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DEPTOR Gene

protein-coding   GIFtS: 49
GCID: GC08P120886

DEP Domain Containing MTOR-Interacting Protein

(Previous name: DEP domain containing 6)
(Previous symbol: DEPDC6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEP Domain Containing MTOR-Interacting Protein1 2     DEP.62
DEPDC61 2 3 5     DEP Domain Containing MTOR Interacting Protein2
DEP Domain Containing 61 2     DEP Domain-Containing MTOR-Interacting Protein2
DEP Domain-Containing Protein 62 3     

External Ids:    HGNC: 229531   Entrez Gene: 647982   Ensembl: ENSG000001557927   OMIM: 6129745   UniProtKB: Q8TB453   

Export aliases for DEPTOR gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DEPTOR Gene:
DEPTOR (DEP domain containing MTOR-interacting protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45
Function: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both
complexes

Gene Wiki entry for DEPTOR (DEPDC6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DEPTOR
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEPTOR promoter sequence
   Search Chromatin IP Primers for DEPTOR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEPTOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q24.12

DEPTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEPTOR gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P120886:  view genomic region     (about GC identifiers)

Start:
120,885,900 bp from pter      End:
121,063,157 bp from pter
Size:
177,258 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45 (See protein sequence)
Recommended Name: DEP domain-containing mTOR-interacting protein  
Size: 409 amino acids; 46294 Da
Subunit: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR,
AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR,
MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both
mammalian target of rapamycin complexes mTORC1 and mTORC2
Sequence caution: Sequence=BAB14723.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RCL9 Q96EQ1 Q9H0R7 Q9H894 Q9HA07

Explore the universe of human proteins at neXtProt for DEPTOR: NX_Q8TB45

Explore proteomics data for DEPTOR at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC21
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DEPTOR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269941.1  NP_073620.2  

    ENSEMBL proteins: 
     ENSP00000430457   ENSP00000286234  

    DEPTOR Human Recombinant Protein Products:

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    OriGene Purified Protein for DEPTOR
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    Novus Biologicals DEPTOR Protein
    Novus Biologicals DEPTOR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DEPTOR 

     
    antibodies-online proteins for DEPTOR (4 products) 

     
    Search antibodies-online for peptides for DEPTOR

    DEPTOR Antibody Products:

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    Cell Signaling Technology (CST) Antibodies for DEPTOR 
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    Novus Biologicals DEPTOR Antibodies
    Search for Antibodies for DEPTOR at Abcam
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    ThermoFisher Antibody for DEPTOR
    antibodies-online antibodies for DEPTOR (31 products) 

    DEPTOR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DEPTOR 
    antibodies-online kits for DEPTOR (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR001478 PDZ
     IPR000591 DEP_dom

    Graphical View of Domain Structure for InterPro Entry Q8TB45

    ProtoNet protein and cluster: Q8TB45

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45
    Similarity: Contains 2 DEP domains
    Similarity: Contains 1 PDZ (DHR) domain


    Find genes that share domains with DEPTOR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPTOR_HUMAN, Q8TB45
    Function: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both
    complexes
    Induction: Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19446321
         
    Find genes that share ontologies with DEPTOR           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DEPTOR

    miRNA
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    Block miRNA regulation of human, mouse, rat DEPTOR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEPTOR (see all 16):
    hsa-miR-3910 hsa-miR-181c hsa-miR-4272 hsa-miR-1271 hsa-miR-181a hsa-miR-628-3p hsa-miR-181d hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidDEPTOR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DEPTOR
    Predesigned siRNA for gene silencing in human, mouse, rat DEPTOR

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPTOR
    Addgene plasmids for DEPTOR 

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DEPTOR 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPTOR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    Find genes that share ontologies with DEPTOR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DEPTOR About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    2PI3K / Akt Signaling
    PI3K / Akt Signaling
    3mTOR signaling pathway
    mTOR signaling pathway
    4Akt Signaling Pathway
    Akt Signaling Pathway


