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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DENR Gene

protein-coding   GIFtS: 53
GCID: GC12P123237

density-regulated protein

 Explore 6 diseases affiliated with
DENR via our new
 Human Malady Compendium 
Biological research products
for DENR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Density-Regulated Protein1 2     Smooth Muscle Cell-Associated Protein 32 3
DRP1 2 3     Smooth Muscle Cell Associated Protein-32
DRP11 2 3     Protein DRP13
SMAP-31 2 3     

External Ids:    HGNC: 27691   Entrez Gene: 85622   Ensembl: ENSG000001397267   OMIM: 6045505   UniProtKB: O435833   

Export aliases for DENR gene to outside databases

Previous GC identifers: GC12U990118 GC12M123069 GC12P123045 GC12P121675 GC12P121674 GC12P121762 GC12P120197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DENR:
This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during
growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene.
The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2
and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have
been found in mammals, insects, and plants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DENR_HUMAN, O43583
Function: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Plays
a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the
translational initiation complex by the oncogene MCTS1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DENR gene promoter:
         c-Fos   AP-1   Bach2   IRF-1   GATA-1   RORalpha2   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDENR promoter sequence
   Search SABiosciences Chromatin IP Primers for DENR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DENR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

DENR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENR gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P123237:  view genomic region     (about GC identifiers)

Start:
123,237,321 bp from pter      End:
123,255,953 bp from pter
Size:
18,633 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DENR_HUMAN, O43583 (See protein sequence)
Recommended Name: Density-regulated protein  
Size: 198 amino acids; 22092 Da
Subunit: Interacts with MCTS1
Sequence caution: Sequence=AAC02985.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9H3U6 Q9UKZ0

Explore the universe of human proteins at neXtProt for DENR: NX_O43583

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43583

  • DENR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003668.2  
    ENSEMBL proteins: 
     ENSP00000280557   ENSP00000413661  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: DENR
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    GenScript Custom Purified and Recombinant Proteins Services for DENR
    Novus Biologicals DENR Proteins
    Novus Biologicals DENR Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for DENR
    Uscn Proteins for DENR

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    DENR for ontologies           About GeneDecksing



    DENR Antibody Products: 
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    Novus Biologicals DENR Antibodies
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    ThermoFisher Antibodies for DENR

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    Uscn ELISAs and CLIAs for DENR


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DENR for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001950 TIF_SUI1
     IPR005873 Drp1

    Graphical View of Domain Structure for InterPro Entry O43583

    ProtoNet protein and cluster: O43583

    1 Blocks protein family: IPB001950 Translation initiation factor SUI1

    UniProtKB/Swiss-Prot: DENR_HUMAN, O43583
    Similarity: Belongs to the DENR family
    Similarity: Contains 1 SUI1 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DENR_HUMAN, O43583
    Function: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Plays
    a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the
    translational initiation complex by the oncogene MCTS1
    Induction: Up-regulated with increasing cell-density by HNRNPD. Up-regulated in ovarian and breast cancer cells by
    ERBB2 overexpression. Not induced by TGFB1

         Genatlas biochemistry entry for DENR:
    density-regulated protein,expressed in cultured cells at high density but not at low density or during growth arrest

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DENR
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate DENR (see all 36):
    hsa-miR-4328 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-624* hsa-miR-500a hsa-miR-3622b-3p hsa-miR-1183 hsa-miR-4264
    SwitchGear 3'UTR luciferase reporter plasmidDENR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DENR (see all 4)
    OriGene shRNA RFP: DENR
    OriGene siRNA: DENR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DENR

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DENR (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DENR
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENR 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENR

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003743translation initiation factor activity IEA--
    GO:0005515protein binding IPI--


    DENR for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DENR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/35 Interacting proteins for DENR (O435831, 2, 3 ENSP000002805574) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARCH5Q9NX472, 3, ENSP000003518134MINT-3374425 MINT-2844192 I2D: score=1 STRING: ENSP00000351813
    MCTS1Q9ULC42, 3, ENSP000003603654MINT-65757 I2D: score=11 STRING: ENSP00000360365
    COBRA1Q8WX921, 3EBI-716083,EBI-347721 I2D: score=1 
    NELFBQ8WX921, 3EBI-716083,EBI-347721 I2D: score=1 
    UBCP0CG482, 3, ENSP000003448184MINT-2844214 MINT-3374463 MINT-3374442 I2D: score=4 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    DENR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for DENR:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DENR
    Search CenterWatch for drugs/clinical trials and news about DENR 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DENR gene: 
    NM_003677.3  

    Unigene Cluster for DENR:

    Density-regulated protein
    Hs.22393  [show with all ESTs]
    Unigene Representative Sequence: NM_003677
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280557(uc001uda.3) ENST00000455982 ENST00000539463 ENST00000537955


    miRNA
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    OriGene 3'-UTR Clone: DENR
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DENR
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate DENR (see all 36):
    hsa-miR-4328 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-624* hsa-miR-500a hsa-miR-3622b-3p hsa-miR-1183 hsa-miR-4264
    SwitchGear 3'UTR luciferase reporter plasmidDENR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DENR (see all 4)
    OriGene shRNA RFP: DENR
    OriGene siRNA: DENR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DENR
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DENR
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    GenScript: all cDNA clones in your preferred vector: DENR (NM_003677)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DENR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENR 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DENR
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DENR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DENR

    Additional cDNA sequence: 

