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Aliases for DEPDC1B Gene

Aliases for DEPDC1B Gene

  • DEP Domain Containing 1B 2 3 5
  • HBV X-Transactivated Gene 8 Protein 3 4
  • HBV XAg-Transactivated Protein 8 3 4
  • Breast Cancer Cell 3 2 3
  • HBxAg Transactivated Protein 1 3
  • BRCC3 3
  • XTP1 3
  • XTP8 4

External Ids for DEPDC1B Gene

Previous GeneCards Identifiers for DEPDC1B Gene

  • GC05M059909
  • GC05M059928
  • GC05M056850
  • GC05M059892

Summaries for DEPDC1B Gene

GeneCards Summary for DEPDC1B Gene

DEPDC1B (DEP Domain Containing 1B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is DEPDC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPDC1B Gene

Genomics for DEPDC1B Gene

Regulatory Elements for DEPDC1B Gene

Promoters for DEPDC1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DEPDC1B on UCSC Golden Path with GeneCards custom track

Genomic Location for DEPDC1B Gene

Chromosome:
5
Start:
60,596,912 bp from pter
End:
60,700,190 bp from pter
Size:
103,279 bases
Orientation:
Minus strand

Genomic View for DEPDC1B Gene

Genes around DEPDC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPDC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPDC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPDC1B Gene

Proteins for DEPDC1B Gene

  • Protein details for DEPDC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUY9-DEP1B_HUMAN
    Recommended name:
    DEP domain-containing protein 1B
    Protein Accession:
    Q8WUY9
    Secondary Accessions:
    • A8K3R9
    • B4DUT4
    • Q86WJ3
    • Q8IZY6
    • Q9NUN3
    • Q9NW57

    Protein attributes for DEPDC1B Gene

    Size:
    529 amino acids
    Molecular mass:
    61771 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10904.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91529.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DEPDC1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEPDC1B Gene

Proteomics data for DEPDC1B Gene at MOPED

Post-translational modifications for DEPDC1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPDC1B Gene

No data available for DME Specific Peptides for DEPDC1B Gene

Domains & Families for DEPDC1B Gene

Suggested Antigen Peptide Sequences for DEPDC1B Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUY9

UniProtKB/Swiss-Prot:

DEP1B_HUMAN :
  • Contains 1 DEP domain.
Domain:
  • Contains 1 DEP domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with DEPDC1B: view

No data available for Gene Families for DEPDC1B Gene

Function for DEPDC1B Gene

Phenotypes for DEPDC1B Gene

genes like me logo Genes that share phenotypes with DEPDC1B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEPDC1B Gene

Localization for DEPDC1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEPDC1B Gene COMPARTMENTS Subcellular localization image for DEPDC1B gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEPDC1B Gene

Pathways & Interactions for DEPDC1B Gene

genes like me logo Genes that share pathways with DEPDC1B: view

Pathways by source for DEPDC1B Gene

Interacting Proteins for DEPDC1B Gene

Gene Ontology (GO) - Biological Process for DEPDC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016477 cell migration IMP 24971537
GO:0030177 positive regulation of Wnt signaling pathway IMP 24971537
GO:0035556 intracellular signal transduction IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with DEPDC1B: view

No data available for SIGNOR curated interactions for DEPDC1B Gene

Drugs & Compounds for DEPDC1B Gene

No Compound Related Data Available

Transcripts for DEPDC1B Gene

Unigene Clusters for DEPDC1B Gene

DEP domain containing 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEPDC1B Gene

No ASD Table

Relevant External Links for DEPDC1B Gene

GeneLoc Exon Structure for
DEPDC1B
ECgene alternative splicing isoforms for
DEPDC1B

Expression for DEPDC1B Gene

mRNA expression in normal human tissues for DEPDC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DEPDC1B Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for DEPDC1B Gene

This gene is overexpressed in Plasma (58.2) and Placenta (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DEPDC1B Gene



