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Aliases for DET1 Gene

Aliases for DET1 Gene

  • De-Etiolated Homolog 1 (Arabidopsis) 2 3 5
  • De-Etiolated-1 Homolog 4

External Ids for DET1 Gene

Previous GeneCards Identifiers for DET1 Gene

  • GC15M086786
  • GC15M086856
  • GC15M089055
  • GC15M065167
  • GC15M088493

Summaries for DET1 Gene

GeneCards Summary for DET1 Gene

DET1 (De-Etiolated Homolog 1 (Arabidopsis)) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for DET1 Gene

  • Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DET1 Gene

Genomics for DET1 Gene

Regulatory Elements for DET1 Gene

Enhancers for DET1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G089124 2 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -586.4 -586381 16.2 HDGF FOXA2 PKNOX1 ZFP64 ARID4B FEZF1 DMAP1 YBX1 ZNF2 YY1 ABHD2 LOC102724566 DET1 ISG20 GC15M089136 RNU7-195P
GH15G089383 1.2 ENCODE dbSUPER 9.7 -837.0 -837007 0.9 FEZF1 ZNF2 GLIS2 ZNF302 ZNF263 YY2 TSHZ1 REST ZNF662 ZNF491 ENSG00000173867 ARPIN RPL36AP43 NIFKP5 POLG DET1 ENSG00000228998 MIR9-3HG GC15P089381 PIR56199
GH15G087751 1 Ensembl ENCODE 11 +794.1 794124 1.7 ZBTB21 NFIB JUN ZNF791 GATA3 CEBPB ZHX2 DPF2 ELF1 EP300 DET1 ENSG00000173867 GC15P087758 LOC102724465
GH15G088538 1 Ensembl ENCODE 10.5 +7.3 7287 2.4 CTCF HINFP DDX20 PYGO2 ZNF644 RAD21 RELA IRF9 GATA3 RFX1 DET1 ENSG00000173867 PIR61736
GH15G088545 1.1 ENCODE 9.1 +0.0 25 1.4 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF143 ZNF548 KLF13 POLG DET1 ENSG00000173867 PIR61736
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DET1 on UCSC Golden Path with GeneCards custom track

Promoters for DET1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080783 298 1601 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF143 ZNF548 KLF13

Genomic Location for DET1 Gene

88,494,440 bp from pter
88,546,698 bp from pter
52,259 bases
Minus strand

Genomic View for DET1 Gene

Genes around DET1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DET1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DET1 Gene

Proteins for DET1 Gene

  • Protein details for DET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DET1 homolog
    Protein Accession:
    Secondary Accessions:
    • B3KNN6
    • Q2VPC0
    • Q9NWD5

    Protein attributes for DET1 Gene

    550 amino acids
    Molecular mass:
    63848 Da
    Quaternary structure:
    • Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1.
    • Sequence=BAA91447.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DET1 Gene


neXtProt entry for DET1 Gene

Post-translational modifications for DET1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DET1 Gene

Domains & Families for DET1 Gene

Protein Domains for DET1 Gene

Suggested Antigen Peptide Sequences for DET1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DET1 family.
  • Belongs to the DET1 family.
genes like me logo Genes that share domains with DET1: view

No data available for Gene Families for DET1 Gene

Function for DET1 Gene

Molecular function for DET1 Gene

UniProtKB/Swiss-Prot Function:
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
genes like me logo Genes that share phenotypes with DET1: view

Animal Model Products

miRNA for DET1 Gene

miRTarBase miRNAs that target DET1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DET1 Gene

Localization for DET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DET1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DET1 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for DET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DET1: view

Pathways & Interactions for DET1 Gene

genes like me logo Genes that share pathways with DET1: view

Gene Ontology (GO) - Biological Process for DET1 Gene


No data available for SIGNOR curated interactions for DET1 Gene

Drugs & Compounds for DET1 Gene

(1) Additional Compounds for DET1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DET1: view

Transcripts for DET1 Gene

Unigene Clusters for DET1 Gene

De-etiolated homolog 1 (Arabidopsis):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DET1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4

Relevant External Links for DET1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DET1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DET1 Gene

Protein differential expression in normal tissues from HIPED for DET1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.7) and Testis (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DET1 Gene

Protein tissue co-expression partners for DET1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DET1 Gene:


SOURCE GeneReport for Unigene cluster for DET1 Gene:


mRNA Expression by UniProt/SwissProt for DET1 Gene:

Tissue specificity: Highly expressed in the ovary, some lymphoid organs and resting leukocytes.

Evidence on tissue expression from TISSUES for DET1 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with DET1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DET1 Gene

Orthologs for DET1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DET1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DET1 34 35
  • 99.76 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 94 (a)
-- 35
  • 92 (a)
(Canis familiaris)
Mammalia DET1 34 35
  • 91.82 (n)
(Rattus norvegicus)
Mammalia Det1 34
  • 89.32 (n)
(Mus musculus)
Mammalia Det1 34 16 35
  • 89.15 (n)
(Bos Taurus)
Mammalia DET1 34 35
  • 87.03 (n)
(Ornithorhynchus anatinus)
Mammalia DET1 35
  • 83 (a)
(Gallus gallus)
Aves DET1 34 35
  • 80.85 (n)
(Anolis carolinensis)
Reptilia DET1 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia det1 34
  • 77.07 (n)
Str.4076 34
(Danio rerio)
Actinopterygii det1 34 35
  • 75.45 (n)
wufc18d06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.492 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001900 34
  • 57.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta abo 35
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DET1 34
  • 46.24 (n)
(Oryza sativa)
Liliopsida Os01g0104600 34
  • 47.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14008 34
Species where no ortholog for DET1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DET1 Gene

Gene Tree for DET1 (if available)
Gene Tree for DET1 (if available)

Paralogs for DET1 Gene

No data available for Paralogs for DET1 Gene

Variants for DET1 Gene

Sequence variations from dbSNP and Humsavar for DET1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000015123 -- 88,539,144(+) AGAAT(C/T)TCCAG intron-variant
rs1000081009 -- 88,503,800(+) TGAGA(C/T)CAGCC intron-variant
rs1000102029 -- 88,522,390(+) TTTTT(A/T)AATGT intron-variant
rs1000114309 -- 88,512,338(+) TTCCC(C/T)GTTGG intron-variant, downstream-variant-500B
rs1000154076 -- 88,538,984(+) GGTAG(C/G)CGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DET1 Gene

Variant ID Type Subtype PubMed ID
esv2749993 CNV deletion 23290073
nsv509581 CNV insertion 20534489
nsv833085 CNV gain+loss 17160897

Variation tolerance for DET1 Gene

Residual Variation Intolerance Score: 7.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DET1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DET1 Gene

Disorders for DET1 Gene

Relevant External Links for DET1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DET1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DET1 Gene

Publications for DET1 Gene

  1. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PMID: 14739464) Wertz I.E. … Dixit V.M. (Science 2004) 2 3 4 64
  2. Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PMID: 17452440) Pick E. … Wei N. (Mol. Cell. Biol. 2007) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation. (PMID: 26871468) Carrero Z.I. … Martinez L.A. (Oncotarget 2016) 3 64

Products for DET1 Gene

Sources for DET1 Gene

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