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DERL2 Gene

protein-coding   GIFtS: 56
GCID: GC17M005374

Derlin 2

(Previous names: Der1-like domain family, member 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Derlin 21 2     F-LANa2 3
Der1-Like Domain Family, Member 21 2     FLANa2
Degradation In Endoplasmic Reticulum Protein 22 3     Carcinoma Related2
Der1-Like Protein 22 3     derlin-22
DERtrin-22 3     DER23
F-LAN-12 3     FLANA3

External Ids:    HGNC: 179431   Entrez Gene: 510092   Ensembl: ENSG000000728497   OMIM: 6103045   UniProtKB: Q9GZP93   

Export aliases for DERL2 gene to outside databases

Previous GC identifers: GC17M005311 GC17M005269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DERL2 Gene:
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain
the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al.,
2006 (PubMed 16449189)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DERL2 Gene:
DERL2 (derlin 2) is a protein-coding gene. An important paralog of this gene is DERL1.

UniProtKB/Swiss-Prot: DERL2_HUMAN, Q9GZP9
Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal
glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the
retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the
proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is
not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a
role in cell proliferation

Gene Wiki entry for DERL2 (Derlin-2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DERL2 gene promoter:
         POU3F1   HNF-3beta   E47   CREB   deltaCREB   Hand1   ZID   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DERL2 promoter sequence
   Search Chromatin IP Primers for DERL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DERL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

DERL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DERL2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M005374:  view genomic region     (about GC identifiers)

Start:
5,374,571 bp from pter      End:
5,390,131 bp from pter
Size:
15,561 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DERL2_HUMAN, Q9GZP9 (See protein sequence)
Recommended Name: Derlin-2  
Size: 239 amino acids; 27567 Da
Subunit: Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1. Interacts with SELK,
VIMP, VCP and EDEM1. Mediates association between VCP and EDEM1, as well as that between VCP and the degradation
substrate. Interacts with the SEL1L/SYVN1 and VCP/VIMP protein complexes. Interacts with OS9. Part of a complex
which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP
Sequence caution: Sequence=AAD34096.1; Type=Frameshift; Positions=122, 128, 136;
Secondary accessions: Q9Y3A7

Explore the universe of human proteins at neXtProt for DERL2: NX_Q9GZP9

Explore proteomics data for DERL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys200, Lys206
  • Modification sites at PhosphoSitePlus

  • See DERL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057125.2  
    ENSEMBL proteins: 
     ENSP00000158771   ENSP00000460671   ENSP00000459083   ENSP00000459072   ENSP00000461603  
     ENSP00000467794   ENSP00000458296   ENSP00000459154   ENSP00000458448  

    DERL2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DERL2

     
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    antibodies-online peptides for DERL2

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    antibodies-online antibodies for DERL2 (29 products) 

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    antibodies-online kits for DERL2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007599 DER1

    Graphical View of Domain Structure for InterPro Entry Q9GZP9

    ProtoNet protein and cluster: Q9GZP9

    UniProtKB/Swiss-Prot: DERL2_HUMAN, Q9GZP9
    Similarity: Belongs to the derlin family


    Find genes that share domains with DERL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DERL2_HUMAN, Q9GZP9
    Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal
    glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the
    retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the
    proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is
    not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a
    role in cell proliferation
    Induction: Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded
    protein response (UPR) (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16449189
         
    Find genes that share ontologies with DERL2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DERL2:
     Decreased POU5F1-GFP protein e  Elongated cells with protrusio  Increased G1 DNA content  Increased cell size 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Derl2):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  reproductive system  respiratory system  skeleton 

    Find genes that share phenotypes with DERL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Derl2tm1.2Hpl for DERL2

       genOway: Develop your customized and physiologically relevant rodent model for DERL2

    miRNA
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    miRTarBase miRNAs that target DERL2:
    hsa-mir-324-3p (MIRT042933)

