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Aliases for DERA Gene

Aliases for DERA Gene

  • Deoxyribose-Phosphate Aldolase (Putative) 2 3
  • 2-Deoxy-D-Ribose 5-Phosphate Aldolase 3 4
  • Phosphodeoxyriboaldolase 3 4
  • Deoxyriboaldolase 3 4
  • EC 4.1.2.4 4 63
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog (C. Elegans) 2
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog 3
  • Putative Deoxyribose-Phosphate Aldolase 3
  • Deoxyribose-Phosphate Aldolase 3
  • CGI-26 3
  • DEOC 3

External Ids for DERA Gene

Previous GeneCards Identifiers for DERA Gene

  • GC12P015956
  • GC12P016064
  • GC12P015833

Summaries for DERA Gene

GeneCards Summary for DERA Gene

DERA (Deoxyribose-Phosphate Aldolase (Putative)) is a Protein Coding gene. Diseases associated with DERA include phlebotomus fever and tick infestation. Among its related pathways are Pentose phosphate pathway (KEGG). GO annotations related to this gene include deoxyribose-phosphate aldolase activity.

UniProtKB/Swiss-Prot for DERA Gene

  • Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DERA Gene

Genomics for DERA Gene

Regulatory Elements for DERA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DERA Gene

Start:
15,911,172 bp from pter
End:
16,037,381 bp from pter
Size:
126,210 bases
Orientation:
Plus strand

Genomic View for DERA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DERA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DERA Gene

Proteins for DERA Gene

  • Protein details for DERA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y315-DEOC_HUMAN
    Recommended name:
    Deoxyribose-phosphate aldolase
    Protein Accession:
    Q9Y315
    Secondary Accessions:
    • Q53HN9
    • Q6PHW2

    Protein attributes for DERA Gene

    Size:
    318 amino acids
    Molecular mass:
    35231 Da
    Quaternary structure:
    • Interacts with YBX1.
    SequenceCaution:
    • Sequence=AAD27735.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH56234.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DERA Gene

Proteomics data for DERA Gene at MOPED

Selected DME Specific Peptides for DERA Gene

Post-translational modifications for DERA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for DERA Gene

Protein Domains for DERA Gene

Suggested Antigen Peptide Sequences for DERA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y315

UniProtKB/Swiss-Prot:

DEOC_HUMAN :
  • Q9Y315
Family:
  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
genes like me logo Genes that share domains with DERA: view

No data available for Gene Families for DERA Gene

Function for DERA Gene

Molecular function for DERA Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
UniProtKB/Swiss-Prot Function: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

Enzyme Numbers (IUBMB) for DERA Gene

Gene Ontology (GO) - Molecular Function for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004139 deoxyribose-phosphate aldolase activity IDA 9226884
GO:0016829 lyase activity --
genes like me logo Genes that share ontologies with DERA: view

Phenotypes for DERA Gene

GenomeRNAi human phenotypes for DERA:
genes like me logo Genes that share phenotypes with DERA: view

Animal Model Products

CRISPR Products

miRNA for DERA Gene

miRTarBase miRNAs that target DERA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DERA

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DERA Gene

Localization for DERA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DERA Gene

Cytoplasm. Cytoplasmic granule. Nucleus. Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation. {ECO:0000269 PubMed:25229427}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DERA Gene COMPARTMENTS Subcellular localization image for DERA gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DERA: view

Pathways for DERA Gene

SuperPathways for DERA Gene

genes like me logo Genes that share pathways with DERA: view

Pathways by source for DERA Gene

1 KEGG pathway for DERA Gene

UniProtKB/Swiss-Prot Q9Y315-DEOC_HUMAN

  • Pathway: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2

Gene Ontology (GO) - Biological Process for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009264 deoxyribonucleotide catabolic process IEA --
GO:0046121 deoxyribonucleoside catabolic process IDA 9226884
GO:0046386 deoxyribose phosphate catabolic process IEA --
genes like me logo Genes that share ontologies with DERA: view

Compounds for DERA Gene

(3) HMDB Compounds for DERA Gene

Compound Synonyms Cas Number PubMed IDs
Acetaldehyde
  • acetaldehyde
75-07-0
Deoxyribose 5-phosphate
  • 2-deoxy-alpha-D-ribose 5-phosphate
102916-66-5
D-Glyceraldehyde 3-phosphate
  • 2-hydroxy-3-(phosphonooxy)-Propanal
142-10-9

