Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DET1 Gene

protein-coding   GIFtS: 47
GCID: GC15M089055

De-Etiolated Homolog 1 (Arabidopsis)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
De-Etiolated Homolog 1 (Arabidopsis)1 2
De-Etiolated-1 Homolog2 3
De-Etiolated 12
DET1 Homolog2

External Ids:    HGNC: 254771   Entrez Gene: 550702   Ensembl: ENSG000001405437   OMIM: 6087275   UniProtKB: Q7L5Y63   

Export aliases for DET1 gene to outside databases

Previous GC identifers: GC15M086786 GC15M086856 GC15M065167


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DET1 Gene:
DET1 (de-etiolated homolog 1 (Arabidopsis)) is a protein-coding gene. Diseases associated with DET1 include malaria.

UniProtKB/Swiss-Prot: DET1_HUMAN, Q7L5Y6
Function: Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and
subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the DET1 gene promoter:
         Egr-2   c-Fos   Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDET1 promoter sequence
   Search Chromatin IP Primers for DET1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DET1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.3   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q25.3

DET1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DET1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M089055:  view genomic region     (about GC identifiers)

Start:
89,054,790 bp from pter      End:
89,089,912 bp from pter
Size:
35,123 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DET1_HUMAN, Q7L5Y6 (See protein sequence)
Recommended Name: DET1 homolog  
Size: 550 amino acids; 63848 Da
Subunit: Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and
COP1
Sequence caution: Sequence=BAA91447.1; Type=Erroneous initiation;
Secondary accessions: B3KNN6 Q2VPC0 Q9NWD5
Alternative splicing: 2 isoforms:  Q7L5Y6-1   Q7L5Y6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DET1: NX_Q7L5Y6

Explore proteomics data for DET1 at MOPED


See DET1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001137546.1  NP_060466.2  

ENSEMBL proteins: 
 ENSP00000452856   ENSP00000456340   ENSP00000452613   ENSP00000268148   ENSP00000453900  
 ENSP00000408994  
Reactome Protein details: Q7L5Y6

DET1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for DET1
OriGene Custom MassSpec
OriGene Custom Protein Services for DET1
GenScript Custom Purified and Recombinant Proteins Services for DET1
Novus Biologicals DET1 Protein
Novus Biologicals DET1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for DET1

DET1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for DET1
Novus Biologicals DET1 Antibody
Abcam antibodies for DET1
Cloud-Clone Corp. Antibodies for DET1
ThermoFisher Antibodies for DET1
LSBio Antibodies in human, mouse, rat for DET1

DET1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DET1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DET1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for DET1
Cloud-Clone Corp. CLIAs for DET1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
1 InterPro protein domain:
 IPR019138 De-etiolated_protein_1_Det1

Graphical View of Domain Structure for InterPro Entry Q7L5Y6

ProtoNet protein and cluster: Q7L5Y6

UniProtKB/Swiss-Prot: DET1_HUMAN, Q7L5Y6
Similarity: Belongs to the DET1 family


DET1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DET1_HUMAN, Q7L5Y6
Function: Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and
subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation

Phenotypes:
     2 GenomeRNAi human phenotypes for DET1:

 Synthetic lethal with Ras  Upregulation of NF-kappaB path 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DET1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DET1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DET1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DET1

miRNA
Products:
    
miRTarBase miRNAs that target DET1:
hsa-mir-155-5p (MIRT000972)

Block miRNA regulation of human, mouse, rat DET1 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate DET1:
hsa-miR-188-3p hsa-miR-149 hsa-miR-155
SwitchGear 3'UTR luciferase reporter plasmidDET1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DET1
Predesigned siRNA for gene silencing in human, mouse, rat DET1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DET1

Clone
Products:
     
OriGene clones in human, mouse for DET1 (see all 13)
OriGene ORF clones in mouse, rat for DET1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): DET1 (NM_001144074)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DET1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DET1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DET1
Browse ESI BIO Cell Lines and PureStem Progenitors for DET1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DET1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
DET1_HUMAN, Q7L5Y6: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
chloroplast2
cytosol2
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

DET1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for DET1 About    
See pathways by source

SuperPathContained pathways About
1Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84
Ubiquitin mediated proteolysis0.35