    AB014731.1 AF038554.1 AF103800.1 AK299463.1 BC000925.2 BC007860.2 

    22 DOTS entries:

    DT.456369  DT.100801894  DT.75187422  DT.99945008  DT.99937125  DT.100038134  DT.100038136  DT.75107859 
    DT.95117564  DT.91651473  DT.100788024  DT.92416533  DT.121149490  DT.40214423  DT.92460373  DT.95185292 
    DT.95188230  DT.99985675  DT.100701522  DT.102822970  DT.95223482  DT.97849240 

    24/130 AceView cDNA sequences (see all 130):

    AA215870 BQ937841 BE889620 AI352466 AA608719 BM264103 AA970644 CK824786 
    BQ051427 BM472061 BQ226713 BQ000443 AW516987 BU164900 CK824787 F11023 
    AA968515 AI753426 CR622756 AL702857 BQ214795 AA738379 BM718083 CB043905 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DENR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAATTACAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DENR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DENR

    SOURCE GeneReport for Unigene cluster: Hs.22393

    UniProtKB/Swiss-Prot: DENR_HUMAN, O43583
    Tissue specificity: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta,
    liver and pancreas. Weakly expressed in the lung and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including DENR: 
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DENR gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Denr1 , 5 density-regulated protein1, 5 91.58(n)1
    96.46(a)1
      5 (63.26 cM)5
    681841  NM_026603.41  NP_080879.11 
     1239071755 
    chicken
    (Gallus gallus)
    Aves DENR1 density-regulated protein 84.34(n)
    91.41(a)
      771794  NM_001079505.1  NP_001072973.1 
    lizard
    (Anolis carolinensis)
    Reptilia DENR6
    --
    89(a)
    1 ↔ 1
    LGb(2138244-2142589)
    zebrafish
    (Danio rerio)
    Actinopterygii denr1 density-regulated protein 74.64(n)
    85.33(a)
      436970  NM_001002697.2  NP_001002697.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90991 CG9099 55.83(n)
    53.37(a)
      32679  NM_132948.3  NP_573176.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.211 Protein Y47D3A.21 58.28(n)
    54.09(a)
      176556  NM_067049.3  NP_499450.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMA22(YJR014W)4
    TMA221
    Protein of unknown function; associates with ribosomes more4
    Tma22p1
    50.4(n)1
    36.31(a)1
      10(461829-462425)4
    8534711, 4  NP_012548.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G119001 Translation initiation factor SUI1 family protein 51.98(n)
    44.05(a)
      831063  NM_121228.4  NP_196751.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g01955001 hypothetical protein 48.75(n)
    44.37(a)
      4327323  NM_001048826.1  NP_001042291.2 


    ENSEMBL Gene Tree for DENR (if available)
    TreeFam Gene Tree for DENR (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DENR gene

    DENR for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for DENR
    PGOHUM00000239861 PGOHUM00000237143 PGOHUM00000237369 PGOHUM00000247517 PGOHUM00000260486


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/338 NCBI SNPs in DENR are shown (see all 338    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107349591,2
    C,H,--123235568(+) CCTCTG/AAGTTC 1 -- us2k110Minor allele frequency- A:0.08NA WA CSA EA 252
    rs128207821,2
    C,F--123235569(+) ctctaG/Agttcc 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1147848521,2
    F,--123235651(+) TAGAGA/GGAAGG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1919558861,2
    --123235755(+) CAATGC/TCTTAA 1 -- us2k10--------
    rs1825665061,2
    --123235827(+) GTAGAG/TGGAAT 1 -- us2k10--------
    rs1857952901,2
    --123235844(+) TCGGGC/TTTTAC 1 -- us2k10--------
    rs110597241,2
    C,A,--123235978(+) GGCTGT/GGGAAT 1 -- us2k12Minor allele frequency- G:0.15NA 122
    rs1898649371,2
    --123236144(+) TAAGGC/TGCATG 1 -- us2k10--------
    rs1431128241,2
    --123236213(+) CCTCAA/GTTGAC 1 -- us2k10--------
    rs1178914401,2
    F,--123236244(+) CACAGG/CGTTGG 1 -- us2k11Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for DENR (123237321 - 123255953 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DENR: --
    Human Gene Mutation Database (HGMD): DENR

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DENR
    DNA2.0 Custom Variant and Variant Library Synthesis for DENR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DENR for disorders           About GeneDecksing

    OMIM gene information: 604550    OMIM disorders: --

    6 diseases for DENR:    About MalaCards
    pleomorphic adenoma    pleomorphic adenoma carcinoma    adenoma    breast cancer
    malaria    carcinoma

    1 disease from the University of Copenhagen DISEASES database for DENR:
    Pleomorphic adenoma carcinoma

    Export disorders for DENR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DENR gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with DENR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Drp, a novel protein expressed at high cell density but not during growth arrest. (PubMed id 9628587)1, 2, 3, 9 Deyo J.E.... Tainsky M.A. (1998)
    2. Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1. (PubMed id 17878526)1, 2 Mazan-Mamczarz K. and Gartenhaus R.B. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PubMed id 10497265)1, 2 Oh J.J.... Slamon D.J. (1999)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8562 HGNC: 2769 AceView: DENR Ensembl:ENSG00000139726 euGenes: HUgn8562
    ECgene: DENR H-InvDB: DENR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DENR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DENR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DENR gene:
    Search GeneIP for patents involving DENR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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     Regulatory tfbs in DENR promoter
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     DENR Proteins, Antibodies, CLIAs, and ELISAs
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