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    Selected qRT-PCR Assays for microRNAs that regulate DERL2 (see all 28):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-1271 hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidDERL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DERL2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DERL2_HUMAN, Q9GZP9: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    endosome2
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IEA--
    GO:0005770late endosome IEA--
    GO:0005783endoplasmic reticulum IDA15215855
    GO:0030176integral component of endoplasmic reticulum membrane IDA16449189

    Find genes that share ontologies with DERL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DERL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with DERL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for DERL2):
        Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Array including DERL2: 
              Unfolded Protein Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DERL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DERL2 (Q9GZP92, 3 ENSP000001587714) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMFRQ9UKV53, ENSP000002906494I2D: score=2 STRING: ENSP00000290649
    DERL1Q9BUN83, ENSP000002595124I2D: score=1 STRING: ENSP00000259512
    MFI2P085823, ENSP000002963504I2D: score=1 STRING: ENSP00000296350
    SEL1LQ9UBV23, ENSP000003370534I2D: score=1 STRING: ENSP00000337053
    SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001967suckling behavior IEA--
    GO:0008284positive regulation of cell proliferation IDA11500051
    GO:0030307positive regulation of cell growth IDA11500051
    GO:0030433ER-associated ubiquitin-dependent protein catabolic process IMP16449189
    GO:0030968endoplasmic reticulum unfolded protein response IDA16449189

    Find genes that share ontologies with DERL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DERL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DERL2 gene: 
    NM_016041.3  

    Unigene Cluster for DERL2:

    Derlin 2
    Hs.286131  [show with all ESTs]
    Unigene Representative Sequence: BM478493
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000158771(uc002gcc.1) ENST00000573547 ENST00000572834 ENST00000575605
    ENST00000570848 ENST00000571476 ENST00000576551 ENST00000571971 ENST00000574952
    ENST00000573637 ENST00000574700 ENST00000575209 ENST00000571968
    miRNA
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    Block miRNA regulation of human, mouse, rat DERL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DERL2 (see all 28):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-1271 hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidDERL2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DERL2
      QuantiFast Probe-based Assays in human, mouse, rat DERL2

    Additional mRNA sequence: 

    AF132289.1 AF151859.1 AF208065.1 AF242523.1 AK024574.1 BC009549.1 BC010890.1 CR457202.1 

    15 DOTS entries:

    DT.416707  DT.97858628  DT.120915551  DT.120915554  DT.91780523  DT.95175796  DT.97789599  DT.95289965 
    DT.100667496  DT.102824189  DT.91733738  DT.91780552  DT.91947548  DT.92325715  DT.95221098 

    Selected AceView cDNA sequences (see all 190):

    BX494802 CA487513 BU431516 BF724670 AI133161 AW268612 AF208065 BE674209 
    CA309968 BE504275 CA308385 AA419545 BM725584 CR457202 CB162369 AK024574 
    CA495258 AI311856 AI240536 AA383378 AF242523 AV725011 AA910984 AI695003 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DERL2 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e
    SP1:                    -                       -           -     -     -                                   -     -     -     -                                 
    SP2:                    -                       -     -           -     -     -                                                                                 
    SP3:                    -                       -           -     -     -                                   -     -     -     -                                 
    SP4:                    -                       -     -     -     -     -                                   -     -     -     -                                 
    SP5:                                            -                 -     -     -     -                       -     -     -     -                                 


    ECgene alternative splicing isoforms for DERL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DERL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTAAATGG
    DERL2 Expression
    About this image


    DERL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Thyroid (Endocrine System)
    DERL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DERL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.286131

    UniProtKB/Swiss-Prot: DERL2_HUMAN, Q9GZP9
    Tissue specificity: Ubiquitous. Overexpressed in various hepatocarcinomas