(3) Novoseek inferred chemical compound relationships for DERA Gene

Compound -log(P) Hits PubMed IDs
deoxyribose-5-phosphate 97.3 2
deoxyribose 76.1 2
aldol 75 2
genes like me logo Genes that share compounds with DERA: view

Transcripts for DERA Gene

Unigene Clusters for DERA Gene

Deoxyribose-phosphate aldolase (putative):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DERA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DERA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DERA Gene

No ASD Table

Relevant External Links for DERA Gene

GeneLoc Exon Structure for
DERA
ECgene alternative splicing isoforms for
DERA

Expression for DERA Gene

mRNA expression in normal human tissues for DERA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DERA Gene

SOURCE GeneReport for Unigene cluster for DERA Gene Hs.39429

mRNA Expression by UniProt/SwissProt for DERA Gene

Q9Y315-DEOC_HUMAN
Tissue specificity: Mainly expressed in liver, lung and colon.
genes like me logo Genes that share expressions with DERA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DERA Gene

Orthologs for DERA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DERA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DERA 35
  • 99.27 (n)
  • 99.06 (a)
DERA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DERA 35
  • 90.67 (n)
  • 94.34 (a)
DERA 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DERA 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dera 35
  • 85.53 (n)
  • 92.45 (a)
Dera 16
Dera 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DERA 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DERA 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dera 35
  • 85.01 (n)
  • 91.51 (a)
chicken
(Gallus gallus)
Aves DERA 35
  • 73.48 (n)
  • 76.73 (a)
DERA 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DERA 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16254 35
zebrafish
(Danio rerio)
Actinopterygii dera 35
  • 69.72 (n)
  • 74.13 (a)
dera 36
  • 74 (a)
OneToOne
zgc56677 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009161 35
  • 55.06 (n)
  • 58.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8525 35
  • 56.24 (n)
  • 55.4 (a)
CG8525 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F09E5.3 35
  • 58.44 (n)
  • 55.65 (a)
F09E5.3 36
  • 46 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.1195 35
corn
(Zea mays)
Liliopsida Zm.2750 35
rice
(Oryza sativa)
Liliopsida Os.15810 35
wheat
(Triticum aestivum)
Liliopsida Ta.30529 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToOne
Species with no ortholog for DERA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for DERA Gene

ENSEMBL:
Gene Tree for DERA (if available)
TreeFam:
Gene Tree for DERA (if available)

Paralogs for DERA Gene

No data available for Paralogs for DERA Gene

Variants for DERA Gene

Sequence variations from dbSNP and Humsavar for DERA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2948 -- 16,034,698(-) CCTCT(A/G)CTTCT intron-variant
rs963595 -- 16,018,359(+) ATAAC(A/C)ATTAT intron-variant
rs1077733 -- 16,008,520(+) TCCCC(C/G)CAGTA intron-variant
rs1376337 -- 15,994,972(-) CTTCA(A/G)GTTTT intron-variant
rs1450965 -- 15,978,096(-) AGCTG(A/G)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DERA Gene

Variant ID Type Subtype PubMed ID
esv2647271 CNV Deletion 19546169
esv2659461 CNV Deletion 23128226

Relevant External Links for DERA Gene

HapMap Linkage Disequilibrium report
DERA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DERA Gene

Disorders for DERA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for DERA Gene including...

Search for DERA Gene in MalaCards »

(2) University of Copenhagen DISEASES for DERA Gene

Relevant External Links for DERA

Genetic Association Database (GAD)
DERA
Human Genome Epidemiology (HuGE) Navigator
DERA
genes like me logo Genes that share disorders with DERA: view

No data available for UniProtKB/Swiss-Prot for DERA Gene

Publications for DERA Gene

  1. Channelling of deoxyribose moiety of exogenous DNA into carbohydrate metabolism: role of deoxyriboaldolase. (PMID: 9226884) Sgarrella F. … Tozzi M.G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 1997) 3 23
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. Phylogenetic analyses of diplomonad genes reveal frequent lateral gene transfers affecting eukaryotes. (PMID: 12546782) Andersson J.O. … Roger A.J. (Curr. Biol. 2003) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for DERA Gene

Sources for DERA Gene

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