DEPDC7 Gene
protein-coding GIFtS : 48
GCID: GC11 P032996
DEP domain containing 7
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Aliasesfor DEPDC7 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases DEP Domain Containing 7 1 2 DJ85M6.4 (Novel 58.3 KDA Protein)2 TR22 5 Novel 58.3 KDA Protein2 DJ85M6.41 Protein TR2/D153 DEP Domain-Containing Protein 72
Export aliases for DEPDC7 gene to outside databases Previous GC identifer: GC11P032732
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Summariesfor DEPDC7 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor DEPDC7 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DEPDC7 gene promoter: AREB6 STAT1 PPAR-gamma1 FOXO4 PPAR-gamma2 AP-2gamma Other transcription factors Search SABiosciences Chromatin IP Primers for DEPDC7 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DEPDC7
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13 DEPDC7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P032996: view genomic region
(about GC identifiers )
Start:
33,037,410 bp from pter
End:
33,055,128 bp from pter
Size:
17,719 bases
Orientation:
plus strand
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Proteinsfor DEPDC7 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DEPD7_HUMAN, Q96QD5 (See
protein sequence )Recommended Name: DEP domain-containing protein 7 Size : 511 amino acids; 58310 Da
Secondary accessions : Q8N602 Q8NCU9 Q9UGK5Alternative splicing : 2 isoforms : Q96QD5-1 Q96QD5-2 Explore the universe of human proteins at neXtProt for DEPDC7: NX_Q96QD5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96QD5 DEPDC7 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001070710.1 NP_631899.2 ENSEMBL proteins: ENSP00000241051 ENSP00000308971 Reactome Protein details: Q96QD5 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
DEPDC7 for ontologies About GeneDecksing DEPDC7 Antibody Products: Assay Products for DEPDC7:
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Protein
Domains / Familiesfor DEPDC7 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DEPDC7 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96QD5 ProtoNet protein and cluster: Q96QD5
UniProtKB/Swiss-Prot: DEPD7_HUMAN, Q96QD5 Similarity : Belongs to the DEPDC7 familySimilarity : Contains 1 DEP domain
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Functionfor DEPDC7 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DEPDC7 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DEPDC7 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): DEPDC7 (NM_001077242 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEPDC7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DEPDC7
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPDC7
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
DEPDC7 for ontologies About GeneDecksing
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Pathways & Interactionsfor DEPDC7 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cell death signalling via NRAGE, NRIF and NADE 2 Signaling by GPCR
Pathway sources See GeneCards unified pathways Show all pathways 3
Reactome Pathways for DEPDC7
DEPDC7 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEPDC7 STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)5/741 Interacting proteins for DEPDC7 (Q96QD5 2 , 3 ENSP00000241051 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 741 )About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007264 small GTPase mediated signal transduction
TAS -- GO:0008150 biological_process
ND -- GO:0035556 intracellular signal transduction
-- -- GO:0051056 regulation of small GTPase mediated signal transduction
TAS --
DEPDC7 for ontologies About GeneDecksing
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Drugs & Compoundsfor DEPDC7 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DEPDC7 Search CenterWatch for drugs/clinical trials and news about DEPDC7 / DEPD7
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Transcriptsfor DEPDC7 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DEPDC7 gene (2 alternative transcripts): NM_001077242.1 NM_139160.2 Unigene Cluster for DEPDC7:
DEP domain containing 7 Hs.280990 [show with all ESTs ] Unigene Representative Sequence: AF447588 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000241051 (uc001mub.3 ) ENST00000427755 (uc010reg.1 ) ENST00000532078 (uc010reh.1 )ENST00000311388 (uc001muc.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DEPDC7 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DEPDC7 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): DEPDC7 (NM_001077242 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEPDC7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DEPDC7
Additional cDNA sequence: AF447588.1 AJ245600.1 AK294934.1 AK295960.1 BC011446.1 BC030970.1
3 DOTS entries : DT.100744593 DT.211132
DT.92028938 24/46 AceView cDNA sequences (see all 46 ):
BI832965 BC011446 AA721670 AJ245600 CR590754 CB161574 BX118181 N48602 AA744629 CR610553 BU178586 CD300610 AI470591 AA766064 AW665379 AW236101 AA663008 BI829885 AA210949 AA744628 AW665985 AF447588 AI796282 AI699380 GeneLoc Exon Structure
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Expression for DEPDC7 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DEPDC7 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCTGTTGCAG
About this image DEPDC7 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See DEPDC7 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DEPDC7 SOURCE GeneReport for Unigene cluster: Hs.280990 UniProtKB/Swiss-Prot: DEPD7_HUMAN, Q96QD5 Tissue specificity : Expressed in liver SABiosciences Custom PCR Arrays for DEPDC7 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DEPDC7Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DEPDC7 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DEPDC7 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DEPDC7 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPDC7
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Orthologsfor DEPDC7 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for DEPDC7 gene from 4/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
DEPDC71
DEP domain containing 7
71.57(n) 71.18(a)
 
421593 NM_001199406.1 NP_001186335.1
lizard (Anolis carolinensis)
Reptilia
DEPDC76
--
64(a)
1 ↔ 1
1(61452029-61471821)
African clawed frog (Xenopus laevis)
Amphibia
Xl.253292
Xenopus laevis transcribed sequence with weak similarity more
72.48(n)
 
CA974437.1
zebrafish (Danio rerio)
Actinopterygii
wufe36f022
Transcribed sequence with weak similarity to protein more
71.55(n)
 
57061697
ENSEMBL Gene Tree for DEPDC7 (if available)TreeFam Gene Tree for DEPDC7 (if available)
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Paralogsfor DEPDC7 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DEPDC7 gene DEPDC4 2 DEPDC1B 2 DEPDC1 2 1 SIMAP similar gene for DEPDC7 using alignment to 2 protein entries: DEPD7_HUMAN (see all proteins ):DEPDC4
DEPDC7 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for DEPDC7 PGOHUM00000248658
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Genomic Variantsfor DEPDC7 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DEPDC7 (33037410 - 33055128 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for DEPDC7 4 CNVs : 85716 71303 3843 85717
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DEPDC7
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Disorders
/ Diseasesfor DEPDC7 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DEPDC7 for disorders About MalaCards
DEPDC7 for disorders About GeneDecksing
OMIM gene information: 612294
OMIM disorders : --Export disorders for DEPDC7 gene to outside databases
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Publicationsfor DEPDC7 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DEPDC7 gene integrated from 9 sources : (articles sorted by number of sources associating them with DEPDC7) Utopia : connect your pdf to the dynamic world of online information
A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. (PubMed id 10568747) 1 , 2 , 3 Gawin B....Gessler M. (1999) Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572) 1 Lee K.A....Doedens J.R. (2011) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811) 2 Taylor T.D....Sakaki Y. (2006) Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. (PubMed id 16009940) 1 Zhao C.... Krug R.M. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DEPDC7 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DEPDC7 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DEPDC7 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DEPDC7 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DEPDC7 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DEPDC7 gene: Search GeneIP for patents involving DEPDC7 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DEPDC7 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DEPDC7 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DEPDC7 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DEPDC7 OriGene Protein Over-expression Lysate for DEPDC7 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DEPDC7 OriGene 3'-UTR Clone for DEPDC7 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DEPDC7 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DEPDC7 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for DEPDC7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DEPDC7 OriGene Custom Protein Services for DEPDC7 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DEPDC7 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DEPDC7 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DEPDC7 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DEPDC7 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DEPDC7 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DEPDC7
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DEPDC7 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPDC7
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DEPDC7
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Aliases for DEPDC7
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