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Aliases for DESI1 Gene

Aliases for DESI1 Gene

  • Desumoylating Isopeptidase 1 2 3 5
  • Family With Sequence Similarity 152, Member B 2 3
  • PPPDE Peptidase Domain-Containing Protein 2 3 4
  • PPPDE Peptidase Domain Containing 2 2 3
  • FAM152B 3 4
  • PPPDE2 3 4
  • DeSI-1 3 4
  • Desumoylating Isopeptidase 2 3
  • Protein FAM152B 4
  • DJ347H13.4 3
  • EC 3.4.-.- 4
  • D15Wsu75e 3
  • DESI2 3

External Ids for DESI1 Gene

Previous HGNC Symbols for DESI1 Gene

  • FAM152B
  • PPPDE2

Previous GeneCards Identifiers for DESI1 Gene

  • GC22M041995

Summaries for DESI1 Gene

GeneCards Summary for DESI1 Gene

DESI1 (Desumoylating Isopeptidase 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and peptidase activity.

UniProtKB/Swiss-Prot for DESI1 Gene

  • Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DESI1 Gene

Genomics for DESI1 Gene

Regulatory Elements for DESI1 Gene

Promoters for DESI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DESI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DESI1 Gene

Chromosome:
22
Start:
41,598,028 bp from pter
End:
41,621,096 bp from pter
Size:
23,069 bases
Orientation:
Minus strand

Genomic View for DESI1 Gene

Genes around DESI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DESI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DESI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DESI1 Gene

Proteins for DESI1 Gene

  • Protein details for DESI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICB0-DESI1_HUMAN
    Recommended name:
    Desumoylating isopeptidase 1
    Protein Accession:
    Q6ICB0

    Protein attributes for DESI1 Gene

    Size:
    168 amino acids
    Molecular mass:
    18263 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DESI1 Gene

neXtProt entry for DESI1 Gene

Proteomics data for DESI1 Gene at MOPED

Post-translational modifications for DESI1 Gene

  • Ubiquitination at Lys 10 and Lys 18
  • Modification sites at PhosphoSitePlus

Other Protein References for DESI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DESI1 Gene

Domains & Families for DESI1 Gene

Gene Families for DESI1 Gene

Protein Domains for DESI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DESI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ICB0

UniProtKB/Swiss-Prot:

DESI1_HUMAN :
  • Contains 1 PPPDE peptidase domain.
  • Belongs to the DeSI family.
Domain:
  • Contains 1 PPPDE peptidase domain.
Family:
  • Belongs to the DeSI family.
genes like me logo Genes that share domains with DESI1: view

Function for DESI1 Gene

Molecular function for DESI1 Gene

UniProtKB/Swiss-Prot Function:
Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity).

Enzyme Numbers (IUBMB) for DESI1 Gene

genes like me logo Genes that share phenotypes with DESI1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DESI1

CRISPR Products

miRNA for DESI1 Gene

miRTarBase miRNAs that target DESI1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DESI1 Gene

Localization for DESI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DESI1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DESI1 Gene COMPARTMENTS Subcellular localization image for DESI1 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DESI1 Gene

Pathways & Interactions for DESI1 Gene

SuperPathways for DESI1 Gene

No Data Available

Interacting Proteins for DESI1 Gene

Gene Ontology (GO) - Biological Process for DESI1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DESI1 Gene

Drugs & Compounds for DESI1 Gene

No Compound Related Data Available

Transcripts for DESI1 Gene

Unigene Clusters for DESI1 Gene

Desumoylating isopeptidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DESI1 Gene

No ASD Table

Relevant External Links for DESI1 Gene

GeneLoc Exon Structure for
DESI1
ECgene alternative splicing isoforms for
DESI1

Expression for DESI1 Gene

mRNA expression in normal human tissues for DESI1 Gene

Protein differential expression in normal tissues from HIPED for DESI1 Gene

This gene is overexpressed in Plasma (43.1), Esophagus (12.6), and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DESI1 Gene



SOURCE GeneReport for Unigene cluster for DESI1 Gene Hs.570455

genes like me logo Genes that share expression patterns with DESI1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DESI1 Gene

Orthologs for DESI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DESI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPPDE2 35
  • 91.67 (n)
  • 95.24 (a)
DESI1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DESI1 35
  • 92.26 (n)
  • 92.26 (a)
DESI1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Desi1 35
  • 92.86 (n)
  • 97.02 (a)
Desi1 16
Desi1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DESI1 35
  • 99.8 (n)
  • 100 (a)
PPPDE2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Desi1 35
  • 93.25 (n)
  • 97.02 (a)
oppossum
(Monodelphis domestica)
Mammalia DESI1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DESI1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DESI1 35
  • 78.44 (n)
  • 81.44 (a)
DESI1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DESI1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia desi1 35
  • 72.09 (n)
  • 79.52 (a)
Str.17268 35
zebrafish
(Danio rerio)
Actinopterygii desi1a 35
  • 70.99 (n)
  • 72.22 (a)
zgc73066 35
desi1a 36
  • 69 (a)
OneToMany
desi1b 36
  • 69 (a)
OneToMany
desi1b 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9252 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03714 35
  • 52.48 (n)
  • 46.81 (a)
Species with no ortholog for DESI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DESI1 Gene

ENSEMBL:
Gene Tree for DESI1 (if available)
TreeFam:
Gene Tree for DESI1 (if available)

Paralogs for DESI1 Gene

No data available for Paralogs for DESI1 Gene

Variants for DESI1 Gene

Sequence variations from dbSNP and Humsavar for DESI1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs132761 -- 41,608,367(+) CTGCC(C/T)TTGAG intron-variant
rs132762 -- 41,610,834(+) CGCCA(C/T)TGTAC intron-variant
rs132763 -- 41,610,873(+) AAAAA(-/A)GACCA intron-variant
rs132764 -- 41,611,610(+) TTTTT(-/TTT)GAGAC intron-variant
rs132765 -- 41,612,064(+) CTTCC(A/G)GGCAC intron-variant

Variation tolerance for DESI1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DESI1 Gene

HapMap Linkage Disequilibrium report
DESI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DESI1 Gene

Disorders for DESI1 Gene

Relevant External Links for DESI1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DESI1

No disorders were found for DESI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DESI1 Gene

Publications for DESI1 Gene

  1. DeSUMOylating isopeptidase: a second class of SUMO protease. (PMID: 22370726) Shin E.J. … Yun Y. (EMBO Rep. 2012) 2 3 67
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for DESI1 Gene

Sources for DESI1 Gene

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