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DESI2 Gene

protein-coding GIFtS: 42
GCID: GC01P244817

Desumoylating Isopeptidase 2

(Previous names: chromosome 1 open reading frame 121, family with sequence...)
(Previous symbols: C1orf121, FAM152A, PPPDE1)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Desumoylating Isopeptidase 2¹ ²		Chromosome 1 Open Reading Frame 121¹
PPPDE1¹ ² ³ ⁵		DESI²
C1orf121¹ ² ³		DESI1²
FAM152A¹ ² ³		PNAS-4²
Family With Sequence Similarity 152, Member A¹ ²		Desumoylating Isopeptidase 1²
PPPDE Peptidase Domain Containing 1¹ ²		EC 3.4.-.-³
DeSI-2² ³		Protein FAM152A³
PPPDE Peptidase Domain-Containing Protein 1² ³

External Ids:	HGNC: 24264¹	Entrez Gene: 51029²	Ensembl: ENSG00000121644⁷	OMIM: 614638⁵	UniProtKB: Q9BSY9³

Export aliases for DESI2 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DESI2 Gene:

DESI2 (desumoylating isopeptidase 2) is a protein-coding gene. Diseases associated with DESI2 include lung adenocarcinoma, and adenocarcinoma. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9

Function: Protease which may deconjugate SUMO from some substrate proteins (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NT_167186.2 NC_018912.2

Regulatory elements:

Search for regulatory transcription factor binding sites for DESI2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DESI2 promoter sequence

Search Chromatin IP Primers for DESI2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DESI2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44

DESI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DESI2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P244817: view genomic region (about GC identifiers)

Start:	244,816,237 bp from pter	End:	244,872,335 bp from pter
Size:	56,099 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9 (See protein sequence)

Recommended Name: Desumoylating isopeptidase 2

Size: 194 amino acids; 21444 Da

Sequence caution: Sequence=AAD34141.1; Type=Frameshift; Positions=149, 175; Sequence=AAF42919.1; Type=Erroneous

initiation; Note=Translation N-terminally shortened;

Secondary accessions: B1APK6 Q5VVC6 Q9NYS2 Q9Y3E4

Alternative splicing: 2 isoforms: Q9BSY9-1 Q9BSY9-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DESI2: NX_Q9BSY9

Explore proteomics data for DESI2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See DESI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_057160.2

ENSEMBL proteins:

ENSP00000306528 ENSP00000263831 ENSP00000394555

DESI2 Human Recombinant Protein Products:

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	Novus Biologicals DESI2 Proteins Novus Biologicals DESI2 Lysate
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DESI2 Antibody Products:

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	Search for Antibodies for DESI2 at Abcam
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	ThermoFisher Antibodies for DESI2
	LSBio Antibodies in human, mouse, rat for DESI2

DESI2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DESI2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR008580 PPPDE_dom

Graphical View of Domain Structure for InterPro Entry Q9BSY9

ProtoNet protein and cluster: Q9BSY9

1 Blocks protein domain: IPB008580 Eukaryotic protein of unknown function DUF862

UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9

Similarity: Belongs to the DeSI family

Similarity: Contains 1 PPPDE peptidase domain

DESI2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DESI2_HUMAN, Q9BSY9

Function: Protease which may deconjugate SUMO from some substrate proteins (By similarity)

Enzyme Number (IUBMB): EC 3.4.-.-¹

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008233	peptidase activity	IEA	--

DESI2 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Desi2):

normal

DESI2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Desi2^tm1Mche for DESI2

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DESI2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DESI2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DESI2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DESI2

miRNA Products:		miRTarBase miRNAs that target DESI2: hsa-mir-497-5p (MIRT041187)

		Block miRNA regulation of human, mouse, rat DESI2 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate DESI2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DESI2
		Predesigned siRNA for gene silencing in human, mouse, rat DESI2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DESI2

Clone Products:		OriGene clones in human, mouse for DESI2 (see all 6) OriGene ORF clones in mouse, rat for DESI2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DESI2
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DESI2
		Browse ESI BIO Cell Lines and PureStem Progenitors for DESI2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

DESI2_HUMAN, Q9BSY9: Cytoplasm (By similarity)

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

DESI2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for DESI2
Interactions:

Search GeneGlobe Interaction Network for DESI2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for DESI2 (Q9BSY9³ ENSP00000306528⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
REXO2	Q9Y3B8³	I2D: score=2
YIF1B	Q5BJH7³	I2D: score=1
CDC73	ENSP00000356405⁴	STRING: ENSP00000356405
NBPF8	ENSP00000358372⁴	STRING: ENSP00000358372
WNT11	ENSP00000325526⁴	STRING: ENSP00000325526

