Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DENR Gene

Aliases for DENR Gene

  • Density-Regulated Protein 2 3
  • DRP 3 4 6
  • Smooth Muscle Cell-Associated Protein 3 3 4
  • SMAP-3 3 4
  • DRP1 3 4
  • Smooth Muscle Cell Associated Protein-3 3
  • Protein DRP1 4

External Ids for DENR Gene

Summaries for DENR Gene

Entrez Gene Summary for DENR Gene

  • This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

GeneCards Summary for DENR Gene

DENR (Density-Regulated Protein) is a Protein Coding gene. Diseases associated with DENR include pleomorphic adenoma. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot for DENR Gene

  • May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENR Gene

Genomics for DENR Gene

Genomic Location for DENR Gene

Start:
122,752,774 bp from pter
End:
122,771,406 bp from pter
Size:
18,633 bases
Orientation:
Plus strand

Genomic View for DENR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENR Gene

Regulatory Elements for DENR Gene

Proteins for DENR Gene

  • Protein details for DENR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43583-DENR_HUMAN
    Recommended name:
    Density-regulated protein
    Protein Accession:
    O43583
    Secondary Accessions:
    • Q9H3U6
    • Q9UKZ0

    Protein attributes for DENR Gene

    Size:
    198 amino acids
    Molecular mass:
    22092 Da
    Quaternary structure:
    • Interacts with MCTS1.
    SequenceCaution:
    • Sequence=AAC02985.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for DENR Gene

Proteomics data for DENR Gene at MOPED

Post-translational modifications for DENR Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys59

Other Protein References for DENR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DENR Gene

Domains for DENR Gene

Protein Domains for DENR Gene

UniProtKB/Swiss-Prot:

DENR_HUMAN
Domain:
  • Contains 1 SUI1 domain.:
    • O43583
Family:
  • Belongs to the DENR family.:
    • O43583
genes like me logo Genes that share domains with DENR: view

No data available for Gene Families for DENR Gene

Function for DENR Gene

Molecular function for DENR Gene

GENATLAS Biochemistry: density-regulated protein,expressed in cultured cells at high density but not at low density or during growth arrest
UniProtKB/Swiss-Prot Function: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
UniProtKB/Swiss-Prot Induction: Up-regulated with increasing cell-density by HNRNPD. Up-regulated in ovarian and breast cancer cells by ERBB2 overexpression. Not induced by TGFB1.

Gene Ontology (GO) - Molecular Function for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 16874301
genes like me logo Genes that share ontologies with DENR: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DENR Gene

Localization for DENR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENR Gene COMPARTMENTS Subcellular localization image for DENR gene
Compartment Confidence
cytosol 2
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with DENR: view

Pathways for DENR Gene

SuperPathways for DENR Gene

No Data Available

Gene Ontology (GO) - Biological Process for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IDA 20713520
GO:0002192 IRES-dependent translational initiation IDA 20713520
GO:0006413 translational initiation --
GO:0032790 ribosome disassembly IDA 20713520
genes like me logo Genes that share ontologies with DENR: view

No data available for Pathways by source for DENR Gene

Transcripts for DENR Gene

mRNA/cDNA for DENR Gene

Unigene Clusters for DENR Gene

Density-regulated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENR Gene

No ASD Table

Relevant External Links for DENR Gene

GeneLoc Exon Structure for
DENR
ECgene alternative splicing isoforms for
DENR

Expression for DENR Gene

mRNA expression in normal human tissues for DENR Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENR Gene

SOURCE GeneReport for Unigene cluster for DENR Gene Hs.22393

mRNA Expression by UniProt/SwissProt for DENR Gene

O43583-DENR_HUMAN
Tissue specificity: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.
genes like me logo Genes that share expressions with DENR: view

Orthologs for DENR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DENR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENR 36
  • 99.66 (n)
  • 100 (a)
DENR 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 95 (a)
OneToMany
DENR 36
  • 94.44 (n)
  • 96.46 (a)
DENR 37
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DENR 36
  • 93.1 (n)
  • 96.46 (a)
DENR 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Denr 36
  • 91.58 (n)
  • 96.46 (a)
Denr 16
Denr 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DENR 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 93 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC687565 36
  • 92.27 (n)
  • 97.42 (a)
chicken
(Gallus gallus)
Aves DENR 36
  • 84.34 (n)
  • 91.41 (a)
DENR 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DENR 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia denr 36
  • 79.36 (n)
  • 85.79 (a)
zebrafish
(Danio rerio)
Actinopterygii denr 36
  • 74.82 (n)
  • 85.33 (a)
denr 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006125 36
  • 53.88 (n)
  • 53.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9099 36
  • 55.83 (n)
  • 53.37 (a)
CG9099 37
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y47D3A.21 36
  • 54.6 (n)
  • 50.31 (a)
Y47D3A.21 37
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL112C 36
  • 42.07 (n)
  • 36.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA22 36
  • 51.23 (n)
  • 37.58 (a)
TMA22 37
  • 28 (a)
OneToOne
TMA22 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21934g 36
  • 49.89 (n)
  • 35.37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11900 36
  • 52.08 (n)
  • 45 (a)
rice
(Oryza sativa)
Liliopsida Os01g0195500 36
  • 48.12 (n)
  • 42.5 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02984 36
  • 47.02 (n)
  • 43.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16C6.05 36
  • 52.97 (n)
  • 41.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7885 37
  • 47 (a)
OneToOne
Species with no ortholog for DENR:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENR Gene

ENSEMBL:
Gene Tree for DENR (if available)
TreeFam:
Gene Tree for DENR (if available)

Paralogs for DENR Gene

genes like me logo Genes that share paralogs with DENR: view

No data available for Paralogs for DENR Gene

Variants for DENR Gene

Sequence variations from dbSNP and Humsavar for DENR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2154 -- 122,769,991(-) GATTC(A/C/T)CACCC utr-variant-3-prime
rs839356 -- 122,767,090(-) GAGTT(G/T)TGAAG intron-variant
rs839357 -- 122,766,820(-) GTTAG(C/T)TCAGG intron-variant
rs1045743 -- 122,769,164(+) tatat(A/G)tacac utr-variant-3-prime
rs1128579 -- 122,769,632(+) CTCCC(A/G)AGTAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DENR Gene

Variant ID Type Subtype PubMed ID
nsv899571 CNV Loss 21882294

Relevant External Links for DENR Gene

HapMap Linkage Disequilibrium report
DENR
Human Gene Mutation Database (HGMD)
DENR

Disorders for DENR Gene

(1) MalaCards Diseases for DENR Gene

Search for DENR Gene in MalaCards »
genes like me logo Genes that share disorders with DENR: view

No data available for UniProtKB/Swiss-Prot for DENR Gene

Publications for DENR Gene

  1. Drp, a novel protein expressed at high cell density but not during growth arrest. (PMID: 9628587) Deyo J.E. … Tainsky M.A. (DNA Cell Biol. 1998) 2 3 4 23
  2. Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PMID: 10497265) Oh J.J. … Slamon D.J. (Nucleic Acids Res. 1999) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1. (PMID: 17878526) Mazan-Mamczarz K. … Gartenhaus R.B. (Cancer Genomics Proteomics 2007) 3 4
  5. Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. (PMID: 20713520) Skabkin M.A. … Pestova T.V. (Genes Dev. 2010) 3 4

Products for DENR Gene

Sources for DENR Gene

Back to Top

Content