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DENR Gene

protein-coding   GIFtS: 54
GCID: GC12P123237

Density-Regulated Protein

  See DENR-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Density-Regulated Protein1 2     SMAP-32 3
DRP2 3 5     Smooth Muscle Cell Associated Protein-32
Smooth Muscle Cell-Associated Protein 32 3     Protein DRP13
DRP12 3     

External Ids:    HGNC: 27691   Entrez Gene: 85622   Ensembl: ENSG000001397267   OMIM: 6045505   UniProtKB: O435833   

Export aliases for DENR gene to outside databases

Previous GC identifers: GC12U990118 GC12M123069 GC12P123045 GC12P121675 GC12P121674 GC12P121762 GC12P120197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DENR Gene:
This gene encodes a protein whose expression was found to increase in cultured cells at high density but not
during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu
proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor
that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site.
Proteins similar to SUI have been found in mammals, insects, and plants. (provided by RefSeq, Jul 2008)

GeneCards Summary for DENR Gene:
DENR (density-regulated protein) is a protein-coding gene. Diseases associated with DENR include pleomorphic adenoma. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot: DENR_HUMAN, O43583
Function: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon.
Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to
the translational initiation complex by the oncogene MCTS1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DENR gene promoter:
         c-Fos   AP-1   Bach2   IRF-1   GATA-1   RORalpha2   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDENR promoter sequence
   Search Chromatin IP Primers for DENR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

DENR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENR gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P123237:  view genomic region     (about GC identifiers)

Start:
123,237,321 bp from pter      End:
123,255,953 bp from pter
Size:
18,633 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DENR_HUMAN, O43583 (See protein sequence)
Recommended Name: Density-regulated protein  
Size: 198 amino acids; 22092 Da
Subunit: Interacts with MCTS1
Sequence caution: Sequence=AAC02985.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9H3U6 Q9UKZ0

Explore the universe of human proteins at neXtProt for DENR: NX_O43583

Explore proteomics data for DENR at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59
  • Modification sites at PhosphoSitePlus

  • See DENR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003668.2  
    ENSEMBL proteins: 
     ENSP00000280557   ENSP00000413661  

    DENR Human Recombinant Protein Products:

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    OriGene Purified Protein for DENR
    OriGene Protein Over-expression Lysate for DENR
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DENR
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    Novus Biologicals DENR Proteins
    Novus Biologicals DENR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DENR
    Cloud-Clone Corp. Proteins for DENR

     
    Search eBioscience for Proteins for DENR 

     
    antibodies-online proteins for DENR (6 products) 

     
    antibodies-online peptides for DENR

    DENR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals DENR Antibodies
    Abcam antibodies for DENR
    Cloud-Clone Corp. Antibodies for DENR
    ThermoFisher Antibody for DENR
    LSBio Antibodies in human, mouse, rat for DENR
    antibodies-online antibodies for DENR (85 products) 

    DENR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DENR
    Cloud-Clone Corp. CLIAs for DENR
    Search eBioscience for ELISAs for DENR 
    antibodies-online kits for DENR (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001950 TIF_SUI1
     IPR005873 Drp1

    Graphical View of Domain Structure for InterPro Entry O43583

    ProtoNet protein and cluster: O43583

    1 Blocks protein domain: IPB001950 Translation initiation factor SUI1

    UniProtKB/Swiss-Prot: DENR_HUMAN, O43583
    Similarity: Belongs to the DENR family
    Similarity: Contains 1 SUI1 domain


    Find genes that share domains with DENR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DENR_HUMAN, O43583
    Function: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon.
    Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to
    the translational initiation complex by the oncogene MCTS1
    Induction: Up-regulated with increasing cell-density by HNRNPD. Up-regulated in ovarian and breast cancer cells by
    ERBB2 overexpression. Not induced by TGFB1

         Genatlas biochemistry entry for DENR:
    density-regulated protein,expressed in cultured cells at high density but not at low density or during growth
    arrest

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003743translation initiation factor activity IEA--
    GO:0005515protein binding IPI16874301
         
