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DEPDC1 Gene

protein-coding   GIFtS: 50
GCID: GC01M068939

DEP Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEP Domain Containing 11 2     SDP352
DEPDC1A2 3     Cell Cycle Control Protein SDP352
DEP.82     DEP Domain-Containing Protein 1A2
DEPDC1-V22     

External Ids:    HGNC: 229491   Entrez Gene: 556352   Ensembl: ENSG000000245267   OMIM: 6120025   UniProtKB: Q5TB303   

Export aliases for DEPDC1 gene to outside databases

Previous GC identifers: GC01M068310 GC01M068652 GC01M068713 GC01M067049


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DEPDC1 Gene:
DEPDC1 (DEP domain containing 1) is a protein-coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is DEPDC4.

UniProtKB/Swiss-Prot: DEP1A_HUMAN, Q5TB30
Function: May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224
complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene,
leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer
cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the DEPDC1 gene promoter:
         SRF   AML1a   SRF (504 AA)   ATF-2   HSF1 (long)   FOXD3   HNF-3beta   POU2F1   POU2F1a   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEPDC1 promoter sequence
   Search Chromatin IP Primers for DEPDC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEPDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.2   Ensembl cytogenetic band:  1p31.2   HGNC cytogenetic band: 1p31.2

DEPDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEPDC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M068939:  view genomic region     (about GC identifiers)

Start:
68,939,835 bp from pter      End:
68,962,904 bp from pter
Size:
23,070 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DEP1A_HUMAN, Q5TB30 (See protein sequence)
Recommended Name: DEP domain-containing protein 1A  
Size: 811 amino acids; 92960 Da
Subunit: Isoform 2 and isoform 5 can form homodimers and heterodimers. Interacts with ZNF224
Sequence caution: Sequence=AAH03511.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA91201.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14246.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14246.1;
Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=CAI22441.1; Type=Erroneous gene model
prediction; Sequence=CAI22443.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for DEPDC1:
2YSR (3D)    
Secondary accessions: A8QXE0 A8QXE1 Q05DU3 Q5TB28 Q9H9I3 Q9NX21 Q9NXZ0
Alternative splicing: 2 isoforms:  Q5TB30-5   Q5TB30-2   

Explore the universe of human proteins at neXtProt for DEPDC1: NX_Q5TB30

Explore proteomics data for DEPDC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DEPDC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107592.1  NP_060249.2  

    ENSEMBL proteins: 
     ENSP00000412292   ENSP00000360005   ENSP00000436464   ENSP00000431477  

    DEPDC1 Human Recombinant Protein Products:

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    Novus Biologicals DEPDC1 Protein
    Novus Biologicals DEPDC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DEPDC1

     
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    antibodies-online proteins for DEPDC1 (2 products) 

     
    antibodies-online peptides for DEPDC1

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    antibodies-online antibodies for DEPDC1 (27 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR011991 WHTH_DNA-bd_dom
     IPR000591 DEP_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q5TB30

    ProtoNet protein and cluster: Q5TB30

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: DEP1A_HUMAN, Q5TB30
    Similarity: Contains 1 DEP domain
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with DEPDC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEP1A_HUMAN, Q5TB30
    Function: May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224
    complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene,
    leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer
    cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with DEPDC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DEPDC1:
     Increased homologous recombina 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DEPDC1

    miRNA
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    miRTarBase miRNAs that target DEPDC1:
    hsa-mir-17-5p (MIRT050884), hsa-mir-24-3p (MIRT050372), hsa-mir-192-5p (MIRT026487), hsa-mir-215-5p (MIRT024325), hsa-mir-331-3p (MIRT043344), hsa-mir-186-5p (MIRT021182), hsa-mir-124-3p (MIRT002615), hsa-mir-340-5p (MIRT019599)

    Block miRNA regulation of human, mouse, rat DEPDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEPDC1 (see all 32):
    hsa-miR-539 hsa-miR-4328 hsa-miR-1271 hsa-miR-301a hsa-miR-410 hsa-miR-1297 hsa-miR-3692 hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidDEPDC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DEPDC1

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPDC1
    Addgene plasmids for DEPDC1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPDC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEP1A_HUMAN, Q5TB30: Nucleus. Note=Colocalizes with ZNF224 at the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0017053transcriptional repressor complex IDA--

    Find genes that share ontologies with DEPDC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DEPDC1
    Interactions:

        Search GeneGlobe Interaction Network for DEPDC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DEPDC1 (Q5TB303 ENSP000004122924) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KBTBD7Q8WVZ93I2D: score=1 
    AGMATENSP000003649864STRING: ENSP00000364986
    ASPMENSP000003563794STRING: ENSP00000356379
    CACHD1ENSP000002900394STRING: ENSP00000290039
    FAM107BENSP000001817964STRING: ENSP00000181796
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0007165signal transduction ----
    GO:0035556intracellular signal transduction IEA--
    GO:0045892negative regulation of transcription, DNA-templated IDA--

    Find genes that share ontologies with DEPDC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DEPDC1 (DEP1A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DEPDC1 gene (2 alternative transcripts): 
    NM_001114120.2  NM_017779.5  

    Unigene Cluster for DEPDC1:

