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Aliases for DERL2 Gene

Aliases for DERL2 Gene

  • Derlin 2 2 3 5
  • Degradation In Endoplasmic Reticulum Protein 2 3 4
  • Der1-Like Domain Family, Member 2 2 3
  • DERtrin-2 3 4
  • F-LAN-1 3 4
  • F-LANa 3 4
  • FLANa 3 4
  • Der1-Like Protein 2 4
  • Carcinoma Related 3
  • Derlin-2 3
  • CGI-101 3
  • DER2 4

External Ids for DERL2 Gene

Previous GeneCards Identifiers for DERL2 Gene

  • GC17M005311
  • GC17M005269
  • GC17M005374

Summaries for DERL2 Gene

Entrez Gene Summary for DERL2 Gene

  • Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DERL2 Gene

DERL2 (Derlin 2) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Signaling by GPCR. An important paralog of this gene is DERL3.

UniProtKB/Swiss-Prot for DERL2 Gene

  • Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.

Gene Wiki entry for DERL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DERL2 Gene

Genomics for DERL2 Gene

Regulatory Elements for DERL2 Gene

Enhancers for DERL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DERL2 on UCSC Golden Path with GeneCards custom track

Promoters for DERL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DERL2 Gene

Chromosome:
17
Start:
5,471,251 bp from pter
End:
5,486,811 bp from pter
Size:
15,561 bases
Orientation:
Minus strand

Genomic View for DERL2 Gene

Genes around DERL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DERL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DERL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DERL2 Gene

Proteins for DERL2 Gene

  • Protein details for DERL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZP9-DERL2_HUMAN
    Recommended name:
    Derlin-2
    Protein Accession:
    Q9GZP9
    Secondary Accessions:
    • Q9Y3A7

    Protein attributes for DERL2 Gene

    Size:
    239 amino acids
    Molecular mass:
    27567 Da
    Quaternary structure:
    • Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1. Interacts with SELK, VIMP, VCP and EDEM1. Mediates association between VCP and EDEM1, as well as that between VCP and the degradation substrate. Interacts with the SEL1L/SYVN1 and VCP/VIMP protein complexes. Interacts with OS9. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP.
    SequenceCaution:
    • Sequence=AAD34096.1; Type=Frameshift; Positions=122, 128, 136; Evidence={ECO:0000305};

neXtProt entry for DERL2 Gene

Post-translational modifications for DERL2 Gene

  • Ubiquitination at Lys 200 and Lys 206
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DERL2 Gene

Domains & Families for DERL2 Gene

Gene Families for DERL2 Gene

Protein Domains for DERL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DERL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZP9

UniProtKB/Swiss-Prot:

DERL2_HUMAN :
  • Belongs to the derlin family.
Family:
  • Belongs to the derlin family.
genes like me logo Genes that share domains with DERL2: view

Function for DERL2 Gene

Molecular function for DERL2 Gene

UniProtKB/Swiss-Prot Function:
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).

Gene Ontology (GO) - Molecular Function for DERL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16449189
genes like me logo Genes that share ontologies with DERL2: view
genes like me logo Genes that share phenotypes with DERL2: view

Animal Models for DERL2 Gene

MGI Knock Outs for DERL2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DERL2 Gene

Localization for DERL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DERL2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DERL2 Gene COMPARTMENTS Subcellular localization image for DERL2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
endosome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for DERL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005770 late endosome IEA --
GO:0005783 endoplasmic reticulum IEA,IDA 15215855
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DERL2: view

Pathways & Interactions for DERL2 Gene

genes like me logo Genes that share pathways with DERL2: view

Pathways by source for DERL2 Gene

Gene Ontology (GO) - Biological Process for DERL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001967 suckling behavior IEA --
GO:0008284 positive regulation of cell proliferation IDA 11500051
GO:0030307 positive regulation of cell growth IDA 11500051
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 16449189
GO:0030968 endoplasmic reticulum unfolded protein response IDA 16449189
genes like me logo Genes that share ontologies with DERL2: view

No data available for SIGNOR curated interactions for DERL2 Gene

Drugs & Compounds for DERL2 Gene

No Compound Related Data Available

Transcripts for DERL2 Gene

Unigene Clusters for DERL2 Gene

Derlin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DERL2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - - -
SP9: - -
SP10: - -
SP11: -
SP12: - - - - - - - - - - - - - - -
SP13: -
SP14: - - - - - -
SP15:

