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Aliases for DENND6A Gene

Aliases for DENND6A Gene

  • DENN Domain Containing 6A 2 3
  • DENN/MADD Domain Containing 6A 2 3 5
  • Family With Sequence Similarity 116, Member A 2 3
  • DENN Domain-Containing Protein 6A 3 4
  • FAM116A 3 4
  • Protein FAM116A 3
  • AFI1A 3

External Ids for DENND6A Gene

Previous HGNC Symbols for DENND6A Gene

  • FAM116A

Summaries for DENND6A Gene

GeneCards Summary for DENND6A Gene

DENND6A (DENN Domain Containing 6A) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND6B.

UniProtKB/Swiss-Prot for DENND6A Gene

  • Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND6A Gene

Genomics for DENND6A Gene

Regulatory Elements for DENND6A Gene

Promoters for DENND6A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DENND6A on UCSC Golden Path with GeneCards custom track

Genomic Location for DENND6A Gene

57,625,454 bp from pter
57,693,089 bp from pter
67,636 bases
Minus strand

Genomic View for DENND6A Gene

Genes around DENND6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND6A Gene

Proteins for DENND6A Gene

  • Protein details for DENND6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DENND6A
    Protein Accession:
    Secondary Accessions:
    • Q7Z5T4
    • Q8N235
    • Q8TEG8

    Protein attributes for DENND6A Gene

    608 amino acids
    Molecular mass:
    69575 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB84982.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC03852.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for DENND6A Gene

Proteomics data for DENND6A Gene at MOPED

Post-translational modifications for DENND6A Gene

  • Ubiquitination at Lys 360
  • Modification sites at PhosphoSitePlus

Other Protein References for DENND6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DENND6A Gene

Domains & Families for DENND6A Gene

Gene Families for DENND6A Gene

Protein Domains for DENND6A Gene

Suggested Antigen Peptide Sequences for DENND6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DENND6 family.
  • Belongs to the DENND6 family.
genes like me logo Genes that share domains with DENND6A: view

Function for DENND6A Gene

Molecular function for DENND6A Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.
genes like me logo Genes that share phenotypes with DENND6A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND6A Gene

Localization for DENND6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND6A Gene

Recycling endosome. Cytoplasm.

Subcellular locations from

Jensen Localization Image for DENND6A Gene COMPARTMENTS Subcellular localization image for DENND6A gene
Compartment Confidence
endosome 5
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DENND6A Gene

Pathways & Interactions for DENND6A Gene

SuperPathways for DENND6A Gene

No Data Available

Interacting Proteins for DENND6A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000311401 for DENND6A Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for DENND6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IDA 22595670
genes like me logo Genes that share ontologies with DENND6A: view

No data available for Pathways by source and SIGNOR curated interactions for DENND6A Gene

Drugs & Compounds for DENND6A Gene

No Compound Related Data Available

Transcripts for DENND6A Gene

Unigene Clusters for DENND6A Gene

DENN/MADD domain containing 6A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND6A Gene

No ASD Table

Relevant External Links for DENND6A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND6A Gene

mRNA expression in normal human tissues for DENND6A Gene

Protein differential expression in normal tissues from HIPED for DENND6A Gene

This gene is overexpressed in Breast (48.2) and Pancreatic juice (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DENND6A Gene

SOURCE GeneReport for Unigene cluster for DENND6A Gene Hs.91085

genes like me logo Genes that share expression patterns with DENND6A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DENND6A Gene

Orthologs for DENND6A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DENND6A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM116A 35
  • 93.91 (n)
  • 95.72 (a)
  • 95 (a)
(Canis familiaris)
Mammalia FAM116A 35
  • 94.02 (n)
  • 96.21 (a)
  • 95 (a)
(Mus musculus)
Mammalia Dennd6a 35
  • 90.96 (n)
  • 95.37 (a)
Dennd6a 16
Dennd6a 36
  • 95 (a)
(Pan troglodytes)
Mammalia DENND6A 35
  • 99.73 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dennd6a 35
  • 90.25 (n)
  • 95.68 (a)
(Monodelphis domestica)
Mammalia DENND6A 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia DENND6A 36
  • 86 (a)
(Gallus gallus)
Aves DENND6A 35
  • 79.06 (n)
  • 84.47 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia DENND6A 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd6a 35
  • 72.56 (n)
  • 81.01 (a)
Str.6642 35
(Danio rerio)
Actinopterygii -- 35
DENND6A (2 of 2) 36
  • 82 (a)
dennd6aa 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10385 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007682 35
  • 53.15 (n)
  • 51.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3309 35
  • 49.91 (n)
  • 43.65 (a)
CG3309 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea F53H1.3 36
  • 42 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73930 35
  • 46.59 (n)
  • 38.05 (a)
(Oryza sativa)
Liliopsida Os03g0259700 35
  • 45.93 (n)
  • 35.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for DENND6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND6A Gene

Gene Tree for DENND6A (if available)
Gene Tree for DENND6A (if available)

Paralogs for DENND6A Gene

Paralogs for DENND6A Gene

(2) SIMAP similar genes for DENND6A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DENND6A: view

Variants for DENND6A Gene

Sequence variations from dbSNP and Humsavar for DENND6A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1010191 -- 57,660,613(+) tgaag(G/T)gggag intron-variant
rs1010192 -- 57,660,708(+) gtctc(A/G)aaaaa intron-variant
rs1473367 -- 57,672,495(-) TATAA(A/T)ATGTT intron-variant
rs2361342 -- 57,684,509(-) gtgct(A/G)ggatt intron-variant
rs2361345 -- 57,680,844(-) ATTGT(A/G)ATTTT intron-variant

Variation tolerance for DENND6A Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DENND6A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DENND6A Gene

Disorders for DENND6A Gene

Relevant External Links for DENND6A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DENND6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND6A Gene

Publications for DENND6A Gene

  1. DENN domain proteins: regulators of Rab GTPases. (PMID: 21330364) Marat A.L. … McPherson P.S. (J. Biol. Chem. 2011) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PMID: 22595670) Linford A. … Barr F.A. (Dev. Cell 2012) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DENND6A Gene

Sources for DENND6A Gene

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