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Aliases for DERA Gene

Aliases for DERA Gene

  • Deoxyribose-Phosphate Aldolase 2 3
  • Deoxyribose-Phosphate Aldolase (Putative) 3 5
  • 2-Deoxy-D-Ribose 5-Phosphate Aldolase 3 4
  • Phosphodeoxyriboaldolase 3 4
  • Deoxyriboaldolase 3 4
  • EC 4 63
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog (C. Elegans) 2
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog 3
  • Putative Deoxyribose-Phosphate Aldolase 3
  • CGI-26 3
  • DEOC 3

External Ids for DERA Gene

Previous GeneCards Identifiers for DERA Gene

  • GC12P015956
  • GC12P016064
  • GC12P015833

Summaries for DERA Gene

GeneCards Summary for DERA Gene

DERA (Deoxyribose-Phosphate Aldolase) is a Protein Coding gene. Diseases associated with DERA include Phlebotomus Fever. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. GO annotations related to this gene include lyase activity and deoxyribose-phosphate aldolase activity.

UniProtKB/Swiss-Prot for DERA Gene

  • Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DERA Gene

Genomics for DERA Gene

Regulatory Elements for DERA Gene

Enhancers for DERA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DERA on UCSC Golden Path with GeneCards custom track

Promoters for DERA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DERA on UCSC Golden Path with GeneCards custom track

Genomic Location for DERA Gene

15,911,172 bp from pter
16,037,381 bp from pter
126,210 bases
Plus strand

Genomic View for DERA Gene

Genes around DERA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DERA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DERA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DERA Gene

Proteins for DERA Gene

  • Protein details for DERA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deoxyribose-phosphate aldolase
    Protein Accession:
    Secondary Accessions:
    • Q53HN9
    • Q6PHW2

    Protein attributes for DERA Gene

    318 amino acids
    Molecular mass:
    35231 Da
    Quaternary structure:
    • Interacts with YBX1.
    • Sequence=AAD27735.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH56234.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DERA Gene

Proteomics data for DERA Gene at MOPED

Selected DME Specific Peptides for DERA Gene

Post-translational modifications for DERA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DERA Gene

Protein Domains for DERA Gene

Suggested Antigen Peptide Sequences for DERA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
genes like me logo Genes that share domains with DERA: view

No data available for Gene Families for DERA Gene

Function for DERA Gene

Molecular function for DERA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
UniProtKB/Swiss-Prot Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

Enzyme Numbers (IUBMB) for DERA Gene

genes like me logo Genes that share phenotypes with DERA: view

Animal Model Products

miRNA for DERA Gene

miRTarBase miRNAs that target DERA

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DERA Gene

Localization for DERA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DERA Gene

Cytoplasm. Cytoplasmic granule. Nucleus. Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation. {ECO:0000269 PubMed:25229427}.

Subcellular locations from

Jensen Localization Image for DERA Gene COMPARTMENTS Subcellular localization image for DERA gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for DERA Gene

Pathways & Interactions for DERA Gene

genes like me logo Genes that share pathways with DERA: view

Pathways by source for DERA Gene

UniProtKB/Swiss-Prot Q9Y315-DEOC_HUMAN

  • Pathway: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.

Gene Ontology (GO) - Biological Process for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016052 carbohydrate catabolic process IBA --
GO:0046121 deoxyribonucleoside catabolic process IDA 9226884
GO:0046386 deoxyribose phosphate catabolic process IEA --
genes like me logo Genes that share ontologies with DERA: view

No data available for SIGNOR curated interactions for DERA Gene

Drugs & Compounds for DERA Gene

(2) Drugs for DERA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyceraldehyde-3-Phosphate Experimental Pharma 0
ACETALDEHYDE Pharma Activation, Activator 0

(5) Additional Compounds for DERA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Deoxyribose 5-monophosphate
Deoxyribose 5-phosphate
  • 2-Deoxy-alpha-D-ribose 5-phosphate
  • 2-Deoxy-alpha-delta-ribose 5-phosphate
  • 2-Deoxy-D-ribose 5-phosphate
  • 2-Deoxy-D-ribose-5-phosphate
  • 2-Deoxyribose 5-phosphate
genes like me logo Genes that share compounds with DERA: view

