Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DESI1 Gene

protein-coding   GIFtS: 38
GCID: GC22M041995

Desumoylating Isopeptidase 1

(Previous names: family with sequence similarity 152, member B, PPPDE peptidase...)
(Previous symbols: FAM152B, PPPDE2)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Desumoylating Isopeptidase 11 2     D15Wsu75e2
PPPDE21 2 3 5     DESI22
FAM152B1 2 3     DJ347H13.42
Family With Sequence Similarity 152, Member B1 2     Desumoylating Isopeptidase 22
PPPDE Peptidase Domain Containing 21 2     EC 3.4.-.-3
DeSI-12 3     Protein FAM152B3
PPPDE Peptidase Domain-Containing Protein 22 3     

External Ids:    HGNC: 245771   Entrez Gene: 273512   Ensembl: ENSG000001004187   OMIM: 6146375   UniProtKB: Q6ICB03   

Export aliases for DESI1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DESI1 Gene:
DESI1 (desumoylating isopeptidase 1) is a protein-coding gene. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0
Function: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but
not SUMO-processing activity. Desumoylates ZBTB46 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DESI1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDESI1 promoter sequence
   Search Chromatin IP Primers for DESI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DESI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

DESI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DESI1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041995:  view genomic region     (about GC identifiers)

Start:
41,994,032 bp from pter      End:
42,017,100 bp from pter
Size:
23,069 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0 (See protein sequence)
Recommended Name: Desumoylating isopeptidase 1  
Size: 168 amino acids; 18263 Da
Subunit: Homodimer (By similarity)
1 PDB 3D structure from and Proteopedia for DESI1:
3EBQ (3D)    

Explore the universe of human proteins at neXtProt for DESI1: NX_Q6ICB0

Explore proteomics data for DESI1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18
  • Modification sites at PhosphoSitePlus

  • See DESI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056519.1  
    ENSEMBL proteins: 
     ENSP00000263256  

    DESI1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DESI1
    OriGene Protein Over-expression Lysate for DESI1
    OriGene MassSpec for DESI1
    OriGene Custom Protein Services for DESI1
    GenScript Custom Purified and Recombinant Proteins Services for DESI1
    Novus Biologicals DESI1 Protein
    Novus Biologicals DESI1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DESI1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DESI1 

     
    antibodies-online proteins for DESI1 (6 products) 

     
    antibodies-online peptides for DESI1

    DESI1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DESI1
    Novus Biologicals DESI1 Antibody
    Search for Antibodies for DESI1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for DESI1
    antibodies-online antibodies for DESI1 (3 products) 

    DESI1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DESI1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DESI1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DESI1 
    antibodies-online kits for DESI1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR008580 PPPDE_dom

    Graphical View of Domain Structure for InterPro Entry Q6ICB0

    ProtoNet protein and cluster: Q6ICB0

    UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0
    Similarity: Belongs to the DeSI family
    Similarity: Contains 1 PPPDE peptidase domain


    Find genes that share domains with DESI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DESI1_HUMAN, Q6ICB0
    Function: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but
    not SUMO-processing activity. Desumoylates ZBTB46 (By similarity)

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008233peptidase activity IEA--
    GO:0042802identical protein binding IEA--
         
    Find genes that share ontologies with DESI1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DESI1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DESI1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DESI1:
    hsa-mir-16-5p (MIRT031588), hsa-mir-103a-3p (MIRT027140), hsa-mir-744-5p (MIRT037590), hsa-mir-375 (MIRT019706), hsa-mir-615-3p (MIRT039862), hsa-mir-149-5p (MIRT045472)

    Block miRNA regulation of human, mouse, rat DESI1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DESI1
    SwitchGear 3'UTR luciferase reporter plasmidDESI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DESI1
    Predesigned siRNA for gene silencing in human, mouse, rat DESI1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DESI1

    Clone
    Products:
         
    OriGene clones in human, mouse for DESI1 (see all 6)
    OriGene ORF clones in mouse, rat for DESI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for DESI1
    Sino Biological Human cDNA Clone for DESI1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DESI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DESI1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DESI1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DESI1_HUMAN, Q6ICB0: Cytoplasm (By similarity). Nucleus (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DESI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DESI1
    Interactions:

        Search GeneGlobe Interaction Network for DESI1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DESI1 (ENSP000002632564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB46ENSP000002456634STRING: ENSP00000245663
    UBCENSP000003448184STRING: ENSP00000344818
    FGF7ENSP000002678434STRING: ENSP00000267843
    NGDNENSP000003861344STRING: ENSP00000386134
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with DESI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DESI1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DESI1 gene: 
    NM_015704.2  

    Unigene Cluster for DESI1:

    Desumoylating isopeptidase 1
    Hs.570455  [show with all ESTs]
    Unigene Representative Sequence: NM_015704
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263256(uc003bam.2 uc011apb.2) ENST00000468151 ENST00000463886
    ENST00000482612
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DESI1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DESI1
    SwitchGear 3'UTR luciferase reporter plasmidDESI1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DESI1
    Predesigned siRNA for gene silencing in human, mouse, rat DESI1
    Clone
    Products:
         
    OriGene clones in human, mouse for DESI1 (see all 6)
    OriGene ORF clones in mouse, rat for DESI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for DESI1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DESI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DESI1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DESI1
      QuantiTect SYBR Green Assays in human, mouse, rat DESI1
      QuantiFast Probe-based Assays in human, mouse, rat DESI1

    Additional mRNA sequence: 

