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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DERL3 Gene

protein-coding   GIFtS: 53
GCID: GC22M024176

Derlin 3

(Previous names: chromosome 22 open reading frame 14, Der1-like domain family,...)
(Previous symbol: C22orf14)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Derlin 31 2     LLN22 3
C22orf141 2 3     Chromosome 22 Open Reading Frame 141
Der1-Like Domain Family, Member 31 2     IZP62
Degradation In Endoplasmic Reticulum Protein 32 3     derlin-32
Der1-Like Protein 32 3     DERtrin 32
DERtrin-32 3     DER33

External Ids:    HGNC: 142361   Entrez Gene: 913192   Ensembl: ENSG000000999587   OMIM: 6103055   UniProtKB: Q96Q803   

Export aliases for DERL3 gene to outside databases

Previous GC identifers: GC22M022504 GC22M007164


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DERL3 Gene:
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER).
Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the
ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several
alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
(provided by RefSeq, Oct 2008)

GeneCards Summary for DERL3 Gene: 
DERL3 (derlin 3) is a protein-coding gene. Diseases associated with DERL3 include gastric cancer. GO annotations related to this gene include protein binding. An important paralog of this gene is DERL2.

UniProtKB/Swiss-Prot: DERL3_HUMAN, Q96Q80
Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal
glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the
retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the
proteasome. May mediate the interaction between VCP and the degradation substrate

Gene Wiki entry for DERL3 (Derlin-3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DERL3 gene promoter:
         NF-1   RFX1   Elk-1   p300   HTF   GATA-1   FOXL1   FAC1   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDERL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DERL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DERL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

DERL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DERL3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M024176:  view genomic region     (about GC identifiers)

Start:
24,176,690 bp from pter      End:
24,181,315 bp from pter
Size:
4,626 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DERL3_HUMAN, Q96Q80 (See protein sequence)
Recommended Name: Derlin-3  
Size: 235 amino acids; 26679 Da
Subunit: Forms homo- and heterooligomers with DERL2 and, to a lesser extent, with DERL1. Interacts with VCP and
EDEM1
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: F2Z3B6 Q6ICJ6 Q6PEX0 Q6ZUB5
Alternative splicing: 5 isoforms:  Q96Q80-1   Q96Q80-2   Q96Q80-3   Q96Q80-4   Q96Q80-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DERL3: NX_Q96Q80

Explore proteomics data for DERL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96Q80

  • DERL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DERL3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001002862.1  NP_001129223.1  NP_940842.2  

    ENSEMBL proteins: 
     ENSP00000384744   ENSP00000384473   ENSP00000315303   ENSP00000419399  

    Human Recombinant Protein Products for DERL3: 
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    Cloud-Clone Corp. Proteins for DERL3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030176integral to endoplasmic reticulum membrane IDA16449189

    DERL3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007599 DER1

    Graphical View of Domain Structure for InterPro Entry Q96Q80

    ProtoNet protein and cluster: Q96Q80

    UniProtKB/Swiss-Prot: DERL3_HUMAN, Q96Q80
    Similarity: Belongs to the derlin family


    DERL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DERL3_HUMAN, Q96Q80
    Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal
    glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the
    retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the
    proteasome. May mediate the interaction between VCP and the degradation substrate
    Induction: Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded
    protein response (UPR) (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16449189
         
    DERL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DERL3:
     Decreased influenza A/WSN/33 r 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Derl3):
     normal 

    DERL3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DERL3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DERL3 
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate DERL3:
    hsa-miR-3622b-3p hsa-miR-3130-3p hsa-miR-491-5p hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidDERL3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DERL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DERL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for DERL3):
        Protein processing in endoplasmic reticulum


    DERL3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DERL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for DERL3 (Q96Q803 ENSP000003847444) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
    MFI2P085823, ENSP000002963504I2D: score=1 STRING: ENSP00000296350
    TRAM1ENSP000002622134STRING: ENSP00000262213
    VIMPENSP000003812824STRING: ENSP00000381282
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018279protein N-linked glycosylation via asparagine IMP--
    GO:0030433ER-associated protein catabolic process NAS16449189
    GO:0030968endoplasmic reticulum unfolded protein response IDA16449189

    DERL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DERL3

    Search CenterWatch for drugs/clinical trials and news about DERL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DERL3 gene (3 alternative transcripts): 
    NM_001002862.2  NM_001135751.1  NM_198440.3  

    Unigene Cluster for DERL3:

    Derlin 3
    Hs.593679  [show with all ESTs]
    Unigene Representative Sequence: AK125830
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464023 ENST00000406855(uc002zyk.4) ENST00000404056 ENST00000290730(uc002zyh.3 uc002zyi.3 uc002zyj.3)
    ENST00000493596 ENST00000464034 ENST00000488272 ENST00000318109 ENST00000476077
    ENST00000464110
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate DERL3:
    hsa-miR-3622b-3p hsa-miR-3130-3p hsa-miR-491-5p hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidDERL3 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DERL3
    Sirion Biotech Customized lentivirus for stable overexpression of DERL3 
                         Customized lentivirus expression plasmids for stable overexpression of DERL3 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DERL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DERL3

    Additional mRNA sequence: 

    AK092582.1 AK096976.1 AK125830.1 AL389876.1 AL389879.1 BC057830.1 CR456372.1 

    9 DOTS entries:

    DT.75148775  DT.101983658  DT.310401  DT.455813  DT.75100295  DT.95364661  DT.100023252  DT.120671507 
    DT.92424325 

    24/90 AceView cDNA sequences (see all 90):

