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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DESI2 Gene

protein-coding   GIFtS: 41
GCID: GC01P244817

Desumoylating Isopeptidase 2

(Previous names: chromosome 1 open reading frame 121, family with sequence...)
(Previous symbols: C1orf121, FAM152A, PPPDE1)
  2 related diseases
at
MalaCards
 

Aliases
for DESI2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Desumoylating Isopeptidase 21 2     Chromosome 1 Open Reading Frame 1211
C1orf1211 2 3     DESI2
FAM152A1 2 3     DESI12
PPPDE11 2 3     PNAS-42
Family With Sequence Similarity 152, Member A1 2     Desumoylating Isopeptidase 12
PPPDE Peptidase Domain Containing 11 2     EC 3.4.-.-3
DeSI-22 3     Protein FAM152A3
PPPDE Peptidase Domain-Containing Protein 12 3     

External Ids:    HGNC: 242641   Entrez Gene: 510292   Ensembl: ENSG000001216447   OMIM: 6146385   UniProtKB: Q9BSY93   

Export aliases for DESI2 gene to outside databases


Summaries
for DESI2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for DESI2 Gene: 
DESI2 (desumoylating isopeptidase 2) is a protein-coding gene. Diseases associated with DESI2 include lung adenocarcinoma, and adenocarcinoma. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9
Function: Protease which may deconjugate SUMO from some substrate proteins (By similarity)




Genomic Views
for DESI2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DESI2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DESI2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DESI2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DESI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

DESI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DESI2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P244817:  view genomic region     (about GC identifiers)

Start:
 244,816,237 bp from pter      End:
 244,872,335 bp from pter
Size:
 56,099 bases      Orientation:
 plus strand

Proteins
for DESI2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9 (See protein sequence)
Recommended Name: Desumoylating isopeptidase 2  
Size: 194 amino acids; 21444 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAD34141.1; Type=Frameshift; Positions=149, 175; Sequence=AAF42919.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: B1APK6 Q5VVC6 Q9NYS2 Q9Y3E4
Alternative splicing: 2 isoforms:  Q9BSY9-1   Q9BSY9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DESI2: NX_Q9BSY9

Explore proteomics data for DESI2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BSY9

    • DESI2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DESI2 Protein Expression
    REFSEQ proteins: NP_057160.2  
    ENSEMBL proteins: 
     ENSP00000306528   ENSP00000263831   ENSP00000394555  

    Human Recombinant Protein Products for DESI2: 
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    Novus Biologicals DESI2 Proteins
    Novus Biologicals DESI2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    DESI2 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.

    Protein Domains /
    Families
    for DESI2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 1 InterPro protein domain:
     IPR008580 DUF862_euk

    Graphical View of Domain Structure for InterPro Entry Q9BSY9

    ProtoNet protein and cluster: Q9BSY9

    1 Blocks protein domain: IPB008580 Eukaryotic protein of unknown function DUF862

    UniProtKB/Swiss-Prot: DESI2_HUMAN, Q9BSY9
    Similarity: Belongs to the DeSI family
    Similarity: Contains 1 PPPDE peptidase domain


    DESI2 for domains           About GeneDecksing


    Function
    for DESI2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DESI2_HUMAN, Q9BSY9
    Function: Protease which may deconjugate SUMO from some substrate proteins (By similarity)

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008233peptidase activity IEA--
         
    DESI2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Desi2):
     normal 

    DESI2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Desi2tm1Mche for DESI2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DESI2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DESI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DESI2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DESI2 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DESI2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DESI2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for DESI2 (see all 7)
    OriGene ORF clones in mouse, rat for DESI2
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                         Customized lentivirus expression plasmids for stable overexpression of DESI2 

    Cell Line
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    Search LifeMap BioReagents cell lines for DESI2
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI2


    Pathways & Interactions
    for DESI2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DESI2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for DESI2 (Q9BSY93 ENSP000003065284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    REXO2Q9Y3B83I2D: score=2 
    YIF1BQ5BJH73I2D: score=1 
    CDC73ENSP000003564054STRING: ENSP00000356405
    NBPF8ENSP000003583724STRING: ENSP00000358372
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    DESI2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DESI2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DESI2

    Search CenterWatch for drugs/clinical trials and news about DESI2

    Transcripts
    for DESI2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DESI2 gene: 
    NM_016076.3  

    Unigene Cluster for DESI2:

    Desumoylating isopeptidase 2
    Hs.498317  [show with all ESTs]
    Unigene Representative Sequence: NM_016076
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302550(uc001iao.3 uc001iap.3) ENST00000263831 ENST00000484738
    ENST00000418162
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DESI2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DESI2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DESI2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DESI2
    Clone
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    OriGene ORF clones in mouse, rat for DESI2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI2
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DESI2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DESI2

    Additional mRNA sequence: 

    AF151904.1 AF229834.1 AK092419.1 AK314664.1 AL049397.1 BC004485.2 BC020640.1 BC040608.1 

    9 DOTS entries:

    DT.100785908  DT.121339094  DT.86853363  DT.40190281  DT.97841758  DT.430675  DT.121339082  DT.121505325 
    DT.100785905 

    24/267 AceView cDNA sequences (see all 267):

