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Aliases for DENND6B Gene

Aliases for DENND6B Gene

  • DENN/MADD Domain Containing 6B 2 3
  • Family With Sequence Similarity 116, Member B 2 3
  • DENN Domain-Containing Protein 6B 3 4
  • FAM116B 3 4
  • Protein DENND6B 3
  • Protein FAM116B 3
  • AFI1B 3

External Ids for DENND6B Gene

Previous HGNC Symbols for DENND6B Gene

  • FAM116B

Previous GeneCards Identifiers for DENND6B Gene

  • GC22M050751

Summaries for DENND6B Gene

GeneCards Summary for DENND6B Gene

DENND6B (DENN/MADD Domain Containing 6B) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND6A.

UniProtKB/Swiss-Prot for DENND6B Gene

  • Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND6B Gene

Genomics for DENND6B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DENND6B Gene

Start:
50,309,030 bp from pter
End:
50,327,088 bp from pter
Size:
18,059 bases
Orientation:
Minus strand

Genomic View for DENND6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENND6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND6B Gene

No data available for Regulatory Elements for DENND6B Gene

Proteins for DENND6B Gene

  • Protein details for DENND6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEG7-DEN6B_HUMAN
    Recommended name:
    Protein DENND6B
    Protein Accession:
    Q8NEG7
    Secondary Accessions:
    • A6X8I5

    Protein attributes for DENND6B Gene

    Size:
    585 amino acids
    Molecular mass:
    66464 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DENND6B Gene

Proteomics data for DENND6B Gene at MOPED

Post-translational modifications for DENND6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DENND6B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DENND6B Gene

Domains for DENND6B Gene

Gene Families for DENND6B Gene

HGNC:
  • DENND :DENN/MADD domain containing

Protein Domains for DENND6B Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEG7

UniProtKB/Swiss-Prot:

DEN6B_HUMAN :
  • Q8NEG7
Family:
  • Belongs to the DENND6 family.
genes like me logo Genes that share domains with DENND6B: view

No data available for Suggested Antigen Peptide Sequences for DENND6B Gene

Function for DENND6B Gene

Molecular function for DENND6B Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.

Gene Ontology (GO) - Molecular Function for DENND6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 22595670
genes like me logo Genes that share ontologies with DENND6B: view

miRNA for DENND6B Gene

miRTarBase miRNAs that target DENND6B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DENND6B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DENND6B Gene

Localization for DENND6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND6B Gene

Recycling endosome. Cytoplasm.

Gene Ontology (GO) - Cellular Components for DENND6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0055037 recycling endosome IBA --
genes like me logo Genes that share ontologies with DENND6B: view

No data available for Subcellular locations from COMPARTMENTS for DENND6B Gene

Pathways for DENND6B Gene

SuperPathways for DENND6B Gene

No Data Available

Interacting Proteins for DENND6B Gene

Selected Interacting proteins: Q8NEG7-DEN6B_HUMAN for DENND6B Gene via I2D

Gene Ontology (GO) - Biological Process for DENND6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DENND6B: view

No data available for Pathways by source for DENND6B Gene

Transcripts for DENND6B Gene

mRNA/cDNA for DENND6B Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DENND6B Gene

DENN/MADD domain containing 6B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DENND6B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND6B Gene

No ASD Table

Relevant External Links for DENND6B Gene

GeneLoc Exon Structure for
DENND6B
ECgene alternative splicing isoforms for
DENND6B

Expression for DENND6B Gene

mRNA expression in normal human tissues for DENND6B Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DENND6B Gene

SOURCE GeneReport for Unigene cluster for DENND6B Gene Hs.530380

genes like me logo Genes that share expressions with DENND6B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for DENND6B Gene

Orthologs for DENND6B Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND6B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM116B 35
  • 88 (n)
  • 87.48 (a)
DENND6B 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM116B 35
  • 89.37 (n)
  • 91.9 (a)
DENND6B 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dennd6b 35
  • 86.15 (n)
  • 91.28 (a)
Dennd6b 16
Dennd6b 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dennd6b 35
  • 86.95 (n)
  • 91.28 (a)
oppossum
(Monodelphis domestica)
Mammalia DENND6B 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DENND6B 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM116B 35
  • 76.3 (n)
  • 81.12 (a)
DENND6B 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DENND6B 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd6b 35
  • 65.38 (n)
  • 64.61 (a)
zebrafish
(Danio rerio)
Actinopterygii dennd6b 35
  • 69.28 (n)
  • 72.01 (a)
dennd6b 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3309 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_F53H1.3 35
  • 51.62 (n)
  • 48.38 (a)
F53H1.3 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for DENND6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND6B Gene

ENSEMBL:
Gene Tree for DENND6B (if available)
TreeFam:
Gene Tree for DENND6B (if available)

Paralogs for DENND6B Gene

Paralogs for DENND6B Gene

Selected SIMAP similar genes for DENND6B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DENND6B: view

Variants for DENND6B Gene

Sequence variations from dbSNP and Humsavar for DENND6B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1132090 -- 50,321,804(-) ctgta(A/G)tccca intron-variant
rs1132091 -- 50,321,791(-) tactc(A/G)ggagg intron-variant
rs4074135 -- 50,325,628(+) CCGCG(C/T)CCGGC intron-variant
rs11553141 -- 50,316,219(+) CCAGG(C/T)GCAGG reference, synonymous-codon, intron-variant, nc-transcript-variant
rs11553142 -- 50,312,052(+) GGGAG(C/T)GTGTG utr-variant-3-prime, downstream-variant-500B

Relevant External Links for DENND6B Gene

HapMap Linkage Disequilibrium report
DENND6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DENND6B Gene

Disorders for DENND6B Gene

No disorders were found for DENND6B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DENND6B Gene

Publications for DENND6B Gene

  1. DENN domain proteins: regulators of Rab GTPases. (PMID: 21330364) Marat A.L. … McPherson P.S. (J. Biol. Chem. 2011) 2 3 4
  2. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PMID: 22595670) Linford A. … Barr F.A. (Dev. Cell 2012) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4

Products for DENND6B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DENND6B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DENND6B
    • Block miRNA regulation of DENND6B using miScript Target Protectors

    Sources for DENND6B Gene

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