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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DEPTOR Gene

protein-coding   GIFtS: 51
GCID: GC08P120886

DEP Domain Containing MTOR-Interacting Protein

(Previous name: DEP domain containing 6)
(Previous symbol: DEPDC6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEP Domain Containing MTOR-Interacting Protein1 2     DEP.62
DEPDC61 2 3 5     DEP Domain Containing MTOR Interacting Protein2
DEP Domain Containing 61 2     DEP Domain-Containing MTOR-Interacting Protein2
DEP Domain-Containing Protein 62 3     

External Ids:    HGNC: 229531   Entrez Gene: 647982   Ensembl: ENSG000001557927   OMIM: 6129745   UniProtKB: Q8TB453   

Export aliases for DEPTOR gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DEPTOR Gene: 
DEPTOR (DEP domain containing MTOR-interacting protein) is a protein-coding gene. Diseases associated with DEPTOR include myeloma, and multiple myeloma, and among its related super-pathways are Development HGF signaling pathway. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45
Function: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both
complexes

Gene Wiki entry for DEPTOR (DEPDC6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DEPTOR
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEPTOR promoter sequence
   Search SABiosciences Chromatin IP Primers for DEPTOR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEPTOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q24.12

DEPTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEPTOR gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P120886:  view genomic region     (about GC identifiers)

Start:
120,885,900 bp from pter      End:
121,063,157 bp from pter
Size:
177,258 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45 (See protein sequence)
Recommended Name: DEP domain-containing mTOR-interacting protein  
Size: 409 amino acids; 46294 Da
Subunit: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR,
AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR,
MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both
mammalian target of rapamycin complexes mTORC1 and mTORC2
Sequence caution: Sequence=BAB14723.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RCL9 Q96EQ1 Q9H0R7 Q9H894 Q9HA07

Explore the universe of human proteins at neXtProt for DEPTOR: NX_Q8TB45

Explore proteomics data for DEPTOR at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TB45

  • DEPTOR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DEPTOR Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269941.1  NP_073620.2  

    ENSEMBL proteins: 
     ENSP00000430457   ENSP00000286234  

    Human Recombinant Protein Products for DEPTOR: 
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    OriGene Protein Over-expression Lysate for DEPTOR
    OriGene MassSpec for DEPTOR 
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    GenScript Custom Purified and Recombinant Proteins Services for DEPTOR
    Novus Biologicals DEPTOR Protein
    Novus Biologicals DEPTOR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    DEPTOR for ontologies           About GeneDecksing



    DEPTOR Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DEPTOR 

    Assay Products for DEPTOR: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR001478 PDZ
     IPR000591 DEP_dom

    Graphical View of Domain Structure for InterPro Entry Q8TB45

    ProtoNet protein and cluster: Q8TB45

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45
    Similarity: Contains 2 DEP domains
    Similarity: Contains 1 PDZ (DHR) domain


    DEPTOR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPTOR_HUMAN, Q8TB45
    Function: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both
    complexes
    Induction: Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19446321
         
    DEPTOR for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DEPTOR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DEPTOR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DEPTOR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DEPTOR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DEPTOR
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate DEPTOR (see all 16):
    hsa-miR-3910 hsa-miR-181c hsa-miR-4272 hsa-miR-1271 hsa-miR-181a hsa-miR-628-3p hsa-miR-181d hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidDEPTOR 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DEPTOR
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    GenScript: all cDNA clones in your preferred vector: DEPTOR (NM_022783)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEPTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPTOR
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                         Customized lentivirus expression plasmids for stable overexpression of DEPTOR 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPTOR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DEPTOR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development HGF signaling pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    2mTOR signaling pathway
    mTOR signaling pathway
    3Akt Signaling Pathway
    Akt Signaling Pathway
    4PI3K / Akt Signaling
    PI3K / Akt Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DEPTOR
        Akt Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for DEPTOR
        PI3K / Akt Signaling