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for DET1
    Antigen processing: Ubiquitination & Proteasome degradation


1 Kegg Pathway  (Kegg details for DET1):
    Ubiquitin mediated proteolysis


DET1 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including DET1: 
          Ubiquitin Ligases in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for DET1

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

Selected Interacting proteins for DET1 (Q7L5Y63 ENSP000004089944) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
InteractantInteraction Details
GeneCardExternal ID(s)
RFWD2Q8NHY23, ENSP000003566414I2D: score=2 STRING: ENSP00000356641
RBX1P628773, ENSP000002162254I2D: score=1 STRING: ENSP00000216225
DDB1Q165313, ENSP000003017644I2D: score=2 STRING: ENSP00000301764
CUL4AQ136193, ENSP000003645894I2D: score=1 STRING: ENSP00000364589
DDA1Q9BW613, ENSP000003529284I2D: score=1 STRING: ENSP00000352928
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DET1

1 Novoseek inferred chemical compound relationship for DET1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
phytochrome 73.9 1 1467650 (1)



DET1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DET1 gene (2 alternative transcripts): 
NM_001144074.1  NM_017996.3  

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000557842(uc002bmp.4 uc010bnk.2) ENST00000564406(uc002bmq.2)
ENST00000557837 ENST00000268148(uc002bmr.2) ENST00000558413 ENST00000559656
ENST00000444300
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DET1 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate DET1:
hsa-miR-188-3p hsa-miR-149 hsa-miR-155
SwitchGear 3'UTR luciferase reporter plasmidDET1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DET1
Predesigned siRNA for gene silencing in human, mouse, rat DET1
Clone
Products:
     
OriGene clones in human, mouse for DET1 (see all 13)
OriGene ORF clones in mouse, rat for DET1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): DET1 (NM_001144074)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DET1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DET1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for DET1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DET1
  QuantiTect SYBR Green Assays in human, mouse, rat DET1
  QuantiFast Probe-based Assays in human, mouse, rat DET1

Selected AceView cDNA sequences (see all 254):

BF356525 CA418788 CK819446 AI433200 AA736871 BM968277 BQ010609 AA683079 
BE257656 BU617959 BX477557 BX280527 NM_017996 BQ929269 BC001242 CR615320 
BG574987 NM_022163 AA322556 CR601389 BQ009644 AA872336 AI222677 BM692342 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DET1    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
SP1:                              
SP2:                              
SP3:                              


ECgene alternative splicing isoforms for DET1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DET1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DET1 Expression
About this image

DET1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DET1 Protein Expression

UniProtKB/Swiss-Prot: DET1_HUMAN, Q7L5Y6
Tissue specificity: Highly expressed in the ovary, some lymphoid organs and resting leukocytes

    Pathway & Disease-focused RT2 Profiler PCR Array including DET1: 
          Ubiquitin Ligases in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for DET1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DET1
QuantiTect SYBR Green Assays in human, mouse, rat DET1
QuantiFast Probe-based Assays in human, mouse, rat DET1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DET1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for DET1 gene from Selected species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Det11 , 5 de-etiolated homolog 1 (Arabidopsis)1, 5 89.15(n)1
99.64(a)1
  7 (44.81 cM)5
763751  NM_029585.31  NP_083861.11 
 788229625 
chicken
(Gallus gallus)
Aves DET11 de-etiolated homolog 1 (Arabidopsis) 80.85(n)
96.55(a)
  415497  XM_413870.4  XP_413870.2 
lizard
(Anolis carolinensis)
Reptilia DET16
de-etiolated homolog 1 (Arabidopsis)
83(a)
1 ↔ 1
GL343389.1(81731-150477)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.40762 Transcribed sequence with weak similarity to protein more 79.72(n)    AL883679.2 
zebrafish
(Danio rerio)
Actinopterygii wufc18d062 wufc18d06 77.9(n)   324089  BC055677.1 
fruit fly
(Drosophila melanogaster)
Insecta abo6
abnormal oocyte
28(a)
1 ↔ 1
2L(10973443-10975273)
thale cress
(Arabidopsis thaliana)
eudicotyledons DET11 DET1 46.24(n)
34.33(a)
  826609  NM_117086.3  NP_192756.2 
rice
(Oryza sativa)
Liliopsida Os01g01046001 Os01g0104600 47.91(n)
34.01(a)
  4326296  NM_001048301.1  NP_001041766.1 