Transcripts for DERA Gene

Unigene Clusters for DERA Gene

Deoxyribose-phosphate aldolase (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DERA Gene

No ASD Table

Relevant External Links for DERA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DERA Gene

mRNA expression in normal human tissues for DERA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DERA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.4) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DERA Gene

SOURCE GeneReport for Unigene cluster for DERA Gene Hs.39429

mRNA Expression by UniProt/SwissProt for DERA Gene

Tissue specificity: Mainly expressed in liver, lung and colon.
genes like me logo Genes that share expression patterns with DERA: view

Protein tissue co-expression partners for DERA Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for DERA Gene

Orthologs for DERA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DERA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DERA 35
  • 90.67 (n)
  • 94.34 (a)
  • 94 (a)
(Mus musculus)
Mammalia Dera 35
  • 85.53 (n)
  • 92.45 (a)
Dera 16
Dera 36
  • 92 (a)
(Pan troglodytes)
Mammalia DERA 35
  • 99.27 (n)
  • 99.06 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dera 35
  • 85.01 (n)
  • 91.51 (a)
(Canis familiaris)
Mammalia DERA 36
  • 93 (a)
(Monodelphis domestica)
Mammalia DERA 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia DERA 36
  • 69 (a)
(Gallus gallus)
Aves DERA 35
  • 73.48 (n)
  • 76.73 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia DERA 36
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16254 35
(Danio rerio)
Actinopterygii dera 35
  • 69.72 (n)
  • 74.13 (a)
zgc56677 35
dera 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009161 35
  • 55.06 (n)
  • 58.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8525 35
  • 56.24 (n)
  • 55.4 (a)
CG8525 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea F09E5.3 35
  • 58.44 (n)
  • 55.65 (a)
F09E5.3 36
  • 46 (a)
(Hordeum vulgare)
Liliopsida Hv.1195 35
(Oryza sativa)
Liliopsida Os.15810 35
(Triticum aestivum)
Liliopsida Ta.30529 35
(Zea mays)
Liliopsida Zm.2750 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
Species with no ortholog for DERA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for DERA Gene

Gene Tree for DERA (if available)
Gene Tree for DERA (if available)

Paralogs for DERA Gene

No data available for Paralogs for DERA Gene

Variants for DERA Gene

Sequence variations from dbSNP and Humsavar for DERA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2034503 -- 15,974,104(-) atggt(C/T)cagaa intron-variant
rs2034504 -- 15,973,973(-) tttgc(A/G)tacca intron-variant
rs2045870 -- 15,972,014(+) AGCAC(C/T)TCGTG intron-variant
rs2045871 -- 15,972,017(+) ACCTC(C/G)TGTAG intron-variant
rs2045872 -- 15,972,140(+) TCCCA(A/G)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DERA Gene

Variant ID Type Subtype PubMed ID
esv2647271 CNV Deletion 19546169
esv2659461 CNV Deletion 23128226

Variation tolerance for DERA Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DERA Gene

Disorders for DERA Gene

MalaCards: The human disease database

(1) MalaCards diseases for DERA Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
- elite association - COSMIC cancer census association via MalaCards
Search DERA in MalaCards View complete list of genes associated with diseases

Relevant External Links for DERA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DERA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DERA Gene

Publications for DERA Gene

  1. DERA is the human deoxyribose phosphate aldolase and is involved in stress response. (PMID: 25229427) Salleron L. … Lane L. (Biochim. Biophys. Acta 2014) 2 3 4 67
  2. Phylogenetic analyses of diplomonad genes reveal frequent lateral gene transfers affecting eukaryotes. (PMID: 12546782) Andersson J.O. … Roger A.J. (Curr. Biol. 2003) 2 3
  3. Channelling of deoxyribose moiety of exogenous DNA into carbohydrate metabolism: role of deoxyriboaldolase. (PMID: 9226884) Sgarrella F. … Tozzi M.G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 1997) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for DERA Gene

Sources for DERA Gene