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Aliases for DENR Gene

Aliases for DENR Gene

  • Density-Regulated Protein 2 3 5
  • Smooth Muscle Cell-Associated Protein 3 3 4
  • SMAP-3 3 4
  • DRP1 3 4
  • DRP 3 4
  • Smooth Muscle Cell Associated Protein-3 3
  • Protein DRP1 4

External Ids for DENR Gene

Previous GeneCards Identifiers for DENR Gene

  • GC12U990118
  • GC12M123069
  • GC12P123045
  • GC12P121675
  • GC12P121674
  • GC12P121762
  • GC12P123237
  • GC12P120197

Summaries for DENR Gene

Entrez Gene Summary for DENR Gene

  • This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

GeneCards Summary for DENR Gene

DENR (Density-Regulated Protein) is a Protein Coding gene. Diseases associated with DENR include Pleomorphic Adenoma Carcinoma. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot for DENR Gene

  • May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENR Gene

Genomics for DENR Gene

Regulatory Elements for DENR Gene

Enhancers for DENR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DENR on UCSC Golden Path with GeneCards custom track

Promoters for DENR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DENR on UCSC Golden Path with GeneCards custom track

Genomic Location for DENR Gene

Chromosome:
12
Start:
122,752,774 bp from pter
End:
122,771,064 bp from pter
Size:
18,291 bases
Orientation:
Plus strand

Genomic View for DENR Gene

Genes around DENR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENR Gene

Proteins for DENR Gene

  • Protein details for DENR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43583-DENR_HUMAN
    Recommended name:
    Density-regulated protein
    Protein Accession:
    O43583
    Secondary Accessions:
    • Q9H3U6
    • Q9UKZ0

    Protein attributes for DENR Gene

    Size:
    198 amino acids
    Molecular mass:
    22092 Da
    Quaternary structure:
    • Interacts with MCTS1.
    SequenceCaution:
    • Sequence=AAC02985.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for DENR Gene

Proteomics data for DENR Gene at MOPED

Post-translational modifications for DENR Gene

  • Ubiquitination at Lys 59
  • Modification sites at PhosphoSitePlus

Other Protein References for DENR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DENR Gene

Domains & Families for DENR Gene

Protein Domains for DENR Gene

Suggested Antigen Peptide Sequences for DENR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43583

UniProtKB/Swiss-Prot:

DENR_HUMAN :
  • Contains 1 SUI1 domain.
  • Belongs to the DENR family.
Domain:
  • Contains 1 SUI1 domain.
Family:
  • Belongs to the DENR family.
genes like me logo Genes that share domains with DENR: view

No data available for Gene Families for DENR Gene

Function for DENR Gene

Molecular function for DENR Gene

GENATLAS Biochemistry:
density-regulated protein,expressed in cultured cells at high density but not at low density or during growth arrest
UniProtKB/Swiss-Prot Function:
May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
UniProtKB/Swiss-Prot Induction:
Up-regulated with increasing cell-density by HNRNPD. Up-regulated in ovarian and breast cancer cells by ERBB2 overexpression. Not induced by TGFB1.

Gene Ontology (GO) - Molecular Function for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DENR: view
genes like me logo Genes that share phenotypes with DENR: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENR Gene

Localization for DENR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENR Gene COMPARTMENTS Subcellular localization image for DENR gene
Compartment Confidence
cytosol 4
mitochondrion 2
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DENR Gene

Pathways & Interactions for DENR Gene

SuperPathways for DENR Gene

No Data Available

Gene Ontology (GO) - Biological Process for DENR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DENR Gene

Drugs & Compounds for DENR Gene

No Compound Related Data Available

Transcripts for DENR Gene

Unigene Clusters for DENR Gene

Density-regulated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENR Gene

No ASD Table

Relevant External Links for DENR Gene

GeneLoc Exon Structure for
DENR
ECgene alternative splicing isoforms for
DENR

Expression for DENR Gene

mRNA expression in normal human tissues for DENR Gene

Protein differential expression in normal tissues from HIPED for DENR Gene

This gene is overexpressed in Lavage (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENR Gene



