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Aliases for DEPDC1B Gene

Aliases for DEPDC1B Gene

  • DEP Domain Containing 1B 2 3 5
  • HBV X-Transactivated Gene 8 Protein 3 4
  • HBV XAg-Transactivated Protein 8 3 4
  • Breast Cancer Cell 3 2 3
  • DEP Domain-Containing Protein 1B 3
  • HBxAg Transactivated Protein 1 3
  • BRCC3 3
  • XTP1 3
  • XTP8 4

External Ids for DEPDC1B Gene

Previous GeneCards Identifiers for DEPDC1B Gene

  • GC05M059909
  • GC05M059928
  • GC05M056850
  • GC05M059892

Summaries for DEPDC1B Gene

GeneCards Summary for DEPDC1B Gene

DEPDC1B (DEP Domain Containing 1B) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is DEPDC1.

Additional gene information for DEPDC1B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPDC1B Gene

Genomics for DEPDC1B Gene

Regulatory Elements for DEPDC1B Gene

Enhancers for DEPDC1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H060676 1.3 Ensembl ENCODE dbSUPER 18 +22.8 22774 1.9 CTCF PKNOX1 FOXA2 SAP130 BATF RAD21 SMC3 ZNF143 HOMEZ GATAD2A DEPDC1B PIR55567
GH05H060540 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +158.6 158559 1.7 TBL1XR1 BMI1 BATF RAD21 RARA ZNF143 ATF7 ETV6 RUNX3 CREM ELOVL7 RPL31P8 ERCC8 DEPDC1B ENSG00000276233 PDE4D
GH05H060687 1.4 Ensembl ENCODE dbSUPER 6.5 +12.0 12037 2.1 ELF3 PKNOX1 FOXA2 ATF1 ARID4B BATF DNMT3B ZNF766 GATA2 FOS DEPDC1B ERCC8 PIR55567
GH05H060651 1 Ensembl ENCODE 6.2 +47.9 47926 1.4 PKNOX1 JUN CEBPG RFX5 FOSL1 CTBP1 GATA3 ZNF316 ZNF547 FOSL2 RPL31P8 ERCC8 DEPDC1B PIR55567 CAB39P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DEPDC1B on UCSC Golden Path with GeneCards custom track

Promoters for DEPDC1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for DEPDC1B Gene

Genomic Locations for DEPDC1B Gene
103,279 bases
Minus strand

Genomic View for DEPDC1B Gene

Genes around DEPDC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPDC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPDC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPDC1B Gene

Proteins for DEPDC1B Gene

  • Protein details for DEPDC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DEP domain-containing protein 1B
    Protein Accession:
    Secondary Accessions:
    • A8K3R9
    • B4DUT4
    • Q86WJ3
    • Q8IZY6
    • Q9NUN3
    • Q9NW57

    Protein attributes for DEPDC1B Gene

    529 amino acids
    Molecular mass:
    61771 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH10904.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91529.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DEPDC1B Gene


neXtProt entry for DEPDC1B Gene

Post-translational modifications for DEPDC1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPDC1B Gene

No data available for DME Specific Peptides for DEPDC1B Gene

Domains & Families for DEPDC1B Gene

Gene Families for DEPDC1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DEPDC1B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DEPDC1B: view

No data available for UniProtKB/Swiss-Prot for DEPDC1B Gene

Function for DEPDC1B Gene

Phenotypes From GWAS Catalog for DEPDC1B Gene

Gene Ontology (GO) - Molecular Function for DEPDC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with DEPDC1B: view

Phenotypes for DEPDC1B Gene

genes like me logo Genes that share phenotypes with DEPDC1B: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEPDC1B Gene

Localization for DEPDC1B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEPDC1B gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DEPDC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DEPDC1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DEPDC1B Gene

Pathways & Interactions for DEPDC1B Gene

genes like me logo Genes that share pathways with DEPDC1B: view

Pathways by source for DEPDC1B Gene

3 Reactome pathways for DEPDC1B Gene

Interacting Proteins for DEPDC1B Gene

Gene Ontology (GO) - Biological Process for DEPDC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0016477 cell migration IMP 24971537
GO:0030177 positive regulation of Wnt signaling pathway IMP 24971537
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DEPDC1B: view

