DESI2 Gene
protein-coding GIFtS: 43
GCID: GC01P244817
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desumoylating isopeptidase 2(Previous names: chromosome 1 open reading frame 121, family with sequence...)
(Previous symbols: C1orf121, FAM152A, PPPDE1)
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Aliases
for DESI2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Desumoylating Isopeptidase 21 2 | | FLJ219981 | | C1orf1211 2 3 | | Chromosome 1 Open Reading Frame 1211 | | FAM152A1 2 3 | | DESI2 | | PPPDE11 2 3 | | DESI12 | | Family With Sequence Similarity 152, Member A1 2 | | PNAS-42 | | PPPDE Peptidase Domain Containing 11 2 | | Desumoylating Isopeptidase 12 | | DeSI-22 3 | | EC 3.4.-.-3 | | PPPDE Peptidase Domain-Containing Protein 12 3 | | Protein FAM152A3 | | CGI-1461 | | |
Export aliases for DESI2 gene to outside databases |
Summaries
for DESI2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9Function: Protease which may deconjugate SUMO from some substrate proteins (By similarity)
|
Genomic Views
for DESI2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DESI2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DESI2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DESI2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44DESI2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P244817: view genomic region
(about GC identifiers)
Start:
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244,816,237 bp from pter |
End:
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244,872,335 bp from pter |
Size:
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56,099 bases |
Orientation:
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plus strand |
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Proteins
for DESI2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9 (See
protein sequence)Recommended Name: Desumoylating isopeptidase 2 Size: 194 amino acids; 21444 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAD34141.1; Type=Frameshift; Positions=149, 175; Sequence=AAF42919.1; Type=Erroneousinitiation; Note=Translation N-terminally shortened;
Secondary accessions: B1APK6 Q5VVC6 Q9NYS2 Q9Y3E4Alternative splicing: 2 isoforms: Q9BSY9-1 Q9BSY9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DESI2: NX_Q9BSY9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BSY9
DESI2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057160.2
ENSEMBL proteins: ENSP00000306528 ENSP00000263831 ENSP00000394555
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
DESI2 for ontologies About GeneDecksing
DESI2 Antibody Products:
Assay Products for DESI2: |
Protein
Domains /
Families
for DESI2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DESI2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BSY9ProtoNet protein and cluster: Q9BSY9 1 Blocks protein family: IPB008580 Eukaryotic protein of unknown function DUF862
UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9Similarity: Belongs to the DeSI familySimilarity: Contains 1 PPPDE peptidase domain |
Function
for DESI2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9Function: Protease which may deconjugate SUMO from some substrate proteins (By similarity)Enzyme Number (IUBMB): EC 3.4.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DESI2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DESI2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for DESI2 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DESI2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008233 | peptidase activity |
IEA | -- |
DESI2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Desi2tm1Mche for DESI2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Desi2):
DESI2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DESI2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DESI2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for DESI2 (Q9BSY93 ENSP000003065284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
DESI2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DESI2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DESI2
Search CenterWatch for drugs/clinical trials and news about DESI2
|
Transcripts
for DESI2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DESI2 gene: NM_016076.3 Unigene Cluster for DESI2: Desumoylating isopeptidase 2 Hs.498317 [show with all ESTs]Unigene Representative Sequence: NM_0160764 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000302550(uc001iao.3 uc001iap.3) ENST00000263831 ENST00000484738
ENST00000418162
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DESI2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DESI2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for DESI2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DESI2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI2 |
Additional cDNA sequence: AF151904.1 AF229834.1 AK092419.1 AK314664.1 AL049397.1 BC004485.2 BC020640.1 BC040608.1 9 DOTS entries: DT.100785908 DT.121339094 DT.86853363 DT.40190281 DT.97841758 DT.430675 DT.121339082 DT.121505325 DT.100785905 24/267 AceView cDNA sequences (see all 267): AI240016 CB161099 AW469897 BU688822 BE045913 BM471387 BU186943 AI274778 AW135153 BM977650 CK903809 BU633581 CA314759 BU738761 CA423828 AI811641 AA488872 AA476837 AI016644 CA393988 N56792 BM455060 BC040608 AA614084
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DESI2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
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| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DESI2
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Expression
for DESI2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See DESI2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DESI2
SOURCE GeneReport for Unigene cluster: Hs.498317
SABiosciences Custom PCR Arrays for DESI2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DESI2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DESI2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DESI2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DESI2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI2 |
Orthologs
for DESI2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DESI2 gene from 9/30 species (see all 30) About this table
ENSEMBL Gene Tree for DESI2 (if available)
TreeFam Gene Tree for DESI2 (if available) |
Paralogs
for DESI2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DESI2 gene
- DESI12
DESI2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DESI2
PGOHUM00000234446
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Genomic Variants
for DESI2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DESI2 (244816237 - 244872335 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DESI2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DESI2 |
|
Disorders
/ Diseases
for DESI2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DESI2 for disorders About GeneDecksing
OMIM gene information: 614638
OMIM disorders: --
3  diseases for DESI2: About MalaCardslung adenocarcinoma adenocarcinoma malaria
Export disorders for DESI2 gene to outside databases
|
Publications
for DESI2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DESI2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with DESI2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- DeSUMOylating isopeptidase: a second class of SUMO pro tease. (PubMed id 22370726)1, 3 Shin E.J....Yun Y. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PNAS-4 expression and its relationship to p53 in color ectal cancer. (PubMed id 21556770)1 Zhou B....Sun X. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A novel pro-apoptosis gene PNAS4 that induces apoptos is in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice. (PubMed id 19133312)1 Yan F....Wei Y. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. (PubMed id 18538138)1 Yao S....Mo X. (2008)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DESI2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DESI2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DESI2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DESI2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DESI2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DESI2 gene:
Search GeneIP for patents involving DESI2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DESI2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for DESI2 | | OriGene shRNA RFP for DESI2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DESI2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DESI2 | | | OriGene Protein Over-expression Lysate for DESI2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for DESI2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DESI2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DESI2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DESI2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DESI2 | | OriGene Custom Protein Services for DESI2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DESI2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DESI2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DESI2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DESI2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DESI2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DESI2 |
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 |  |  |  | |
| | | | Search Tocris compounds for DESI2 |
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 | | | DESI2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI2 |
|  |  |  | | | | ThermoFisher Antibodies for DESI2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI2 |
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