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DENND5A Gene

protein-coding   GIFtS: 53
GCID: GC11M009162

DENN/MADD Domain Containing 5A

(Previous name: RAB6 interacting protein 1)
(Previous symbol: RAB6IP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DENN/MADD Domain Containing 5A1 2     DENN Domain-Containing Protein 5A2
RAB6IP11 2 3     KIAA10913
RAB6 Interacting Protein 11 2     Rab6IP13
Rab6-Interacting Protein 12 3     

External Ids:    HGNC: 193441   Entrez Gene: 232582   Ensembl: ENSG000001840147   UniProtKB: Q6IQ263   

Export aliases for DENND5A gene to outside databases

Previous GC identifers: GC11M009117 GC11M008832


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DENND5A Gene:
DENND5A (DENN/MADD domain containing 5A) is a protein-coding gene. Diseases associated with DENND5A include stomatitis, and malaria. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity and calcium channel activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot: DEN5A_HUMAN, Q6IQ26
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the
exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DENND5A gene promoter:
         ER-alpha   GR   GR-beta   Arnt   Max   POU2F1   POU2F1a   GR-alpha   MRF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDENND5A promoter sequence
   Search Chromatin IP Primers for DENND5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENND5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.3

DENND5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENND5A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M009162:  view genomic region     (about GC identifiers)

Start:
9,160,372 bp from pter      End:
9,286,937 bp from pter
Size:
126,566 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DEN5A_HUMAN, Q6IQ26 (See protein sequence)
Recommended Name: DENN domain-containing protein 5A  
Size: 1287 amino acids; 147096 Da
Subunit: Probably interacts with RAB6A bound to GTP (By similarity)
Sequence caution: Sequence=BAA83043.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB15155.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DJ15 E9PS91 Q96GN3 Q9H6U7 Q9UFV0 Q9UPR1
Alternative splicing: 2 isoforms:  Q6IQ26-1   Q6IQ26-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DENND5A: NX_Q6IQ26

Explore proteomics data for DENND5A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr479, Ser482
  • Modification sites at PhosphoSitePlus

  • See DENND5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230183.1  NP_056028.2  

    ENSEMBL proteins: 
     ENSP00000328524   ENSP00000435866   ENSP00000434237   ENSP00000432549   ENSP00000435368  
     ENSP00000433483   ENSP00000435038   ENSP00000432428   ENSP00000436780   ENSP00000434397  
     ENSP00000433925  

    DENND5A Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DENND: DENN/MADD domain containing

    Selected InterPro protein domains (see all 6):
     IPR005112 dDENN_dom
     IPR001024 PLAT/LH2_dom
     IPR008976 Lipase_LipOase
     IPR004012 Run
     IPR005113 uDENN_dom

    Graphical View of Domain Structure for InterPro Entry Q6IQ26

    ProtoNet protein and cluster: Q6IQ26

    1 Blocks protein domain: IPB001024 Lipoxygenase

    UniProtKB/Swiss-Prot: DEN5A_HUMAN, Q6IQ26
    Similarity: Belongs to the RAB6IP1 family
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 PLAT domain
    Similarity: Contains 2 RUN domains
    Similarity: Contains 1 uDENN domain


    DENND5A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEN5A_HUMAN, Q6IQ26
    Function: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the
    exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005262NOT calcium channel activity IBA--
    GO:0005515protein binding ----
    GO:0017112Rab guanyl-nucleotide exchange factor activity IDA--
    GO:0017137Rab GTPase binding IEA--
         
    DENND5A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DENND5A:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DENND5A
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    miRNA
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    miRTarBase miRNAs that target DENND5A:
    hsa-mir-30d-5p (MIRT047785), hsa-mir-25-3p (MIRT050288), hsa-mir-92a-3p (MIRT049154)

