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Aliases for DEPTOR Gene

Aliases for DEPTOR Gene

  • DEP Domain Containing MTOR Interacting Protein 2 3
  • DEP Domain-Containing Protein 6 3 4
  • DEP Domain Containing 6 2 3
  • DEPDC6 3 4
  • DEP Domain-Containing MTOR-Interacting Protein 3
  • DEP Domain Containing MTOR-Interacting Protein 5
  • DEP.6 3

External Ids for DEPTOR Gene

Previous HGNC Symbols for DEPTOR Gene

  • DEPDC6

Previous GeneCards Identifiers for DEPTOR Gene

  • GC08P120886

Summaries for DEPTOR Gene

GeneCards Summary for DEPTOR Gene

DEPTOR (DEP Domain Containing MTOR Interacting Protein) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (KEGG) and Development HGF signaling pathway.

UniProtKB/Swiss-Prot for DEPTOR Gene

  • Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.

Gene Wiki entry for DEPTOR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPTOR Gene

Genomics for DEPTOR Gene

Regulatory Elements for DEPTOR Gene

Enhancers for DEPTOR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F119981 1.3 FANTOM5 Ensembl ENCODE 25.4 +109.0 108993 3.8 PKNOX1 ZNF146 JUN MAX RAD21 E2F1 GATA3 CTBP1 ZNF366 RCOR1 DEPTOR COL14A1 DSCC1 ENSG00000254343 ENSG00000245330 GC08M119936 GC08P120015
GH08F119968 1.1 Ensembl ENCODE 25.3 +100.6 100614 11.1 HDGF PKNOX1 ZFP64 FEZF1 RAD21 RFX5 YY1 ZNF121 HSF1 FOS DEPTOR TAF2 COL14A1 DSCC1 ENSG00000254343 ENSG00000245330 GC08M119936 GC08P120015
GH08F119894 0.8 ENCODE 27.8 +22.1 22108 1.8 ELF3 SOX13 TFAP4 MAX RARA ZNF316 GATA4 HNF4G NR2F6 ZNF652 DEPTOR ENSG00000245330 TAF2 DSCC1 RNA5SP277 GC08M119893 PIR41964
GH08F120082 1.2 Ensembl ENCODE 18.5 +210.0 210018 3.2 PKNOX1 ARID4B SIN3A YY1 ELK1 FOS DEK ZHX2 MIER2 REST DEPTOR ENSG00000254343 DSCC1 TAF2 COL14A1 PIR54850
GH08F119918 1.2 Ensembl ENCODE 17.9 +46.4 46365 2.7 PKNOX1 ARID4B YY1 REST KAT8 NFIL3 ATF4 ETV4 RCOR2 STAT3 DSCC1 DEPTOR ENSG00000245330 PIR41964 GC08M119936
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DEPTOR on UCSC Golden Path with GeneCards custom track

Promoters for DEPTOR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001400047 945 2800 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF143

Genomic Location for DEPTOR Gene

Chromosome:
8
Start:
119,873,655 bp from pter
End:
120,050,918 bp from pter
Size:
177,264 bases
Orientation:
Plus strand

Genomic View for DEPTOR Gene

Genes around DEPTOR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPTOR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPTOR Gene

Proteins for DEPTOR Gene

  • Protein details for DEPTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB45-DPTOR_HUMAN
    Recommended name:
    DEP domain-containing mTOR-interacting protein
    Protein Accession:
    Q8TB45
    Secondary Accessions:
    • B2RCL9
    • B4DN97
    • E7EV87
    • Q96EQ1
    • Q9H0R7
    • Q9H894
    • Q9HA07

    Protein attributes for DEPTOR Gene

    Size:
    409 amino acids
    Molecular mass:
    46294 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2.
    SequenceCaution:
    • Sequence=BAB14723.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DEPTOR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEPTOR Gene

Post-translational modifications for DEPTOR Gene

  • Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPTOR Gene

Antibody Products

  • R&D Systems Antibodies for DEPTOR (DEPTOR/DEPDC6)
  • Cell Signaling Technology (CST) Antibodies for DEPTOR (DEPTOR)
  • Abcam antibodies for DEPTOR

No data available for DME Specific Peptides for DEPTOR Gene

Domains & Families for DEPTOR Gene

Gene Families for DEPTOR Gene

Protein Domains for DEPTOR Gene

Suggested Antigen Peptide Sequences for DEPTOR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TB45

UniProtKB/Swiss-Prot:

DPTOR_HUMAN :
  • Contains 2 DEP domains.
Domain:
  • Contains 2 DEP domains.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with DEPTOR: view

Function for DEPTOR Gene

Molecular function for DEPTOR Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
UniProtKB/Swiss-Prot Induction:
Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level).