SOURCE GeneReport for Unigene cluster for DEPDC1B Gene Hs.482233

genes like me logo Genes that share expression patterns with DEPDC1B: view

Protein tissue co-expression partners for DEPDC1B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DEPDC1B Gene

Orthologs for DEPDC1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPDC1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEPDC1B 35
  • 99.56 (n)
  • 99.24 (a)
DEPDC1B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DEPDC1B 36
  • 96 (a)
OneToOne
DEPDC1B 35
  • 91.72 (n)
  • 95.07 (a)
dog
(Canis familiaris)
Mammalia DEPDC1B 35
  • 92.14 (n)
  • 95.91 (a)
DEPDC1B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Depdc1b 36
  • 94 (a)
OneToOne
Depdc1b 16
Depdc1b 35
  • 86.45 (n)
  • 93.95 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DEPDC1B 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Depdc1b 35
  • 87.08 (n)
  • 94.14 (a)
chicken
(Gallus gallus)
Aves DEPDC1B 36
  • 71 (a)
OneToOne
DEPDC1B 35
  • 74.35 (n)
  • 75.43 (a)
lizard
(Anolis carolinensis)
Reptilia DEPDC1B 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13922 35
tropical clawed frog
(Silurana tropicalis)
Amphibia depdc1b 35
  • 67.23 (n)
  • 67.99 (a)
zebrafish
(Danio rerio)
Actinopterygii depdc1b 36
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
CSA.8846 36
  • 36 (a)
ManyToMany
Species with no ortholog for DEPDC1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPDC1B Gene

ENSEMBL:
Gene Tree for DEPDC1B (if available)
TreeFam:
Gene Tree for DEPDC1B (if available)

Paralogs for DEPDC1B Gene

Paralogs for DEPDC1B Gene

(2) SIMAP similar genes for DEPDC1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DEPDC1B: view

Variants for DEPDC1B Gene

Sequence variations from dbSNP and Humsavar for DEPDC1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17856590 - 60,605,760(+) TCATC(A/C)TCATC downstream-variant-500B, reference, missense
rs17851707 - 60,603,450(+) AGGGA(C/G)TTTCA reference, missense
rs206789 -- 60,608,144(-) GCTAC(A/G)TCCCC intron-variant
rs1026418 -- 60,679,180(-) aagat(A/G)taaat intron-variant
rs897671 -- 60,700,257(+) ACCCG(A/C)GGCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DEPDC1B Gene

Variant ID Type Subtype PubMed ID
nsv436477 CNV Deletion 17901297
esv2730238 CNV Deletion 23290073
esv5002 CNV Deletion 18987735
esv2675953 CNV Deletion 23128226
esv2658588 CNV Deletion 23128226
esv2730240 CNV Deletion 23290073
esv2662567 CNV Deletion 23128226
esv2730241 CNV Deletion 23290073
nsv328716 CNV Loss 16902084
nsv4850 CNV Loss 18451855
nsv508362 CNV Loss 20534489

Variation tolerance for DEPDC1B Gene

Residual Variation Intolerance Score: 7.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEPDC1B Gene

HapMap Linkage Disequilibrium report
DEPDC1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPDC1B Gene

Disorders for DEPDC1B Gene

Relevant External Links for DEPDC1B

Human Genome Epidemiology (HuGE) Navigator
DEPDC1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEPDC1B

No disorders were found for DEPDC1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEPDC1B Gene

Publications for DEPDC1B Gene

  1. DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis. (PMID: 25458010) Marchesi S. … Nicassio F. (Dev. Cell 2014) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2. (PMID: 25704760) Wu D. … Wei Q. (Exp. Cell Res. 2015) 3
  4. DEPDC1B enhances migration and invasion of non-small cell lung cancer cells via activating Wnt/I^-catenin signaling. (PMID: 24971537) Yang Y. … Li M. (Biochem. Biophys. Res. Commun. 2014) 3
  5. A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK. (PMID: 25091805) Su Y.F. … Yang J.J. (J. Biomed. Sci. 2014) 3

Products for DEPDC1B Gene

Sources for DEPDC1B Gene

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