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Aliases for DENND5B Gene

Aliases for DENND5B Gene

  • DENN/MADD Domain Containing 5B 2 3
  • Rab6IP1-Like Protein 4

External Ids for DENND5B Gene

Summaries for DENND5B Gene

GeneCards Summary for DENND5B Gene

DENND5B (DENN/MADD Domain Containing 5B) is a Protein Coding gene. GO annotations related to this gene include calcium channel activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2C.

UniProtKB/Swiss-Prot for DENND5B Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND5B Gene

Genomics for DENND5B Gene

Genomic Location for DENND5B Gene

31,382,223 bp from pter
31,591,097 bp from pter
208,875 bases
Minus strand

Genomic View for DENND5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENND5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND5B Gene

Regulatory Elements for DENND5B Gene

Proteins for DENND5B Gene

  • Protein details for DENND5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 5B
    Protein Accession:
    Secondary Accessions:
    • B5ME75
    • Q59FW8
    • Q68CZ7
    • Q6NUJ0
    • Q7Z3F9
    • Q8N973
    • Q8WUC8

    Protein attributes for DENND5B Gene

    1274 amino acids
    Molecular mass:
    145020 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04583.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND5B Gene


neXtProt entry for DENND5B Gene

Proteomics data for DENND5B Gene at MOPED

Post-translational modifications for DENND5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DENND5B Gene

No data available for DME Specific Peptides for DENND5B Gene

Domains for DENND5B Gene

Gene Families for DENND5B Gene

  • DENND :DENN/MADD domain containing

Protein Domains for DENND5B Gene

Suggested Antigen Peptide Sequences for DENND5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 dDENN domain.:
    • Q6ZUT9
  • Contains 1 DENN domain.:
    • Q6ZUT9
  • Contains 1 PLAT domain.:
    • Q6ZUT9
  • Contains 2 RUN domains.:
    • Q6ZUT9
  • Contains 1 uDENN domain.:
    • Q6ZUT9
  • Belongs to the RAB6IP1 family.:
    • Q6ZUT9
genes like me logo Genes that share domains with DENND5B: view

Function for DENND5B Gene

Molecular function for DENND5B Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene Ontology (GO) - Molecular Function for DENND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 NOT calcium channel activity IBA --
GO:0005515 protein binding --
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with DENND5B: view
genes like me logo Genes that share phenotypes with DENND5B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DENND5B Gene

Localization for DENND5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND5B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DENND5B Gene COMPARTMENTS Subcellular localization image for DENND5B gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DENND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DENND5B: view

Pathways for DENND5B Gene

SuperPathways for DENND5B Gene

No Data Available

Interacting Proteins for DENND5B Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000373734 for DENND5B Gene via STRING

Gene Ontology (GO) - Biological Process for DENND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:0050982 NOT detection of mechanical stimulus IBA --
genes like me logo Genes that share ontologies with DENND5B: view

No data available for Pathways by source for DENND5B Gene

Transcripts for DENND5B Gene

Unigene Clusters for DENND5B Gene

DENN/MADD domain containing 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND5B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: - - -

ExUns: 22 ^ 23 ^ 24

Relevant External Links for DENND5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND5B Gene

mRNA expression in normal human tissues for DENND5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND5B Gene

SOURCE GeneReport for Unigene cluster for DENND5B Gene Hs.118166

genes like me logo Genes that share expressions with DENND5B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DENND5B Gene

Orthologs for DENND5B Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DENND5B 35
  • 99.84 (n)
  • 99.92 (a)
  • 95 (a)
(Bos Taurus)
Mammalia DENND5B 35
  • 92.75 (n)
  • 97.17 (a)
  • 97 (a)
(Canis familiaris)
Mammalia DENND5B 35
  • 92.61 (n)
  • 97.41 (a)
  • 97 (a)
(Mus musculus)
Mammalia Dennd5b 35
  • 90.66 (n)
  • 95.37 (a)
Dennd5b 16
Dennd5b 36
  • 95 (a)
(Monodelphis domestica)
Mammalia DENND5B 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia DENND5B 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Dennd5b 35
  • 89.13 (n)
  • 94.14 (a)
(Gallus gallus)
Aves DENND5B 35
  • 80.51 (n)
  • 92.12 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia DENND5B 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd5b 35
  • 74.99 (n)
  • 86.32 (a)
Str.10985 35
(Danio rerio)
Actinopterygii dennd5b 35
  • 68.15 (n)
  • 76.55 (a)
dennd5b 36
  • 72 (a)
wufb96b01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011351 35
  • 50.78 (n)
  • 47.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7852 35
  • 52.03 (n)
  • 49.48 (a)
CG7852 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea lst-6 36
  • 32 (a)
Species with no ortholog for DENND5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND5B Gene

Gene Tree for DENND5B (if available)
Gene Tree for DENND5B (if available)

Paralogs for DENND5B Gene

Selected SIMAP similar genes for DENND5B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DENND5B: view

Variants for DENND5B Gene

Sequence variations from dbSNP and Humsavar for DENND5B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs708196 -- 31,404,020(+) gttca(A/C/T)gacca intron-variant
rs708197 -- 31,403,605(+) aaaaa(A/G)aaaga intron-variant
rs708198 -- 31,403,193(+) AATGG(A/C)ACCTC intron-variant
rs708199 -- 31,402,754(-) GATAG(A/C)TCATA intron-variant
rs708200 -- 31,386,369(+) TTTTG(G/T)TCTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DENND5B Gene

Variant ID Type Subtype PubMed ID
esv2751046 CNV Gain 17911159
nsv832364 CNV Loss 17160897
nsv898965 CNV Loss 21882294
esv2659095 CNV Deletion 23128226
nsv832365 CNV Loss 17160897
nsv52934 CNV Loss 16902084
esv2663530 CNV Deletion 23128226
esv28191 CNV Loss 19812545

Relevant External Links for DENND5B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND5B Gene

Disorders for DENND5B Gene

Relevant External Links for DENND5B

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DENND5B: view

No data available for UniProtKB/Swiss-Prot for DENND5B Gene

Publications for DENND5B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for DENND5B Gene

Sources for DENND5B Gene

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