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Aliases for DENND5B Gene

Aliases for DENND5B Gene

  • DENN Domain Containing 5B 2 3
  • DENN/MADD Domain Containing 5B 2 5
  • Rab6IP1-Like Protein 4

External Ids for DENND5B Gene

Previous GeneCards Identifiers for DENND5B Gene

  • GC12M031426
  • GC12M031535
  • GC12M031287
  • GC12M031384
  • GC12M031385

Summaries for DENND5B Gene

GeneCards Summary for DENND5B Gene

DENND5B (DENN Domain Containing 5B) is a Protein Coding gene. GO annotations related to this gene include calcium channel activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is SBF1.

UniProtKB/Swiss-Prot for DENND5B Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND5B Gene

Genomics for DENND5B Gene

Regulatory Elements for DENND5B Gene

Enhancers for DENND5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DENND5B on UCSC Golden Path with GeneCards custom track

Promoters for DENND5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DENND5B on UCSC Golden Path with GeneCards custom track

Genomic Location for DENND5B Gene

31,382,223 bp from pter
31,591,097 bp from pter
208,875 bases
Minus strand

Genomic View for DENND5B Gene

Genes around DENND5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND5B Gene

Proteins for DENND5B Gene

  • Protein details for DENND5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 5B
    Protein Accession:
    Secondary Accessions:
    • B5ME75
    • Q59FW8
    • Q68CZ7
    • Q6NUJ0
    • Q7Z3F9
    • Q8N973
    • Q8WUC8

    Protein attributes for DENND5B Gene

    1274 amino acids
    Molecular mass:
    145020 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04583.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND5B Gene


neXtProt entry for DENND5B Gene

Proteomics data for DENND5B Gene at MOPED

Post-translational modifications for DENND5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DENND5B Gene

No data available for DME Specific Peptides for DENND5B Gene

Domains & Families for DENND5B Gene

Gene Families for DENND5B Gene

Protein Domains for DENND5B Gene

Suggested Antigen Peptide Sequences for DENND5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 dDENN domain.
  • Belongs to the RAB6IP1 family.
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 PLAT domain.
  • Contains 2 RUN domains.
  • Contains 1 uDENN domain.
  • Belongs to the RAB6IP1 family.
genes like me logo Genes that share domains with DENND5B: view

Function for DENND5B Gene

Molecular function for DENND5B Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene Ontology (GO) - Molecular Function for DENND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with DENND5B: view
genes like me logo Genes that share phenotypes with DENND5B: view

Animal Model Products

CRISPR Products

miRNA for DENND5B Gene

miRTarBase miRNAs that target DENND5B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND5B Gene

Localization for DENND5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND5B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DENND5B Gene COMPARTMENTS Subcellular localization image for DENND5B gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DENND5B Gene

Pathways & Interactions for DENND5B Gene

SuperPathways for DENND5B Gene

No Data Available

Interacting Proteins for DENND5B Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000373734 for DENND5B Gene via STRING

Gene Ontology (GO) - Biological Process for DENND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050982 detection of mechanical stimulus IBA --
genes like me logo Genes that share ontologies with DENND5B: view

No data available for Pathways by source and SIGNOR curated interactions for DENND5B Gene

Drugs & Compounds for DENND5B Gene

No Compound Related Data Available

Transcripts for DENND5B Gene

Unigene Clusters for DENND5B Gene

DENN/MADD domain containing 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND5B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: - - -

ExUns: 22 ^ 23 ^ 24

Relevant External Links for DENND5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND5B Gene

mRNA expression in normal human tissues for DENND5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DENND5B Gene

This gene is overexpressed in Breast (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DENND5B Gene

SOURCE GeneReport for Unigene cluster for DENND5B Gene Hs.118166

genes like me logo Genes that share expression patterns with DENND5B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DENND5B Gene

Orthologs for DENND5B Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DENND5B 35
  • 92.75 (n)
  • 97.17 (a)
  • 97 (a)
(Canis familiaris)
Mammalia DENND5B 35
  • 92.61 (n)
  • 97.41 (a)
  • 97 (a)
(Mus musculus)
Mammalia Dennd5b 35
  • 90.66 (n)
  • 95.37 (a)
Dennd5b 16
Dennd5b 36
  • 95 (a)
(Pan troglodytes)
Mammalia DENND5B 35
  • 99.84 (n)
  • 99.92 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Dennd5b 35
  • 89.13 (n)
  • 94.14 (a)
(Monodelphis domestica)
Mammalia DENND5B 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia DENND5B 36
  • 97 (a)
(Gallus gallus)
Aves DENND5B 35
  • 80.51 (n)
  • 92.12 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia DENND5B 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd5b 35
  • 74.99 (n)
  • 86.32 (a)
Str.10985 35
(Danio rerio)
Actinopterygii dennd5b 35
  • 68.15 (n)
  • 76.55 (a)
wufb96b01 35
dennd5b 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011351 35
  • 50.78 (n)
  • 47.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7852 35
  • 52.03 (n)
  • 49.48 (a)
CG7852 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea lst-6 36
  • 32 (a)
Species with no ortholog for DENND5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND5B Gene

Gene Tree for DENND5B (if available)
Gene Tree for DENND5B (if available)

Paralogs for DENND5B Gene

(8) SIMAP similar genes for DENND5B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DENND5B: view

Variants for DENND5B Gene

Sequence variations from dbSNP and Humsavar for DENND5B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4930979 - 31,495,892(+) TTCTT(C/T)TCAAA reference, missense
rs1056320 - 31,452,110(-) AACTG(A/C)ATTGT reference, missense
rs1966635 -- 31,403,390(+) TTTTT(C/T)TTTTT intron-variant
rs1996693 -- 31,531,396(+) TGTTT(C/T)GCCAT intron-variant
rs2023447 -- 31,494,205(+) CCACC(C/T)ACCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND5B Gene

Variant ID Type Subtype PubMed ID
esv2751046 CNV Gain 17911159
nsv832364 CNV Loss 17160897
nsv898965 CNV Loss 21882294
esv2659095 CNV Deletion 23128226
nsv832365 CNV Loss 17160897
nsv52934 CNV Loss 16902084
esv2663530 CNV Deletion 23128226
esv28191 CNV Loss 19812545

Variation tolerance for DENND5B Gene

Residual Variation Intolerance Score: 8.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.12; 96.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DENND5B Gene

Disorders for DENND5B Gene

Relevant External Links for DENND5B

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DENND5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND5B Gene

Publications for DENND5B Gene

  1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for DENND5B Gene

Sources for DENND5B Gene