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Aliases for DESI2 Gene

Aliases for DESI2 Gene

  • Desumoylating Isopeptidase 2 2 3
  • PPPDE1 3 4 6
  • Family With Sequence Similarity 152, Member A 2 3
  • PPPDE Peptidase Domain-Containing Protein 1 3 4
  • C1orf121 3 4
  • FAM152A 3 4
  • DeSI-2 3 4
  • Chromosome 1 Open Reading Frame 121 2
  • PPPDE Peptidase Domain Containing 1 2
  • Desumoylating Isopeptidase 1 3
  • Protein FAM152A 4
  • EC 3.4.-.- 4
  • CGI-146 3
  • PNAS-4 3
  • DESI1 3
  • DESI 3

External Ids for DESI2 Gene

Previous Symbols for DESI2 Gene

  • C1orf121
  • FAM152A
  • PPPDE1

Summaries for DESI2 Gene

GeneCards Summary for DESI2 Gene

DESI2 (Desumoylating Isopeptidase 2) is a Protein Coding gene. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for DESI2 Gene

  • Protease which may deconjugate SUMO from some substrate proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DESI2 Gene

Genomics for DESI2 Gene

Genomic Location for DESI2 Gene

Start:
244,652,935 bp from pter
End:
244,709,033 bp from pter
Size:
56,099 bases
Orientation:
Plus strand

Genomic View for DESI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DESI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DESI2 Gene

No data available for Regulatory Elements for DESI2 Gene

Proteins for DESI2 Gene

  • Protein details for DESI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSY9-DESI2_HUMAN
    Recommended name:
    Desumoylating isopeptidase 2
    Protein Accession:
    Q9BSY9
    Secondary Accessions:
    • B1APK6
    • Q5VVC6
    • Q9NYS2
    • Q9Y3E4

    Protein attributes for DESI2 Gene

    Size:
    194 amino acids
    Molecular mass:
    21444 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34141.1; Type=Frameshift; Positions=149, 175; Evidence={ECO:0000305}; Sequence=AAF42919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DESI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DESI2 Gene

Proteomics data for DESI2 Gene at MOPED

Post-translational modifications for DESI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DESI2 Gene

No data available for DME Specific Peptides for DESI2 Gene

Domains for DESI2 Gene

Protein Domains for DESI2 Gene

UniProtKB/Swiss-Prot:

DESI2_HUMAN
Domain:
  • Contains 1 PPPDE peptidase domain.:
    • Q9BSY9
Family:
  • Belongs to the DeSI family.:
    • Q9BSY9
genes like me logo Genes that share domains with DESI2: view

No data available for Gene Families for DESI2 Gene

Function for DESI2 Gene

Molecular function for DESI2 Gene

UniProtKB/Swiss-Prot Function: Protease which may deconjugate SUMO from some substrate proteins.

Enzyme Numbers (IUBMB) for DESI2 Gene

Gene Ontology (GO) - Molecular Function for DESI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with DESI2: view

Phenotypes for DESI2 Gene

MGI mutant phenotypes for DESI2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with DESI2: view

Animal Models for DESI2 Gene

MGI Knock Outs for DESI2:

miRNA for DESI2 Gene

miRTarBase miRNAs that target DESI2

No data available for Transcription Factor Targeting and HOMER Transcription for DESI2 Gene

Localization for DESI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DESI2 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for DESI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DESI2: view

Pathways for DESI2 Gene

SuperPathways for DESI2 Gene

No Data Available

Interacting Proteins for DESI2 Gene

Gene Ontology (GO) - Biological Process for DESI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with DESI2: view

No data available for Pathways by source for DESI2 Gene

Transcripts for DESI2 Gene

Unigene Clusters for DESI2 Gene

Desumoylating isopeptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DESI2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5:

Relevant External Links for DESI2 Gene

GeneLoc Exon Structure for
DESI2
ECgene alternative splicing isoforms for
DESI2

Expression for DESI2 Gene

mRNA expression in normal human tissues for DESI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DESI2 Gene

SOURCE GeneReport for Unigene cluster for DESI2 Gene Hs.498317

genes like me logo Genes that share expressions with DESI2: view

Orthologs for DESI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DESI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DESI2 36
  • 98.23 (n)
  • 97.87 (a)
DESI2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPPDE1 36
  • 93.82 (n)
  • 98.88 (a)
PPPDE1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DESI2 36
  • 89.26 (n)
  • 98.89 (a)
DESI2 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Desi2 36
  • 90.72 (n)
  • 96.91 (a)
Desi2 16
Desi2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DESI2 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DESI2 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Desi2 36
  • 89.52 (n)
  • 96.39 (a)
chicken
(Gallus gallus)
Aves DESI2 37
  • 95 (a)
OneToOne
PPPDE1 36
  • 85.24 (n)
  • 95.31 (a)
lizard
(Anolis carolinensis)
Reptilia DESI2 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia desi2 36
  • 76.91 (n)
  • 85.94 (a)
Str.20134 36
zebrafish
(Danio rerio)
Actinopterygii desi2 36
  • 77.37 (n)
  • 88.27 (a)
desi2 37
  • 81 (a)
OneToOne
sbcb238 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012058 36
  • 61.38 (n)
  • 65.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12231 37
  • 37 (a)
OneToMany
CG7222 36
  • 62.22 (n)
  • 63.64 (a)
CG7222 37
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F36D4.5 36
  • 60.51 (n)
  • 60.51 (a)
F36D4.5 37
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17486 36
  • 50.5 (n)
  • 47.01 (a)
rice
(Oryza sativa)
Liliopsida Os03g0100900 36
  • 51.56 (n)
  • 41.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1830 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToOne
Species with no ortholog for DESI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DESI2 Gene

ENSEMBL:
Gene Tree for DESI2 (if available)
TreeFam:
Gene Tree for DESI2 (if available)

Paralogs for DESI2 Gene

Pseudogenes.org Pseudogenes for DESI2 Gene

genes like me logo Genes that share paralogs with DESI2: view

No data available for Paralogs for DESI2 Gene

Variants for DESI2 Gene

Sequence variations from dbSNP and Humsavar for DESI2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10936 -- 244,708,834(-) TTTTC(A/T)AACAG utr-variant-3-prime, nc-transcript-variant
rs13270 -- 244,705,602(+) TGCCT(A/G)CTTCA reference, missense, nc-transcript-variant
rs878964 -- 244,673,660(+) ATTTT(G/T)TTTCA intron-variant
rs879604 -- 244,666,231(+) ACCAC(C/T)GTTTT intron-variant
rs905252 -- 244,657,222(+) AACAG(A/G)GTGTC intron-variant

Relevant External Links for DESI2 Gene

HapMap Linkage Disequilibrium report
DESI2
Human Gene Mutation Database (HGMD)
DESI2

No data available for Structural Variations from Database of Genomic Variants (DGV) for DESI2 Gene

Disorders for DESI2 Gene

No disorders were found for DESI2 Gene.

No data available for UniProtKB/Swiss-Prot for DESI2 Gene

Publications for DESI2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. DeSUMOylating isopeptidase: a second class of SUMO protease. (PMID: 22370726) Shin E.J. … Yun Y. (EMBO Rep. 2012) 2 3
  4. hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells. (PMID: 23322088) Li L. … Wei Y.Q. (Apoptosis 2013) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for DESI2 Gene

  • Addgene plasmids for DESI2

Sources for DESI2 Gene

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