    Block miRNA regulation of human, mouse, rat DENND5A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DENND5A (see all 10):
    hsa-miR-3934 hsa-miR-595 hsa-miR-429 hsa-miR-575 hsa-miR-618 hsa-miR-545 hsa-miR-888* hsa-miR-200c
    SwitchGear 3'UTR luciferase reporter plasmidDENND5A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DENND5A

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENND5A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND5A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    golgi apparatus2
    nucleus2
    endosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0016020membrane IBA--

    DENND5A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DENND5A
    Interactions:

        Search GeneGlobe Interaction Network for DENND5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for DENND5A (Q6IQ262, 3 ENSP000003285244) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253231 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253231 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253231 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253231 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253231 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity IDA--
    GO:0050982NOT detection of mechanical stimulus IBA--

    DENND5A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DENND5A (DEN5A)

    1 HMDB Compound for DENND5A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DENND5A gene (2 alternative transcripts): 
    NM_001243254.1  NM_015213.3  

    Unigene Cluster for DENND5A:

    DENN/MADD domain containing 5A
    Hs.501857  [show with all ESTs]
    Unigene Representative Sequence: NM_015213
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328194(uc001mhl.3 uc010rbw.2 uc010rbx.2) ENST00000529977
    ENST00000530044 ENST00000528725 ENST00000527700(uc001mhk.3) ENST00000533737
    ENST00000525784 ENST00000531747 ENST00000524446 ENST00000526707 ENST00000531580
    ENST00000527896 ENST00000526523 ENST00000530867 ENST00000532696 ENST00000530780

    miRNA
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    Block miRNA regulation of human, mouse, rat DENND5A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DENND5A (see all 10):
    hsa-miR-3934 hsa-miR-595 hsa-miR-429 hsa-miR-575 hsa-miR-618 hsa-miR-545 hsa-miR-888* hsa-miR-200c
    SwitchGear 3'UTR luciferase reporter plasmidDENND5A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DENND5A
    Predesigned siRNA for gene silencing in human, mouse, rat DENND5A
    Clone
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    OriGene clones in human, mouse for DENND5A (see all 7)
    OriGene ORF clones in mouse, rat for DENND5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DENND5A (NM_015213)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DENND5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENND5A
    Primer
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    OriGene qPCR primer pairs and template standards for DENND5A
    OriGene qSTAR qPCR primer pairs in human, mouse for DENND5A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DENND5A
      QuantiTect SYBR Green Assays in human, mouse, rat DENND5A
      QuantiFast Probe-based Assays in human, mouse, rat DENND5A

    Additional mRNA sequence: 

    AB029014.1 AK025499.1 AK026007.1 AK091148.1 AK125444.1 AK295881.1 AK302478.1 AL117448.1 
    BC005100.1 BC009354.2 BC018797.1 BC071596.1 

    15 DOTS entries:

    DT.87017134  DT.101956321  DT.101986352  DT.95329667  DT.100784277  DT.100784278  DT.91823780  DT.95329646 
    DT.97844609  DT.100784279  DT.102829477  DT.92024766  DT.92437017  DT.97844610  DT.112569 

    Selected AceView cDNA sequences (see all 290):

    BQ673860 BM127030 BF940240 BQ894287 AI301842 BQ898005 AI168202 BI861576 
    BU553540 BF982271 CB131470 BQ070757 BM678505 AI208378 AA127443 NM_015213 
    AL117448 AA349597 BQ690492 BQ878926 CA440880 CA309194 F10598 AI927774 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DENND5A (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^
    SP1:                    -                                                                 -     -                                                               
    SP2:                                                                                                                                            -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e
    SP1:              -                                         -                                 
    SP2:  -     -     -     -     -     -                       -                                 
    SP3:  -           -                                                                           
    SP4:              -                 -     -     -           -                                 
    SP5:                                                        -                                 


    ECgene alternative splicing isoforms for DENND5A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DENND5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAACAGG
    DENND5A Expression
    About this image

