DENR Gene
protein-coding GIFtS: 53
GCID: GC12P123237
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density-regulated protein
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Aliases for DENR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Density-Regulated Protein1 2 | | Smooth Muscle Cell-Associated Protein 32 3 | | DRP1 2 3 | | Smooth Muscle Cell Associated Protein-32 | | DRP11 2 3 | | Protein DRP13 | | SMAP-31 2 3 | | |
Export aliases for DENR gene to outside databasesPrevious GC identifers: GC12U990118 GC12M123069 GC12P123045 GC12P121675 GC12P121674 GC12P121762 GC12P120197 |
Summaries for DENR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DENR: This gene encodes a protein whose expression was found to increase in cultured cells at high density but not duringgrowth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene.The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI havebeen found in mammals, insects, and plants. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: DENR_HUMAN, O43583Function: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Playsa role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to thetranslational initiation complex by the oncogene MCTS1
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Genomic Views for DENR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009755.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DENR gene promoter: c-Fos AP-1 Bach2 IRF-1 GATA-1 RORalpha2 POU2F1 POU2F1a c-Jun Other transcription factors
Search SABiosciences Chromatin IP Primers for DENR
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DENR |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31DENR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P123237: view genomic region
(about GC identifiers)
Start:
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123,237,321 bp from pter |
End:
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123,255,953 bp from pter |
Size:
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18,633 bases |
Orientation:
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plus strand |
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Proteins for DENR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DENR_HUMAN, O43583 (See
protein sequence)Recommended Name: Density-regulated protein Size: 198 amino acids; 22092 Da
Subunit: Interacts with MCTS1
Sequence caution: Sequence=AAC02985.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9H3U6 Q9UKZ0Explore the universe of human proteins at neXtProt for DENR: NX_O43583
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43583 DENR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003668.2 ENSEMBL proteins: ENSP00000280557 ENSP00000413661 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
DENR for ontologies About GeneDecksing
DENR Antibody Products: Assay Products for DENR: |
Protein
Domains / Families for DENR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DENR for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43583ProtoNet protein and cluster: O43583 1 Blocks protein family: IPB001950 Translation initiation factor SUI1
UniProtKB/Swiss-Prot: DENR_HUMAN, O43583Similarity: Belongs to the DENR familySimilarity: Contains 1 SUI1 domain |
Function for DENR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: DENR_HUMAN, O43583Function: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Playsa role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to thetranslational initiation complex by the oncogene MCTS1Induction: Up-regulated with increasing cell-density by HNRNPD. Up-regulated in ovarian and breast cancer cells byERBB2 overexpression. Not induced by TGFB1 Genatlas biochemistry entry for DENR:density-regulated protein,expressed in cultured cells at high density but not at low density or during growth arrest
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DENR (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DENR OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DENR (NM_003677) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DENR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENR  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENR |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0003743 | translation initiation factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
DENR for ontologies About GeneDecksing
|
Pathways & Interactions for DENR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DENR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
 5/35 Interacting proteins for DENR (O435831, 2, 3 ENSP000002805574) via UniProtKB, MINT, STRING, and/or I2D (see all 35)| Interactant | Interaction Details |
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| GeneCard | External ID(s) |
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| MARCH5 | Q9NX472, 3, ENSP000003518134 | MINT-3374425 MINT-2844192 I2D:
score=1 STRING: ENSP00000351813 | | MCTS1 | Q9ULC42, 3, ENSP000003603654 | MINT-65757 I2D:
score=11 STRING: ENSP00000360365 | | COBRA1 | Q8WX921, 3 | EBI-716083,EBI-347721 I2D:
score=1 | | NELFB | Q8WX921, 3 | EBI-716083,EBI-347721 I2D:
score=1 | | UBC | P0CG482, 3, ENSP000003448184 | MINT-2844214 MINT-3374463 MINT-3374442 I2D:
score=4 STRING: ENSP00000344818 | About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
DENR for ontologies About GeneDecksing
|
Drugs & Compounds for DENR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DENR Search CenterWatch for drugs/clinical trials and news about DENR 
|