ENSEMBL Gene Tree for DET1 (if available)
TreeFam Gene Tree for DET1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for DET1 (see all 948)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1504283851,2
--89055245(+) AATGTA/GACAGA 3 -- ds50010--------
rs1382412171,2
C--89055324(+) TCTGGA/TCTCTG 3 -- ds50010--------
rs1495582651,2
--89055429(+) TCTTCC/TACCTG 3 -- ds50010--------
rs1460683001,2
--89055441(+) ATGACA/GCAGAT 3 -- ds50010--------
rs1920635711,2
--89055633(+) TCTTTC/TACAGT 3 -- ds50010--------
rs1842923191,2
--89055665(+) TGAAAC/GCATTG 3 -- ds50010--------
rs1387434051,2
--89055690(+) ATAAAC/GCAGTC 3 -- ds50010--------
rs1878434041,2
--89055760(+) TAGCCA/GTGCTT 3 -- ut31 nc-transcript-variant0--------
rs1927591731,2
--89055794(+) TGTCAG/TTCTCA 3 -- ut31 nc-transcript-variant0--------
rs1418666921,2
--89055981(+) ATAACA/CATCAG 3 -- ut31 nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for DET1 (89054790 - 89089912 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for DET1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2749993CNV Deletion23290073
nsv509581CNV Insertion20534489
nsv833085CNV Gain+Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DET1
DNA2.0 Custom Variant and Variant Library Synthesis for DET1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 608727    OMIM disorders: --

1 disease for DET1:    
About MalaCards
malaria


DET1 for disorders           About GeneDecksing


Export disorders for DET1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DET1 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with DET1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PubMed id 14739464)1, 2, 3 Wertz I.E.... Dixit V.M. (Science 2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PubMed id 17452440)1, 9 Pick E.... Wei N. (Mol. Cell. Biol. 2007)
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
  6. COP1 is a tumour suppressor that causes degradation of ETS transcription factors. (PubMed id 21572435)1 Vitari A.C....Dixit V.M. (Nature 2011)
  7. An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)1 Olma M.H....Pintard L. (J. Cell. Sci. 2009)
  8. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1 Jin J.... Walter J.C. (Mol. Cell 2006)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  10. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PubMed id 16964240)1 Angers S.... Zheng N. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 55070 HGNC: 25477 AceView: DET1andMRPL46 Ensembl:ENSG00000140543 euGenes: HUgn55070
ECgene: DET1 Kegg: 55070 H-InvDB: DET1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for DET1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for DET1 gene:
Search GeneIP for patents involving DET1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DET1  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DET1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for DET1  
 OriGene qSTAR qPCR primer pairs in human, mouse for DET1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for DET1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DET1   OriGene Custom Protein Services for DET1  

 
 
 Block miRNA regulation of human, mouse, rat DET1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DET1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DET1 Predesigned siRNA for gene silencing in human, mouse, rat DET1
 QuantiFast Probe-based Assays in human, mouse, rat DET1 QuantiTect SYBR Green Assays in human, mouse, rat DET1
 PCR Arrays including human, mouse, rat DET1 Search Chromatin IP Primers for DET1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DET1  Search GeneGlobe Interaction Network for DET1
 Regulatory tfbs in DET1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for DET1 GenScript cDNA clones with any tag delivered in your preferred vector for DET1
 GenScript Custom Assay Services for DET1 GenScript Custom overexpressing Cell Line Services for DET1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for DET1
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 DET1 antibodies
 DET1 proteins
 DET1 lysates
 Antibodies for DET1
 See all of Abcam's Antibodies, Kits and Proteins for DET1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for DET1
 Antibodies for DET1
 ELISAs for DET1
 CLIAs for DET1



 Browse ESI BIO Cell Lines and PureStem Progenitors for DET1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DET1
 SwitchGear 3'UTR luciferase reporter plasmids for DET1
 SwitchGear Promoter luciferase reporter plasmids for DET1
 ThermoFisher Antibodies for DET1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DET1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DET1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DET1
 LSBio Antibodies in human, mouse, rat for DET1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DET1 gene at Home site.
Version: 3.12.166 28 Aug 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4