    2 BioSystems Pathways for DEPTOR
        mTOR signaling pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)



    DEPTOR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEPTOR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for DEPTOR (Q8TB451, 3 ENSP000002862344) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTORP423451, 3, ENSP000003545584EBI-2359040,EBI-359260 I2D: score=2 STRING: ENSP00000354558
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    MLST8Q9BVC43, ENSP000003718884I2D: score=1 STRING: ENSP00000371888
    RICTORQ6R3273, ENSP000003499594I2D: score=1 STRING: ENSP00000349959
    RPTORQ8N1223, ENSP000003072724I2D: score=1 STRING: ENSP00000307272
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity IMP19446321
    GO:0032007negative regulation of TOR signaling cascade IMP19446321
    GO:0035556intracellular signal transduction IEA--
    GO:0045792negative regulation of cell size IMP19446321
    GO:2001236regulation of extrinsic apoptotic signaling pathway IMP19446321

    DEPTOR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DEPTOR (DPTOR)

    Search CenterWatch for drugs/clinical trials and news about DEPTOR / DPTOR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DEPTOR gene (2 alternative transcripts): 
    NM_001283012.1  NM_022783.3  

    Unigene Cluster for DEPTOR:

    DEP domain containing MTOR-interacting protein
    Hs.112981  [show with all ESTs]
    Unigene Representative Sequence: NM_022783
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523492 ENST00000286234(uc003yow.4 uc011lid.2) ENST00000518057

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DEPTOR
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate DEPTOR (see all 16):
    hsa-miR-3910 hsa-miR-181c hsa-miR-4272 hsa-miR-1271 hsa-miR-181a hsa-miR-628-3p hsa-miR-181d hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidDEPTOR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEPTOR
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DEPTOR (NM_022783)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEPTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPTOR
    Sirion Biotech Customized lentivirus for stable overexpression of DEPTOR 
                         Customized lentivirus expression plasmids for stable overexpression of DEPTOR 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DEPTOR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEPTOR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEPTOR

    Additional mRNA sequence: 

    AK022490.1 AK023916.1 AK225168.1 AK225675.1 AK297822.1 AK315175.1 AL136678.1 BC012040.1 
    BC024746.1 

    4 DOTS entries:

    DT.109138  DT.121480945  DT.95089526  DT.101975330 

    24/87 AceView cDNA sequences (see all 87):

    AA299911 BM854254 AI805626 BM791387 BM725381 AK023916 AA293513 AU141638 
    CR615062 BI253286 AI344359 BM928150 AA293446 AA574103 CB216685 BQ676812 
    NM_022783 AA863125 CB217146 AI377127 AI758594 AI289654 AA252924 BQ921229 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DEPTOR expression in normal human tissues (normalized intensities)      DEPTOR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGTGTG
    DEPTOR Expression
    About this image


    DEPTOR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Umbilical cord blood-derived hematopoietic stem cells
             lung ; macrophages   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             heart muscle ; myocytes   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             Salivary gland   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See DEPTOR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DEPTOR

    SOURCE GeneReport for Unigene cluster: Hs.112981
        SABiosciences Expression via Pathway-Focused PCR Array including DEPTOR: 
              mTOR Signaling in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPTOR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DEPTOR gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Deptor1 , 5 DEP domain containing MTOR-interacting protein1, 5 89.98(n)1
    96.09(a)1
      15 (21.96 cM)5
    979981  NM_145470.21  NP_663445.21 
     551123175 
    chicken
    (Gallus gallus)
    Aves DEPDC61 DEP domain containing 6 79.97(n)
    89.51(a)
      420357  NM_001199502.1  NP_001186431.1 
    lizard
    (Anolis carolinensis)
    Reptilia DEPTOR6
    --
    --
    85(a)
    68(a)
    1 ↔ 1
    possible ortholog
    GL343269.1(1151324-1225157)
    4(153485000-153517759)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59562 Xenopus laevis transcribed sequence with weak similarity to protein refNP_073620.1 (H.sapiens) hypothetical protein FLJ12428 [Homo sapiens] less 73.3(n)    BJ070062.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.268652 Transcribed sequence with moderate similarity to protein refNP_073620.1 (H.sapiens) hypothetical protein FLJ12428 [Homo sapiens] less 77.56(n)    CF102154.1 