    Find genes that share SuperPaths with DEPTOR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DEPTOR
        Akt Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for DEPTOR
        PI3K / Akt Signaling

    2 BioSystems Pathways for DEPTOR
        Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    mTOR signaling pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including DEPTOR: 
              mTOR Signaling in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DEPTOR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for DEPTOR (Q8TB451, 3 ENSP000002862344) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTORP423451, 3, ENSP000003545584EBI-2359040,EBI-359260 I2D: score=2 STRING: ENSP00000354558
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    MLST8Q9BVC43, ENSP000003718884I2D: score=1 STRING: ENSP00000371888
    RICTORQ6R3273, ENSP000003499594I2D: score=1 STRING: ENSP00000349959
    RPTORQ8N1223, ENSP000003072724I2D: score=1 STRING: ENSP00000307272
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity IMP19446321
    GO:0032007negative regulation of TOR signaling IMP19446321
    GO:0035556intracellular signal transduction IEA--
    GO:0045792negative regulation of cell size IMP19446321
    GO:2001236regulation of extrinsic apoptotic signaling pathway IMP19446321

    Find genes that share ontologies with DEPTOR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DEPTOR (DPTOR)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DEPTOR gene (2 alternative transcripts): 
    NM_001283012.1  NM_022783.3  

    Unigene Cluster for DEPTOR:

    DEP domain containing MTOR-interacting protein
    Hs.112981  [show with all ESTs]
    Unigene Representative Sequence: NM_022783
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523492 ENST00000286234(uc003yow.4 uc011lid.2) ENST00000518057

    miRNA
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    Block miRNA regulation of human, mouse, rat DEPTOR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEPTOR (see all 16):
    hsa-miR-3910 hsa-miR-181c hsa-miR-4272 hsa-miR-1271 hsa-miR-181a hsa-miR-628-3p hsa-miR-181d hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidDEPTOR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DEPTOR
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DEPTOR (NM_022783)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEPTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPTOR
    Addgene plasmids for DEPTOR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DEPTOR
    OriGene qSTAR qPCR primer pairs in human, mouse for DEPTOR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEPTOR
      QuantiTect SYBR Green Assays in human, mouse, rat DEPTOR
      QuantiFast Probe-based Assays in human, mouse, rat DEPTOR

    Additional mRNA sequence: 

    AK022490.1 AK023916.1 AK225168.1 AK225675.1 AK297822.1 AK315175.1 AL136678.1 BC012040.1 
    BC024746.1 

    4 DOTS entries:

    DT.109138  DT.121480945  DT.95089526  DT.101975330 

    Selected AceView cDNA sequences (see all 87):

    AI805626 AU141638 BM791387 AA293513 BM854254 AA299911 CR615062 BI253286 
    AK023916 BM725381 AA348962 AW168810 AA252924 BM068869 AA315866 AU122789 
    AI799804 BX397705 CB216685 AK022490 AW088676 AA574103 AI300131 AI655686 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DEPTOR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGTGTG
    DEPTOR Expression
    About this image


    DEPTOR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    DEPTOR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DEPTOR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.112981
        Pathway & Disease-focused RT2 Profiler PCR Array including DEPTOR: 
              mTOR Signaling in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPTOR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DEPTOR gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Deptor1 , 5 DEP domain containing MTOR-interacting protein1, 5 89.98(n)1
    96.09(a)1
      15 (21.96 cM)5
    979981  NM_145470.31  NP_663445.21 
     551123175 
    chicken
    (Gallus gallus)
    Aves DEPDC61 DEP domain containing 6 80.5(n)
    90.6(a)
      420357  NM_001199502.1  NP_001186431.1 
    lizard
    (Anolis carolinensis)
    Reptilia DEPTOR6
    DEP domain containing MTOR-interacting protein
    85(a)
    1 ↔ 1
    GL343269.1(1151324-1225157)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59562 Xenopus laevis transcribed sequence with weak similarity to protein refNP_073620.1 (H.sapiens) hypothetical protein FLJ12428 [Homo sapiens] less 73.3(n)    BJ070062.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.268652 Transcribed sequence with moderate similarity to protein refNP_073620.1 (H.sapiens) hypothetical protein FLJ12428 [Homo sapiens] less 77.56(n)    CF102154.1 


