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Aliases for DERA Gene

Aliases for DERA Gene

  • Deoxyribose-Phosphate Aldolase (Putative) 2 3
  • 2-Deoxy-D-Ribose 5-Phosphate Aldolase 3 4
  • Phosphodeoxyriboaldolase 3 4
  • Deoxyriboaldolase 3 4
  • EC 4.1.2.4 4 63
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog (C. Elegans) 2
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog 3
  • Putative Deoxyribose-Phosphate Aldolase 3
  • CGI-26 3
  • DEOC 3

External Ids for DERA Gene

Previous GeneCards Identifiers for DERA Gene

  • GC12P015956
  • GC12P016064
  • GC12P015833

Summaries for DERA Gene

GeneCards Summary for DERA Gene

DERA (Deoxyribose-Phosphate Aldolase (Putative)) is a Protein Coding gene. Diseases associated with DERA include phlebotomus fever. Among its related pathways are Pentose phosphate pathway and 2-deoxy-alpha-D-ribose 1-phosphate degradation. GO annotations related to this gene include lyase activity and deoxyribose-phosphate aldolase activity.

UniProtKB/Swiss-Prot for DERA Gene

  • Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DERA Gene

Genomics for DERA Gene

Regulatory Elements for DERA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DERA Gene

Chromosome:
12
Start:
15,911,172 bp from pter
End:
16,037,381 bp from pter
Size:
126,210 bases
Orientation:
Plus strand

Genomic View for DERA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DERA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DERA Gene

Proteins for DERA Gene

  • Protein details for DERA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y315-DEOC_HUMAN
    Recommended name:
    Deoxyribose-phosphate aldolase
    Protein Accession:
    Q9Y315
    Secondary Accessions:
    • Q53HN9
    • Q6PHW2

    Protein attributes for DERA Gene

    Size:
    318 amino acids
    Molecular mass:
    35231 Da
    Quaternary structure:
    • Interacts with YBX1.
    SequenceCaution:
    • Sequence=AAD27735.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH56234.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DERA Gene

Proteomics data for DERA Gene at MOPED

Selected DME Specific Peptides for DERA Gene

Post-translational modifications for DERA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DERA Gene

Protein Domains for DERA Gene

Suggested Antigen Peptide Sequences for DERA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y315

UniProtKB/Swiss-Prot:

DEOC_HUMAN :
  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
Family:
  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
genes like me logo Genes that share domains with DERA: view

No data available for Gene Families for DERA Gene

Function for DERA Gene

Molecular function for DERA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
UniProtKB/Swiss-Prot Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

Enzyme Numbers (IUBMB) for DERA Gene

Gene Ontology (GO) - Molecular Function for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004139 deoxyribose-phosphate aldolase activity IDA 9226884
GO:0016829 lyase activity --
genes like me logo Genes that share ontologies with DERA: view

Phenotypes for DERA Gene

GenomeRNAi human phenotypes for DERA:
genes like me logo Genes that share phenotypes with DERA: view

Animal Model Products

miRNA for DERA Gene

miRTarBase miRNAs that target DERA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DERA

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DERA Gene

Localization for DERA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DERA Gene

Cytoplasm. Cytoplasmic granule. Nucleus. Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation. {ECO:0000269 PubMed:25229427}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DERA Gene COMPARTMENTS Subcellular localization image for DERA gene
Compartment Confidence
extracellular 5
nucleus 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DERA: view

Pathways & Interactions for DERA Gene

genes like me logo Genes that share pathways with DERA: view

Pathways by source for DERA Gene

1 BioSystems pathway for DERA Gene
1 KEGG pathway for DERA Gene

UniProtKB/Swiss-Prot Q9Y315-DEOC_HUMAN

  • Pathway: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2

Gene Ontology (GO) - Biological Process for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009264 deoxyribonucleotide catabolic process IBA --
GO:0016052 carbohydrate catabolic process IBA --
GO:0046121 deoxyribonucleoside catabolic process IDA 9226884
GO:0046386 deoxyribose phosphate catabolic process IEA --
genes like me logo Genes that share ontologies with DERA: view

No data available for SIGNOR curated interactions for DERA Gene

Drugs & Compounds for DERA Gene

(2) Drugs for DERA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyceraldehyde-3-Phosphate Experimental Pharma 0
ACETALDEHYDE Pharma Activation, Activator 0

(5) Additional Compounds for DERA Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Deoxyribose 5-monophosphate
Deoxyribose 5-phosphate
  • 2-Deoxy-alpha-D-ribose 5-phosphate
  • 2-Deoxy-alpha-delta-ribose 5-phosphate
  • 2-Deoxy-D-ribose 5-phosphate
  • 2-Deoxy-D-ribose-5-phosphate
  • 2-Deoxyribose 5-phosphate
102916-66-5
Aldol
deoxyribose
  • 2'-Deoxy-D-ribose
533-67-5
deoxyribose-5-phosphate
genes like me logo Genes that share compounds with DERA: view

