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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DESI1 Gene

protein-coding   GIFtS: 37
GCID: GC22M041995

Desumoylating Isopeptidase 1

(Previous names: family with sequence similarity 152, member B, PPPDE peptidase...)
(Previous symbols: FAM152B, PPPDE2)
  Search for DESI1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Desumoylating Isopeptidase 11 2     D15Wsu75e2
FAM152B1 2 3     DESI22
PPPDE21 2 3     DJ347H13.42
Family With Sequence Similarity 152, Member B1 2     Desumoylating Isopeptidase 22
PPPDE Peptidase Domain Containing 21 2     EC 3.4.-.-3
DeSI-12 3     Protein FAM152B3
PPPDE Peptidase Domain-Containing Protein 22 3     

External Ids:    HGNC: 245771   Entrez Gene: 273512   Ensembl: ENSG000001004187   OMIM: 6146375   UniProtKB: Q6ICB03   

Export aliases for DESI1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DESI1 Gene: 
DESI1 (desumoylating isopeptidase 1) is a protein-coding gene. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0
Function: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but
not SUMO-processing activity. Desumoylates ZBTB46 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DESI1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDESI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DESI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DESI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

DESI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DESI1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041995:  view genomic region     (about GC identifiers)

Start:
41,994,032 bp from pter      End:
42,017,100 bp from pter
Size:
23,069 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0 (See protein sequence)
Recommended Name: Desumoylating isopeptidase 1  
Size: 168 amino acids; 18263 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
1 PDB 3D structure from and Proteopedia for DESI1:
3EBQ (3D)    

Explore the universe of human proteins at neXtProt for DESI1: NX_Q6ICB0

Explore proteomics data for DESI1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ICB0

  • DESI1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DESI1 Protein Expression
    REFSEQ proteins: NP_056519.1  
    ENSEMBL proteins: 
     ENSP00000263256  

    Human Recombinant Protein Products for DESI1: 
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    OriGene Protein Over-expression Lysate for DESI1
    OriGene MassSpec for DESI1 
    OriGene Custom Protein Services for DESI1
    GenScript Custom Purified and Recombinant Proteins Services for DESI1
    Novus Biologicals DESI1 Protein
    Novus Biologicals DESI1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    DESI1 for ontologies           About GeneDecksing



    DESI1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DESI1 

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    GenScript Custom Assay Services for DESI1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008580 DUF862_euk

    Graphical View of Domain Structure for InterPro Entry Q6ICB0

    ProtoNet protein and cluster: Q6ICB0

    UniProtKB/Swiss-Prot: DESI1_HUMAN, Q6ICB0
    Similarity: Belongs to the DeSI family
    Similarity: Contains 1 PPPDE peptidase domain


    DESI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DESI1_HUMAN, Q6ICB0
    Function: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but
    not SUMO-processing activity. Desumoylates ZBTB46 (By similarity)

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008233peptidase activity IEA--
         
    DESI1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DESI1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DESI1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DESI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DESI1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DESI1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DESI1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DESI1
    SwitchGear 3'UTR luciferase reporter plasmidDESI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DESI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DESI1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DESI1
    Sirion Biotech Customized adenovirus for overexpression of DESI1

    Clone
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    OriGene ORF clones in mouse, rat for DESI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for DESI1
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DESI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI1
    Sirion Biotech Customized lentivirus for stable overexpression of DESI1 
                         Customized lentivirus expression plasmids for stable overexpression of DESI1 

    Cell Line
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    Search LifeMap BioReagents cell lines for DESI1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DESI1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for DESI1 (ENSP000002632564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB46ENSP000002456634STRING: ENSP00000245663
    UBCENSP000003448184STRING: ENSP00000344818
    FGF7ENSP000002678434STRING: ENSP00000267843
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    DESI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DESI1

    Search CenterWatch for drugs/clinical trials and news about DESI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DESI1 gene: 
    NM_015704.2  

    Unigene Cluster for DESI1:

    Desumoylating isopeptidase 1
    Hs.570455  [show with all ESTs]
    Unigene Representative Sequence: NM_015704
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263256(uc003bam.2 uc011apb.2) ENST00000468151 ENST00000463886
    ENST00000482612
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DESI1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DESI1
    SwitchGear 3'UTR luciferase reporter plasmidDESI1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DESI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DESI1
    Clone
    Products:
         
    OriGene clones in human, mouse for DESI1 (see all 7)
    OriGene ORF clones in mouse, rat for DESI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for DESI1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DESI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI1
    Sirion Biotech Customized lentivirus for stable overexpression of DESI1 
                         Customized lentivirus expression plasmids for stable overexpression of DESI1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DESI1
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat DESI1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DESI1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DESI1

    Additional mRNA sequence: 

    AF038183.1 AK090725.1 BC008357.1 BC039554.2 BC093956.1 BC112179.1 BC171724.1 CR456458.1 

    12 DOTS entries:

    DT.100817361  DT.92430678  DT.100817360  DT.95070115  DT.100044471  DT.100842834  DT.95169621  DT.105973 
    DT.120663580  DT.95169622  DT.120969051  DT.86859399 