    AF038183.1 AK090725.1 BC008357.1 BC039554.2 BC093956.1 BC112179.1 BC171724.1 CR456458.1 

    12 DOTS entries:

    DT.100817361  DT.92430678  DT.100817360  DT.95070115  DT.100044471  DT.100842834  DT.95169621  DT.105973 
    DT.120663580  DT.95169622  DT.120969051  DT.86859399 

    Selected AceView cDNA sequences (see all 194):

    BI261027 BX399727 AI564813 CD723257 BX105460 CR456458 CR605156 CD105783 
    AA342535 BG421629 AA323503 AI350381 BX478162 AI202240 BM474455 AI572839 
    BQ227848 AI570265 BQ276443 BQ428506 BF001450 BU584053 BQ057935 BE464345 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DESI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DESI1 Expression
    About this image

    DESI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DESI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.570455
        Custom PCR Arrays for DESI1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DESI1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DESI1
    QuantiTect SYBR Green Assays in human, mouse, rat DESI1
    QuantiFast Probe-based Assays in human, mouse, rat DESI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DESI1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Desi11 , 5 PPPDE peptidase domain containing 25
    desumoylating isopeptidase 11
    92.86(n)1
    97.02(a)1
      15 (38.34 cM)5
    280751  NM_134095.21  NP_598856.11 
     819925235 
    chicken
    (Gallus gallus)
    Aves DESI11 desumoylating isopeptidase 1 78.44(n)
    81.44(a)
      770448  XM_001233782.3  XP_001233783.1 
    lizard
    (Anolis carolinensis)
    Reptilia DESI16
    desumoylating isopeptidase 1
    84(a)
    1 ↔ 1
    5(26607054-26617151)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.172682 Transcribed sequence with weak similarity to protein more 77.09(n)    141991444 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc730662 hypothetical protein MGC73066 77.77(n)   393673  BC059442.1 


    ENSEMBL Gene Tree for DESI1 (if available)
    TreeFam Gene Tree for DESI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DESI1 (see all 407)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145061081,2
    C,F--41993542(+) GCCTCG/ATCCCA 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1487892381,2
    --41993979(+) AGCCTC/GGGGTC 1 -- int10--------
    rs1816695191,2
    --41994036(+) ATGCAC/GCAGGC 1 -- ut310--------
    rs1176553731,2
    C,F--41994055(+) GTTTAT/CTGCAT 1 -- ut311Minor allele frequency- C:0.02NA 120
    rs1868315721,2
    --41994073(+) AACACC/TGAAGA 1 -- ut310--------
    rs768830971,2
    F--41994096(+) ACCTCC/TGTACT 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1424647481,2
    --41994248(+) AAGTAC/TGTGAC 1 -- ut310--------
    rs1512433231,2
    C--41994309(+) ACAATA/GAGAAT 1 -- ut310--------
    rs1121604921,2
    C--41994342(+) CAGAAAT/-ATGAG 1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs744760431,2
    C,F--41994353(+) GGATGG/CGGGTA 1 -- ut311Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for DESI1 (41994032 - 42017100 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DESI1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DESI1
    DNA2.0 Custom Variant and Variant Library Synthesis for DESI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614637    OMIM disorders: --


    Find genes that share disorders with DESI1           About GenesLikeMe


    Export disorders for DESI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DESI1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with DESI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DeSUMOylating isopeptidase: a second class of SUMO protease. (PubMed id 22370726)1, 3 Shin E.J....Yun Y. (EMBO Rep. 2012)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    3. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    4. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27351 HGNC: 24577 AceView: D15Wsu75e Ensembl:ENSG00000100418 euGenes: HUgn27351
    ECgene: DESI1 H-InvDB: DESI1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DESI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DESI1 gene:
    Search GeneIP for patents involving DESI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DESI1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DESI1  
     OriGene MassSpec for DESI1   OriGene clones in human, mouse for DESI1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DESI1   OriGene Purified Protein for DESI1  
     OriGene ORF clones in mouse, rat for DESI1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DESI1   OriGene Custom Protein Services for DESI1  

     
     
     Block miRNA regulation of human, mouse, rat DESI1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DESI1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DESI1 Predesigned siRNA for gene silencing in human, mouse, rat DESI1
     QuantiFast Probe-based Assays in human, mouse, rat DESI1 QuantiTect SYBR Green Assays in human, mouse, rat DESI1
     Custom PCR Arrays for DESI1 Search Chromatin IP Primers for DESI1
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DESI1 Search GeneGlobe Interaction Network for DESI1
     Search Regulatory tfbs for DESI1
     GenScript Custom Purified and Recombinant Proteins Services for DESI1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for DESI1
     GenScript Custom Assay Services for DESI1 GenScript Custom overexpressing Cell Line Services for DESI1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DESI1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DESI1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DESI1 antibodies
     DESI1 proteins
     DESI1 lysates
     Search for Antibodies for DESI1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DESI1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DESI1
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for DESI1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI1
     SwitchGear 3'UTR luciferase reporter plasmids for DESI1
     SwitchGear Promoter luciferase reporter plasmids for DESI1
     Search ThermoFisher Antibodies for DESI1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI1
     Browse compounds at ApexBio
     Search Addgene for plasmids for DESI1
      Search eBioscience for proteins for DESI1
      Search eBioscience for elisas for DESI1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DESI1
     antibodies-online antibodies for DESI1 (3 products)
     antibodies-online kits for DESI1 (6 products)
     antibodies-online peptides for DESI1
     antibodies-online proteins for DESI1 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DESI1 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4