    Find genes that share ontologies with DENR           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DENR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DENR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DENR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DENR

    miRNA
    Products:
        
    miRTarBase miRNAs that target DENR:
    hsa-mir-221-3p (MIRT046970), hsa-mir-615-3p (MIRT039906), hsa-mir-877-3p (MIRT036874), hsa-mir-425-5p (MIRT039320), hsa-mir-106b-3p (MIRT038550), hsa-mir-15b-5p (MIRT046512), hsa-mir-148a-3p (MIRT048024), hsa-let-7b-5p (MIRT051880)

    Block miRNA regulation of human, mouse, rat DENR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DENR (see all 36):
    hsa-miR-4328 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-624* hsa-miR-500a hsa-miR-3622b-3p hsa-miR-1183 hsa-miR-4264
    SwitchGear 3'UTR luciferase reporter plasmidDENR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DENR
    Predesigned siRNA for gene silencing in human, mouse, rat DENR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DENR

    Clone
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    OriGene clones in human, mouse for DENR (see all 7)
    OriGene ORF clones in mouse, rat for DENR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DENR (NM_003677)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DENR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DENR
    Browse ESI BIO Cell Lines and PureStem Progenitors for DENR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    extracellular1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with DENR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DENR: 
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DENR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DENR (O435831, 2, 3 ENSP000002805574) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCTS1Q9ULC42, 3, ENSP000003603654MINT-65757 I2D: score=11 STRING: ENSP00000360365
    NELFBQ8WX921, 3EBI-716083,EBI-347721 I2D: score=1 
    UBCP0CG481, 2, 3, ENSP000003448184EBI-716083,EBI-3390054 MINT-2844214 MINT-3374463 MINT-3374442 I2D: score=4 STRING: ENSP00000344818
    MARCH5Q9NX471, 2, 3, ENSP000003518134EBI-716083,EBI-2341610 MINT-3374425 MINT-2844192 I2D: score=1 STRING: ENSP00000351813
    RPS9P467813, ENSP000003028964I2D: score=3 STRING: ENSP00000302896
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006413translational initiation ----
    GO:0008150biological_process ND--

    Find genes that share ontologies with DENR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DENR



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DENR gene: 
    NM_003677.3  

    Unigene Cluster for DENR:

    Density-regulated protein
    Hs.22393  [show with all ESTs]
    Unigene Representative Sequence: NM_003677
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280557(uc001uda.3) ENST00000455982 ENST00000539463 ENST00000537955

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DENR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DENR (see all 36):
    hsa-miR-4328 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-624* hsa-miR-500a hsa-miR-3622b-3p hsa-miR-1183 hsa-miR-4264
    SwitchGear 3'UTR luciferase reporter plasmidDENR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DENR
    Predesigned siRNA for gene silencing in human, mouse, rat DENR
    Clone
    Products:
         
    OriGene clones in human, mouse for DENR (see all 7)
    OriGene ORF clones in mouse, rat for DENR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DENR (NM_003677)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DENR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DENR
    OriGene qSTAR qPCR primer pairs in human, mouse for DENR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DENR
      QuantiTect SYBR Green Assays in human, mouse, rat DENR
      QuantiFast Probe-based Assays in human, mouse, rat DENR

    Additional mRNA sequence: 

    AB014731.1 AF038554.1 AF103800.1 AK299463.1 BC000925.2 BC007860.2 

    22 DOTS entries:

    DT.456369  DT.100801894  DT.75187422  DT.99945008  DT.99937125  DT.100038134  DT.100038136  DT.75107859 
    DT.95117564  DT.91651473  DT.100788024  DT.92416533  DT.121149490  DT.40214423  DT.92460373  DT.95185292 
    DT.95188230  DT.99985675  DT.100701522  DT.102822970  DT.95223482  DT.97849240 

    Selected AceView cDNA sequences (see all 130):

    BU164900 BM264103 AA738379 AI753426 BQ214795 BQ937841 BM718083 AL702857 
    BQ226713 CK824787 CR622756 CK824786 AA968515 AA215870 F11023 AW516987 
    BQ051427 AA608719 BQ000443 BE889620 AA970644 BM472061 AI352466 BM714743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DENR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATTACAA
    DENR Expression
    About this image

    DENR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DENR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22393