Transcripts for DERA Gene

Unigene Clusters for DERA Gene

Deoxyribose-phosphate aldolase (putative):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DERA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DERA Gene

No ASD Table

Relevant External Links for DERA Gene

GeneLoc Exon Structure for
DERA
ECgene alternative splicing isoforms for
DERA

Expression for DERA Gene

mRNA expression in normal human tissues for DERA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DERA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.4) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DERA Gene



SOURCE GeneReport for Unigene cluster for DERA Gene Hs.39429

mRNA Expression by UniProt/SwissProt for DERA Gene

Q9Y315-DEOC_HUMAN
Tissue specificity: Mainly expressed in liver, lung and colon.
genes like me logo Genes that share expression patterns with DERA: view

Protein tissue co-expression partners for DERA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DERA Gene

Orthologs for DERA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DERA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DERA 35
  • 90.67 (n)
  • 94.34 (a)
DERA 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dera 35
  • 85.53 (n)
  • 92.45 (a)
Dera 16
Dera 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DERA 35
  • 99.27 (n)
  • 99.06 (a)
DERA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dera 35
  • 85.01 (n)
  • 91.51 (a)
dog
(Canis familiaris)
Mammalia DERA 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DERA 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DERA 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DERA 35
  • 73.48 (n)
  • 76.73 (a)
DERA 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DERA 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16254 35
zebrafish
(Danio rerio)
Actinopterygii dera 35
  • 69.72 (n)
  • 74.13 (a)
zgc56677 35
dera 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009161 35
  • 55.06 (n)
  • 58.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8525 35
  • 56.24 (n)
  • 55.4 (a)
CG8525 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F09E5.3 35
  • 58.44 (n)
  • 55.65 (a)
F09E5.3 36
  • 46 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.1195 35
rice
(Oryza sativa)
Liliopsida Os.15810 35
wheat
(Triticum aestivum)
Liliopsida Ta.30529 35
corn
(Zea mays)
Liliopsida Zm.2750 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToOne
Species with no ortholog for DERA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for DERA Gene

ENSEMBL:
Gene Tree for DERA (if available)
TreeFam:
Gene Tree for DERA (if available)

Paralogs for DERA Gene

No data available for Paralogs for DERA Gene

Variants for DERA Gene

Sequence variations from dbSNP and Humsavar for DERA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2948 -- 16,034,698(-) CCTCT(A/G)CTTCT intron-variant
rs963595 -- 16,018,359(+) ATAAC(A/C)ATTAT intron-variant
rs1077733 -- 16,008,520(+) TCCCC(C/G)CAGTA intron-variant
rs1450965 -- 15,978,096(-) AGCTG(A/G)CACTT intron-variant
rs1450966 -- 15,978,008(-) GGTGG(A/G)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DERA Gene

Variant ID Type Subtype PubMed ID
esv2647271 CNV Deletion 19546169
esv2659461 CNV Deletion 23128226

Variation tolerance for DERA Gene

Residual Variation Intolerance Score: 38.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DERA Gene

HapMap Linkage Disequilibrium report
DERA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DERA Gene

Disorders for DERA Gene

MalaCards: The human disease database

(1) MalaCards diseases for DERA Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • sandfly-borne arboviral fever
- elite association
Search DERA in MalaCards View complete list of genes associated with diseases

Relevant External Links for DERA

Genetic Association Database (GAD)
DERA
Human Genome Epidemiology (HuGE) Navigator
DERA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DERA
genes like me logo Genes that share disorders with DERA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DERA Gene

Publications for DERA Gene

  1. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. (PMID: 17594457) Feron G. … Blin-Perrin C. (Lett. Appl. Microbiol. 2007) 23 67
  2. Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates. (PMID: 15069189) Greenberg W.A. … Burk M.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 23 67
  3. Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase. (PMID: 12467706) DeSantis G. … Wong C.H. (Bioorg. Med. Chem. 2003) 23 67
  4. Phylogenetic analyses of diplomonad genes reveal frequent lateral gene transfers affecting eukaryotes. (PMID: 12546782) Andersson J.O. … Roger A.J. (Curr. Biol. 2003) 2 67
  5. Channelling of deoxyribose moiety of exogenous DNA into carbohydrate metabolism: role of deoxyriboaldolase. (PMID: 9226884) Sgarrella F. … Tozzi M.G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 1997) 23 67

Products for DERA Gene

Sources for DERA Gene

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