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Aliases for DENND4C Gene

Aliases for DENND4C Gene

  • DENN Domain Containing 4C 2 3
  • DENN/MADD Domain Containing 4C 2 3 5
  • C9orf55B 3 4
  • C9orf55 3 4
  • DENN/MADD Domain Containing 4A Pseudogene 3
  • Chromosome 9 Open Reading Frame 55B 2
  • Chromosome 9 Open Reading Frame 55 2
  • BA513M16.3 3

External Ids for DENND4C Gene

Previous HGNC Symbols for DENND4C Gene

  • C9orf55B
  • C9orf55

Previous GeneCards Identifiers for DENND4C Gene

  • GC09P019281
  • GC09P019252

Summaries for DENND4C Gene

GeneCards Summary for DENND4C Gene

DENND4C (DENN Domain Containing 4C) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is SBF1.

UniProtKB/Swiss-Prot for DENND4C Gene

  • Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND4C Gene

Genomics for DENND4C Gene

Regulatory Elements for DENND4C Gene

Enhancers for DENND4C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DENND4C on UCSC Golden Path with GeneCards custom track

Promoters for DENND4C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DENND4C on UCSC Golden Path with GeneCards custom track

Genomic Location for DENND4C Gene

Chromosome:
9
Start:
19,230,435 bp from pter
End:
19,374,268 bp from pter
Size:
143,834 bases
Orientation:
Plus strand

Genomic View for DENND4C Gene

Genes around DENND4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND4C Gene

Proteins for DENND4C Gene

  • Protein details for DENND4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ89-DEN4C_HUMAN
    Recommended name:
    DENN domain-containing protein 4C
    Protein Accession:
    Q5VZ89
    Secondary Accessions:
    • A2A3R1
    • A2A3R2
    • A2A3R3
    • A2A3R9
    • Q6AI48
    • Q6ZUB3
    • Q8NCY7
    • Q9H6N4
    • Q9NUT1
    • Q9NWA5
    • Q9NWT3

    Protein attributes for DENND4C Gene

    Size:
    1673 amino acids
    Molecular mass:
    186857 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91478.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10466.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAM21141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND4C Gene

neXtProt entry for DENND4C Gene

Proteomics data for DENND4C Gene at MOPED

Post-translational modifications for DENND4C Gene

Other Protein References for DENND4C Gene

No data available for DME Specific Peptides for DENND4C Gene

Domains & Families for DENND4C Gene

Gene Families for DENND4C Gene

Protein Domains for DENND4C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DENND4C Gene

Graphical View of Domain Structure for InterPro Entry

Q5VZ89

UniProtKB/Swiss-Prot:

DEN4C_HUMAN :
  • Contains 1 dDENN domain.
  • Contains 1 PPR (pentatricopeptide) repeat.
Domain:
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
Similarity:
  • Contains 1 PPR (pentatricopeptide) repeat.
genes like me logo Genes that share domains with DENND4C: view

Function for DENND4C Gene

Molecular function for DENND4C Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
genes like me logo Genes that share phenotypes with DENND4C: view

Animal Models for DENND4C Gene

MGI Knock Outs for DENND4C:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DENND4C Gene

Localization for DENND4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND4C Gene

Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENND4C Gene COMPARTMENTS Subcellular localization image for DENND4C gene
Compartment Confidence
cytosol 5
plasma membrane 5
golgi apparatus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DENND4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,ISS --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with DENND4C: view

Pathways & Interactions for DENND4C Gene

SuperPathways for DENND4C Gene

No Data Available

Interacting Proteins for DENND4C Gene

Selected Interacting proteins: Q5VZ89-DEN4C_HUMAN for DENND4C Gene via I2D

Symbol External ID(s) Details
MAP1LC3C

Gene Ontology (GO) - Biological Process for DENND4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0032869 cellular response to insulin stimulus IEA,ISS --
genes like me logo Genes that share ontologies with DENND4C: view

No data available for Pathways by source and SIGNOR curated interactions for DENND4C Gene

Drugs & Compounds for DENND4C Gene

No Compound Related Data Available

Transcripts for DENND4C Gene

mRNA/cDNA for DENND4C Gene

(6) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DENND4C Gene

DENN/MADD domain containing 4C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND4C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ·
SP1: - -
SP2: - - - - - - - - - - - - - - - - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: -
SP9:

ExUns: 18c ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1: - -
SP2: - - - - - - - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for DENND4C Gene

GeneLoc Exon Structure for
DENND4C
ECgene alternative splicing isoforms for
DENND4C

Expression for DENND4C Gene

mRNA expression in normal human tissues for DENND4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DENND4C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.0) and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DENND4C Gene



SOURCE GeneReport for Unigene cluster for DENND4C Gene Hs.249591

genes like me logo Genes that share expression patterns with DENND4C: view

Protein tissue co-expression partners for DENND4C Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DENND4C Gene

Orthologs for DENND4C Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND4C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DENND4C 35
  • 91.8 (n)
  • 91.89 (a)
DENND4C 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DENND4C 35
  • 92.26 (n)
  • 92.45 (a)
DENND4C 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dennd4c 35
  • 86.3 (n)
  • 87.19 (a)
Dennd4c 16
Dennd4c 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DENND4C 35
  • 99.72 (n)
  • 99.7 (a)
DENND4C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1308489 35
  • 85.07 (n)
  • 85.84 (a)
oppossum
(Monodelphis domestica)
Mammalia DENND4C 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves DENND4C 35
  • 74.74 (n)
  • 77.42 (a)
DENND4C 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DENND4C 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd4c 35
  • 67.73 (n)
  • 70.21 (a)
Str.16012 35
zebrafish
(Danio rerio)
Actinopterygii dennd4c 35
  • 63.43 (n)
  • 65.98 (a)
dennd4c 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Crag 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea denn-4 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1014 36
  • 37 (a)
OneToMany
Species with no ortholog for DENND4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND4C Gene

ENSEMBL:
Gene Tree for DENND4C (if available)
TreeFam:
Gene Tree for DENND4C (if available)

Paralogs for DENND4C Gene

(2) SIMAP similar genes for DENND4C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DENND4C: view

Variants for DENND4C Gene

Sequence variations from dbSNP and Humsavar for DENND4C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs17818730 - 19,346,712(+) GCATG(A/G/T)CTACT nc-transcript-variant, reference, missense
rs6475322 - 19,346,943(+) TAGTA(A/C)ATTCT nc-transcript-variant, reference, missense
rs34267952 - 19,346,596(-) CAATA(A/C)CTGGA nc-transcript-variant, reference, missense
rs928128 -- 19,341,047(+) GATGC(A/G)GAAAT nc-transcript-variant, reference, synonymous-codon
rs928129 -- 19,341,207(+) ATTAT(G/T)TTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND4C Gene

Variant ID Type Subtype PubMed ID
nsv892702 CNV Gain 21882294
nsv466286 CNV Gain 19166990
esv2677622 CNV Deletion 23128226
esv2665168 CNV Deletion 23128226
esv24621 CNV Loss 19812545
nsv824872 CNV Loss 20364138

Variation tolerance for DENND4C Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DENND4C Gene

Disorders for DENND4C Gene

Relevant External Links for DENND4C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DENND4C

No disorders were found for DENND4C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND4C Gene

Publications for DENND4C Gene

  1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4 67
  2. Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. (PMID: 12906859) Semova N. … Semov A. (Genomics 2003) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DENND4C Gene

Sources for DENND4C Gene

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