    BE218231 BM713985 AA243616 BE503794 NM_001002862 AI867737 NM_198440 BM713999 
    BM723688 BF433930 AI216564 AA830970 AW296853 BG149188 BM769484 BE467075 
    BM792257 BM129595 AI968197 AW135031 AI681837 BE466009 AI148507 BM790476 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DERL3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8
    SP1:        -                       -                       -           -     -         
    SP2:        -                       -                       -           -               
    SP3:        -                       -                       -                           
    SP4:                                -                       -                           
    SP5:                                                                                    


    ECgene alternative splicing isoforms for DERL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DERL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGGGCCCA
    DERL3 Expression
    About this image


    See DERL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DERL3

    SOURCE GeneReport for Unigene cluster: Hs.593679

    UniProtKB/Swiss-Prot: DERL3_HUMAN, Q96Q80
    Tissue specificity: Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta,
    pancreas, spleen and small intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DERL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DERL3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Derl31 , 5 Der1-like domain family, member 31, 5 87.02(n)1
    91.15(a)1
      10 (38.61 cM)5
    703771  NM_024440.21  NP_077760.11 
     758933985 
    chicken
    (Gallus gallus)
    Aves DERL36
    Der1-like domain family, member 3
    68(a)
    1 ↔ 1
    15(8010321-8014793)
    zebrafish
    (Danio rerio)
    Actinopterygii derl31 Der1-like domain family, member 3 73.36(n)
    78.54(a)
      393877  NM_200903.1  NP_957197.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Der-26
    Derlin-2
    49(a)
    1 → many
    3R(12308416-12310125)
    worm
    (Caenorhabditis elegans)
    Secernentea R151.66
    Derlin-2
    54(a)
    1 → many
    III(7221740-7223131)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DFM16
    Endoplasmic reticulum (ER) localized protein invol...
    14(a)
    1 → many
    IV(1293369-1294394)
    wheat
    (Triticum aestivum)
    Liliopsida Ta.137292 Triticum aestivum transcribed sequence with moderate more 75.47(n)    CK209641.1 


    ENSEMBL Gene Tree for DERL3 (if available)
    TreeFam Gene Tree for DERL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DERL3 gene
    DERL22  DERL12  
    2 SIMAP similar genes for DERL3 using alignment to 2 protein entries:     DERL3_HUMAN (see all proteins):
    DERL2    DERL1

    DERL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/189 SNPs in DERL3 are shown (see all 189)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131010091,2
    C--7170845(+) AAAAAA/-CCAGT 3 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs1917569811,2
    --24177224(+) TGGGGC/TCCTTT 3 -- ut31 int10--------
    rs566808991,2
    C,F--24177476(+) AAACTG/AGCTCG 3 -- ut31 int12Minor allele frequency- A:0.30CSA WA 120
    rs96124841,2
    C,F,A,H--24177511(+) TGGGCA/CCAGAT 3 -- ut31 int111Minor allele frequency- C:0.21NA EA NS 560
    rs573880341,2
    C,F--24177532(+) ATCCCA/GGCACA 3 -- ut31 int12Minor allele frequency- G:0.31CSA WA 120
    rs1151659041,2
    C,F--24177572(+) TCCCAT/CGCTGC 3 -- ut31 int11Minor allele frequency- C:0.07WA 118
    rs287133361,2
    C--24177636(+) CCCATG/ATGGGG 3 -- ut31 int14Minor allele frequency- A:0.10CSA WA NA EA 360
    rs1446604281,2
    --24177666(+) AGGGAC/TTGGGG 3 -- ut31 int10--------
    rs286792811,2
    C,F--24177697(+) AGAGGA/GGGGCT 3 -- ut31 int1 trp33Minor allele frequency- G:0.10WA NA EA 358
    rs1478661531,2
    --24177730(+) GGACTC/TTTCCC 3 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for DERL3 (24176690 - 24181315 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for DERL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724041CNV Deletion23290073
    dgv4907n71CNV Loss21882294
    nsv914598CNV Loss21882294
    dgv4908n71CNV Loss21882294
    nsv526567CNV Gain19592680
    dgv4906n71CNV Gain21882294
    nsv914599CNV Gain21882294
    nsv834155CNV Gain+Loss17160897
    nsv511075CNV Complex20534489
    nsv7350OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610305    OMIM disorders: --

    2 diseases for DERL3:    About MalaCards
    gastric cancer    


    DERL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DERL3

    Export disorders for DERL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DERL3 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with DERL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. (PubMed id 16449189)1, 2 Oda Y.... Mori K. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A membrane protein required for dislocation of misfolded proteins from the ER. (PubMed id 15215855)1, 3 Lilley B.N. and Ploegh H.L. (2004)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    7. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
    8. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PubMed id 22607976)2 Sato T.... Kai H. (2012)
    9. The transmembrane segment of a tail-anchored protein d etermines its degradative fate through dislocation from the endoplasmic reticulu m. (PubMed id 20435896)1 Claessen J.H....Ploegh H.L. (2010)
    10. USP14 inhibits ER-associated degradation via interaction with IRE1alpha. (PubMed id 19135427)1 Nagai A.... Ichijo H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91319 HGNC: 14236 AceView: C22orf14 Ensembl:ENSG00000099958 euGenes: HUgn91319
    ECgene: DERL3 Kegg: 91319 H-InvDB: DERL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DERL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DERL3 gene:
    Search GeneIP for patents involving DERL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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