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Aliases for DERA Gene

Aliases for DERA Gene

  • Deoxyribose-Phosphate Aldolase 2 3 5
  • 2-Deoxy-D-Ribose 5-Phosphate Aldolase 3 4
  • Phosphodeoxyriboaldolase 3 4
  • Deoxyriboaldolase 3 4
  • EC 4.1.2.4 4 61
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog (C. Elegans) 2
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog 3
  • Deoxyribose-Phosphate Aldolase (Putative) 3
  • Putative Deoxyribose-Phosphate Aldolase 3
  • CGI-26 3
  • DEOC 3

External Ids for DERA Gene

Previous GeneCards Identifiers for DERA Gene

  • GC12P015956
  • GC12P016064
  • GC12P015833

Summaries for DERA Gene

GeneCards Summary for DERA Gene

DERA (Deoxyribose-Phosphate Aldolase) is a Protein Coding gene. Diseases associated with DERA include Phlebotomus Fever. Among its related pathways are Innate Immune System and Pentose phosphate pathway. GO annotations related to this gene include lyase activity and deoxyribose-phosphate aldolase activity.

UniProtKB/Swiss-Prot for DERA Gene

  • Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DERA Gene

Genomics for DERA Gene

Regulatory Elements for DERA Gene

Enhancers for DERA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G015977 1 Ensembl ENCODE 9.2 +68.2 68227 4.1 SOX13 CTCF PKNOX1 FOXA2 JUN ZNF644 RAD21 YY1 GATA2 ZNF350 DERA EGLN3P1 GC12M015990
GH12G015927 1 Ensembl ENCODE 8.5 +17.5 17451 2.1 JUN EBF1 ZFHX2 PRDM10 RELB FOS IKZF2 ZNF652 ZBTB20 NR2F1 DERA EGLN3P1
GH12G015962 0.6 ENCODE 10.9 +52.0 52046 2.0 JUND GATA2 JUN CEBPB FOS EP300 ATF2 DERA EGLN3P1
GH12G015919 0.4 ENCODE 10.7 +8.5 8479 0.9 FEZF1 DERA EGLN3P1
GH12G015955 0.5 ENCODE 5.8 +45.7 45677 2.9 JUND HNF4A FOS EP300 DERA EGLN3P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DERA on UCSC Golden Path with GeneCards custom track

Promoters for DERA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000049304 428 1601 SIN3A DMAP1 ZNF48 GLIS2 GATA2 ZNF143 FOS ZNF263 SP3 MXD4

Genomic Location for DERA Gene

Chromosome:
12
Start:
15,911,172 bp from pter
End:
16,037,381 bp from pter
Size:
126,210 bases
Orientation:
Plus strand

Genomic View for DERA Gene

Genes around DERA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DERA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DERA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DERA Gene

Proteins for DERA Gene

  • Protein details for DERA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y315-DEOC_HUMAN
    Recommended name:
    Deoxyribose-phosphate aldolase
    Protein Accession:
    Q9Y315
    Secondary Accessions:
    • Q53HN9
    • Q6PHW2

    Protein attributes for DERA Gene

    Size:
    318 amino acids
    Molecular mass:
    35231 Da
    Quaternary structure:
    • Interacts with YBX1.
    SequenceCaution:
    • Sequence=AAD27735.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH56234.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DERA Gene

Selected DME Specific Peptides for DERA Gene

Q9Y315:
  • AHLKTILATGEL
  • FIKTSTG

Post-translational modifications for DERA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DERA Gene

Protein Domains for DERA Gene

Suggested Antigen Peptide Sequences for DERA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y315

UniProtKB/Swiss-Prot:

DEOC_HUMAN :
  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
Family:
  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
genes like me logo Genes that share domains with DERA: view

No data available for Gene Families for DERA Gene

Function for DERA Gene

Molecular function for DERA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
UniProtKB/Swiss-Prot Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

Enzyme Numbers (IUBMB) for DERA Gene

Gene Ontology (GO) - Molecular Function for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004139 deoxyribose-phosphate aldolase activity IEA,TAS --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with DERA: view
genes like me logo Genes that share phenotypes with DERA: view

Animal Model Products

CRISPR Products

miRNA for DERA Gene

miRTarBase miRNAs that target DERA

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DERA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DERA Gene

Localization for DERA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DERA Gene

Cytoplasm. Cytoplasmic granule. Nucleus. Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation. {ECO:0000269 PubMed:25229427}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DERA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with DERA: view

Pathways & Interactions for DERA Gene

genes like me logo Genes that share pathways with DERA: view

Pathways by source for DERA Gene

UniProtKB/Swiss-Prot Q9Y315-DEOC_HUMAN

  • Pathway: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.

