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Aliases for DENR Gene

Aliases for DENR Gene

  • Density Regulated Re-Initiation And Release Factor 2 3 5
  • Density-Regulated Protein 2 3
  • SMAP-3 3 4
  • DRP1 3 4
  • DRP 3 4
  • Smooth Muscle Cell Associated Protein-3 3
  • Smooth Muscle Cell-Associated Protein 3 4
  • Protein DRP1 4

External Ids for DENR Gene

Previous GeneCards Identifiers for DENR Gene

  • GC12U990118
  • GC12M123069
  • GC12P123045
  • GC12P121675
  • GC12P121674
  • GC12P121762
  • GC12P123237
  • GC12P120197

Summaries for DENR Gene

Entrez Gene Summary for DENR Gene

  • This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

GeneCards Summary for DENR Gene

DENR (Density Regulated Re-Initiation And Release Factor) is a Protein Coding gene. Diseases associated with DENR include Pleomorphic Adenoma Carcinoma and Charcot-Marie-Tooth Disease, Axonal, Type 2L. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot for DENR Gene

  • May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

Additional gene information for DENR Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENR Gene

Genomics for DENR Gene

Regulatory Elements for DENR Gene

Enhancers for DENR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H122637 1.1 Ensembl ENCODE 13.1 -114.8 -114774 0 CTCF PKNOX1 SAP130 ARID4B MAX RAD21 RFX5 CC2D1A CTBP1 SMC3 DENR ENSG00000256044 HCAR1 CCDC62 ENSG00000274191 ENSG00000256249
GH12H122699 1 Ensembl ENCODE dbSUPER 12.3 -51.0 -50974 4 CEBPA HLF CEBPB ZNF384 HCAR3 HCAR2 HCAR1 ENSG00000256044 DENR LOC101927415 ENSG00000256249
GH12H122419 1.8 FANTOM5 ENCODE dbSUPER 1.9 -330.7 -330666 4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 SLC30A9 ZNF766 ZNF143 REST ZNF592 RSRC2 ZCCHC8 PSMD9 KNTC1 LINC01089 ENSG00000252192 ENSG00000272849 CLIP1 KDM2B C12orf65
GH12H122751 1.1 ENCODE 0.7 -0.2 -153 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 HCAR1 HCAR3 CCDC150P1 VPS37B PITPNM2 DENR ENSG00000256044
GH12H122750 0.7 ENCODE 0.7 -2.6 -2646 0 NFIB MAX CTBP1 GATA3 POLR2A RCOR1 TCF7L2 USF2 NFYC MNT DENR ENSG00000256044
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DENR on UCSC Golden Path with GeneCards custom track

Promoters for DENR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058635 126 1401 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for DENR Gene

Chromosome:
12
Start:
122,752,774 bp from pter
End:
122,771,064 bp from pter
Size:
18,291 bases
Orientation:
Plus strand

Genomic View for DENR Gene

Genes around DENR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENR Gene

Proteins for DENR Gene

  • Protein details for DENR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43583-DENR_HUMAN
    Recommended name:
    Density-regulated protein
    Protein Accession:
    O43583
    Secondary Accessions:
    • Q9H3U6
    • Q9UKZ0

    Protein attributes for DENR Gene

    Size:
    198 amino acids
    Molecular mass:
    22092 Da
    Quaternary structure:
    • Interacts with MCTS1.
    SequenceCaution:
    • Sequence=AAC02985.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for DENR Gene

Post-translational modifications for DENR Gene

  • Ubiquitination at isoforms=59
  • Modification sites at PhosphoSitePlus

Other Protein References for DENR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DENR Gene

Domains & Families for DENR Gene

Gene Families for DENR Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DENR Gene

Suggested Antigen Peptide Sequences for DENR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43583

UniProtKB/Swiss-Prot:

DENR_HUMAN :
  • Belongs to the DENR family.
Family:
  • Belongs to the DENR family.
genes like me logo Genes that share domains with DENR: view

Function for DENR Gene

Molecular function for DENR Gene

GENATLAS Biochemistry:
density-regulated protein,expressed in cultured cells at high density but not at low density or during growth arrest
UniProtKB/Swiss-Prot Function:
May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
UniProtKB/Swiss-Prot Induction:
Up-regulated with increasing cell-density by HNRNPD. Up-regulated in ovarian and breast cancer cells by ERBB2 overexpression. Not induced by TGFB1.

