Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DEPDC7 Gene

Aliases for DEPDC7 Gene

  • DEP Domain Containing 7 2 3 5
  • DJ85M6.4 (Novel 58.3 KDA Protein) 3
  • Novel 58.3 KDA Protein 3
  • Protein TR2/D15 4
  • DJ85M6.4 3
  • TR2 3

External Ids for DEPDC7 Gene

Previous GeneCards Identifiers for DEPDC7 Gene

  • GC11P032732

Summaries for DEPDC7 Gene

GeneCards Summary for DEPDC7 Gene

DEPDC7 (DEP Domain Containing 7) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. An important paralog of this gene is DEPDC1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPDC7 Gene

Genomics for DEPDC7 Gene

Regulatory Elements for DEPDC7 Gene

Enhancers for DEPDC7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DEPDC7 on UCSC Golden Path with GeneCards custom track

Promoters for DEPDC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DEPDC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for DEPDC7 Gene

Chromosome:
11
Start:
33,015,864 bp from pter
End:
33,033,582 bp from pter
Size:
17,719 bases
Orientation:
Plus strand

Genomic View for DEPDC7 Gene

Genes around DEPDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPDC7 Gene

Proteins for DEPDC7 Gene

  • Protein details for DEPDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QD5-DEPD7_HUMAN
    Recommended name:
    DEP domain-containing protein 7
    Protein Accession:
    Q96QD5
    Secondary Accessions:
    • G5E941
    • Q8N602
    • Q8NCU9
    • Q9UGK5

    Protein attributes for DEPDC7 Gene

    Size:
    511 amino acids
    Molecular mass:
    58310 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM22871.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DEPDC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEPDC7 Gene

Proteomics data for DEPDC7 Gene at MOPED

Post-translational modifications for DEPDC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPDC7 Gene

No data available for DME Specific Peptides for DEPDC7 Gene

Domains & Families for DEPDC7 Gene

Protein Domains for DEPDC7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEPDC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QD5

UniProtKB/Swiss-Prot:

DEPD7_HUMAN :
  • Contains 1 DEP domain.
  • Belongs to the DEPDC7 family.
Domain:
  • Contains 1 DEP domain.
Family:
  • Belongs to the DEPDC7 family.
genes like me logo Genes that share domains with DEPDC7: view

No data available for Gene Families for DEPDC7 Gene

Function for DEPDC7 Gene

genes like me logo Genes that share phenotypes with DEPDC7: view

Animal Model Products

miRNA for DEPDC7 Gene

miRTarBase miRNAs that target DEPDC7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEPDC7 Gene

Localization for DEPDC7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEPDC7 Gene COMPARTMENTS Subcellular localization image for DEPDC7 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DEPDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DEPDC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DEPDC7 Gene

Pathways & Interactions for DEPDC7 Gene

genes like me logo Genes that share pathways with DEPDC7: view

Pathways by source for DEPDC7 Gene

3 Reactome pathways for DEPDC7 Gene

Gene Ontology (GO) - Biological Process for DEPDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with DEPDC7: view

No data available for SIGNOR curated interactions for DEPDC7 Gene

Drugs & Compounds for DEPDC7 Gene

No Compound Related Data Available

Transcripts for DEPDC7 Gene

Unigene Clusters for DEPDC7 Gene

DEP domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEPDC7 Gene

No ASD Table

Relevant External Links for DEPDC7 Gene

GeneLoc Exon Structure for
DEPDC7
ECgene alternative splicing isoforms for
DEPDC7

Expression for DEPDC7 Gene

mRNA expression in normal human tissues for DEPDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DEPDC7 Gene

This gene is overexpressed in Liver (x15.2) and Testis (x5.3).

Protein differential expression in normal tissues from HIPED for DEPDC7 Gene

This gene is overexpressed in Testis (60.7) and Serum (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DEPDC7 Gene



SOURCE GeneReport for Unigene cluster for DEPDC7 Gene Hs.280990

mRNA Expression by UniProt/SwissProt for DEPDC7 Gene

Q96QD5-DEPD7_HUMAN
Tissue specificity: Expressed in liver.
genes like me logo Genes that share expression patterns with DEPDC7: view

Protein tissue co-expression partners for DEPDC7 Gene

Primer Products

In Situ Assay Products

Orthologs for DEPDC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPDC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DEPDC7 35
  • 90.61 (n)
  • 89.82 (a)
DEPDC7 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DEPDC7 35
  • 90.98 (n)
  • 91.96 (a)
DEPDC7 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Depdc7 35
  • 84.93 (n)
  • 87.08 (a)
Depdc7 16
Depdc7 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DEPDC7 35
  • 99.61 (n)
  • 99.61 (a)
DEPDC7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Depdc7 35
  • 85.4 (n)
  • 88.41 (a)
oppossum
(Monodelphis domestica)
Mammalia DEPDC7 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DEPDC7 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves DEPDC7 35
  • 71.57 (n)
  • 71.18 (a)
DEPDC7 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DEPDC7 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia depdc7 35
  • 64.16 (n)
  • 65.02 (a)
Str.6544 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25329 35
zebrafish
(Danio rerio)
Actinopterygii depdc7 35
  • 58.02 (n)
  • 53.29 (a)
wufe36f02 35
depdc7 36
  • 50 (a)
OneToMany
DEPDC7 (1 of 2) 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for DEPDC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPDC7 Gene

ENSEMBL:
Gene Tree for DEPDC7 (if available)
TreeFam:
Gene Tree for DEPDC7 (if available)

Paralogs for DEPDC7 Gene

Paralogs for DEPDC7 Gene

(1) SIMAP similar genes for DEPDC7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DEPDC7 Gene

genes like me logo Genes that share paralogs with DEPDC7: view

Variants for DEPDC7 Gene

Sequence variations from dbSNP and Humsavar for DEPDC7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs34161108 - 33,027,795(-) GGTTG(C/T)AGAGA reference, missense
rs17852859 - 33,033,310(+) CAATA(C/T)AGAGA reference, missense
rs966191 -- 33,031,561(-) TGAAC(A/G)TCAGA reference, synonymous-codon
rs1059432 -- 33,033,532(+) GTAAG(C/T)GTGGA utr-variant-3-prime
rs1884925 -- 33,027,490(+) AAAAT(A/G)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEPDC7 Gene

Variant ID Type Subtype PubMed ID
essv7540 CNV CNV 17122850
dgv1065n71 CNV Gain 21882294
esv24235 CNV Gain 19812545

Variation tolerance for DEPDC7 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEPDC7 Gene

HapMap Linkage Disequilibrium report
DEPDC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPDC7 Gene

Disorders for DEPDC7 Gene

Relevant External Links for DEPDC7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEPDC7

No disorders were found for DEPDC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEPDC7 Gene

Publications for DEPDC7 Gene

  1. A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. (PMID: 10568747) Gawin B. … Gessler M. (Genome Res. 1999) 2 3 4 67
  2. Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins. (PMID: 25952135) CA^rdova-Palomera A. … FaA+anA!s L. (Eur. Psychiatry 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-I_B activation. (PMID: 25541973) D'Andrea E.L. … Stilo R. (PLoS ONE 2014) 3

Products for DEPDC7 Gene

Sources for DEPDC7 Gene

Content