    DENND5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DENND5A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501857
        Custom PCR Arrays for DENND5A
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    QuantiFast Probe-based Assays in human, mouse, rat DENND5A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DENND5A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dennd5a1 , 5 DENN/MADD domain containing 5A1, 5 90.99(n)1
    97.75(a)1
      7 (57.62 cM)5
    193471  NM_021494.11  NP_067469.11 
     1098937805 
    chicken
    (Gallus gallus)
    Aves DENND5A1 DENN/MADD domain containing 5A 80.55(n)
    93.56(a)
      423048  XM_004941379.1  XP_004941436.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    91(a)
    90(a)
    1 ↔ many
    1 ↔ many
    1(64362486-64369254)
    1(64294654-64353998)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dennd5a1 DENN/MADD domain containing 5A 77.02(n)
    88.4(a)
      100158564  NM_001127996.1  NP_001121468.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dennd5a1 DENN/MADD domain containing 5A 75.24(n)
    83.7(a)
      799847  XM_001340126.5  XP_001340162.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78526
    --
    39(a)
    1 → many
    3L(1537137-1544823)
    worm
    (Caenorhabditis elegans)
    Secernentea C52E12.41 C52E12.4 48.05(n)
    41.73(a)
      174146  NM_063036.4  NP_495437.2 


    ENSEMBL Gene Tree for DENND5A (if available)
    TreeFam Gene Tree for DENND5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DENND5A gene
    ST52  DENND2D2  DENND2A2  DENND32  DENND1C2  DENND4A2  DENND4B2  DENND1B2  
    DENND1A2  DENND5B2  DENND2C2  DENND4C2  
    2 SIMAP similar genes for DENND5A using alignment to 10 protein entries:     DEN5A_HUMAN (see all proteins):
    DENND5B    MGC24039

    DENND5A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DENND5A (see all 2617)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862889901,2
    --9159907(+) CTGAAA/GAATAA 2 -- ds50010--------
    rs1920200931,2
    --9159938(+) CTCATA/CAAGGT 2 -- ds50010--------
    rs1134712111,2
    C,F--9159940(+) CATAAG/AGGTCT 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1493751081,2
    --9159955(+) CCTGCA/CATCCC 2 -- ds50010--------
    rs1446982931,2
    C--9159972(+) AGCAAA/GCCTTT 2 -- ds50010--------
    rs13537301,2
    C,F,O,A,H--9160070(+) GACAAC/TCTCTG 2 -- ds500129Minor allele frequency- N:0.00MN EA NA NS WA CSA 3166
    rs1875312451,2
    C--9160282(+) GGTGAC/TGCCAC 2 -- ds50010--------
    rs1912153311,2
    --9160425(+) TAAGTC/TGCAAA 2 -- ut310--------
    rs1825068101,2
    --9160466(+) TTAGAC/TTGTGA 2 -- ut310--------
    rs1173446971,2
    C,F--9160523(+) ATGGCG/AGGTTA 2 -- ut311Minor allele frequency- A:0.05NA 120

    HapMap Linkage Disequilibrium report for DENND5A (9160372 - 9286937 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DENND5A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33264CNV Loss17666407
    nsv526778CNV Loss19592680
    nsv515891CNV Gain19592680
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): DENND5A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DENND5A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for DENND5A:    
    About MalaCards
    stomatitis    malaria


    DENND5A for disorders           About GeneDecksing


    Export disorders for DENND5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DENND5A gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with DENND5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R.... Ohara O. (DNA Res. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Mapping the interactions between a RUN domain from DENND5/Rab6IP1 and sorting nexin 1. (PubMed id 22558185)1 Fernandes H....Khan A.R. (PLoS ONE 2012)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PubMed id 20937701)2 Yoshimura S.... Barr F.A. (J. Cell Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23258 HGNC: 19344 AceView: RAB6IP1 Ensembl:ENSG00000184014 euGenes: HUgn23258
    ECgene: DENND5A H-InvDB: DENND5A

    (According to HUGE)
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    HUGE: KIAA1091

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DENND5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DENND5A gene:
    Search GeneIP for patents involving DENND5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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