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DESI2 Gene(Protein Coding)

Desumoylating Isopeptidase 2

GCID:
GC01P244652
GIFtS:
45
Genes Participants
UDN Logo

Aliases for DESI2 Gene

Aliases for DESI2 Gene

  • Desumoylating Isopeptidase 2 2 3 5
  • Family With Sequence Similarity 152, Member A 2 3
  • PPPDE Peptidase Domain-Containing Protein 1 3 4
  • C1orf121 3 4
  • FAM152A 3 4
  • PPPDE1 3 4
  • DeSI-2 3 4
  • Chromosome 1 Open Reading Frame 121 2
  • PPPDE Peptidase Domain Containing 1 2
  • Desumoylating Isopeptidase 1 3
  • Protein FAM152A 4
  • EC 3.4.-.- 4
  • CGI-146 3
  • PNAS-4 3
  • DESI1 3
  • DESI 3

External Ids for DESI2 Gene

Previous HGNC Symbols for DESI2 Gene

  • C1orf121
  • FAM152A
  • PPPDE1

Previous GeneCards Identifiers for DESI2 Gene

  • GC01P244817

Summaries for DESI2 Gene

GeneCards Summary for DESI2 Gene

DESI2 (Desumoylating Isopeptidase 2) is a Protein Coding gene. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for DESI2 Gene

  • Protease which may deconjugate SUMO from some substrate proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DESI2 Gene

Genomics for DESI2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DESI2 Gene

Enhancers for DESI2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DESI2 on UCSC Golden Path with GeneCards custom track

Promoters for DESI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DESI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DESI2 Gene

Chromosome:
1
Start:
244,652,935 bp from pter
End:
244,709,034 bp from pter
Size:
56,100 bases
Orientation:
Plus strand

Genomic View for DESI2 Gene

Genes around DESI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DESI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DESI2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DESI2 Gene

Proteins for DESI2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DESI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSY9-DESI2_HUMAN
    Recommended name:
    Desumoylating isopeptidase 2
    Protein Accession:
    Q9BSY9
    Secondary Accessions:
    • B1APK6
    • Q5VVC6
    • Q9NYS2
    • Q9Y3E4

    Protein attributes for DESI2 Gene

    Size:
    194 amino acids
    Molecular mass:
    21444 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34141.1; Type=Frameshift; Positions=149, 175; Evidence={ECO:0000305}; Sequence=AAF42919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DESI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DESI2 Gene

Proteomics data for DESI2 Gene at MOPED

Protein Expression for DESI2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DESI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DESI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DESI2

No data available for DME Specific Peptides for DESI2 Gene

Domains & Families for DESI2 Gene

Gene Families for DESI2 Gene

HGNC:

Protein Domains for DESI2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DESI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSY9

UniProtKB/Swiss-Prot:

DESI2_HUMAN :
  • Contains 1 PPPDE peptidase domain.
  • Belongs to the DeSI family.
Domain:
  • Contains 1 PPPDE peptidase domain.
Family:
  • Belongs to the DeSI family.
genes like me logo Genes that share domains with DESI2: view

Function for DESI2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DESI2 Gene

UniProtKB/Swiss-Prot Function:
Protease which may deconjugate SUMO from some substrate proteins.

Enzyme Numbers (IUBMB) for DESI2 Gene

Phenotypes for DESI2 Gene

MGI mutant phenotypes for DESI2:
inferred from 1 alleles
GenomeRNAi human phenotypes for DESI2:
genes like me logo Genes that share phenotypes with DESI2: view

Animal Models for DESI2 Gene

MGI Knock Outs for DESI2:

Animal Model Products

CRISPR Products

miRNA for DESI2 Gene

miRTarBase miRNAs that target DESI2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DESI2 Gene

Localization for DESI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DESI2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DESI2 Gene COMPARTMENTS Subcellular localization image for DESI2 gene
Compartment Confidence
cytosol 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for DESI2 Gene

Pathways & Interactions for DESI2 Gene

SuperPathways for DESI2 Gene

PathCards logoMore details on SuperPathways for DESI2
No Data Available

Interacting Proteins for DESI2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000306528%0d%0a9606.ENSP00000325526%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000348459%0d%0a9606.ENSP00000171887%0d%0a
Selected Interacting proteins: ENSP00000306528 Q9BSY9-DESI2_HUMAN for DESI2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DESI2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DESI2 Gene

Drugs & Compounds for DESI2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DESI2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DESI2 Gene

(8) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(267) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DESI2 Gene

