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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DEPTOR Gene

protein-coding   GIFtS: 51
GCID: GC08P120886

DEP domain containing MTOR-interacting protein

(Previous name: DEP domain containing 6 )
(Previous symbol: DEPDC6)
 Explore 5 diseases affiliated with
DEPTOR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DEPTOR    

Aliases
for DEPTOR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DEP Domain Containing MTOR-Interacting Protein1 2     DEP Domain-Containing Protein 62 3
DEPDC61 2 3 5     FLJ124281
DEP.61 2     DEP Domain Containing MTOR Interacting Protein2
DEP Domain Containing 61 2     DEP Domain-Containing MTOR-Interacting Protein2

External Ids:    HGNC: 229531   Entrez Gene: 647982   Ensembl: ENSG000001557927   OMIM: 6129745   UniProtKB: Q8TB453   

Export aliases for DEPTOR gene to outside databases


Summaries
for DEPTOR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45
Function: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both
complexes

Gene Wiki entry for DEPTOR (DEPDC6)


Genomic Views
for DEPTOR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DEPTOR
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DEPTOR promoter sequence
   Search SABiosciences Chromatin IP Primers for DEPTOR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEPTOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q24.12

DEPTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEPTOR gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P120886:  view genomic region     (about GC identifiers)

Start:
 120,885,900 bp from pter      End:
 121,063,157 bp from pter
Size:
 177,258 bases      Orientation:
 plus strand

Proteins
for DEPTOR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45 (See protein sequence)
Recommended Name: DEP domain-containing mTOR-interacting protein  
Size: 409 amino acids; 46294 Da
Subunit: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40
and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR,
MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of
rapamycin complexes mTORC1 and mTORC2
Sequence caution: Sequence=BAB14723.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RCL9 Q96EQ1 Q9H0R7 Q9H894 Q9HA07

Explore the universe of human proteins at neXtProt for DEPTOR: NX_Q8TB45

Post-translational modifications:

  • Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TB45

    • DEPTOR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_073620.2  
    ENSEMBL proteins: 
     ENSP00000430457   ENSP00000286234  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: DEPTOR
    OriGene Custom Protein Services for DEPTOR 
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    Novus Biologicals DEPTOR Protein
    Novus Biologicals DEPTOR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DEPTOR

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--


    DEPTOR for ontologies           About GeneDecksing



    DEPTOR Antibody Products: 
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    Uscn ELISAs and CLIAs for DEPTOR

    Protein Domains /
    Families
    for DEPTOR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DEPTOR for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR001478 PDZ
     IPR000591 DEP_dom

    Graphical View of Domain Structure for InterPro Entry Q8TB45

    ProtoNet protein and cluster: Q8TB45

    1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45
    Similarity: Contains 2 DEP domains
    Similarity: Contains 1 PDZ (DHR) domain


    Function
    for DEPTOR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DPTOR_HUMAN, Q8TB45
    Function: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both
    complexes
    Induction: Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DEPTOR
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DEPTOR
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate DEPTOR (see all 16):
    hsa-miR-3910 hsa-miR-181c hsa-miR-4272 hsa-miR-1271 hsa-miR-181a hsa-miR-628-3p hsa-miR-181d hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: DEPTOR 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEPTOR (see all 3)
    OriGene siRNA: DEPTOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEPTOR

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DEPTOR

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEPTOR (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPTOR 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DEPTOR
    Search LifeMap BioReagents cell lines for DEPTOR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPTOR

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19446321


    DEPTOR for ontologies           About GeneDecksing



    Pathways & Interactions
    for DEPTOR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mTOR signaling pathway
    		mTOR signaling pathway1.00
    2PI3K / Akt Signaling
    		PI3K / Akt Signaling1.00
    3Development HGF signaling pathway
    		Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.23

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DEPTOR
        PI3K / Akt Signaling

    2 BioSystems Pathways for DEPTOR 
        Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    mTOR signaling pathway



    DEPTOR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEPTOR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for DEPTOR (Q8TB451, 3 ENSP000002862344) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTORP423451, 3, ENSP000003545584EBI-2359040,EBI-359260 I2D: score=2 STRING: ENSP00000354558
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    MLST8Q9BVC43, ENSP000003718884I2D: score=1 STRING: ENSP00000371888
    RICTORQ6R3273, ENSP000003499594I2D: score=1 STRING: ENSP00000349959
    RPTORQ8N1223, ENSP000003072724I2D: score=1 STRING: ENSP00000307272
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity IMP19446321
    GO:0032007negative regulation of TOR signaling cascade IMP19446321
    GO:0035556intracellular signal transduction IEA--
    GO:0042981regulation of apoptotic process IMP19446321
    GO:0045792negative regulation of cell size IMP19446321


    DEPTOR for ontologies           About GeneDecksing



    Drugs & Compounds
    for DEPTOR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DEPTOR
    Search CenterWatch for drugs/clinical trials and news about DEPTOR / DPTOR 

    Transcripts
    for DEPTOR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DEPTOR gene: 
    NM_022783.2  

    Unigene Cluster for DEPTOR:

    DEP domain containing MTOR-interacting protein
    Hs.112981  [show with all ESTs]
    Unigene Representative Sequence: NM_022783
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523492 ENST00000286234(uc003yow.4 uc011lid.2) ENST00000518057


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DEPTOR
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate DEPTOR (see all 16):
    hsa-miR-3910 hsa-miR-181c hsa-miR-4272 hsa-miR-1271 hsa-miR-181a hsa-miR-628-3p hsa-miR-181d hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: DEPTOR 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEPTOR (see all 3)
    OriGene siRNA: DEPTOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEPTOR
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEPTOR
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    GenScript: all cDNA clones in your preferred vector: DEPTOR (NM_022783)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEPTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPTOR 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEPTOR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DEPTOR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEPTOR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEPTOR

    Additional cDNA sequence: 

    AK022490.1 AK023916.1 AK225168.1 AK225675.1 AK297822.1 AK315175.1 AL136678.1 BC012040.1 
    BC024746.1 

    4 DOTS entries:

    DT.109138  DT.121480945  DT.95089526  DT.101975330 

    24/87 AceView cDNA sequences (see all 87):

    BM725381 AI805626 BM791387 BI253286 AA299911 AK023916 AU141638 CR615062 
    BM854254 AA293513 BM928150 BP343835 BC024746 AL136678 BQ718646 CA405506 
    BQ676812 AI344359 CK904684 AA252924 CB046275 CB216685 F37575 BE873102 

    GeneLoc Exon Structure


    Expression
    for DEPTOR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DEPTOR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATTGTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DEPTOR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DEPTOR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DEPTOR

    SOURCE GeneReport for Unigene cluster: Hs.112981
        SABiosciences Expression via Pathway-Focused PCR Array including DEPTOR: 
              mTOR Signaling in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPTOR

    Orthologs
    for DEPTOR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DEPTOR gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Deptor1 , 5 DEP domain containing MTOR-interacting protein1, 5 89.98(n)1
    96.09(a)1    		   15 (21.96 cM)5
    979981  NM_145470.21  NP_663445.21 
     551123175 
    chicken
    (Gallus gallus)    		 Aves DEPDC61 DEP domain containing 6 79.97(n)
    89.51(a)    		   420357  NM_001199502.1  NP_001186431.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DEPTOR6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343269.1(1165414-1221395)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.59562 Xenopus laevis transcribed sequence with weak similarity more 73.3(n)    BJ070062.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.268652 Transcribed sequence with moderate similarity to protein more 77.56(n)    CF102154.1 


    ENSEMBL Gene Tree for DEPTOR (if available)
    TreeFam Gene Tree for DEPTOR (if available) 

    Paralogs
    for DEPTOR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DEPTOR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3437 NCBI SNPs in DEPTOR are shown (see all 3437)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1380951241,2
    		--120883943(+) AACCAC/TACCTG 1 -- us2k10--------
    rs1508593831,2
    		C,--120883961(+) ATTTT-/GTGGTTTT 1 -- us2k10--------
    rs784558231,2
    		--120883973(+) TTTTTG/TTAGAG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs69806791,2
    		C,F,A,--120884031(+) AAGCAG/ATCCTC 1 -- us2k17Minor allele frequency- A:0.38NA WA CSA EA 365
    rs70182861,2
    		C,A,--120884039(+) CTCCCA/GCCCTA 1 -- us2k15Minor allele frequency- G:0.38WA CSA NA EA 361
    rs70006691,2
    		C,F,A,H,--120884065(+) GGGATT/CACATT 1 -- us2k112Minor allele frequency- C:0.35NS EA NA WA CSA 783
    rs786831381,2
    		F,--120884087(+) GCCACG/CCAACA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1426733891,2
    		--120884167(+) ATAAGC/GTTGCA 1 -- us2k10--------
    rs800138931,2
    		C,F,--120884184(+) GCAAAC/TGACAG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs48709861,2
    		C,F,A,H,--120884318(+) CTGTTG/CAATGA 1 -- us2k115Minor allele frequency- C:0.35NS EA NA WA CSA 915

    HapMap Linkage Disequilibrium report for DEPTOR (120885900 - 121063157 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DEPTOR: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEPTOR
    DNA2.0 Custom Variant and Variant Library Synthesis for DEPTOR

    Disorders / Diseases
    for DEPTOR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DEPTOR for disorders           About GeneDecksing

    OMIM gene information: 612974    OMIM disorders: --

    5 diseases for DEPTOR:    About MalaCards
    multiple myeloma    myeloma    thyroid carcinoma    thyroiditis
    carcinoma


    Export disorders for DEPTOR gene to outside databases

    Publications
    for DEPTOR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DEPTOR gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with DEPTOR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. (PubMed id 19446321)1, 2, 3 Peterson T.R.... Sabatini D.M. (2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. DEPTOR ubiquitination and destruction by SCF(b-TrCP). (PubMed id 22454292)1 Wang Z....Wei W. (2012)
    5. Functional characterization of glycine N-methyltransfe rase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma. (PubMed id 22160218)1 Yen C.H....Chen Y.M. (2012)
    6. Placental DEPTOR as a stress sensor during pregnancy. (PubMed id 21992080)1 Mparmpakas D....Karteris E. (2012)
    7. Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
    8. DEPTOR, an mTOR inhibitor, is a physiological substra te of SCF(I^TrCP) E3 ubiquitin ligase and regulates survival and autophagy. (PubMed id 22017876)1 Zhao Y....Sun Y. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. mTOR drives its own activation via SCF(I^TrCP)-depende nt degradation of the mTOR inhibitor DEPTOR. (PubMed id 22017875)1 Gao D....Wei W. (2011)

    External Searches for DEPTOR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DEPTOR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64798 HGNC: 22953 AceView: DEPDC6 Ensembl:ENSG00000155792 euGenes: HUgn64798
    ECgene: DEPTOR H-InvDB: DEPTOR

    Other Databases showing DEPTOR gene

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    Specialized Databases showing DEPTOR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DEPTOR Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    IP news from LifeMap Sciences, Inc.)
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