    ENSEMBL Gene Tree for DEPTOR (if available)
    TreeFam Gene Tree for DEPTOR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DEPTOR gene
    1 SIMAP similar gene for DEPTOR using alignment to 2 protein entries:     DPTOR_HUMAN (see all proteins):
    CGEF2

    Find genes that share paralogs with DEPTOR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DEPTOR (see all 3961)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713049321,2
    C,F--116324264(+) TCTTT-/TC/TT 
            
    CTTTC
    1 -- int12NA CSA 4
    rs1380951241,2
    C--120883943(+) AACCAC/TACCTG 1 -- us2k10--------
    rs1508593831,2
    C--120883961(+) ATTTT-/GTGGTTTT 1 -- cds10--------
    rs605947781,2
    C--120883963(+) TTTGT-/GGT/
    TTT
    /TGTT
    TTTTT
    2 -- us2k1 cds10--------
    rs784558231,2
    --120883973(+) TTTTTG/TTAGAG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs69806791,2
    C,F,A--120884031(+) AAGCAG/ATCCTC 1 -- us2k17Minor allele frequency- A:0.38NA WA CSA EA 365
    rs70182861,2
    C,A--120884039(+) CTCCCA/GCCCTA 1 -- us2k15Minor allele frequency- G:0.38WA CSA NA EA 361
    rs70006691,2
    C,F,A,H--120884065(+) GGGATT/CACATT 1 -- us2k112Minor allele frequency- C:0.35NS EA NA WA CSA 783
    rs786831381,2
    F--120884087(+) GCCACG/CCAACA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1426733891,2
    --120884167(+) ATAAGC/GTTGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DEPTOR (120885900 - 121063157 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DEPTOR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678781CNV Deletion23128226
    nsv528705CNV Loss19592680
    nsv891419CNV Loss21882294
    nsv524750CNV Loss19592680
    nsv528628CNV Loss19592680
    nsv891418CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DEPTOR
    DNA2.0 Custom Variant and Variant Library Synthesis for DEPTOR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612974    OMIM disorders: --


    Find genes that share disorders with DEPTOR           About GenesLikeMe


    Export disorders for DEPTOR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DEPTOR gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with DEPTOR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. (PubMed id 19446321)1, 2, 3 Peterson T.R.... Sabatini D.M. (Cell 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    4. The human myometrium differentially expresses mTOR signalling components before and during pregnancy: evidence for regulation by progesterone. (PubMed id 23541542)1 Foster H.A....Karteris E. (J. Steroid Biochem. Mol. Biol. 2014)
    5. Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro. (PubMed id 23503641)1 Zhang H....Zhou L. (Int. J. Mol. Med. 2013)
    6. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. (PubMed id 23563706)1 Meng Z.X....Lin J.D. (Nat. Med. 2013)
    7. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    8. Knockdown of DEPTOR inhibits cell proliferation and increases chemosensitivity to melphalan in human multiple myeloma RPMI-8226 cells via inhibiting PI3K/AKT activity. (PubMed id 23613505)1 Zhang H.R....Que W.Z. (J. Int. Med. Res. 2013)
    9. DEPTOR regulates vascular endothelial cell activation and proinflammatory and angiogenic responses. (PubMed id 23881914)1 Bruneau S....Briscoe D.M. (Blood 2013)
    10. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. (PubMed id 23583980)1 Fingerlin T.E....Schwartz D.A. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64798 HGNC: 22953 AceView: DEPDC6 Ensembl:ENSG00000155792 euGenes: HUgn64798
    ECgene: DEPTOR H-InvDB: DEPTOR

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DEPTOR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DEPTOR gene:
    Search GeneIP for patents involving DEPTOR

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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