    ENSEMBL Gene Tree for DEPTOR (if available)
    TreeFam Gene Tree for DEPTOR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DEPTOR gene
    1 SIMAP similar gene for DEPTOR using alignment to 2 protein entries:     DPTOR_HUMAN (see all proteins):
    CGEF2

    DEPTOR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3961 SNPs in DEPTOR are shown (see all 3961)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713049321,2
    C,F--116324264(+) TCTTT-/TC/TT 
            
    CTTTC
    1 -- int12NA CSA 4
    rs1380951241,2
    C--120883943(+) AACCAC/TACCTG 1 -- us2k10--------
    rs1508593831,2
    C--120883961(+) ATTTT-/GTGGTTTT 1 -- cds10--------
    rs605947781,2
    C--120883963(+) TTTGT-/GGT/
    TTT
    /TGTT
    TTTTT
    2 -- us2k1 cds10--------
    rs784558231,2
    --120883973(+) TTTTTG/TTAGAG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs69806791,2
    C,F,A--120884031(+) AAGCAG/ATCCTC 1 -- us2k17Minor allele frequency- A:0.38NA WA CSA EA 365
    rs70182861,2
    C,A--120884039(+) CTCCCA/GCCCTA 1 -- us2k15Minor allele frequency- G:0.38WA CSA NA EA 361
    rs70006691,2
    C,F,A,H--120884065(+) GGGATT/CACATT 1 -- us2k112Minor allele frequency- C:0.35NS EA NA WA CSA 783
    rs786831381,2
    F--120884087(+) GCCACG/CCAACA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1426733891,2
    --120884167(+) ATAAGC/GTTGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DEPTOR (120885900 - 121063157 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DEPTOR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678781CNV Deletion23128226
    nsv528705CNV Loss19592680
    nsv891419CNV Loss21882294
    nsv524750CNV Loss19592680
    nsv528628CNV Loss19592680
    nsv891418CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DEPTOR
    DNA2.0 Custom Variant and Variant Library Synthesis for DEPTOR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612974    OMIM disorders: --

    4 diseases for DEPTOR:    About MalaCards
    myeloma    multiple myeloma    thyroiditis    hepatocellular carcinoma


    DEPTOR for disorders           About GeneDecksing


    Export disorders for DEPTOR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DEPTOR gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with DEPTOR)
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    world of online information

    1. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. (PubMed id 19446321)1, 2, 3 Peterson T.R.... Sabatini D.M. (2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. (PubMed id 23563706)1 Meng Z.X....Lin J.D. (2013)
    5. Genome-wide association study identifies multiple susc eptibility loci for pulmonary fibrosis. (PubMed id 23583980)1 Fingerlin T.E....Schwartz D.A. (2013)
    6. DEPTOR ubiquitination and destruction by SCF(b-TrCP). (PubMed id 22454292)1 Wang Z....Wei W. (2012)
    7. Functional characterization of glycine N-methyltransfe rase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma. (PubMed id 22160218)1 Yen C.H....Chen Y.M. (2012)
    8. Placental DEPTOR as a stress sensor during pregnancy. (PubMed id 21992080)1 Mparmpakas D....Karteris E. (2012)
    9. Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
    10. DEPTOR, an mTOR inhibitor, is a physiological substra te of SCF(I^TrCP) E3 ubiquitin ligase and regulates survival and autophagy. (PubMed id 22017876)1 Zhao Y....Sun Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64798 HGNC: 22953 AceView: DEPDC6 Ensembl:ENSG00000155792 euGenes: HUgn64798
    ECgene: DEPTOR H-InvDB: DEPTOR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DEPTOR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DEPTOR gene:
    Search GeneIP for patents involving DEPTOR

    GeneCards and IP:
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