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DERL3 Gene

protein-coding   GIFtS: 51
GCID: GC22M024176

Derlin 3

(Previous names: chromosome 22 open reading frame 14, Der1-like domain family,...)
(Previous symbol: C22orf14)
  Search for DERL3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Derlin 31 2     LLN22 3
C22orf141 2 3     Chromosome 22 Open Reading Frame 141
Der1-Like Domain Family, Member 31 2     IZP62
Degradation In Endoplasmic Reticulum Protein 32 3     derlin-32
Der1-Like Protein 32 3     DERtrin 32
DERtrin-32 3     DER33

External Ids:    HGNC: 142361   Entrez Gene: 913192   Ensembl: ENSG000000999587   OMIM: 6103055   UniProtKB: Q96Q803   
ORGUL members:         

Export aliases for DERL3 gene to outside databases

Previous GC identifers: GC22M022504 GC22M007164


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DERL3 Gene:
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER).
Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the
ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several
alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
(provided by RefSeq, Oct 2008)

GeneCards Summary for DERL3 Gene:
DERL3 (derlin 3) is a protein-coding gene. An important paralog of this gene is DERL2.

UniProtKB/Swiss-Prot: DERL3_HUMAN, Q96Q80
Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal
glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the
retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the
proteasome. May mediate the interaction between VCP and the degradation substrate

Gene Wiki entry for DERL3 (Derlin-3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NT_187633.1  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DERL3 gene promoter:
         NF-1   RFX1   Elk-1   p300   HTF   GATA-1   FOXL1   FAC1   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDERL3 promoter sequence
   Search Chromatin IP Primers for DERL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DERL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

DERL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DERL3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M024176:  view genomic region     (about GC identifiers)

Start:
24,176,690 bp from pter      End:
24,181,315 bp from pter
Size:
4,626 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DERL3_HUMAN, Q96Q80 (See protein sequence)
Recommended Name: Derlin-3  
Size: 235 amino acids; 26679 Da
Subunit: Forms homo- and heterooligomers with DERL2 and, to a lesser extent, with DERL1. Interacts with VCP,
EDEM1, SELK and VIMP/SELS
Secondary accessions: F2Z3B6 Q6ICJ6 Q6PEX0 Q6ZUB5
Alternative splicing: 5 isoforms:  Q96Q80-1   Q96Q80-2   Q96Q80-3   Q96Q80-4   Q96Q80-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DERL3: NX_Q96Q80

Explore proteomics data for DERL3 at MOPED


See DERL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001002862.1  NP_001129223.1  NP_940842.2  

ENSEMBL proteins: 
 ENSP00000384744   ENSP00000384473   ENSP00000315303   ENSP00000419399  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007599 DER1

Graphical View of Domain Structure for InterPro Entry Q96Q80

ProtoNet protein and cluster: Q96Q80

UniProtKB/Swiss-Prot: DERL3_HUMAN, Q96Q80
Similarity: Belongs to the derlin family


DERL3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DERL3_HUMAN, Q96Q80
Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal
glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the
retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the
proteasome. May mediate the interaction between VCP and the degradation substrate
Induction: Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded
protein response (UPR) (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI16449189
     
DERL3 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for DERL3:
 Decreased influenza A/WSN/33 r 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Derl3):
 normal 

DERL3 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DERL3
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4 qRT-PCR Assays for microRNAs that regulate DERL3:
hsa-miR-3622b-3p hsa-miR-3130-3p hsa-miR-491-5p hsa-miR-1291
SwitchGear 3'UTR luciferase reporter plasmidDERL3 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DERL3_HUMAN, Q96Q80: Endoplasmic reticulum membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane3
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030176integral component of endoplasmic reticulum membrane IDA16449189

DERL3 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DERL3 About    
See pathways by source

SuperPathContained pathways About
1Protein processing in endoplasmic reticulum
Protein processing in endoplasmic reticulum