    DEP domain containing 1
    Hs.445098  [show with all ESTs]
    Unigene Representative Sequence: NM_001114120
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456315(uc001dej.4 uc001dek.4 uc001dem.4) ENST00000370966(uc001del.4)
    ENST00000488146 ENST00000489862 ENST00000525124
    miRNA
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    Block miRNA regulation of human, mouse, rat DEPDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEPDC1 (see all 32):
    hsa-miR-539 hsa-miR-4328 hsa-miR-1271 hsa-miR-301a hsa-miR-410 hsa-miR-1297 hsa-miR-3692 hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidDEPDC1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): DEPDC1 (NM_017779)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEPDC1
    Addgene plasmids for DEPDC1 
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    OriGene qPCR primer pairs and template standards for DEPDC1
    OriGene qSTAR qPCR primer pairs in human, mouse for DEPDC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEPDC1
      QuantiTect SYBR Green Assays in human, mouse, rat DEPDC1
      QuantiFast Probe-based Assays in human, mouse, rat DEPDC1

    Additional mRNA sequence: 

    AB281187.1 AB281274.1 AJ278112.1 AK000361.1 AK000490.1 AK022792.1 AK225735.1 AK299324.1 
    AL834208.1 BC003511.1 BC011743.2 BC035506.2 BC041580.1 BC065304.1 

    4 DOTS entries:

    DT.101981619  DT.40117712  DT.91743777  DT.87046403 

    Selected AceView cDNA sequences (see all 102):

    BF511058 AK000490 AA251010 AJ278112 BC041580 NM_017779 AA768104 BQ929463 
    BC011743 CB121202 BC003511 BC035506 BQ425546 AW451526 AW296950 AA825936 
    BF062472 AL834208 BM718534 BG777676 BC065304 BU161270 AK000361 BE278231 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DEPDC1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                                                                                          
    SP2:                                                              -     -                     
    SP3:                                                                                          
    SP4:              -                                                                           


    ECgene alternative splicing isoforms for DEPDC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DEPDC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATTTCCCA
    DEPDC1 Expression
    About this image


    DEPDC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Fibroblasts (Uncategorized)
    DEPDC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DEPDC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445098

    UniProtKB/Swiss-Prot: DEP1A_HUMAN, Q5TB30
    Tissue specificity: Expressed in testis. Up-regulated in bladder cancer cells (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEPDC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DEPDC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Depdc1a1 , 5 DEP domain containing 1a1, 5 87.15(n)1
    83.08(a)1
      3 (82.47 cM)5
    761311  NM_001172092.11  NP_001165563.11 
     1594954335 
    chicken
    (Gallus gallus)
    Aves DEPDC11 DEP domain containing 1 72.67(n)
    72.41(a)
      424710  NM_001012928.1  NP_001012946.1 
    lizard
    (Anolis carolinensis)
    Reptilia DEPDC16
    DEP domain containing 1
    59(a)
    1 ↔ 1
    GL343328.1(453565-475876)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.47242 Xenopus laevis transcribed sequence with moderate similarity more 76.08(n)    48056855 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb412 sbcb41 74.24(n)   321057  BC044382.1 


    ENSEMBL Gene Tree for DEPDC1 (if available)
    TreeFam Gene Tree for DEPDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DEPDC1 gene
    DEPDC42  DEPDC1B2  DEPDC72  
    2 SIMAP similar genes for DEPDC1 using alignment to 4 protein entries:     DEP1A_HUMAN (see all proteins):
    DKFZp434K0831    DEPDC1B

    Find genes that share paralogs with DEPDC1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for DEPDC1
    PGOHUM00000246719 PGOHUM00000236746


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DEPDC1 (see all 531)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs574174971,2
    C--67060632(+) CACAC-/AC    
       
    /ACAC
    TCTTA
    2 -- int11NA 2
    rs740819951,2
    C--68939339(+) AAGTCG/AAACAA 2 -- int12Minor allele frequency- A:0.03WA 120
    rs13294581,2
    H--68939373(+) CTGTTT/GCCTCA 2 -- int14Minor allele frequency- G:0.00NS EA 414
    rs740819971,2
    C,F--68939577(+) ATTAAG/AACTAG 2 -- int11Minor allele frequency- A:0.50WA 2
    rs2011537771,2
    --68939634(+) CCCCC-/CACACAC 2 -- int10--------
    rs342021801,2
    C,F--68939644(+) ACACAC/TGCATG 2 -- int12Minor allele frequency- T:0.08NA 122
    rs1139853841,2
    C--68939645(+) CACACA/GCATGC 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs1401888281,2
    C--68939663(+) CACAT-/TCTCTCT 2 -- int10--------
    rs104934441,2
    C,F,H--68939716(+) TTGGTC/TGTACA 2 -- int118Minor allele frequency- T:0.03NS EA NA WA 1634
    rs570351961,2
    C,F--68939744(+) ATTCCA/GTAACC 2 -- int17Minor allele frequency- G:0.23WA NA CSA EA 366

    HapMap Linkage Disequilibrium report for DEPDC1 (68939835 - 68962904 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DEPDC1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DEPDC1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612002    OMIM disorders: --


    Find genes that share disorders with DEPDC1           About GenesLikeMe

    Genetic Association Database (GAD): DEPDC1
    Human Genome Epidemiology (HuGE) Navigator: DEPDC1 (1 document)

    Export disorders for DEPDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DEPDC1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DEPDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. (PubMed id 20587513)1, 2 Harada Y.... Katagiri T. (Cancer Res. 2010)
    3. Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis. (PubMed id 17452976)1, 2 Kanehira M.... Katagiri T. (Oncogene 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma, delays growth and induces mature plasma cell markers in malignant plasma cells. (PubMed id 23646139)1 Kassambara A....Klein B. (PLoS ONE 2013)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55635 HGNC: 22949 AceView: DEPDC1 Ensembl:ENSG00000024526 euGenes: HUgn55635
    ECgene: DEPDC1 H-InvDB: DEPDC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DEPDC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DEPDC1 gene:
    Search GeneIP for patents involving DEPDC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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