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Aliases for DENND5A Gene

Aliases for DENND5A Gene

  • DENN/MADD Domain Containing 5A 2 3
  • RAB6 Interacting Protein 1 2 3
  • Rab6-Interacting Protein 1 3 4
  • RAB6IP1 3 4
  • DENN Domain-Containing Protein 5A 3
  • KIAA1091 4

External Ids for DENND5A Gene

Previous HGNC Symbols for DENND5A Gene

  • RAB6IP1

Previous GeneCards Identifiers for DENND5A Gene

  • GC11M009117
  • GC11M008832

Summaries for DENND5A Gene

GeneCards Summary for DENND5A Gene

DENND5A (DENN/MADD Domain Containing 5A) is a Protein Coding gene. GO annotations related to this gene include calcium channel activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2C.

UniProtKB/Swiss-Prot for DENND5A Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND5A Gene

Genomics for DENND5A Gene

Regulatory Elements for DENND5A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DENND5A Gene

9,138,825 bp from pter
9,265,390 bp from pter
126,566 bases
Minus strand

Genomic View for DENND5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENND5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND5A Gene

Proteins for DENND5A Gene

  • Protein details for DENND5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 5A
    Protein Accession:
    Secondary Accessions:
    • B4DJ15
    • E9PS91
    • Q96GN3
    • Q9H6U7
    • Q9UFV0
    • Q9UPR1

    Protein attributes for DENND5A Gene

    1287 amino acids
    Molecular mass:
    147096 Da
    Quaternary structure:
    • Probably interacts with RAB6A bound to GTP.
    • Sequence=BAA83043.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15155.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND5A Gene


neXtProt entry for DENND5A Gene

Proteomics data for DENND5A Gene at MOPED

Post-translational modifications for DENND5A Gene

  • Glycosylation at Thr479 and Ser482
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DENND5A

No data available for DME Specific Peptides for DENND5A Gene

Domains for DENND5A Gene

Gene Families for DENND5A Gene

  • DENND :DENN/MADD domain containing

Protein Domains for DENND5A Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6IQ26
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 PLAT domain.
  • Contains 2 RUN domains.
  • Contains 1 uDENN domain.
  • Belongs to the RAB6IP1 family.
genes like me logo Genes that share domains with DENND5A: view

Function for DENND5A Gene

Molecular function for DENND5A Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene Ontology (GO) - Molecular Function for DENND5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 NOT calcium channel activity IBA --
GO:0005515 protein binding --
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
GO:0017137 Rab GTPase binding IEA --
genes like me logo Genes that share ontologies with DENND5A: view

Phenotypes for DENND5A Gene

GenomeRNAi human phenotypes for DENND5A:
genes like me logo Genes that share phenotypes with DENND5A: view

Animal Model Products

CRISPR Products

miRNA for DENND5A Gene

miRTarBase miRNAs that target DENND5A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DENND5A Gene

Localization for DENND5A Gene

Subcellular locations from

Jensen Localization Image for DENND5A Gene COMPARTMENTS Subcellular localization image for DENND5A gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DENND5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus --
GO:0005802 trans-Golgi network IDA 19619496
GO:0016020 membrane IBA --
GO:0030904 colocalizes_with retromer complex IDA 19619496
genes like me logo Genes that share ontologies with DENND5A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DENND5A Gene

Pathways for DENND5A Gene

SuperPathways for DENND5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DENND5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042147 retrograde transport, endosome to Golgi IMP 19619496
GO:0043547 positive regulation of GTPase activity IEA --
GO:0050982 NOT detection of mechanical stimulus IBA --
genes like me logo Genes that share ontologies with DENND5A: view

No data available for Pathways by source for DENND5A Gene

Compounds for DENND5A Gene

(1) HMDB Compounds for DENND5A Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with DENND5A: view

Transcripts for DENND5A Gene

Unigene Clusters for DENND5A Gene

DENN/MADD domain containing 5A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DENND5A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND5A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^
SP1: - - -
SP2: - - -
SP8: -
SP9: - - - - - -
SP10: -

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e
SP1: - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - -
SP5: -

Relevant External Links for DENND5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND5A Gene

mRNA expression in normal human tissues for DENND5A Gene

Protein differential expression in normal tissues for DENND5A Gene

This gene is overexpressed in Islet of Langerhans (18.9), Ovary (17.1), Platelet (13.2), and Adrenal (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND5A Gene

SOURCE GeneReport for Unigene cluster for DENND5A Gene Hs.501857

genes like me logo Genes that share expressions with DENND5A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for DENND5A Gene

Orthologs for DENND5A Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND5A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DENND5A 35
  • 92.96 (n)
  • 97.81 (a)
  • 97 (a)
(Canis familiaris)
Mammalia DENND5A 35
  • 94.25 (n)
  • 98.52 (a)
  • 98 (a)
(Mus musculus)
Mammalia Dennd5a 35
  • 90.99 (n)
  • 97.75 (a)
Dennd5a 16
Dennd5a 36
  • 98 (a)
(Pan troglodytes)
Mammalia DENND5A 35
  • 99.64 (n)
  • 99.77 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dennd5a 35
  • 90.7 (n)
  • 97.59 (a)
(Monodelphis domestica)
Mammalia DENND5A 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia DENND5A 36
  • 93 (a)
(Gallus gallus)
Aves DENND5A 35
  • 80.55 (n)
  • 93.56 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
-- 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd5a 35
  • 77.02 (n)
  • 88.4 (a)
(Danio rerio)
Actinopterygii dennd5a 35
  • 75.24 (n)
  • 83.7 (a)
dennd5a 36
  • 83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7852 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea C52E12.4 35
  • 48.05 (n)
  • 41.73 (a)
lst-6 36
  • 33 (a)
Species with no ortholog for DENND5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND5A Gene

Gene Tree for DENND5A (if available)
Gene Tree for DENND5A (if available)

Paralogs for DENND5A Gene

Selected SIMAP similar genes for DENND5A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with DENND5A: view

Variants for DENND5A Gene

Sequence variations from dbSNP and Humsavar for DENND5A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs770 -- 9,222,621(-) CTATT(C/T)ATCCC intron-variant
rs868132 -- 9,247,352(+) tgcaa(A/G)tatca intron-variant
rs883550 -- 9,156,934(-) TCTGC(A/G)GGAAT intron-variant
rs952374 - 9,203,939(+) TTGCT(C/G)CAGCA missense, reference, nc-transcript-variant
rs954235 -- 9,180,299(+) AAAAA(A/T)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND5A Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
esv33264 CNV Loss 17666407
nsv526778 CNV Loss 19592680
nsv515891 CNV Gain 19592680

Relevant External Links for DENND5A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND5A Gene

Disorders for DENND5A Gene

No disorders were found for DENND5A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DENND5A Gene

Publications for DENND5A Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. (PMID: 19619496) Wassmer T. … Cullen P.J. (Dev. Cell 2009) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4

Products for DENND5A Gene

Sources for DENND5A Gene

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