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Aliases for DEPTOR Gene

Aliases for DEPTOR Gene

  • DEP Domain Containing MTOR-Interacting Protein 2 3 5
  • DEP Domain-Containing Protein 6 3 4
  • DEP Domain Containing 6 2 3
  • DEPDC6 3 4
  • DEP Domain Containing MTOR Interacting Protein 3
  • DEP.6 3

External Ids for DEPTOR Gene

Previous HGNC Symbols for DEPTOR Gene

  • DEPDC6

Previous GeneCards Identifiers for DEPTOR Gene

  • GC08P120886

Summaries for DEPTOR Gene

GeneCards Summary for DEPTOR Gene

DEPTOR (DEP Domain Containing MTOR-Interacting Protein) is a Protein Coding gene. Among its related pathways are p53 Pathway (RnD) and Akt Signaling Pathway.

UniProtKB/Swiss-Prot for DEPTOR Gene

  • Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.

Gene Wiki entry for DEPTOR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPTOR Gene

Genomics for DEPTOR Gene

Regulatory Elements for DEPTOR Gene

Promoters for DEPTOR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DEPTOR on UCSC Golden Path with GeneCards custom track

Genomic Location for DEPTOR Gene

Chromosome:
8
Start:
119,873,655 bp from pter
End:
120,050,918 bp from pter
Size:
177,264 bases
Orientation:
Plus strand

Genomic View for DEPTOR Gene

Genes around DEPTOR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPTOR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPTOR Gene

Proteins for DEPTOR Gene

  • Protein details for DEPTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB45-DPTOR_HUMAN
    Recommended name:
    DEP domain-containing mTOR-interacting protein
    Protein Accession:
    Q8TB45
    Secondary Accessions:
    • B2RCL9
    • B4DN97
    • E7EV87
    • Q96EQ1
    • Q9H0R7
    • Q9H894
    • Q9HA07

    Protein attributes for DEPTOR Gene

    Size:
    409 amino acids
    Molecular mass:
    46294 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2.
    SequenceCaution:
    • Sequence=BAB14723.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DEPTOR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEPTOR Gene

Proteomics data for DEPTOR Gene at MOPED

Post-translational modifications for DEPTOR Gene

  • Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPTOR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for DEPTOR (DEPTOR/DEPDC6)
  • Cell Signaling Technology (CST) Antibodies for DEPTOR (DEPTOR)

No data available for DME Specific Peptides for DEPTOR Gene

Domains & Families for DEPTOR Gene

Gene Families for DEPTOR Gene

Protein Domains for DEPTOR Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DEPTOR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TB45

UniProtKB/Swiss-Prot:

DPTOR_HUMAN :
  • Contains 2 DEP domains.
Domain:
  • Contains 2 DEP domains.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with DEPTOR: view

Function for DEPTOR Gene

Molecular function for DEPTOR Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
UniProtKB/Swiss-Prot Induction:
Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level).

Phenotypes for DEPTOR Gene

GenomeRNAi human phenotypes for DEPTOR:
genes like me logo Genes that share phenotypes with DEPTOR: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEPTOR Gene

Localization for DEPTOR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEPTOR Gene COMPARTMENTS Subcellular localization image for DEPTOR gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEPTOR Gene

Pathways & Interactions for DEPTOR Gene

genes like me logo Genes that share pathways with DEPTOR: view

Pathways by source for DEPTOR Gene

SIGNOR curated interactions for DEPTOR Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DEPTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032007 negative regulation of TOR signaling IMP 19446321
GO:0045792 negative regulation of cell size IMP 19446321
GO:2001236 regulation of extrinsic apoptotic signaling pathway IMP 19446321
genes like me logo Genes that share ontologies with DEPTOR: view

Drugs & Compounds for DEPTOR Gene

(3) Drugs for DEPTOR Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AZD8055 Pharma inhibitor MTOR inhibitor, Kinase Inhibitors 0
MLN0128 Pharma inhibitor Kinase Inhibitors 0
OSI-027 Pharma inhibitor MTORC1/ mTORC2 inhibitor, Kinase Inhibitors 0
genes like me logo Genes that share compounds with DEPTOR: view

Transcripts for DEPTOR Gene

Unigene Clusters for DEPTOR Gene

DEP domain containing MTOR-interacting protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEPTOR Gene

No ASD Table

Relevant External Links for DEPTOR Gene

GeneLoc Exon Structure for
DEPTOR
ECgene alternative splicing isoforms for
DEPTOR

Expression for DEPTOR Gene

mRNA expression in normal human tissues for DEPTOR Gene

mRNA differential expression in normal tissues according to GTEx for DEPTOR Gene

This gene is overexpressed in Muscle - Skeletal (x9.7).