Gene Ontology (GO) - Molecular Function for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003729 mRNA binding IBA --
GO:0003743 translation initiation factor activity IBA,IEA --
GO:0005515 protein binding IPI 16169070
GO:0043022 ribosome binding IBA --
genes like me logo Genes that share ontologies with DENR: view
genes like me logo Genes that share phenotypes with DENR: view

Animal Models for DENR Gene

MGI Knock Outs for DENR:
  • Denr tm1b(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DENR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DENR Gene

Localization for DENR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENR gene
Compartment Confidence
cytosol 4
mitochondrion 2
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005840 colocalizes_with ribosome IBA --
GO:0070992 translation initiation complex IBA --
genes like me logo Genes that share ontologies with DENR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DENR Gene

Pathways & Interactions for DENR Gene

No Data Available

Gene Ontology (GO) - Biological Process for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IDA 20713520
GO:0002188 translation reinitiation IBA --
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0032790 ribosome disassembly IDA 20713520
genes like me logo Genes that share ontologies with DENR: view

No data available for Pathways by source and SIGNOR curated interactions for DENR Gene

Drugs & Compounds for DENR Gene

No Compound Related Data Available

Transcripts for DENR Gene

Unigene Clusters for DENR Gene

Density-regulated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DENR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DENR Gene

No ASD Table

Relevant External Links for DENR Gene

GeneLoc Exon Structure for
DENR
ECgene alternative splicing isoforms for
DENR

Expression for DENR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DENR Gene

Protein differential expression in normal tissues from HIPED for DENR Gene

This gene is overexpressed in Lavage (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DENR Gene



Protein tissue co-expression partners for DENR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DENR Gene:

DENR

SOURCE GeneReport for Unigene cluster for DENR Gene:

Hs.22393

mRNA Expression by UniProt/SwissProt for DENR Gene:

O43583-DENR_HUMAN
Tissue specificity: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.

Evidence on tissue expression from TISSUES for DENR Gene

  • Heart(4.5)
  • Liver(4.3)
  • Nervous system(3.5)
  • Muscle(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with DENR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENR Gene

Orthologs for DENR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DENR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENR 33 34
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 95 (a)
OneToMany
DENR 33 34
  • 94.44 (n)
dog
(Canis familiaris)
Mammalia DENR 33 34
  • 93.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
OneToMany
-- 34
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC687565 33
  • 92.27 (n)
oppossum
(Monodelphis domestica)
Mammalia DENR 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Denr 33 16 34
  • 91.58 (n)
chicken
(Gallus gallus)
Aves DENR 33 34
  • 84.34 (n)
lizard
(Anolis carolinensis)
Reptilia DENR 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia denr 33
  • 79.36 (n)
zebrafish
(Danio rerio)
Actinopterygii denr 33 34
  • 74.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9099 33 34
  • 55.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006125 33
  • 53.88 (n)
worm
(Caenorhabditis elegans)
Secernentea Y47D3A.21 33 34
  • 54.6 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA22 33 34 36
  • 51.23 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21934g 33
  • 49.89 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL112C 33
  • 42.07 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11900 33
  • 52.08 (n)
rice
(Oryza sativa)
Liliopsida Os01g0195500 33
  • 48.12 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16C6.05 33
  • 52.97 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02984 33
  • 47.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7885 34
  • 47 (a)
OneToOne
Species where no ortholog for DENR was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENR Gene

ENSEMBL:
Gene Tree for DENR (if available)
TreeFam:
Gene Tree for DENR (if available)

Paralogs for DENR Gene

genes like me logo Genes that share paralogs with DENR: view

No data available for Paralogs for DENR Gene

Variants for DENR Gene

Sequence variations from dbSNP and Humsavar for DENR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000183997 -- 122,755,151(+) AGATT(C/T)TTGGG intron-variant
rs1000189425 -- 122,752,241(+) GAAAG(-/AGAC)AGAAA upstream-variant-2KB
rs1000323860 -- 122,760,701(+) AGTCC(A/G)GCCTG intron-variant
rs1000794879 -- 122,753,296(+) TTCCT(A/G)GGCAC intron-variant
rs1000890113 -- 122,754,828(+) AAATC(C/T)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENR Gene

Variant ID Type Subtype PubMed ID
nsv975535 CNV duplication 23825009

Variation tolerance for DENR Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DENR Gene

Human Gene Mutation Database (HGMD)
DENR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DENR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENR Gene

Disorders for DENR Gene

MalaCards: The human disease database

(2) MalaCards diseases for DENR Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
pleomorphic adenoma carcinoma
  • carcinoma ex pleomorphic adenoma
charcot-marie-tooth disease, axonal, type 2l
  • charcot-marie-tooth disease, type 2i
- elite association - COSMIC cancer census association via MalaCards
Search DENR in MalaCards View complete list of genes associated with diseases

Relevant External Links for DENR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DENR
genes like me logo Genes that share disorders with DENR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DENR Gene

Publications for DENR Gene

  1. drp, a novel protein expressed at high cell density but not during growth arrest. (PMID: 9628587) Deyo JE … Tainsky MA (DNA and cell biology 1998) 2 3 4 22 60
  2. Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. (PMID: 20713520) Skabkin MA … Pestova TV (Genes & development 2010) 2 3 4 60
  3. MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles. (PMID: 16982740) Reinert LS … Gartenhaus RB (Cancer research 2006) 2 3 4 60
  4. De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation. (PMID: 27239039) Haas MA … Heng JI (Cell reports 2016) 2 3 60
  5. Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1. (PMID: 17878526) Mazan-Mamczarz K … Gartenhaus RB (Cancer genomics & proteomics 2007) 3 4 60

Products for DENR Gene

Sources for DENR Gene

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