DEPDC1B Gene
protein-coding GIFtS: 48
GCID: GC05M059928
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DEP domain containing 1B
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Aliases
for DEPDC1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DEP Domain Containing 1B1 2 | | Breast Cancer Cell 32 | | BRCC31 2 | | DEP Domain-Containing Protein 1B2 | | XTP11 2 | | HBxAg Transactivated Protein 12 | | HBV X-Transactivated Gene 8 Protein2 3 | | XTP83 | | HBV XAg-Transactivated Protein 82 3 | | |
Export aliases for DEPDC1B gene to outside databasesPrevious GC identifers: GC05M059909 GC05M056850 |
Summaries
for DEPDC1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DEPDC1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DEPDC1B gene promoter:
Max1 p300 XBP-1 Meis-1b E47 POU2F1 POU2F1a Hand1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for DEPDC1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEPDC1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q12.1 Ensembl cytogenetic band: 5q12.1 HGNC cytogenetic band: 5q12DEPDC1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M059928: view genomic region
(about GC identifiers)
Start:
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59,892,739 bp from pter |
End:
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59,996,017 bp from pter |
Size:
|
103,279 bases |
Orientation:
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minus strand |
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Proteins
for DEPDC1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DEP1B_HUMAN, Q8WUY9 (See
protein sequence)Recommended Name: DEP domain-containing protein 1B Size: 529 amino acids; 61771 Da
Sequence caution: Sequence=AAH10904.1; Type=Erroneous initiation; Sequence=BAA91529.1; Type=Erroneous initiation;
Secondary accessions: A8K3R9 B4DUT4 Q86WJ3 Q8IZY6 Q9NUN3 Q9NW57Alternative splicing: 2 isoforms: Q8WUY9-1 Q8WUY9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DEPDC1B: NX_Q8WUY9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUY9
DEPDC1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138680.1 NP_060839.2
ENSEMBL proteins: ENSP00000265036 ENSP00000389101 ENSP00000427527 ENSP00000426979 ENSP00000438320 Reactome Protein details: Q8WUY9
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
DEPDC1B for ontologies About GeneDecksing
DEPDC1B Antibody Products:
Assay Products for DEPDC1B: |
Protein
Domains /
Families
for DEPDC1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DEPDC1B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WUY9ProtoNet protein and cluster: Q8WUY9 2 Blocks protein families: IPB000198 RhoGAP domain IPB000591 Pleckstrin putative G-protein interacting domain
UniProtKB/Swiss-Prot: DEP1B_HUMAN, Q8WUY9Similarity: Contains 1 DEP domainSimilarity: Contains 1 Rho-GAP domain |
Function
for DEPDC1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEPDC1B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEPDC1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DEPDC1B (NM_001145208) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEPDC1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPDC1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPDC1B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IEA | -- |
DEPDC1B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DEPDC1B:
|
Pathways & Interactions
for DEPDC1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for DEPDC1B
DEPDC1B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEPDC1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/35 Interacting proteins for DEPDC1B (ENSP000002650364) via UniProtKB, MINT, STRING, and/or I2D (see all 35)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0035556 | intracellular signal transduction |
-- | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
TAS | -- |
DEPDC1B for ontologies About GeneDecksing
|
Drugs & Compounds
for DEPDC1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DEPDC1B
Search CenterWatch for drugs/clinical trials and news about DEPDC1B / DEP1B
|
Transcripts
for DEPDC1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DEPDC1B gene (2 alternative transcripts): NM_001145208.1 NM_018369.2 Unigene Cluster for DEPDC1B: DEP domain containing 1B Hs.744118 [show with all ESTs]Unigene Representative Sequence: NM_0183697 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000265036(uc003jsh.3 uc011cqm.2 uc011cqn.2) ENST00000453022
ENST00000512078 ENST00000509006 ENST00000505017 ENST00000512452 ENST00000545085
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEPDC1B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEPDC1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DEPDC1B (NM_001145208) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEPDC1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPDC1B |
Additional cDNA sequence: AF303178.1 AF488828.1 AF490257.1 AK001166.1 AK002114.1 AK290684.1 AK299242.1 AK300782.1 BC010904.1 BC019075.1 6 DOTS entries: DT.212838 DT.100751636 DT.91660149 DT.407195 DT.92045791 DT.425510 24/84 AceView cDNA sequences (see all 84): BG503526 AW237743 BF732696 BG777843 AA830503 BX100635 BM836122 AA745250 AK001166 AA644541 AF488828 BQ437452 BP359422 BG779247 AI094462 BC010904 AA830747 AA916901 BX475753 CF994900 AU137953 BG498558 BM750919 AW181987
GeneLoc Exon Structure
|
Expression
for DEPDC1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DEPDC1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTTTATTA
About this image
See DEPDC1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DEPDC1B
SOURCE GeneReport for Unigene cluster: Hs.744118
SABiosciences Custom PCR Arrays for DEPDC1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEPDC1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DEPDC1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEPDC1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEPDC1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPDC1B |
Orthologs
for DEPDC1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DEPDC1B gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for DEPDC1B (if available)
TreeFam Gene Tree for DEPDC1B (if available) |
Paralogs
for DEPDC1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DEPDC1B gene
- DEPDC42 DEPDC12 DEPDC72
2 SIMAP similar genes for DEPDC1B using alignment to 4 protein entries: DEP1B_HUMAN (see all proteins):DEPDC1 DKFZp434K0831
DEPDC1B for paralogs About GeneDecksing
|
Genomic Variants
for DEPDC1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DEPDC1B (59892739 - 59996017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for DEPDC1B
3 CNVs: 22587 43340 36424
1 Indel: 12690 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEPDC1B |
|
Disorders
/ Diseases
for DEPDC1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DEPDC1B for disorders About GeneDecksing
1  disease for DEPDC1B: About MalaCardsbreast cancer
Human Genome Epidemiology (HuGE) Navigator: DEPDC1B (1 document)
Export disorders for DEPDC1B gene to outside databases
|
Publications
for DEPDC1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DEPDC1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with DEPDC1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PubMed id 20923822)1 Niu N....Wang L. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for DEPDC1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DEPDC1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DEPDC1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEPDC1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DEPDC1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DEPDC1B gene:
Search GeneIP for patents involving DEPDC1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DEPDC1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEPDC1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEPDC1B | | | OriGene Protein Over-expression Lysate for DEPDC1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DEPDC1B | | OriGene 3'-UTR Clone for DEPDC1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEPDC1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEPDC1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DEPDC1B | | OriGene Custom Protein Services for DEPDC1B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DEPDC1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEPDC1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEPDC1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEPDC1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEPDC1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEPDC1B |
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 |  |  |  | |
| | | | Search Tocris compounds for DEPDC1B |
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 | | | DEPDC1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPDC1B |
|  |  |  | | | | Search ThermoFisher Antibodies for DEPDC1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPDC1B |
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