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Aliases for DEPDC7 Gene

Aliases for DEPDC7 Gene

  • DEP Domain Containing 7 2 3
  • TR2 3 6
  • DJ85M6.4 (Novel 58.3 KDA Protein) 3
  • DEP Domain-Containing Protein 7 3
  • Novel 58.3 KDA Protein 3
  • Protein TR2/D15 4
  • DJ85M6.4 3

External Ids for DEPDC7 Gene

Summaries for DEPDC7 Gene

GeneCards Summary for DEPDC7 Gene

DEPDC7 (DEP Domain Containing 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. An important paralog of this gene is DEPDC1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPDC7 Gene

Genomics for DEPDC7 Gene

Genomic Location for DEPDC7 Gene

Start:
33,015,864 bp from pter
End:
33,033,582 bp from pter
Size:
17,719 bases
Orientation:
Plus strand

Genomic View for DEPDC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEPDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPDC7 Gene

Regulatory Elements for DEPDC7 Gene

Proteins for DEPDC7 Gene

  • Protein details for DEPDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QD5-DEPD7_HUMAN
    Recommended name:
    DEP domain-containing protein 7
    Protein Accession:
    Q96QD5
    Secondary Accessions:
    • G5E941
    • Q8N602
    • Q8NCU9
    • Q9UGK5

    Protein attributes for DEPDC7 Gene

    Size:
    511 amino acids
    Molecular mass:
    58310 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM22871.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DEPDC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEPDC7 Gene

Proteomics data for DEPDC7 Gene at MOPED

Post-translational modifications for DEPDC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPDC7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEPDC7 Gene

Domains for DEPDC7 Gene

Protein Domains for DEPDC7 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DEPD7_HUMAN
Domain:
  • Contains 1 DEP domain.:
    • Q96QD5
Family:
  • Belongs to the DEPDC7 family.:
    • Q96QD5
genes like me logo Genes that share domains with DEPDC7: view

No data available for Gene Families for DEPDC7 Gene

Function for DEPDC7 Gene

Gene Ontology (GO) - Molecular Function for DEPDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DEPDC7: view

miRNA for DEPDC7 Gene

miRTarBase miRNAs that target DEPDC7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DEPDC7 Gene

Localization for DEPDC7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEPDC7 Gene COMPARTMENTS Subcellular localization image for DEPDC7 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DEPDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DEPDC7: view

Pathways for DEPDC7 Gene

genes like me logo Genes that share pathways with DEPDC7: view

Pathways by source for DEPDC7 Gene

3 Reactome pathways for DEPDC7 Gene

Gene Ontology (GO) - Biological Process for DEPDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008150 biological_process ND --
GO:0035556 intracellular signal transduction --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with DEPDC7: view

Transcripts for DEPDC7 Gene

Unigene Clusters for DEPDC7 Gene

DEP domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEPDC7 Gene

No ASD Table

Relevant External Links for DEPDC7 Gene

GeneLoc Exon Structure for
DEPDC7
ECgene alternative splicing isoforms for
DEPDC7

Expression for DEPDC7 Gene

mRNA expression in normal human tissues for DEPDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DEPDC7 Gene

This gene is overexpressed in Liver (15.2) and Testis (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DEPDC7 Gene

SOURCE GeneReport for Unigene cluster for DEPDC7 Gene Hs.280990

mRNA Expression by UniProt/SwissProt for DEPDC7 Gene

Q96QD5-DEPD7_HUMAN
Tissue specificity: Expressed in liver.
genes like me logo Genes that share expressions with DEPDC7: view

Orthologs for DEPDC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPDC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEPDC7 36
  • 99.61 (n)
  • 99.61 (a)
DEPDC7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DEPDC7 36
  • 90.61 (n)
  • 89.82 (a)
DEPDC7 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DEPDC7 36
  • 90.98 (n)
  • 91.96 (a)
DEPDC7 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Depdc7 36
  • 84.93 (n)
  • 87.08 (a)
Depdc7 16
Depdc7 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DEPDC7 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DEPDC7 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Depdc7 36
  • 85.4 (n)
  • 88.41 (a)
chicken
(Gallus gallus)
Aves DEPDC7 36
  • 71.57 (n)
  • 71.18 (a)
DEPDC7 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DEPDC7 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25329 36
tropical clawed frog
(Silurana tropicalis)
Amphibia depdc7 36
  • 64.16 (n)
  • 65.02 (a)
Str.6544 36
zebrafish
(Danio rerio)
Actinopterygii depdc7 36
  • 58.02 (n)
  • 53.29 (a)
depdc7 37
  • 50 (a)
OneToMany
DEPDC7 (1 of 2) 37
  • 39 (a)
OneToMany
wufe36f02 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToMany
Species with no ortholog for DEPDC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPDC7 Gene

ENSEMBL:
Gene Tree for DEPDC7 (if available)
TreeFam:
Gene Tree for DEPDC7 (if available)

Paralogs for DEPDC7 Gene

Paralogs for DEPDC7 Gene

Selected SIMAP similar genes for DEPDC7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DEPDC7 Gene

genes like me logo Genes that share paralogs with DEPDC7: view

Variants for DEPDC7 Gene

Sequence variations from dbSNP and Humsavar for DEPDC7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs966191 -- 33,031,561(-) TGAAC(A/G)TCAGA reference, synonymous-codon
rs1059432 -- 33,033,532(+) GTAAG(C/T)GTGGA utr-variant-3-prime
rs1884925 -- 33,027,490(+) AAAAT(A/G)TTCAA intron-variant
rs2273536 -- 33,033,016(+) TTCAG(A/G)TGTTT intron-variant
rs2273537 -- 33,033,050(+) AGTTG(A/G)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEPDC7 Gene

Variant ID Type Subtype PubMed ID
essv7540 CNV CNV 17122850
dgv1065n71 CNV Gain 21882294
esv24235 CNV Gain 19812545

Relevant External Links for DEPDC7 Gene

HapMap Linkage Disequilibrium report
DEPDC7

Disorders for DEPDC7 Gene

No disorders were found for DEPDC7 Gene.

No data available for UniProtKB/Swiss-Prot for DEPDC7 Gene

Publications for DEPDC7 Gene

  1. A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. (PMID: 10568747) Gawin B. … Gessler M. (Genome Res. 1999) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. (PMID: 16009940) Zhao C. … Krug R.M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3
  4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PMID: 21987572) Lee K.A. … Doedens J.R. (J. Biol. Chem. 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for DEPDC7 Gene

Sources for DEPDC7 Gene

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