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Aliases for DET1 Gene

Aliases for DET1 Gene

  • De-Etiolated Homolog 1 (Arabidopsis) 2 3 5
  • De-Etiolated-1 Homolog 4

External Ids for DET1 Gene

Previous GeneCards Identifiers for DET1 Gene

  • GC15M086786
  • GC15M086856
  • GC15M089055
  • GC15M065167
  • GC15M088493

Summaries for DET1 Gene

GeneCards Summary for DET1 Gene

DET1 (De-Etiolated Homolog 1 (Arabidopsis)) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System.

UniProtKB/Swiss-Prot for DET1 Gene

  • Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DET1 Gene

Genomics for DET1 Gene

Regulatory Elements for DET1 Gene

Enhancers for DET1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DET1 on UCSC Golden Path with GeneCards custom track

Promoters for DET1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DET1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DET1 Gene

88,511,482 bp from pter
88,546,698 bp from pter
35,217 bases
Minus strand

Genomic View for DET1 Gene

Genes around DET1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DET1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DET1 Gene

Proteins for DET1 Gene

  • Protein details for DET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DET1 homolog
    Protein Accession:
    Secondary Accessions:
    • B3KNN6
    • Q2VPC0
    • Q9NWD5

    Protein attributes for DET1 Gene

    550 amino acids
    Molecular mass:
    63848 Da
    Quaternary structure:
    • Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1.
    • Sequence=BAA91447.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DET1 Gene


neXtProt entry for DET1 Gene

Proteomics data for DET1 Gene at MOPED

Post-translational modifications for DET1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DET1 Gene

Domains & Families for DET1 Gene

Protein Domains for DET1 Gene


Suggested Antigen Peptide Sequences for DET1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DET1 family.
  • Belongs to the DET1 family.
genes like me logo Genes that share domains with DET1: view

No data available for Gene Families for DET1 Gene

Function for DET1 Gene

Molecular function for DET1 Gene

UniProtKB/Swiss-Prot Function:
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
genes like me logo Genes that share phenotypes with DET1: view

Animal Model Products

miRNA for DET1 Gene

miRTarBase miRNAs that target DET1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DET1 Gene

Localization for DET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DET1 Gene

Subcellular locations from

Jensen Localization Image for DET1 Gene COMPARTMENTS Subcellular localization image for DET1 gene
Compartment Confidence
nucleus 4
chloroplast 2
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DET1 Gene

Pathways & Interactions for DET1 Gene

genes like me logo Genes that share pathways with DET1: view

Gene Ontology (GO) - Biological Process for DET1 Gene


No data available for SIGNOR curated interactions for DET1 Gene

Drugs & Compounds for DET1 Gene

(1) Additional Compounds for DET1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DET1: view

Transcripts for DET1 Gene

Unigene Clusters for DET1 Gene

De-etiolated homolog 1 (Arabidopsis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DET1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4

Relevant External Links for DET1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DET1 Gene

mRNA expression in normal human tissues for DET1 Gene

Protein differential expression in normal tissues from HIPED for DET1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.7) and Testis (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DET1 Gene

SOURCE GeneReport for Unigene cluster for DET1 Gene Hs.690871

mRNA Expression by UniProt/SwissProt for DET1 Gene

Tissue specificity: Highly expressed in the ovary, some lymphoid organs and resting leukocytes.
genes like me logo Genes that share expression patterns with DET1: view

Protein tissue co-expression partners for DET1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DET1 Gene

Orthologs for DET1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DET1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DET1 35
  • 87.03 (n)
  • 98.36 (a)
DET1 36
  • 99 (a)
(Canis familiaris)
Mammalia DET1 35
  • 91.82 (n)
  • 99.27 (a)
DET1 36
  • 98 (a)
(Mus musculus)
Mammalia Det1 35
  • 89.15 (n)
  • 99.64 (a)
Det1 16
Det1 36
  • 99 (a)
(Pan troglodytes)
Mammalia DET1 35
  • 99.76 (n)
  • 100 (a)
DET1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Det1 35
  • 89.32 (n)
  • 98.98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
-- 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia DET1 36
  • 83 (a)
(Gallus gallus)
Aves DET1 35
  • 80.85 (n)
  • 96.55 (a)
DET1 36
  • 96 (a)
(Anolis carolinensis)
Reptilia DET1 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia det1 35
  • 77.07 (n)
  • 91.83 (a)
Str.4076 35
(Danio rerio)
Actinopterygii det1 35
  • 75.45 (n)
  • 89.32 (a)
wufc18d06 35
det1 36
  • 86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.492 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001900 35
  • 57.38 (n)
  • 56.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta abo 36
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DET1 35
  • 46.24 (n)
  • 34.33 (a)
(Oryza sativa)
Liliopsida Os01g0104600 35
  • 47.91 (n)
  • 34.01 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14008 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for DET1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DET1 Gene

Gene Tree for DET1 (if available)
Gene Tree for DET1 (if available)

Paralogs for DET1 Gene

No data available for Paralogs for DET1 Gene

Variants for DET1 Gene

Sequence variations from dbSNP and Humsavar for DET1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1735 -- 88,538,959(-) CAACC(C/T)AGTAG intron-variant
rs13835 -- 88,512,809(-) AGAGA(G/T)GAGTG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs4932451 -- 88,522,685(+) ttttg(C/G/T)atttt intron-variant
rs6416544 -- 88,547,893(+) ggagg(C/T)cttgt upstream-variant-2KB
rs6416545 -- 88,547,922(+) gggga(A/G/T)gttag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DET1 Gene

Variant ID Type Subtype PubMed ID
nsv833085 CNV Gain+Loss 17160897
esv2749993 CNV Deletion 23290073
nsv509581 CNV Insertion 20534489

Variation tolerance for DET1 Gene

Residual Variation Intolerance Score: 7.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DET1 Gene

Disorders for DET1 Gene

Relevant External Links for DET1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DET1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DET1 Gene

Publications for DET1 Gene

  1. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PMID: 14739464) Wertz I.E. … Dixit V.M. (Science 2004) 2 3 4 67
  2. Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PMID: 17452440) Pick E. … Wei N. (Mol. Cell. Biol. 2007) 3 23
  3. Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation. (PMID: 26871468) Carrero Z.I. … Martinez L.A. (Oncotarget 2016) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. (PMID: 25117710) Lu G. … Kaelin W.G. (Cancer Cell 2014) 3

Products for DET1 Gene

Sources for DET1 Gene