        Pathway & Disease-focused RT2 Profiler PCR Array including DERL2: 
              Unfolded Protein Response in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat DERL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DERL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DERL2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Derl21 , 5 Der1-like domain family, member 21, 5 92.89(n)1
    98.74(a)1
      11 (43.21 cM)5
    1168911  NM_033562.31  NP_291040.11 
     710071645 
    chicken
    (Gallus gallus)
    Aves DERL26
    derlin 2
    93(a)
    1 ↔ 1
    19(3416634-3420724)
    lizard
    (Anolis carolinensis)
    Reptilia DERL26
    derlin 2
    92(a)
    1 ↔ 1
    GL343393.1(344984-350515)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168152 Xenopus laevis transcribed sequence with weak similarity more 78.03(n)    48050457 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639912 hypothetical protein MGC63991 73.62(n)   393877  BC064666.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Der-21 Derlin-2 64.52(n)
    64.81(a)
      42005  NM_142296.3  NP_650553.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R151.61 R151.6 63.79(n)
    69.55(a)
      176018  NM_066189.5  NP_498590.4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DER2.11 DER2.1 55.76(n)
    50.23(a)
      828269  NM_118301.6  NP_193912.3 
    rice
    (Oryza sativa)
    Liliopsida Os03g08522001 Os03g0852200 56.87(n)
    52.19(a)
      4334809  NM_001058456.1  NP_001051921.1 


    ENSEMBL Gene Tree for DERL2 (if available)
    TreeFam Gene Tree for DERL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DERL2 gene
    DERL12  DERL32  
    2 SIMAP similar genes for DERL2 using alignment to 8 protein entries:     DERL2_HUMAN (see all proteins):
    DERL3    DERL1

    Find genes that share paralogs with DERL2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for DERL2
    PGOHUM00000262493 PGOHUM00000233586


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DERL2 (see all 210)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911488011,2
    --5377119(+) AAAAAA/TTTTTT 1 -- int10--------
    rs1117102061,2
    C--5377160(+) AAAAAG/ATCTAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1825177001,2
    --5377316(+) AACCAC/TCCTCC 1 -- int10--------
    rs1488035831,2
    --5377526(+) CAGCTA/GTGTAA 1 -- int10--------
    rs1879741181,2
    --5377547(+) GCTCAA/GATCTA 1 -- int10--------
    rs30261511,2
    C,F,H--5377672(+) ACACCA/GTGGCC 1 -- ut3110Minor allele frequency- G:0.02NA NS EA WA 800
    rs1423800771,2
    --5377678(+) TGGCCA/TCATCT 1 -- ut310--------
    rs1479334781,2
    --5377679(+) GGCCTC/TATCTA 1 -- ut310--------
    rs30261521,2
    C--5377736(+) TACTCA/GTGTAC 1 -- ut31 ese30--------
    rs1454978961,2
    --5377748(+) TGTTAA/GAGGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DERL2 (5374571 - 5390131 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DERL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1956CNV Loss18451855
    nsv528302CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DERL2
    DNA2.0 Custom Variant and Variant Library Synthesis for DERL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610304    OMIM disorders: --


    Find genes that share disorders with DERL2           About GenesLikeMe


    Export disorders for DERL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DERL2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with DERL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of F-LANa, upregulated in human liver cancer. (PubMed id 11500051)1, 2, 3 Ying H.... Xu Y. (Biochem. Biophys. Res. Commun. 2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. (PubMed id 16186509)1, 2, 9 Lilley B.N. and Ploegh H.L. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    4. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. (PubMed id 16449189)1, 2 Oda Y.... Mori K. (J. Cell Biol. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A membrane protein required for dislocation of misfolded proteins from the ER. (PubMed id 15215855)1, 2 Lilley B.N. and Ploegh H.L. (Nature 2004)
    7. EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites. (PubMed id 17360537)1, 9 Zuber C....Roth J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    8. Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum. (PubMed id 23867461)1 Huang C.H....Chen X. (J. Biol. Chem. 2013)
    9. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. (PubMed id 23097496)1 Tyler R.E....Kopito R.R. (Mol. Biol. Cell 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51009 HGNC: 17943 AceView: F-LANa Ensembl:ENSG00000072849 euGenes: HUgn51009
    ECgene: DERL2 Kegg: 51009 H-InvDB: DERL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DERL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DERL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DERL2 gene:
    Search GeneIP for patents involving DERL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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