Gene Ontology (GO) - Biological Process for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006098 pentose-phosphate shunt TAS --
GO:0009264 deoxyribonucleotide catabolic process IBA,IEA --
GO:0016052 carbohydrate catabolic process IBA --
GO:0043312 neutrophil degranulation TAS --
GO:0046121 deoxyribonucleoside catabolic process IDA 9226884
genes like me logo Genes that share ontologies with DERA: view

No data available for SIGNOR curated interactions for DERA Gene

Drugs & Compounds for DERA Gene

(2) Drugs for DERA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyceraldehyde-3-Phosphate Experimental Pharma 0
ACETALDEHYDE Pharma Activation, Activator 0

(5) Additional Compounds for DERA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Deoxyribose 5-monophosphate
Deoxyribose 5-phosphate
  • 2-Deoxy-alpha-D-ribose 5-phosphate
  • 2-Deoxy-alpha-delta-ribose 5-phosphate
  • 2-Deoxy-D-ribose 5-phosphate
  • 2-Deoxy-D-ribose-5-phosphate
  • 2-Deoxyribose 5-phosphate
102916-66-5
genes like me logo Genes that share compounds with DERA: view

Transcripts for DERA Gene

Unigene Clusters for DERA Gene

Deoxyribose-phosphate aldolase (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DERA

Alternative Splicing Database (ASD) splice patterns (SP) for DERA Gene

No ASD Table

Relevant External Links for DERA Gene

GeneLoc Exon Structure for
DERA
ECgene alternative splicing isoforms for
DERA

Expression for DERA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DERA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DERA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.4) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DERA Gene



Protein tissue co-expression partners for DERA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DERA Gene:

DERA

SOURCE GeneReport for Unigene cluster for DERA Gene:

Hs.39429

mRNA Expression by UniProt/SwissProt for DERA Gene:

Q9Y315-DEOC_HUMAN
Tissue specificity: Mainly expressed in liver, lung and colon.

Evidence on tissue expression from TISSUES for DERA Gene

  • Liver(4.3)
  • Skin(4.3)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with DERA: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DERA Gene

Orthologs for DERA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DERA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DERA 34 35
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia DERA 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DERA 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DERA 34 35
  • 90.67 (n)
mouse
(Mus musculus)
Mammalia Dera 34 16 35
  • 85.53 (n)
rat
(Rattus norvegicus)
Mammalia Dera 34
  • 85.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DERA 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DERA 34 35
  • 73.48 (n)
lizard
(Anolis carolinensis)
Reptilia DERA 35
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16254 34
zebrafish
(Danio rerio)
Actinopterygii dera 34 35
  • 69.72 (n)
zgc56677 34
fruit fly
(Drosophila melanogaster)
Insecta CG8525 34 35
  • 56.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009161 34
  • 55.06 (n)
worm
(Caenorhabditis elegans)
Secernentea F09E5.3 34 35
  • 58.44 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.1195 34
rice
(Oryza sativa)
Liliopsida Os.15810 34
wheat
(Triticum aestivum)
Liliopsida Ta.30529 34
corn
(Zea mays)
Liliopsida Zm.2750 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 68 (a)
OneToOne
Species where no ortholog for DERA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for DERA Gene

ENSEMBL:
Gene Tree for DERA (if available)
TreeFam:
Gene Tree for DERA (if available)

Paralogs for DERA Gene

No data available for Paralogs for DERA Gene

Variants for DERA Gene

Sequence variations from dbSNP and Humsavar for DERA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000013391 -- 16,008,487(+) TAACT(C/T)GTGTC intron-variant
rs1000018454 -- 15,990,510(+) AACTT(A/G)TGTCA intron-variant
rs1000033884 -- 16,034,868(+) AAATG(G/T)TCCTA intron-variant
rs1000053510 -- 15,909,221(+) CTGCT(C/G)TCTCT upstream-variant-2KB
rs1000073933 -- 15,949,556(+) CACAG(C/T)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DERA Gene

Variant ID Type Subtype PubMed ID
dgv1395n100 CNV loss 25217958
esv2647271 CNV deletion 19546169
esv2659461 CNV deletion 23128226
esv2760899 CNV gain 21179565
esv3358865 CNV insertion 20981092
esv3580160 CNV loss 25503493
esv3628681 CNV loss 21293372
esv3892147 CNV loss 25118596
nsv1036638 CNV loss 25217958
nsv557636 CNV loss 21841781

Variation tolerance for DERA Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DERA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DERA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DERA Gene

Disorders for DERA Gene

MalaCards: The human disease database

(1) MalaCards diseases for DERA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
- elite association - COSMIC cancer census association via MalaCards
Search DERA in MalaCards View complete list of genes associated with diseases

Relevant External Links for DERA

Genetic Association Database (GAD)
DERA
Human Genome Epidemiology (HuGE) Navigator
DERA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DERA
genes like me logo Genes that share disorders with DERA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DERA Gene

Publications for DERA Gene

  1. DERA is the human deoxyribose phosphate aldolase and is involved in stress response. (PMID: 25229427) Salleron L. … Lane L. (Biochim. Biophys. Acta 2014) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Phylogenetic analyses of diplomonad genes reveal frequent lateral gene transfers affecting eukaryotes. (PMID: 12546782) Andersson J.O. … Roger A.J. (Curr. Biol. 2003) 2 3 64
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 64
  5. Channelling of deoxyribose moiety of exogenous DNA into carbohydrate metabolism: role of deoxyriboaldolase. (PMID: 9226884) Sgarrella F. … Tozzi M.G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 1997) 3 22 64

Products for DERA Gene

Sources for DERA Gene

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