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Aliases for DEPDC4 Gene

Aliases for DEPDC4 Gene

  • DEP Domain Containing 4 2 3 5
  • DEP.4 3

External Ids for DEPDC4 Gene

Previous GeneCards Identifiers for DEPDC4 Gene

  • GC12M099100
  • GC12M099101
  • GC12M100597
  • GC12M097707

Summaries for DEPDC4 Gene

GeneCards Summary for DEPDC4 Gene

DEPDC4 (DEP Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is DEPDC1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPDC4 Gene

Genomics for DEPDC4 Gene

Regulatory Elements for DEPDC4 Gene

Promoters for DEPDC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DEPDC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for DEPDC4 Gene

100,203,669 bp from pter
100,267,172 bp from pter
63,504 bases
Minus strand

Genomic View for DEPDC4 Gene

Genes around DEPDC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPDC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPDC4 Gene

Proteins for DEPDC4 Gene

  • Protein details for DEPDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DEP domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q496C8
    • Q96BW0

    Protein attributes for DEPDC4 Gene

    294 amino acids
    Molecular mass:
    33694 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DEPDC4 Gene


neXtProt entry for DEPDC4 Gene

Proteomics data for DEPDC4 Gene at MOPED

Post-translational modifications for DEPDC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DEPDC4 Gene

Domains & Families for DEPDC4 Gene

Protein Domains for DEPDC4 Gene


Suggested Antigen Peptide Sequences for DEPDC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DEP domain.
  • Contains 1 DEP domain.
genes like me logo Genes that share domains with DEPDC4: view

No data available for Gene Families for DEPDC4 Gene

Function for DEPDC4 Gene

Phenotypes for DEPDC4 Gene

genes like me logo Genes that share phenotypes with DEPDC4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DEPDC4 Gene

Localization for DEPDC4 Gene

Subcellular locations from

Jensen Localization Image for DEPDC4 Gene COMPARTMENTS Subcellular localization image for DEPDC4 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEPDC4 Gene

Pathways & Interactions for DEPDC4 Gene

SuperPathways for DEPDC4 Gene

No Data Available

Interacting Proteins for DEPDC4 Gene

Gene Ontology (GO) - Biological Process for DEPDC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for DEPDC4 Gene

Drugs & Compounds for DEPDC4 Gene

No Compound Related Data Available

Transcripts for DEPDC4 Gene

mRNA/cDNA for DEPDC4 Gene

Unigene Clusters for DEPDC4 Gene

DEP domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEPDC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -

Relevant External Links for DEPDC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEPDC4 Gene

mRNA expression in normal human tissues for DEPDC4 Gene

mRNA differential expression in normal tissues according to GTEx for DEPDC4 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for DEPDC4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DEPDC4 Gene

SOURCE GeneReport for Unigene cluster for DEPDC4 Gene Hs.653118

genes like me logo Genes that share expression patterns with DEPDC4: view

Protein tissue co-expression partners for DEPDC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DEPDC4 Gene

Orthologs for DEPDC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPDC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEPDC4 35
  • 96.77 (n)
  • 96.89 (a)
  • 95 (a)
(Monodelphis domestica)
Mammalia DEPDC4 36
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia DEPDC4 36
  • 25 (a)
(Danio rerio)
Actinopterygii DEPDC4 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
Species with no ortholog for DEPDC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPDC4 Gene

Gene Tree for DEPDC4 (if available)
Gene Tree for DEPDC4 (if available)

Paralogs for DEPDC4 Gene

Paralogs for DEPDC4 Gene

(1) SIMAP similar genes for DEPDC4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DEPDC4: view

Variants for DEPDC4 Gene

Sequence variations from dbSNP and Humsavar for DEPDC4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7307415 - 100,263,686(+) AAAGA(C/T)GAACC intron-variant, nc-transcript-variant, reference, missense
rs723104 -- 100,256,658(-) TCTCA(A/G)AAAAA intron-variant
rs1896575 -- 100,259,692(-) aaaag(A/G)gaaaa intron-variant
rs2363701 -- 100,231,108(-) gtggc(A/G)ggcgc intron-variant
rs3054280 -- 100,257,976(-) CTATC(-/TATCTATCTATC)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEPDC4 Gene

Variant ID Type Subtype PubMed ID
esv2746276 CNV Deletion 23290073

Variation tolerance for DEPDC4 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEPDC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPDC4 Gene

Disorders for DEPDC4 Gene

Relevant External Links for DEPDC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DEPDC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEPDC4 Gene

Publications for DEPDC4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2. (PMID: 23422819) Hawthorne F. … Young T.L. (Invest. Ophthalmol. Vis. Sci. 2013) 3
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3

Products for DEPDC4 Gene

Sources for DEPDC4 Gene

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