    UniProtKB/Swiss-Prot: DENR_HUMAN, O43583
    Tissue specificity: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta,
    liver and pancreas. Weakly expressed in the lung and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including DENR: 
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DENR
    OriGene qSTAR qPCR primer pairs in human, mouse for DENR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DENR
    QuantiTect SYBR Green Assays in human, mouse, rat DENR
    QuantiFast Probe-based Assays in human, mouse, rat DENR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DENR gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Denr1 , 5 density-regulated protein1, 5 91.58(n)1
    96.46(a)1
      5 (63.26 cM)5
    681841  NM_026603.41  NP_080879.11 
     1239071755 
    chicken
    (Gallus gallus)
    Aves DENR1 density-regulated protein 84.34(n)
    91.41(a)
      771794  NM_001079505.1  NP_001072973.1 
    lizard
    (Anolis carolinensis)
    Reptilia DENR6
    density-regulated protein
    89(a)
    1 ↔ 1
    LGb(2136997-2142606)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia denr1 density-regulated protein 79.36(n)
    85.79(a)
      448530  NM_001006813.1  NP_001006814.1 
    zebrafish
    (Danio rerio)
    Actinopterygii denr1 density-regulated protein 74.82(n)
    85.33(a)
      436970  NM_001002697.2  NP_001002697.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90991 CG9099 55.83(n)
    53.37(a)
      32679  NM_001272701.1  NP_001259630.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.211 Y47D3A.21 54.6(n)
    50.31(a)
      176556  NM_067049.4  NP_499450.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMA22(YJR014W)4
    TMA221
    Protein of unknown function; associates with ribosomes more4
    TMA221
    51.23(n)1
    37.58(a)1
      10(461829-462425)4
    8534711, 4  NP_012548.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G119001 AT5G11900 52.08(n)
    45(a)
      831063  NM_121228.4  NP_196751.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g01955001 Os01g0195500 48.12(n)
    42.5(a)
      4327323  NM_001048826.1  NP_001042291.2 


    ENSEMBL Gene Tree for DENR (if available)
    TreeFam Gene Tree for DENR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DENR gene

    Find genes that share paralogs with DENR           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for DENR
    PGOHUM00000239861 PGOHUM00000237143 PGOHUM00000237369 PGOHUM00000247517 PGOHUM00000260486


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DENR (see all 420)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107349591,2
    C,H--123235568(+) CCTCTG/AAGTTC 1 -- us2k110Minor allele frequency- A:0.08NA WA CSA EA 252
    rs128207821,2
    C,F--123235569(+) ctctaG/Agttcc 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1147848521,2
    C,F--123235651(+) TAGAGA/GGAAGG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1919558861,2
    --123235755(+) CAATGC/TCTTAA 1 -- us2k10--------
    rs1825665061,2
    --123235827(+) GTAGAG/TGGAAT 1 -- us2k10--------
    rs1857952901,2
    C--123235844(+) TCGGGC/TTTTAC 1 -- us2k10--------
    rs110597241,2
    C,A--123235978(+) GGCTGT/GGGAAT 1 -- us2k12Minor allele frequency- G:0.15NA 122
    rs1898649371,2
    C--123236144(+) TAAGGC/TGCATG 1 -- us2k10--------
    rs1431128241,2
    C--123236213(+) CCTCAA/GTTGAC 1 -- us2k10--------
    rs1178914401,2
    F--123236244(+) CACAGG/CGTTGG 1 -- us2k11Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for DENR (123237321 - 123255953 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DENR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899571CNV Loss21882294

    Human Gene Mutation Database (HGMD): DENR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DENR
    DNA2.0 Custom Variant and Variant Library Synthesis for DENR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604550    OMIM disorders: --

    1 disease for DENR:    
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    pleomorphic adenoma


    Find genes that share disorders with DENR           About GenesLikeMe


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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DENR gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with DENR)
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    1. Drp, a novel protein expressed at high cell density but not during growth arrest. (PubMed id 9628587)1, 2, 3, 9 Deyo J.E.... Tainsky M.A. (DNA Cell Biol. 1998)
    2. Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1. (PubMed id 17878526)1, 2 Mazan-Mamczarz K. and Gartenhaus R.B. (Cancer Genomics Proteomics 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PubMed id 10497265)1, 2 Oh J.J.... Slamon D.J. (Nucleic Acids Res. 1999)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8562 HGNC: 2769 AceView: DENR Ensembl:ENSG00000139726 euGenes: HUgn8562
    ECgene: DENR H-InvDB: DENR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DENR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DENR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DENR gene:
    Search GeneIP for patents involving DENR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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