Relevant External Links for DERL2 Gene

GeneLoc Exon Structure for
DERL2
ECgene alternative splicing isoforms for
DERL2

Expression for DERL2 Gene

mRNA expression in normal human tissues for DERL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DERL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DERL2 Gene



Protein tissue co-expression partners for DERL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DERL2 Gene:

DERL2

SOURCE GeneReport for Unigene cluster for DERL2 Gene:

Hs.286131

mRNA Expression by UniProt/SwissProt for DERL2 Gene:

Q9GZP9-DERL2_HUMAN
Tissue specificity: Ubiquitous. Overexpressed in various hepatocarcinomas.
genes like me logo Genes that share expression patterns with DERL2: view

Primer Products

No data available for mRNA differential expression in normal tissues for DERL2 Gene

Orthologs for DERL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DERL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DERL2 34
  • 95.26 (n)
  • 100 (a)
DERL2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DERL2 34
  • 93.58 (n)
  • 100 (a)
DERL2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Derl2 34
  • 92.89 (n)
  • 98.74 (a)
Derl2 16
Derl2 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DERL2 34
  • 99.16 (n)
  • 100 (a)
DERL2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910823 34
  • 87.87 (n)
  • 92.98 (a)
oppossum
(Monodelphis domestica)
Mammalia DERL2 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DERL2 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves DERL2 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DERL2 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia derl2 34
  • 78.1 (n)
  • 92.05 (a)
Str.17564 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16815 34
zebrafish
(Danio rerio)
Actinopterygii derl2 34
  • 75.87 (n)
  • 88.7 (a)
zgc63991 34
derl2 35
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4763 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000832 34
  • 65.22 (n)
  • 71.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Der-2 34
  • 64.52 (n)
  • 64.81 (a)
Der-2 35
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R151.6 34
  • 63.79 (n)
  • 69.55 (a)
R151.6 35
  • 64 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DFM1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons DER2.1 34
  • 55.76 (n)
  • 50.23 (a)
rice
(Oryza sativa)
Liliopsida Os03g0852200 34
  • 56.87 (n)
  • 52.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00146 34
  • 50.56 (n)
  • 44.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 71 (a)
OneToMany
Species where no ortholog for DERL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DERL2 Gene

ENSEMBL:
Gene Tree for DERL2 (if available)
TreeFam:
Gene Tree for DERL2 (if available)

Paralogs for DERL2 Gene

Paralogs for DERL2 Gene

(2) SIMAP similar genes for DERL2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for DERL2 Gene

genes like me logo Genes that share paralogs with DERL2: view

Variants for DERL2 Gene

Sequence variations from dbSNP and Humsavar for DERL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9023 -- 5,474,459(-) AGCCA(A/G)AAAAC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1805431 -- 5,479,931(+) GCTCA(A/G)TCTGC intron-variant
rs1805432 -- 5,483,173(+) GACTA(C/G)GTTAA intron-variant
rs1805443 -- 5,471,872(+) GCCCA(C/T)TACTC nc-transcript-variant, utr-variant-3-prime
rs1805444 -- 5,472,435(+) TGGTT(A/G)TAGGG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DERL2 Gene

Variant ID Type Subtype PubMed ID
nsv1956 CNV deletion 18451855
nsv528302 CNV loss 19592680

Variation tolerance for DERL2 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DERL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DERL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DERL2 Gene

Disorders for DERL2 Gene

Relevant External Links for DERL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DERL2

No disorders were found for DERL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DERL2 Gene

Publications for DERL2 Gene

  1. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. (PMID: 16186509) Lilley B.N. … Ploegh H.L. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 65
  2. Cloning and characterization of F-LANa, upregulated in human liver cancer. (PMID: 11500051) Ying H. … Xu Y. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 65
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 65
  4. EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites. (PMID: 17360537) Zuber C. … Roth J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 22 65
  5. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. (PMID: 16449189) Oda Y. … Mori K. (J. Cell Biol. 2006) 3 4 65

Products for DERL2 Gene

Sources for DERL2 Gene

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