Protein differential expression in normal tissues from HIPED for DEPTOR Gene

This gene is overexpressed in Skin (21.5), Bone marrow stromal cell (13.7), and Salivary gland (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DEPTOR Gene



SOURCE GeneReport for Unigene cluster for DEPTOR Gene Hs.112981

genes like me logo Genes that share expression patterns with DEPTOR: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DEPTOR Gene

Orthologs for DEPTOR Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPTOR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DEPTOR 35
  • 87.03 (n)
  • 94.32 (a)
DEPTOR 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DEPTOR 35
  • 92.79 (n)
  • 98.77 (a)
DEPTOR 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Deptor 35
  • 89.98 (n)
  • 96.09 (a)
Deptor 16
Deptor 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DEPTOR 35
  • 99.84 (n)
  • 100 (a)
DEPTOR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Deptor 35
  • 90.42 (n)
  • 99.19 (a)
oppossum
(Monodelphis domestica)
Mammalia DEPTOR 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DEPTOR 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves DEPDC6 35
  • 80.5 (n)
  • 90.6 (a)
DEPDC6 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DEPTOR 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493830 35
  • 74.74 (n)
  • 82.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5956 35
zebrafish
(Danio rerio)
Actinopterygii deptor 35
  • 74.51 (n)
  • 80.29 (a)
Dr.26865 35
deptor 36
  • 75 (a)
OneToOne
Species with no ortholog for DEPTOR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPTOR Gene

ENSEMBL:
Gene Tree for DEPTOR (if available)
TreeFam:
Gene Tree for DEPTOR (if available)

Paralogs for DEPTOR Gene

(1) SIMAP similar genes for DEPTOR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DEPTOR: view

No data available for Paralogs for DEPTOR Gene

Variants for DEPTOR Gene

Sequence variations from dbSNP and Humsavar for DEPTOR Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs34057546 - 119,965,249(+) TGAAA(A/G)CACAC reference, missense
rs2271900 - 120,001,531(+) GTCCA(A/G)CAAGC reference, missense
rs4871827 - 120,049,640(+) CGTGA(A/G)CAATC reference, missense
rs939241 -- 119,912,297(-) GTGTG(C/T)ATGCC intron-variant
rs939242 -- 119,912,030(-) TTAAT(C/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEPTOR Gene

Variant ID Type Subtype PubMed ID
nsv891418 CNV Gain 21882294
esv2678781 CNV Deletion 23128226
nsv524750 CNV Loss 19592680
nsv891419 CNV Loss 21882294
nsv528705 CNV Loss 19592680
nsv528628 CNV Loss 19592680

Variation tolerance for DEPTOR Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.83; 89.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEPTOR Gene

HapMap Linkage Disequilibrium report
DEPTOR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPTOR Gene

Disorders for DEPTOR Gene

Relevant External Links for DEPTOR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEPTOR

No disorders were found for DEPTOR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEPTOR Gene

Publications for DEPTOR Gene

  1. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. (PMID: 19446321) Peterson T.R. … Sabatini D.M. (Cell 2009) 2 3 4 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR. (PMID: 25605718) Verma R. … Marchese A. (J. Biol. Chem. 2015) 3
  4. DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells. (PMID: 25843797) Obara A. … Inagaki N. (Biochem. Biophys. Res. Commun. 2015) 3
  5. Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid. (PMID: 25936805) Yoon M.S. … Chen J. (Mol. Cell 2015) 3

Products for DEPTOR Gene

Sources for DEPTOR Gene

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