Gene Ontology (GO) - Molecular Function for DEPTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19446321
genes like me logo Genes that share ontologies with DEPTOR: view

Phenotypes for DEPTOR Gene

GenomeRNAi human phenotypes for DEPTOR:
genes like me logo Genes that share phenotypes with DEPTOR: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEPTOR Gene

Localization for DEPTOR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEPTOR gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DEPTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DEPTOR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DEPTOR Gene

Pathways & Interactions for DEPTOR Gene

genes like me logo Genes that share pathways with DEPTOR: view

Pathways by source for DEPTOR Gene

1 GeneTex pathway for DEPTOR Gene
1 Cell Signaling Technology pathway for DEPTOR Gene

SIGNOR curated interactions for DEPTOR Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DEPTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IMP 19446321
GO:0032007 negative regulation of TOR signaling IMP 19446321
GO:0035556 intracellular signal transduction IEA --
GO:0045792 negative regulation of cell size IMP 19446321
GO:2001236 regulation of extrinsic apoptotic signaling pathway IMP 19446321
genes like me logo Genes that share ontologies with DEPTOR: view

Drugs & Compounds for DEPTOR Gene

(3) Drugs for DEPTOR Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AZD8055 Pharma inhibitor MTOR inhibitor, Kinase Inhibitors 0
MLN0128 Pharma inhibitor Kinase Inhibitors 0
OSI-027 Pharma inhibitor MTORC1/ mTORC2 inhibitor, Kinase Inhibitors 0
genes like me logo Genes that share compounds with DEPTOR: view

Transcripts for DEPTOR Gene

Unigene Clusters for DEPTOR Gene

DEP domain containing MTOR-interacting protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEPTOR Gene

No ASD Table

Relevant External Links for DEPTOR Gene

GeneLoc Exon Structure for
DEPTOR
ECgene alternative splicing isoforms for
DEPTOR

Expression for DEPTOR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DEPTOR Gene

mRNA differential expression in normal tissues according to GTEx for DEPTOR Gene

This gene is overexpressed in Muscle - Skeletal (x9.7).

Protein differential expression in normal tissues from HIPED for DEPTOR Gene

This gene is overexpressed in Skin (21.5), Bone marrow stromal cell (13.7), and Salivary gland (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DEPTOR Gene



NURSA nuclear receptor signaling pathways regulating expression of DEPTOR Gene:

DEPTOR

SOURCE GeneReport for Unigene cluster for DEPTOR Gene:

Hs.112981
genes like me logo Genes that share expression patterns with DEPTOR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DEPTOR Gene

Orthologs for DEPTOR Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPTOR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEPTOR 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia DEPTOR 34 35
  • 92.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DEPTOR 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Deptor 34
  • 90.42 (n)
oppossum
(Monodelphis domestica)
Mammalia DEPTOR 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Deptor 34 16 35
  • 89.98 (n)
cow
(Bos Taurus)
Mammalia DEPTOR 34 35
  • 87.03 (n)
chicken
(Gallus gallus)
Aves DEPDC6 34 35
  • 80.5 (n)
lizard
(Anolis carolinensis)
Reptilia DEPTOR 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493830 34
  • 74.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5956 34
zebrafish
(Danio rerio)
Actinopterygii deptor 34 35
  • 74.51 (n)
Dr.26865 34
Species where no ortholog for DEPTOR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPTOR Gene

ENSEMBL:
Gene Tree for DEPTOR (if available)
TreeFam:
Gene Tree for DEPTOR (if available)

Paralogs for DEPTOR Gene

(1) SIMAP similar genes for DEPTOR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DEPTOR: view

No data available for Paralogs for DEPTOR Gene

Variants for DEPTOR Gene

Sequence variations from dbSNP and Humsavar for DEPTOR Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086000 -- 119,994,155(+) aaaaa(A/G)aaaaa intron-variant
rs10086797 -- 119,981,583(+) GCCTG(A/G)AAAAG intron-variant
rs10087490 -- 120,042,560(+) GTTGC(C/T)CAGGC intron-variant
rs10087551 -- 120,012,320(+) CCTGG(A/G)TGGTA intron-variant
rs10087605 -- 119,948,809(+) tgaga(C/T)ggagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEPTOR Gene

Variant ID Type Subtype PubMed ID
nsv612111 CNV gain 21841781
nsv528705 CNV loss 19592680
nsv528628 CNV loss 19592680
nsv524750 CNV loss 19592680
nsv1144233 CNV deletion 24896259
nsv1128450 CNV deletion 24896259
nsv1125953 CNV tandem duplication 24896259
nsv1077064 CNV deletion 25765185
nsv1018953 CNV loss 25217958
esv3891474 CNV gain 25118596
esv3572963 CNV loss 25503493
esv3544111 CNV deletion 23714750
esv3418648 CNV insertion 20981092
esv2678781 CNV deletion 23128226
dgv3894n106 CNV deletion 24896259

Variation tolerance for DEPTOR Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.83; 89.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEPTOR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEPTOR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPTOR Gene

Disorders for DEPTOR Gene

Relevant External Links for DEPTOR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEPTOR

No disorders were found for DEPTOR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEPTOR Gene

Publications for DEPTOR Gene

  1. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. (PMID: 19446321) Peterson T.R. … Sabatini D.M. (Cell 2009) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  4. Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. (PMID: 26608079) Rosario F.J. … Jansson T. (Clin. Sci. 2016) 3 64
  5. Cul1 promotes melanoma cell proliferation by promoting DEPTOR degradation and enhancing cap-dependent translation. (PMID: 26717892) Chen L. … Cao Y. (Oncol. Rep. 2016) 3 64

Products for DEPTOR Gene

Sources for DEPTOR Gene

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