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Kegg Pathway  (Kegg details for DERL3):
    Protein processing in endoplasmic reticulum


DERL3 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DERL3
Interactions:

    Search GeneGlobe Interaction Network for DERL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DERL3 (Q96Q803 ENSP000003847444) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
InteractantInteraction Details
GeneCardExternal ID(s)
AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
MFI2P085823, ENSP000002963504I2D: score=1 STRING: ENSP00000296350
TRAM1ENSP000002622134STRING: ENSP00000262213
VIMPENSP000003812824STRING: ENSP00000381282
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0018279protein N-linked glycosylation via asparagine IMP--
GO:0030433ER-associated ubiquitin-dependent protein catabolic process NAS16449189
GO:0030968endoplasmic reticulum unfolded protein response IDA16449189

DERL3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DERL3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DERL3 gene (3 alternative transcripts): 
NM_001002862.2  NM_001135751.1  NM_198440.3  

Unigene Cluster for DERL3:

Derlin 3
Hs.593679  [show with all ESTs]
Unigene Representative Sequence: AK125830
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000464023 ENST00000406855(uc002zyk.4) ENST00000404056 ENST00000290730(uc002zyh.3 uc002zyi.3 uc002zyj.3)
ENST00000493596 ENST00000464034 ENST00000488272 ENST00000318109 ENST00000476077
ENST00000464110
miRNA
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4 qRT-PCR Assays for microRNAs that regulate DERL3:
hsa-miR-3622b-3p hsa-miR-3130-3p hsa-miR-491-5p hsa-miR-1291
SwitchGear 3'UTR luciferase reporter plasmidDERL3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat DERL3
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GenScript: all cDNA clones in your preferred vector (see all 3): DERL3 (NM_001002862)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DERL3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DERL3
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DERL3
  QuantiTect SYBR Green Assays in human, mouse, rat DERL3
  QuantiFast Probe-based Assays in human, mouse, rat DERL3

Additional mRNA sequence: 

AK092582.1 AK096976.1 AK125830.1 AL389876.1 AL389879.1 BC057830.1 CR456372.1 

9 DOTS entries:

DT.75148775  DT.101983658  DT.310401  DT.455813  DT.75100295  DT.95364661  DT.100023252  DT.120671507 
DT.92424325 

Selected AceView cDNA sequences (see all 90):

BG149188 AW135031 BM723688 BF433930 AA243616 BM129595 BE218231 BM792257 
BM713985 AI968197 NM_001002862 BE467075 BE466009 BM769484 AI216564 NM_198440 
AI148507 AW296853 AI867737 AA830970 AI681837 BM713999 BE503794 BE670394 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DERL3 (see all 7)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8
SP1:        -                       -                       -           -     -         
SP2:        -                       -                       -           -               
SP3:        -                       -                       -                           
SP4:                                -                       -                           
SP5:                                                                                    


ECgene alternative splicing isoforms for DERL3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DERL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAAGGGCCCA
DERL3 Expression
About this image

DERL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DERL3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.593679

UniProtKB/Swiss-Prot: DERL3_HUMAN, Q96Q80
Tissue specificity: Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta,
pancreas, spleen and small intestine

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for DERL3 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Derl31 , 5 Der1-like domain family, member 31, 5 87.02(n)1
91.15(a)1
  10 (38.61 cM)5
703771  NM_024440.21  NP_077760.11 
 758933985 
chicken
(Gallus gallus)
Aves DERL36
Uncharacterized protein
74(a)
1 ↔ 1
15(8010321-8014793)
zebrafish
(Danio rerio)
Actinopterygii derl36
Der1-like domain family, member 3
65(a)
1 ↔ 1
8(31769445-31777680) ENSDARG00000033871
fruit fly
(Drosophila melanogaster)
Insecta Der-26
Derlin-2
50(a)
1 → many
3R(12308416-12310125)
worm
(Caenorhabditis elegans)
Secernentea R151.66
Protein R151.6 (R151.6) mRNA, complete cds
55(a)
1 → many
III(7221740-7223129) WBGene00020109
wheat
(Triticum aestivum)
Liliopsida Ta.137292 Triticum aestivum transcribed sequence with moderate more 75.47(n)    CK209641.1 