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	--	--

DESI2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DESI2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DESI2 gene:

NM_016076.3

Unigene Cluster for DESI2:

Desumoylating isopeptidase 2

Hs.498317 [show with all ESTs]

Unigene Representative Sequence: NM_016076

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302550(uc001iao.3 uc001iap.3) ENST00000263831 ENST00000484738

ENST00000418162

miRNA Products:		Block miRNA regulation of human, mouse, rat DESI2 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate DESI2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DESI2
		Predesigned siRNA for gene silencing in human, mouse, rat DESI2

Clone Products:		OriGene clones in human, mouse for DESI2 (see all 6) OriGene ORF clones in mouse, rat for DESI2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for DESI2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DESI2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI2

Primer Products:		OriGene qPCR primer pairs and template standards for DESI2 OriGene qSTAR qPCR primer pairs in human, mouse for DESI2
		Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat DESI2
		QuantiTect SYBR Green Assays in human, mouse, rat DESI2
		QuantiFast Probe-based Assays in human, mouse, rat DESI2

Additional mRNA sequence:

AF151904.1 AF229834.1 AK092419.1 AK314664.1 AL049397.1 BC004485.2 BC020640.1 BC040608.1

9 DOTS entries:

DT.100785908 DT.121339094 DT.86853363 DT.40190281 DT.97841758 DT.430675 DT.121339082 DT.121505325

DT.100785905

Selected AceView cDNA sequences (see all 267):

BG033867 AI964069 AI811641 CR626654 NM_016076 AI985507 BM977650 CB161099

AI355790 BU688822 BM676550 BU631980 BE719786 AW135153 AI274778 BQ014649

BC040608 AL049397 AI890940 AA608534 BE874772 AI240016 C01528 AI149870

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DESI2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c
SP1:											-		-
SP2:											-		-		-
SP3:											-		-		-				-
SP4:											-		-		-				-
SP5:

ECgene alternative splicing isoforms for DESI2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DESI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

DESI2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Testis (Reproductive System)
XY Germ Cells Testis Cord

Gonad
XY Germ Cells Testis Cord

DESI2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DESI2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.498317

Custom PCR Arrays for DESI2

Primer Products:		OriGene qPCR primer pairs and template standards for DESI2 OriGene qSTAR qPCR primer pairs in human, mouse for DESI2
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		QuantiFast Probe-based Assays in human, mouse, rat DESI2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for DESI2 gene from Selected species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Desi2^{1 , 5}	PPPDE peptidase domain containing 1⁵ desumoylating isopeptidase 2¹	90.72(n)¹ 96.91(a)¹		1 (82.93 cM)⁵ 78825¹ NM_024282.3¹ NP_077244.1¹ 178187417⁵
chicken (Gallus gallus)	Aves	PPPDE1¹	PPPDE peptidase domain containing 1	85.24(n) 95.31(a)		421494 NM_001008460.1 NP_001008460.1
lizard (Anolis carolinensis)	Reptilia	DESI2⁶	desumoylating isopeptidase 2	90(a)	1 ↔ 1	GL343285.1(1182526-1201706)
African clawed frog (Xenopus laevis)	Amphibia	BJ039519.1²	--	80.63(n)		BJ039519.1
zebrafish (Danio rerio)	Actinopterygii	sbcb238²	sbcb238	77.35(n)		321167 57063624
fruit fly (Drosophila melanogaster)	Insecta	CG7222¹	CG7222	62.22(n) 63.64(a)		36138 NM_136769.3 NP_610613.1
worm (Caenorhabditis elegans)	Secernentea	F36D4.5¹	F36D4.5	60.51(n) 60.51(a)		179324 NM_171506.1 NP_741591.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G17486¹	AT4G17486	50.5(n) 47.01(a)		827462 NM_117853.3 NP_567528.2
rice (Oryza sativa)	Liliopsida	Os03g0100900¹	Os03g0100900	51.56(n) 41.33(a)		4331282 NM_001055183.1 NP_001048648.1

ENSEMBL Gene Tree for DESI2 (if available)
TreeFam Gene Tree for DESI2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DESI2 gene

DESI2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DESI2
PGOHUM00000234446