Transcripts for DENR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DENR gene: NM_003677.3 Unigene Cluster for DENR: Density-regulated protein Hs.22393 [show with all ESTs]Unigene Representative Sequence: NM_0036774 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000280557(uc001uda.3) ENST00000455982 ENST00000539463 ENST00000537955
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DENR (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DENR OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DENR (NM_003677) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DENR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENR  |
Additional cDNA sequence: AB014731.1 AF038554.1 AF103800.1 AK299463.1 BC000925.2 BC007860.2 22 DOTS entries: DT.456369 DT.100801894 DT.75187422 DT.99945008 DT.99937125 DT.100038134 DT.100038136 DT.75107859 DT.95117564 DT.91651473 DT.100788024 DT.92416533 DT.121149490 DT.40214423 DT.92460373 DT.95185292 DT.95188230 DT.99985675 DT.100701522 DT.102822970 DT.95223482 DT.97849240 24/130 AceView cDNA sequences (see all 130): AA215870 BQ937841 BE889620 AI352466 AA608719 BM264103 AA970644 CK824786 BQ051427 BM472061 BQ226713 BQ000443 AW516987 BU164900 CK824787 F11023 AA968515 AI753426 CR622756 AL702857 BQ214795 AA738379 BM718083 CB043905 GeneLoc Exon Structure
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Expression for DENR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DENR expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CAAATTACAA
About this image See DENR Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DENR
SOURCE GeneReport for Unigene cluster: Hs.22393 UniProtKB/Swiss-Prot: DENR_HUMAN, O43583Tissue specificity: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta,liver and pancreas. Weakly expressed in the lung and kidney SABiosciences Expression via Pathway-Focused PCR Array including DENR:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DENR Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DENR | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DENR | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DENR | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENR |
Orthologs for DENR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DENR gene from 9/32 species (see all 32) About this table
ENSEMBL Gene Tree for DENR (if available) TreeFam Gene Tree for DENR (if available)  |
Paralogs for DENR gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for DENR gene
DENR for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for DENR PGOHUM00000239861 PGOHUM00000237143 PGOHUM00000237369 PGOHUM00000247517 PGOHUM00000260486
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Genomic Variants for DENR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for DENR (123237321 - 123255953 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DENR: -- Human Gene Mutation Database (HGMD): DENR
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DENR |
|
Disorders
/ Diseases for DENR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DENR for disorders About GeneDecksing
OMIM gene information: 604550
OMIM disorders: --
6 diseases for DENR: About MalaCardspleomorphic adenoma pleomorphic adenoma carcinoma adenoma breast cancer malaria carcinoma 1 disease from the University of Copenhagen DISEASES database for DENR:Pleomorphic adenoma carcinoma Export disorders for DENR gene to outside databases
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Publications for DENR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DENR gene, integrated from 9 sources (see all 23): (articles sorted by number of sources associating them with DENR) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Drp, a novel protein expressed at high cell density but not during growth arrest. (PubMed id 9628587)1, 2, 3, 9 Deyo J.E.... Tainsky M.A. (1998)
- Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1. (PubMed id 17878526)1, 2 Mazan-Mamczarz K. and Gartenhaus R.B. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PubMed id 10497265)1, 2 Oh J.J.... Slamon D.J. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for DENR gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DENR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DENR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DENR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for DENR gene: Search GeneIP for patents involving DENR
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DENR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for DENR | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DENR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DENR | | OriGene Protein Over-expression Lysate for DENR | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for DENR | | OriGene 3'-UTR Clone for DENR | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DENR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DENR | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for DENR | | OriGene Custom Protein Services for DENR | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DENR | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DENR | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DENR | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DENR | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DENR | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DENR |
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 |  |  |  | |
| | | Search Tocris compounds for DENR |
| |  |  |  |  | | | | | Recombinant Protein for DENR |
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 | | DENR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENR |
|  |  |  | | | ThermoFisher Antibodies for DENR |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENR |
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