    Size:
    550 amino acids
    Molecular mass:
    63848 Da
    Quaternary structure:
    • Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1.
    SequenceCaution:
    • Sequence=BAA91447.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DET1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DET1 Gene

Proteomics data for DET1 Gene at MOPED

Post-translational modifications for DET1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DET1 Gene

No data available for DME Specific Peptides for DET1 Gene

Domains for DET1 Gene

Protein Domains for DET1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DET1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L5Y6

UniProtKB/Swiss-Prot:

DET1_HUMAN :
  • Q7L5Y6
Family:
  • Belongs to the DET1 family.
genes like me logo Genes that share domains with DET1: view

No data available for Gene Families for DET1 Gene

Function for DET1 Gene

Molecular function for DET1 Gene

UniProtKB/Swiss-Prot Function: Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.

Phenotypes for DET1 Gene

genes like me logo Genes that share phenotypes with DET1: view

Animal Model Products

CRISPR Products

miRNA for DET1 Gene

miRTarBase miRNAs that target DET1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for DET1 Gene

Localization for DET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DET1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DET1 Gene COMPARTMENTS Subcellular localization image for DET1 gene
Compartment Confidence
nucleus 4
chloroplast 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for DET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DET1: view

Pathways for DET1 Gene

genes like me logo Genes that share pathways with DET1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DET1 Gene

None

Compounds for DET1 Gene

(1) Novoseek inferred chemical compound relationships for DET1 Gene

Compound -log(P) Hits PubMed IDs
phytochrome 73.9 1
genes like me logo Genes that share compounds with DET1: view

Transcripts for DET1 Gene

Unigene Clusters for DET1 Gene

De-etiolated homolog 1 (Arabidopsis):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DET1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DET1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DET1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2:
SP3:

Relevant External Links for DET1 Gene

GeneLoc Exon Structure for
DET1
ECgene alternative splicing isoforms for
DET1

Expression for DET1 Gene

mRNA expression in normal human tissues for DET1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DET1 Gene

SOURCE GeneReport for Unigene cluster for DET1 Gene Hs.690871

mRNA Expression by UniProt/SwissProt for DET1 Gene

Q7L5Y6-DET1_HUMAN
Tissue specificity: Highly expressed in the ovary, some lymphoid organs and resting leukocytes.
genes like me logo Genes that share expressions with DET1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DET1 Gene

Orthologs for DET1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DET1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DET1 35
  • 99.76 (n)
  • 100 (a)
DET1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DET1 35
  • 87.03 (n)
  • 98.36 (a)
DET1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DET1 35
  • 91.82 (n)
  • 99.27 (a)
DET1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Det1 35
  • 89.15 (n)
  • 99.64 (a)
Det1 16
Det1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DET1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Det1 35
  • 89.32 (n)
  • 98.98 (a)
chicken
(Gallus gallus)
Aves DET1 35
  • 80.85 (n)
  • 96.55 (a)
DET1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DET1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia det1 35
  • 77.07 (n)
  • 91.83 (a)
Str.4076 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.492 35
zebrafish
(Danio rerio)
Actinopterygii det1 35
  • 75.45 (n)
  • 89.32 (a)
det1 36
  • 86 (a)
OneToOne
wufc18d06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001900 35
  • 57.38 (n)
  • 56.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta abo 36
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons DET1 35
  • 46.24 (n)
  • 34.33 (a)
rice
(Oryza sativa)
Liliopsida Os01g0104600 35
  • 47.91 (n)
  • 34.01 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14008 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for DET1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DET1 Gene

ENSEMBL:
Gene Tree for DET1 (if available)
TreeFam:
Gene Tree for DET1 (if available)

Paralogs for DET1 Gene

No data available for Paralogs for DET1 Gene

Variants for DET1 Gene

Sequence variations from dbSNP and Humsavar for DET1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1735 -- 88,538,959(-) CAACC(C/T)AGTAG intron-variant
rs13835 -- 88,512,809(-) AGAGA(G/T)GAGTG utr-variant-3-prime, nc-transcript-variant, intron-variant
rs752278 -- 88,493,903(-) GACCA(C/T)TGGGT utr-variant-3-prime
rs893823 -- 88,493,578(+) GAATT(G/T)AGAGG utr-variant-3-prime
rs893824 -- 88,495,130(+) TGGTA(C/G)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DET1 Gene

Variant ID Type Subtype PubMed ID
nsv833085 CNV Gain+Loss 17160897
esv2749993 CNV Deletion 23290073
nsv509581 CNV Insertion 20534489

Relevant External Links for DET1 Gene

HapMap Linkage Disequilibrium report
DET1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DET1 Gene

Disorders for DET1 Gene

No disorders were found for DET1 Gene.

No data available for UniProtKB/Swiss-Prot for DET1 Gene

Publications for DET1 Gene

  1. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PMID: 14739464) Wertz I.E. … Dixit V.M. (Science 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PMID: 17452440) Pick E. … Wei N. (Mol. Cell. Biol. 2007) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Altered plastid levels and potential for improved fruit nutrient content by downregulation of the tomato DDB1-interacting protein CUL4. (PMID: 18363785) Wang S. … Liu Y. (Plant J. 2008) 23

Products for DET1 Gene

Sources for DET1 Gene

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