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2806597^1,2	C,F,A,H	--	244814405(-)	`aagagC/Ttatgg`	1	--	us2k¹		27		NS EA NA WA	2970
rs146164516^1,2	C	--	244814426(+)	`CCCCA-/GGCCTG`	1	--	us2k¹		0	--	--	--	--
rs116656853^1,2	C,F	--	244814602(+)	`TATTTC/TGGTCT`	1	--	us2k¹		1		WA	118
rs139405855^1,2	C	--	244814640(+)	`CTTGCC/TGGCAT`	1	--	us2k¹		0	--	--	--	--
rs150074548^1,2		--	244814774(+)	`ATCCAC/TGTGGT`	1	--	us2k¹		0	--	--	--	--
rs187244910^1,2		--	244814801(+)	`TAGTCC/TGGGAG`	1	--	us2k¹		0	--	--	--	--
rs35181949^1,2	C,F	--	244814817(+)	`CACATG/ATTCGC`	1	--	us2k¹		4		NA	126
rs74152146^1,2	C,F	--	244814952(+)	`AAGCCC/TCAACT`	1	--	us2k¹		2		WA	120
rs192519209^1,2		--	244815184(+)	`ATTTTC/TAAACA`	1	--	us2k¹		0	--	--	--	--
rs145300364^1,2	C	--	244815245(+)	`TACAAC/TCCCTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DESI2 (244816237 - 244872335 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for DESI2: --
Human Gene Mutation Database (HGMD): DESI2

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing DESI2

DNA2.0 Custom Variant and Variant Library Synthesis for DESI2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614638 OMIM disorders: --

4 diseases for DESI2:
About MalaCards

lung adenocarcinoma adenocarcinoma colorectal cancer malaria

DESI2 for disorders About GeneDecksing

Export disorders for DESI2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DESI2 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with DESI2)

Utopia: connect your pdf to the dynamic
world of online information

Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2, 3} Lai C.-H.... Lin W.-C. (Genome Res. 2000)
DeSUMOylating isopeptidase: a second class of SUMO protease. (PubMed id 22370726)^{1, 3} Shin E.J....Yun Y. (EMBO Rep. 2012)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells. (PubMed id 23322088)¹ Li L....Wei Y.Q. (Apoptosis 2013)
PNAS-4 expression and its relationship to p53 in colorectal cancer. (PubMed id 21556770)¹ Zhou B....Sun X. (Mol. Biol. Rep. 2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice. (PubMed id 19133312)¹ Yan F....Wei Y. (Biochimie 2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (EMBO J. 2009)
Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. (PubMed id 18538138)¹ Yao S....Mo X. (FEBS Lett. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51029	HGNC: 24264	AceView: PNAS-4	Ensembl:ENSG00000121644	euGenes: HUgn51029
ECgene: DESI2	H-InvDB: DESI2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DESI2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DESI2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DESI2 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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DESI2 Gene

Desumoylating Isopeptidase 2

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DESI2 Gene

Desumoylating Isopeptidase 2

Aliasesfor DESI2 gene

Summariesfor DESI2 gene

Genomic Viewsfor DESI2 gene

Proteinsfor DESI2 gene

DESI2 Human Recombinant Protein Products:

DESI2 Antibody Products:

DESI2 Assay Products:

Domains /Familiesfor DESI2 gene

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Localizationfor DESI2 gene

Pathways & Interactionsfor DESI2 gene

Drugs & Compoundsfor DESI2 gene

Transcriptsfor DESI2 gene

Expression for DESI2 gene

Orthologsfor DESI2 gene

Paralogsfor DESI2 gene

Genomic Variantsfor DESI2 gene

Disorders / Diseasesfor DESI2 gene

Publicationsfor DESI2 gene

External Searches for DESI2 gene

Genome Databases showing DESI2 gene

Other Databases showing DESI2 gene

Specialized Databases showing DESI2 gene

Intellectual Propertyfor DESI2 gene

Productsfor DESI2 gene

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Aliases
for DESI2 gene

Summaries
for DESI2 gene

Genomic Views
for DESI2 gene

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for DESI2 gene

Domains /
Families
for DESI2 gene

Function
for DESI2 gene

Localization
for DESI2 gene

Pathways & Interactions
for DESI2 gene

Drugs & Compounds
for DESI2 gene

Transcripts
for DESI2 gene

Expression
for DESI2 gene

Orthologs
for DESI2 gene

Paralogs
for DESI2 gene

Genomic Variants
for DESI2 gene

Disorders / Diseases
for DESI2 gene

Publications
for DESI2 gene

Intellectual Property
for DESI2 gene

Products
for DESI2 gene