    24/194 AceView cDNA sequences (see all 194):

    AI570265 BM474455 AI572839 CD723257 AW237018 AA342535 BX399727 BG421629 
    CR605886 BI261027 BX478162 BX443106 AI350381 BF001450 AI564813 AA766371 
    F11096 BQ057935 CR456458 AI202240 BQ276443 BQ428506 BM449736 CB529353 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DESI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DESI1 Expression
    About this image


    See DESI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DESI1

    SOURCE GeneReport for Unigene cluster: Hs.570455
        SABiosciences Custom PCR Arrays for DESI1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DESI1
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat DESI1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DESI1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DESI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DESI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DESI1 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Desi11 , 5 PPPDE peptidase domain containing 25
    desumoylating isopeptidase 11
    92.86(n)1
    97.02(a)1
      15 (38.34 cM)5
    280751  NM_134095.21  NP_598856.11 
     819925235 
    chicken
    (Gallus gallus)
    Aves PPPDE21 PPPDE peptidase domain containing 2 78.44(n)
    81.44(a)
      770448  XM_001233782.2  XP_001233783.1 
    lizard
    (Anolis carolinensis)
    Reptilia DESI16
    Uncharacterized protein
    85(a)
    1 ↔ 1
    5(26607054-26617151)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.172682 Transcribed sequence with weak similarity to protein more 77.09(n)    141991444 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc730662 hypothetical protein MGC73066 77.77(n)   393673  BC059442.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG122316
    CG72226
    --
    20(a)
    19(a)
    many ↔ many
    many ↔ many
    X(19425065-19425775)
    2R(6701054-6703286)
    worm
    (Caenorhabditis elegans)
    Secernentea F36D4.56
    Protein F36D4.5, isoform a
    15(a)
    1 → many
    V(9419295-9425762)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G070901 PPPDE putative thiol peptidase family protein 50.99(n)
    47.68(a)
      819895  NM_111589.4  NP_187365.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g08140001 hypothetical protein 57.18(n)
    50.69(a)
      4331115  NM_001055023.1  NP_001048488.1 


    ENSEMBL Gene Tree for DESI1 (if available)
    TreeFam Gene Tree for DESI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/407 SNPs in DESI1 are shown (see all 407)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145061081,2
    C,F--41993542(+) GCCTCG/ATCCCA 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1487892381,2
    --41993979(+) AGCCTC/GGGGTC 1 -- int10--------
    rs1816695191,2
    --41994036(+) ATGCAC/GCAGGC 1 -- ut310--------
    rs1176553731,2
    C,F--41994055(+) GTTTAT/CTGCAT 1 -- ut311Minor allele frequency- C:0.02NA 120
    rs1868315721,2
    --41994073(+) AACACC/TGAAGA 1 -- ut310--------
    rs768830971,2
    F--41994096(+) ACCTCC/TGTACT 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1424647481,2
    --41994248(+) AAGTAC/TGTGAC 1 -- ut310--------
    rs1512433231,2
    C--41994309(+) ACAATA/GAGAAT 1 -- ut310--------
    rs1121604921,2
    C--41994342(+) CAGAAAT/-ATGAG 1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs744760431,2
    C,F--41994353(+) GGATGG/CGGGTA 1 -- ut311Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for DESI1 (41994032 - 42017100 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DESI1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DESI1
    DNA2.0 Custom Variant and Variant Library Synthesis for DESI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DESI1 for disorders           About MalaCards
    OMIM gene information: 614637    OMIM disorders: --


    DESI1 for disorders           About GeneDecksing


    Export disorders for DESI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DESI1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with DESI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DeSUMOylating isopeptidase: a second class of SUMO pro tease. (PubMed id 22370726)1, 3 Shin E.J....Yun Y. (2012)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    3. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    4. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27351 HGNC: 24577 AceView: D15Wsu75e Ensembl:ENSG00000100418 euGenes: HUgn27351
    ECgene: DESI1 H-InvDB: DESI1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DESI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DESI1 gene:
    Search GeneIP for patents involving DESI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DESI1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DESI1  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DESI1
     QIAGEN SeqTarget long-range PCR primers for resequencing DESI1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DESI1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DESI1
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     GenScript Custom Purified and Recombinant Proteins Services for DESI1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for DESI1
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     Search for Antibodies & Assays

     Search Regulatory tfbs for DESI1
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     Search RT2 qPCR Primer Assays in human, mouse, rat DESI1
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     Search Tocris compounds for DESI1
     Browse Sino Biological Proteins and Antibodies
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for DESI1
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     SwitchGear 3'UTR luciferase reporter plasmids for DESI1
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     Search ThermoFisher Antibodies for DESI1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DESI1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DESI1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DESI1
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     LSBio Antibodies in human, mouse, rat for DESI1
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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