DESI1 Gene
protein-coding GIFtS: 38
GCID: GC22M041995
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desumoylating isopeptidase 1(Previous names: family with sequence similarity 152, member B, PPPDE peptidase...)
(Previous symbols: FAM152B, PPPDE2)
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Aliases
for DESI1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Desumoylating Isopeptidase 11 2 | | PPPDE Peptidase Domain-Containing Protein 22 3 | | FAM152B1 2 3 | | DESI22 | | PPPDE21 2 3 | | DJ347H13.42 | | D15Wsu75e1 2 | | Desumoylating Isopeptidase 22 | | Family With Sequence Similarity 152, Member B1 2 | | EC 3.4.-.-3 | | PPPDE Peptidase Domain Containing 21 2 | | Protein FAM152B3 | | DeSI-12 3 | | |
Export aliases for DESI1 gene to outside databases |
Summaries
for DESI1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0Function: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but notSUMO-processing activity. Desumoylates ZBTB46 (By similarity)
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Genomic Views
for DESI1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DESI1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DESI1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DESI1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2DESI1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M041995: view genomic region
(about GC identifiers)
Start:
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41,994,032 bp from pter |
End:
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42,017,100 bp from pter |
Size:
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23,069 bases |
Orientation:
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minus strand |
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Proteins
for DESI1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0 (See
protein sequence)Recommended Name: Desumoylating isopeptidase 1 Size: 168 amino acids; 18263 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
1 PDB 3D structure from  and Proteopedia  for DESI1:3EBQ (3D)
Explore the universe of human proteins at neXtProt for DESI1: NX_Q6ICB0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ICB0
DESI1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056519.1
ENSEMBL proteins: ENSP00000263256
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
DESI1 for ontologies About GeneDecksing
DESI1 Antibody Products:
Assay Products for DESI1: |
Protein
Domains /
Families
for DESI1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DESI1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6ICB0ProtoNet protein and cluster: Q6ICB0 UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0Similarity: Belongs to the DeSI familySimilarity: Contains 1 PPPDE peptidase domain |
Function
for DESI1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0Function: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but notSUMO-processing activity. Desumoylates ZBTB46 (By similarity)Enzyme Number (IUBMB): EC 3.4.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DESI1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DESI1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for DESI1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DESI1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008233 | peptidase activity |
IEA | -- |
DESI1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DESI1:
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Pathways & Interactions
for DESI1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DESI1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for DESI1 (ENSP000002632564) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
DESI1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DESI1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DESI1
Search CenterWatch for drugs/clinical trials and news about DESI1
|
Transcripts
for DESI1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DESI1 gene: NM_015704.2 Unigene Cluster for DESI1: Desumoylating isopeptidase 1 Hs.570455 [show with all ESTs]Unigene Representative Sequence: NM_0157044 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263256(uc003bam.2 uc011apb.2) ENST00000468151 ENST00000463886
ENST00000482612
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DESI1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DESI1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for DESI1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DESI1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI1 |
Additional cDNA sequence: AF038183.1 AK090725.1 BC008357.1 BC039554.2 BC093956.1 BC112179.1 BC171724.1 CR456458.1 12 DOTS entries: DT.100817361 DT.92430678 DT.100817360 DT.95070115 DT.100044471 DT.100842834 DT.95169621 DT.105973 DT.120663580 DT.95169622 DT.120969051 DT.86859399 24/194 AceView cDNA sequences (see all 194): BM449736 AI572839 AA342535 CR626044 F09458 AI350381 AA766371 BE464345 CB529353 AW237018 BX105460 BU584053 BM474455 BQ276443 BX478162 BM784637 BX443106 CR605886 BI261027 AI202240 BG421629 CD105783 BQ428506 CR605156
GeneLoc Exon Structure
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Expression
for DESI1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See DESI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DESI1
SOURCE GeneReport for Unigene cluster: Hs.570455
SABiosciences Custom PCR Arrays for DESI1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DESI1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DESI1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DESI1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DESI1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI1 |
Orthologs
for DESI1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DESI1 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for DESI1 (if available)
TreeFam Gene Tree for DESI1 (if available) |
Paralogs
for DESI1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DESI1 gene
- DESI22
DESI1 for paralogs About GeneDecksing
|
Genomic Variants
for DESI1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DESI1 (41994032 - 42017100 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DESI1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DESI1 |
|
Disorders
/ Diseases
for DESI1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DESI1 for disorders About GeneDecksing
OMIM gene information: 614637
OMIM disorders: --
1  disease for DESI1: About MalaCardsmalaria
Export disorders for DESI1 gene to outside databases
|
Publications
for DESI1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DESI1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with DESI1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DeSUMOylating isopeptidase: a second class of SUMO pro tease. (PubMed id 22370726)1, 3 Shin E.J....Yun Y. (2012)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
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External Searches for DESI1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DESI1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DESI1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DESI1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DESI1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DESI1 gene:
Search GeneIP for patents involving DESI1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DESI1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DESI1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DESI1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DESI1 | | | OriGene Protein Over-expression Lysate for DESI1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DESI1 | | OriGene 3'-UTR Clone for DESI1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DESI1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DESI1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DESI1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DESI1 | | OriGene Custom Protein Services for DESI1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DESI1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DESI1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DESI1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DESI1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DESI1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DESI1 |
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 |  |  |  | |
| | | | Search Tocris compounds for DESI1 |
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 | | | DESI1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DESI1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI1 |
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