No data available for SIGNOR curated interactions for DEPDC1B Gene

Drugs & Compounds for DEPDC1B Gene

No Compound Related Data Available

Transcripts for DEPDC1B Gene

Unigene Clusters for DEPDC1B Gene

DEP domain containing 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEPDC1B Gene

No ASD Table

Relevant External Links for DEPDC1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEPDC1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEPDC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DEPDC1B Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for DEPDC1B Gene

This gene is overexpressed in Plasma (58.2) and Placenta (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DEPDC1B Gene

Protein tissue co-expression partners for DEPDC1B Gene

NURSA nuclear receptor signaling pathways regulating expression of DEPDC1B Gene:


SOURCE GeneReport for Unigene cluster for DEPDC1B Gene:


Evidence on tissue expression from TISSUES for DEPDC1B Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with DEPDC1B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEPDC1B Gene

Orthologs for DEPDC1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPDC1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEPDC1B 33 34
  • 99.56 (n)
(Canis familiaris)
Mammalia DEPDC1B 33 34
  • 92.14 (n)
(Bos Taurus)
Mammalia DEPDC1B 33 34
  • 91.72 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
-- 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Depdc1b 33
  • 87.08 (n)
(Mus musculus)
Mammalia Depdc1b 33 16 34
  • 86.45 (n)
(Ornithorhynchus anatinus)
Mammalia DEPDC1B 34
  • 61 (a)
(Gallus gallus)
Aves DEPDC1B 33 34
  • 74.35 (n)
(Anolis carolinensis)
Reptilia DEPDC1B 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia depdc1b 33
  • 67.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13922 33
(Danio rerio)
Actinopterygii depdc1b 34
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8846 34
  • 36 (a)
-- 34
  • 27 (a)
Species where no ortholog for DEPDC1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPDC1B Gene

Gene Tree for DEPDC1B (if available)
Gene Tree for DEPDC1B (if available)

Paralogs for DEPDC1B Gene

Paralogs for DEPDC1B Gene

(2) SIMAP similar genes for DEPDC1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DEPDC1B: view

Variants for DEPDC1B Gene

Sequence variations from dbSNP and Humsavar for DEPDC1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000096413 -- 60,640,702(+) ACAGA(A/C/T)GGGCT intron-variant
rs1000151928 -- 60,663,871(+) GGGCT(A/G)AAATT intron-variant
rs1000193614 -- 60,666,692(+) ACTCT(G/T)TGAGG intron-variant
rs1000205606 -- 60,623,449(+) ACAGG(C/T)AATGT intron-variant
rs1000224463 -- 60,616,032(+) AACAG(A/G)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEPDC1B Gene

Variant ID Type Subtype PubMed ID
nsv968916 CNV duplication 23825009
nsv598298 CNV loss 21841781
nsv598288 CNV loss 21841781
nsv508362 CNV deletion 20534489
nsv4850 CNV deletion 18451855
nsv436477 CNV deletion 17901297
nsv328716 CNV deletion 16902084
nsv1132608 CNV duplication 24896259
nsv1109701 CNV deletion 24896259
nsv1023403 CNV gain 25217958
nsv1018614 CNV loss 25217958
esv5002 CNV loss 18987735
esv3894195 CNV loss 25118596
esv3605193 CNV loss 21293372
esv3605192 CNV loss 21293372
esv3565978 CNV deletion 23714750
esv3565977 CNV deletion 23714750
esv3565976 CNV deletion 23714750
esv2730241 CNV deletion 23290073
esv2730240 CNV deletion 23290073
esv2730238 CNV deletion 23290073
esv2675953 CNV deletion 23128226
esv2662567 CNV deletion 23128226
esv2658588 CNV deletion 23128226

Variation tolerance for DEPDC1B Gene

Residual Variation Intolerance Score: 7.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEPDC1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPDC1B Gene

Disorders for DEPDC1B Gene

Relevant External Links for DEPDC1B

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DEPDC1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEPDC1B Gene

Publications for DEPDC1B Gene

  1. DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis. (PMID: 25458010) Marchesi S … Nicassio F (Developmental cell 2014) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  5. Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2. (PMID: 25704760) Wu D … Wei Q (Experimental cell research 2015) 3 60

Products for DEPDC1B Gene

Sources for DEPDC1B Gene

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