SOURCE GeneReport for Unigene cluster for DENR Gene Hs.22393

mRNA Expression by UniProt/SwissProt for DENR Gene

O43583-DENR_HUMAN
Tissue specificity: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.
genes like me logo Genes that share expression patterns with DENR: view

Protein tissue co-expression partners for DENR Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DENR Gene

Orthologs for DENR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DENR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DENR 35
  • 94.44 (n)
  • 96.46 (a)
-- 36
  • 95 (a)
OneToMany
DENR 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DENR 35
  • 93.1 (n)
  • 96.46 (a)
DENR 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Denr 35
  • 91.58 (n)
  • 96.46 (a)
Denr 16
Denr 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DENR 35
  • 99.66 (n)
  • 100 (a)
DENR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC687565 35
  • 92.27 (n)
  • 97.42 (a)
oppossum
(Monodelphis domestica)
Mammalia DENR 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves DENR 35
  • 84.34 (n)
  • 91.41 (a)
DENR 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DENR 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia denr 35
  • 79.36 (n)
  • 85.79 (a)
zebrafish
(Danio rerio)
Actinopterygii denr 35
  • 74.82 (n)
  • 85.33 (a)
denr 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006125 35
  • 53.88 (n)
  • 53.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9099 35
  • 55.83 (n)
  • 53.37 (a)
CG9099 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y47D3A.21 35
  • 54.6 (n)
  • 50.31 (a)
Y47D3A.21 36
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL112C 35
  • 42.07 (n)
  • 36.55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21934g 35
  • 49.89 (n)
  • 35.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA22 35
  • 51.23 (n)
  • 37.58 (a)
TMA22 36
  • 28 (a)
OneToOne
TMA22 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11900 35
  • 52.08 (n)
  • 45 (a)
rice
(Oryza sativa)
Liliopsida Os01g0195500 35
  • 48.12 (n)
  • 42.5 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02984 35
  • 47.02 (n)
  • 43.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16C6.05 35
  • 52.97 (n)
  • 41.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7885 36
  • 47 (a)
OneToOne
Species with no ortholog for DENR:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENR Gene

ENSEMBL:
Gene Tree for DENR (if available)
TreeFam:
Gene Tree for DENR (if available)

Paralogs for DENR Gene

genes like me logo Genes that share paralogs with DENR: view

No data available for Paralogs for DENR Gene

Variants for DENR Gene

Sequence variations from dbSNP and Humsavar for DENR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1975761 -- 122,770,152(-) CTTAC(G/T)GGTTC utr-variant-3-prime
rs2154 -- 122,769,991(-) GATTC(A/C/T)CACCC utr-variant-3-prime
rs7297797 -- 122,755,169(+) TGGAA(C/T)GAGGT intron-variant
rs12820782 -- 122,751,022(+) ctcta(A/G)gttcc upstream-variant-2KB
rs2133634 -- 122,751,186(-) tatat(G/T)cacat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DENR Gene

Variant ID Type Subtype PubMed ID
nsv899571 CNV Loss 21882294

Variation tolerance for DENR Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DENR Gene

Human Gene Mutation Database (HGMD)
DENR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENR Gene

Disorders for DENR Gene

MalaCards: The human disease database

(1) MalaCards diseases for DENR Gene - From: DISEASES

Disorder Aliases PubMed IDs
pleomorphic adenoma carcinoma
  • carcinoma ex pleomorphic adenoma
- elite association - COSMIC cancer census association via MalaCards
Search DENR in MalaCards View complete list of genes associated with diseases

Relevant External Links for DENR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DENR
genes like me logo Genes that share disorders with DENR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DENR Gene

Publications for DENR Gene

  1. Drp, a novel protein expressed at high cell density but not during growth arrest. (PMID: 9628587) Deyo J.E. … Tainsky M.A. (DNA Cell Biol. 1998) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3

Products for DENR Gene

Sources for DENR Gene

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