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Aliases for DEPDC1 Gene

Aliases for DEPDC1 Gene

  • DEP Domain Containing 1 2 3
  • DEPDC1A 3 4
  • DEP Domain-Containing Protein 1A 3
  • Cell Cycle Control Protein SDP35 3
  • DEPDC1-V2 3
  • DEP.8 3
  • SDP35 3

External Ids for DEPDC1 Gene

Summaries for DEPDC1 Gene

GeneCards Summary for DEPDC1 Gene

DEPDC1 (DEP Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is DEPDC1B.

UniProtKB/Swiss-Prot for DEPDC1 Gene

  • May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPDC1 Gene

Genomics for DEPDC1 Gene

Genomic Location for DEPDC1 Gene

Start:
68,474,152 bp from pter
End:
68,497,221 bp from pter
Size:
23,070 bases
Orientation:
Minus strand

Genomic View for DEPDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEPDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPDC1 Gene

Regulatory Elements for DEPDC1 Gene

Proteins for DEPDC1 Gene

  • Protein details for DEPDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TB30-DEP1A_HUMAN
    Recommended name:
    DEP domain-containing protein 1A
    Protein Accession:
    Q5TB30
    Secondary Accessions:
    • A8QXE0
    • A8QXE1
    • Q05DU3
    • Q5TB28
    • Q9H9I3
    • Q9NX21
    • Q9NXZ0

    Protein attributes for DEPDC1 Gene

    Size:
    811 amino acids
    Molecular mass:
    92960 Da
    Quaternary structure:
    • Isoform 2 and isoform 5 can form homodimers and heterodimers. Interacts with ZNF224.
    SequenceCaution:
    • Sequence=AAH03511.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91201.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14246.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14246.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAI22441.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22443.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DEPDC1 Gene

    Alternative splice isoforms for DEPDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEPDC1 Gene

Proteomics data for DEPDC1 Gene at MOPED

Post-translational modifications for DEPDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPDC1 Gene

No data available for DME Specific Peptides for DEPDC1 Gene

Domains for DEPDC1 Gene

Protein Domains for DEPDC1 Gene

UniProtKB/Swiss-Prot:

DEP1A_HUMAN
Domain:
  • Contains 1 DEP domain.:
    • Q5TB30
  • Contains 1 Rho-GAP domain.:
    • Q5TB30
genes like me logo Genes that share domains with DEPDC1: view

No data available for Gene Families for DEPDC1 Gene

Function for DEPDC1 Gene

Molecular function for DEPDC1 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Gene Ontology (GO) - Molecular Function for DEPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 20587513
genes like me logo Genes that share ontologies with DEPDC1: view

Phenotypes for DEPDC1 Gene

GenomeRNAi human phenotypes for DEPDC1:
genes like me logo Genes that share phenotypes with DEPDC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DEPDC1 Gene

Localization for DEPDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEPDC1 Gene

Nucleus. Note=Colocalizes with ZNF224 at the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEPDC1 Gene COMPARTMENTS Subcellular localization image for DEPDC1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DEPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 20587513
GO:0005654 nucleoplasm IDA --
GO:0017053 transcriptional repressor complex IDA 20587513
genes like me logo Genes that share ontologies with DEPDC1: view

Pathways for DEPDC1 Gene

SuperPathways for DEPDC1 Gene

No Data Available

Interacting Proteins for DEPDC1 Gene

Gene Ontology (GO) - Biological Process for DEPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007165 signal transduction --
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 20587513
genes like me logo Genes that share ontologies with DEPDC1: view

No data available for Pathways by source for DEPDC1 Gene

Transcripts for DEPDC1 Gene

Unigene Clusters for DEPDC1 Gene

DEP domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEPDC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1:
SP2: - -
SP3:
SP4: -

Relevant External Links for DEPDC1 Gene

GeneLoc Exon Structure for
DEPDC1
ECgene alternative splicing isoforms for
DEPDC1

Expression for DEPDC1 Gene

mRNA expression in normal human tissues for DEPDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DEPDC1 Gene

This gene is overexpressed in Testis (9.2) and Esophagus - Mucosa (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DEPDC1 Gene

SOURCE GeneReport for Unigene cluster for DEPDC1 Gene Hs.445098

mRNA Expression by UniProt/SwissProt for DEPDC1 Gene

Q5TB30-DEP1A_HUMAN
Tissue specificity: Expressed in testis. Up-regulated in bladder cancer cells (at protein level).
genes like me logo Genes that share expressions with DEPDC1: view

Orthologs for DEPDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEPDC1 36
  • 99.84 (n)
  • 99.51 (a)
DEPDC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DEPDC1 36
  • 90.51 (n)
  • 88.02 (a)
DEPDC1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DEPDC1 36
  • 91.31 (n)
  • 87.03 (a)
DEPDC1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Depdc1a 36
  • 87.15 (n)
  • 83.08 (a)
Depdc1a 16
Depdc1a 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DEPDC1 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DEPDC1 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Depdc1 36
  • 86.78 (n)
  • 82.53 (a)
chicken
(Gallus gallus)
Aves DEPDC1 36
  • 72.67 (n)
  • 72.41 (a)
DEPDC1 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DEPDC1 37
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4724 36
tropical clawed frog
(Silurana tropicalis)
Amphibia depdc1 36
  • 63.42 (n)
  • 60.41 (a)
Str.1808 36
zebrafish
(Danio rerio)
Actinopterygii depdc1a 36
  • 55.71 (n)
  • 52.37 (a)
depdc1a 37
  • 48 (a)
OneToOne
sbcb41 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
ManyToMany
CSA.8846 37
  • 38 (a)
ManyToMany
Species with no ortholog for DEPDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPDC1 Gene

ENSEMBL:
Gene Tree for DEPDC1 (if available)
TreeFam:
Gene Tree for DEPDC1 (if available)

Paralogs for DEPDC1 Gene

Paralogs for DEPDC1 Gene

Selected SIMAP similar genes for DEPDC1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DEPDC1 Gene

genes like me logo Genes that share paralogs with DEPDC1: view

Variants for DEPDC1 Gene

Sequence variations from dbSNP and Humsavar for DEPDC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs445045 -- 68,474,225(-) ACGCT(C/T)GATTT utr-variant-3-prime
rs1329457 -- 68,473,683(+) ATAAA(G/T)TCTGT downstream-variant-500B
rs1329458 -- 68,473,690(+) CTGTT(G/T)CCTCA downstream-variant-500B
rs1924542 -- 68,477,753(-) GTAAA(C/T)ATTTT intron-variant
rs1924543 -- 68,475,524(-) AGTAT(C/T)CCATT utr-variant-3-prime

Relevant External Links for DEPDC1 Gene

HapMap Linkage Disequilibrium report
DEPDC1

No data available for Structural Variations from Database of Genomic Variants (DGV) for DEPDC1 Gene

Disorders for DEPDC1 Gene

Relevant External Links for DEPDC1

Genetic Association Database (GAD)
DEPDC1
Human Genome Epidemiology (HuGE) Navigator
DEPDC1
genes like me logo Genes that share disorders with DEPDC1: view

No data available for UniProtKB/Swiss-Prot for DEPDC1 Gene

Publications for DEPDC1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. (PMID: 20587513) Harada Y. … Katagiri T. (Cancer Res. 2010) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis. (PMID: 17452976) Kanehira M. … Katagiri T. (Oncogene 2007) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for DEPDC1 Gene

Sources for DEPDC1 Gene

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