Desumoylating isopeptidase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DESI2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5:

Relevant External Links for DESI2 Gene

GeneLoc Exon Structure for
DESI2
ECgene alternative splicing isoforms for
DESI2

Expression for DESI2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for DESI2 Gene

mRNA expression in normal human tissues for DESI2 Gene
mRNA expression by BioGPS for DESI2 GenemRNA expression by GTEx for DESI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DESI2 Gene

This gene is overexpressed in Pancreas (24.5), Retina (10.3), Testis (9.8), Fetal heart (8.3), Fetal testis (8.2), and Ovary (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DESI2 Gene



SOURCE GeneReport for Unigene cluster for DESI2 Gene Hs.498317

genes like me logo Genes that share expression patterns with DESI2: view

Protein tissue co-expression partners for DESI2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DESI2 Gene

Orthologs for DESI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DESI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia PPPDE1 35
  • 93.82 (n)
  • 98.88 (a)
PPPDE1 36
  • 93 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia DESI2 35
  • 89.26 (n)
  • 98.89 (a)
DESI2 36
  • 93 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Desi2 35
  • 90.72 (n)
  • 96.91 (a)
Desi2 16
Desi2 36
  • 97 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia DESI2 35
  • 98.23 (n)
  • 97.87 (a)
DESI2 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Desi2 35
  • 89.52 (n)
  • 96.39 (a)
oppossum
(Monodelphis domestica)
 Mammalia DESI2 36
  • 94 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DESI2 36
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PPPDE1 35
  • 85.24 (n)
  • 95.31 (a)
DESI2 36
  • 95 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DESI2 36
  • 90 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia desi2 35
  • 76.91 (n)
  • 85.94 (a)
Str.20134 35
zebrafish
(Danio rerio)
 Actinopterygii desi2 35
  • 77.37 (n)
  • 88.27 (a)
sbcb238 35
desi2 36
  • 81 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP012058 35
  • 61.38 (n)
  • 65.24 (a)
fruit fly
(Drosophila melanogaster)
 Insecta CG7222 35
  • 62.22 (n)
  • 63.64 (a)
CG12231 36
  • 37 (a)
 OneToMany
CG7222 36
  • 51 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea F36D4.5 35
  • 60.51 (n)
  • 60.51 (a)
F36D4.5 36
  • 30 (a)
 OneToOne
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT4G17486 35
  • 50.5 (n)
  • 47.01 (a)
rice
(Oryza sativa)
 Liliopsida Os03g0100900 35
  • 51.56 (n)
  • 41.33 (a)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.1830 35
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 60 (a)
 OneToOne
Species with no ortholog for DESI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DESI2 Gene

ENSEMBL:
Gene Tree for DESI2 (if available)
TreeFam:
Gene Tree for DESI2 (if available)

Paralogs for DESI2 Gene

Pseudogenes.org Pseudogenes for DESI2 Gene

genes like me logo Genes that share paralogs with DESI2: view

No data available for Paralogs for DESI2 Gene

Variants for DESI2 Gene

Sequence variations from dbSNP and Humsavar for DESI2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10936 -- 244,708,834(-) TTTTC(A/T)AACAG nc-transcript-variant, utr-variant-3-prime
rs13270 -- 244,705,602(+) TGCCT(A/G)CTTCA nc-transcript-variant, reference, missense
rs878964 -- 244,673,660(+) ATTTT(G/T)TTTCA intron-variant
rs879604 -- 244,666,231(+) ACCAC(C/T)GTTTT intron-variant
rs905252 -- 244,657,222(+) AACAG(A/G)GTGTC intron-variant

Variation tolerance for DESI2 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DESI2 Gene

Human Gene Mutation Database (HGMD)
DESI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DESI2 Gene

Disorders for DESI2 Gene

Relevant External Links for DESI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DESI2

No disorders were found for DESI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DESI2 Gene

Publications for DESI2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. DeSUMOylating isopeptidase: a second class of SUMO protease. (PMID: 22370726) Shin E.J. … Yun Y. (EMBO Rep. 2012) 2 3
  3. High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma. (PMID: 25079376) Shen C.C. … Gou L.T. (Pathol. Oncol. Res. 2015) 3
  4. PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells. (PMID: 25918161) Yuan Z. … Wei Y. (J. Biol. Chem. 2015) 3
  5. hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells. (PMID: 23322088) Li L. … Wei Y.Q. (Apoptosis 2013) 3

Products for DESI2 Gene

Sources for DESI2 Gene

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