    BC020640 CB044529 AL049397 AI143042 AI985507 F11055 AA985607 CR626654 
    CA445256 AA643175 CA393988 BU633866 AA614084 AI811641 BM977346 N56792 
    CB161026 AA488872 BC040608 BF475572 AA476837 BQ229027 AI149870 N33562 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DESI2    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                                -     -                                             
    SP2:                                -     -     -                                       
    SP3:                                -     -     -           -                           
    SP4:                                -     -     -           -                           
    SP5:                                                                                    


    ECgene alternative splicing isoforms for DESI2

    Expression
    for DESI2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DESI2 expression in normal human tissues (normalized intensities)      DESI2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DESI2 Expression
    About this image


    DESI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord

    See DESI2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DESI2

    SOURCE GeneReport for Unigene cluster: Hs.498317
        SABiosciences Custom PCR Arrays for DESI2
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    In Situ
    Assay Products:     
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    Orthologs
    for DESI2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DESI2 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Desi21 , 5 PPPDE peptidase domain containing 15
    desumoylating isopeptidase 21    		 90.72(n)1
    96.91(a)1    		   1 (82.93 cM)5
    788251  NM_024282.31  NP_077244.11 
     1781874175 
    chicken
    (Gallus gallus)    		 Aves DESI21 PPPDE peptidase domain containing 1 85.24(n)
    95.31(a)    		   421494  NM_001008460.1  NP_001008460.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DESI26
    		 desumoylating isopeptidase 2
    		 90(a)
    		 1 ↔ 1
    		 GL343285.1(1182526-1201706)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ039519.12   -- 80.63(n)    BJ039519.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb2382 sbcb238 77.35(n)   321167  57063624 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG72221 CG7222 62.22(n)
    63.64(a)    		   36138  NM_136769.2  NP_610613.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F36D4.51 Protein F36D4.5 57.77(n)
    56.82(a)    		   179324  NM_171507.3  NP_741592.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G174861 PPPDE putative thiol peptidase-like protein 49.7(n)
    43.11(a)    		   827462  NM_117853.3  NP_567528.2 
    rice
    (Oryza sativa)    		 Liliopsida Os03g01009001 hypothetical protein 50.51(n)
    39.39(a)    		   4331282  NM_001055183.1  NP_001048648.1 


    ENSEMBL Gene Tree for DESI2 (if available)
    TreeFam Gene Tree for DESI2 (if available)

    Paralogs
    for DESI2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DESI2 gene

    DESI2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DESI2
    PGOHUM00000234446


    Genomic Variants
    for DESI2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1103 SNPs in DESI2 are shown (see all 1103)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs28065971,2
    		C,F,A,H--244814405(-) aagagC/Ttatgg 1 -- us2k127Minor allele frequency- T:0.17NS EA NA WA 2970
    rs1461645161,2
    		C--244814426(+) CCCCA-/GGCCTG 1 -- us2k10--------
    rs1166568531,2
    		C,F--244814602(+) TATTTC/TGGTCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1394058551,2
    		C--244814640(+) CTTGCC/TGGCAT 1 -- us2k10--------
    rs1500745481,2
    		--244814774(+) ATCCAC/TGTGGT 1 -- us2k10--------
    rs1872449101,2
    		--244814801(+) TAGTCC/TGGGAG 1 -- us2k10--------
    rs351819491,2
    		C,F--244814817(+) CACATG/ATTCGC 1 -- us2k14Minor allele frequency- A:0.03NA 126
    rs741521461,2
    		C,F--244814952(+) AAGCCC/TCAACT 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs1925192091,2
    		--244815184(+) ATTTTC/TAAACA 1 -- us2k10--------
    rs1453003641,2
    		C--244815245(+) TACAAC/TCCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DESI2 (244816237 - 244872335 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DESI2: --
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DESI2
    DNA2.0 Custom Variant and Variant Library Synthesis for DESI2

    Disorders / Diseases
    for DESI2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 614638    OMIM disorders: --

    2 diseases for DESI2:    About MalaCards
    lung adenocarcinoma    adenocarcinoma


    DESI2 for disorders           About GeneDecksing


    Export disorders for DESI2 gene to outside databases

    Publications
    for DESI2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DESI2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with DESI2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    2. DeSUMOylating isopeptidase: a second class of SUMO pro tease. (PubMed id 22370726)1, 3 Shin E.J....Yun Y. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. PNAS-4 expression and its relationship to p53 in color ectal cancer. (PubMed id 21556770)1 Zhou B....Sun X. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. A novel pro-apoptosis gene PNAS4 that induces apoptos is in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice. (PubMed id 19133312)1 Yan F....Wei Y. (2009)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. (PubMed id 18538138)1 Yao S....Mo X. (2008)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)

    External Searches for DESI2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DESI2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51029 HGNC: 24264 AceView: PNAS-4 Ensembl:ENSG00000121644 euGenes: HUgn51029
    ECgene: DESI2 H-InvDB: DESI2

    Other Databases showing DESI2 gene

    (According to HUGE)
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    Specialized Databases showing DESI2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DESI2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DESI2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for DESI2 gene:
    Search GeneIP for patents involving DESI2

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