ENSEMBL Gene Tree for DERL3 (if available)
TreeFam Gene Tree for DERL3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DERL3 gene
DERL22  DERL12  
2 SIMAP similar genes for DERL3 using alignment to 2 protein entries:     DERL3_HUMAN (see all proteins):
DERL2    DERL1

DERL3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DERL3 (see all 189)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1131010091,2
C--7170845(+) AAAAAA/-CCAGT 3 -- us2k11Minor allele frequency- -:0.00CSA 2
rs1917569811,2
--24177224(+) TGGGGC/TCCTTT 3 -- ut31 int10--------
rs566808991,2
C,F--24177476(+) AAACTG/AGCTCG 3 -- ut31 int12Minor allele frequency- A:0.30CSA WA 120
rs96124841,2
C,F,A,H--24177511(+) TGGGCA/CCAGAT 3 -- ut31 int111Minor allele frequency- C:0.21NA EA NS 560
rs573880341,2
C,F--24177532(+) ATCCCA/GGCACA 3 -- ut31 int12Minor allele frequency- G:0.31CSA WA 120
rs1151659041,2
C,F--24177572(+) TCCCAT/CGCTGC 3 -- ut31 int11Minor allele frequency- C:0.07WA 118
rs287133361,2
C--24177636(+) CCCATG/ATGGGG 3 -- ut31 int14Minor allele frequency- A:0.10CSA WA NA EA 360
rs1446604281,2
--24177666(+) AGGGAC/TTGGGG 3 -- ut31 int10--------
rs286792811,2
C,F--24177697(+) AGAGGA/GGGGCT 3 -- ut31 int1 trp33Minor allele frequency- G:0.10WA NA EA 358
rs1478661531,2
--24177730(+) GGACTC/TTTCCC 3 -- ut31 int10--------

HapMap Linkage Disequilibrium report for DERL3 (24176690 - 24181315 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for DERL3:    About this table    
Variant IDTypeSubtypePubMed ID
esv2724041CNV Deletion23290073
dgv4907n71CNV Loss21882294
nsv914598CNV Loss21882294
dgv4908n71CNV Loss21882294
nsv526567CNV Gain19592680
dgv4906n71CNV Gain21882294
nsv914599CNV Gain21882294
nsv834155CNV Gain+Loss17160897
nsv511075CNV Complex20534489
nsv7350OTHER Inversion18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DERL3
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610305    OMIM disorders: --


DERL3 for disorders           About GeneDecksing

Genetic Association Database (GAD): DERL3

Export disorders for DERL3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DERL3 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with DERL3)
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  1. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. (PubMed id 16449189)1, 2 Oda Y.... Mori K. (J. Cell Biol. 2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. A membrane protein required for dislocation of misfolded proteins from the ER. (PubMed id 15215855)1, 3 Lilley B.N. and Ploegh H.L. (Nature 2004)
  5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
  6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
  7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
  8. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PubMed id 22607976)2 Sato T.... Kai H. (Mol. Cell 2012)
  9. Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis. (PubMed id 22016385)2 Shchedrina V.A....Gladyshev V.N. (J. Biol. Chem. 2011)
  10. The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum. (PubMed id 20435896)1 Claessen J.H....Ploegh H.L. (J. Biol. Chem. 2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 91319 HGNC: 14236 AceView: C22orf14 Ensembl:ENSG00000099958 euGenes: HUgn91319
ECgene: DERL3 Kegg: 91319 H-InvDB: DERL3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DERL3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DERL3 gene:
Search GeneIP for patents involving DERL3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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