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DENND4C Gene

protein-coding GIFtS: 43
GCID: GC09P019289

DENN/MADD Domain Containing 4C

(Previous names: chromosome 9 open reading frame 55B, chromosome 9 open reading...)
(Previous symbols: C9orf55B, C9orf55)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
DENN/MADD Domain Containing 4C¹ ²		Chromosome 9 Open Reading Frame 55B¹
C9orf55¹ ² ³		bA513M16.3²
C9orf55B¹ ² ³		DENN Domain-Containing Protein 4C²
Chromosome 9 Open Reading Frame 55¹		DENN/MADD Domain Containing 4A Pseudogene²

External Ids:	HGNC: 26079¹	Entrez Gene: 55667²	Ensembl: ENSG00000137145⁷	UniProtKB: Q5VZ89³

Export aliases for DENND4C gene to outside databases

Previous GC identifers: GC09P019281 GC09P019252

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DENND4C Gene:

DENND4C (DENN/MADD domain containing 4C) is a protein-coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot: DEN4C_HUMAN, Q5VZ89

Function: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP,

converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose

transporter-enriched vesicles delivery to the plasma membrane in response to insulin

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000009.11 NT_008413.19 NC_018920.2

Regulatory elements:

Regulatory transcription factor binding sites in the DENND4C gene promoter:
AREB6 ISGF-3 AML1a GATA-6 FOXF2 FOXJ2 (long isoform) HFH-1 FOXJ2 Ik-3 c-Ets-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for DENND4C

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENND4C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.1 Ensembl cytogenetic band: 9p22.1 HGNC cytogenetic band: 9p22.1

DENND4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENND4C gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P019289: view genomic region (about GC identifiers)

Start:	19,230,433 bp from pter	End:	19,374,139 bp from pter
Size:	143,707 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DEN4C_HUMAN, Q5VZ89 (See protein sequence)

Recommended Name: DENN domain-containing protein 4C

Size: 1673 amino acids; 186857 Da

Sequence caution: Sequence=BAA91294.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA91478.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA92039.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15221.1; Type=Erroneous

initiation; Note=Translation N-terminally extended; Sequence=CAH10466.1; Type=Erroneous initiation;

Note=Translation N-terminally extended; Sequence=CAM21141.1; Type=Erroneous initiation; Note=Translation

N-terminally extended;

Secondary accessions: A2A3R1 A2A3R2 A2A3R3 A2A3R9 Q6AI48 Q6ZUB3 Q8NCY7 Q9H6N4 Q9NUT1 Q9NWA5

Q9NWT3

Alternative splicing: 6 isoforms: Q5VZ89-1 Q5VZ89-2 Q5VZ89-3 Q5VZ89-4 Q5VZ89-5 Q5VZ89-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DENND4C: NX_Q5VZ89

Explore proteomics data for DENND4C at MOPED

Post-translational modifications:

Phosphorylated in response to insulin (By similarity)¹

Ubiquitination² at Lys51

Modification sites at PhosphoSitePlus

See DENND4C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060395.5

ENSEMBL proteins:

ENSP00000473469 ENSP00000473565 ENSP00000473273 ENSP00000369792 ENSP00000354301

ENSP00000369789 ENSP00000369797

DENND4C Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

DENND: DENN/MADD domain containing

3 InterPro protein domains:

IPR005112 dDENN_dom

IPR005113 uDENN_dom

IPR001194 DENN_dom

Graphical View of Domain Structure for InterPro Entry Q5VZ89

ProtoNet protein and cluster: Q5VZ89

UniProtKB/Swiss-Prot: DEN4C_HUMAN, Q5VZ89

Similarity: Contains 1 dDENN domain

Similarity: Contains 1 DENN domain

Similarity: Contains 1 PPR (pentatricopeptide) repeat

Similarity: Contains 1 uDENN domain

Find genes that share domains with DENND4C About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DEN4C_HUMAN, Q5VZ89

Function: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP,

converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose

transporter-enriched vesicles delivery to the plasma membrane in response to insulin

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0017112	Rab guanyl-nucleotide exchange factor activity	IDA	--

Find genes that share ontologies with DENND4C About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for DENND4C

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

DEN4C_HUMAN, Q5VZ89: Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with

SLC2A4/GLUT4 storage vesicles

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	5
plasma membrane	5
golgi apparatus	3
endoplasmic reticulum	1

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	ISS	--
GO:0005886	plasma membrane	ISS	--
GO:0030659	cytoplasmic vesicle membrane	IEA	--
GO:0030904	retromer complex	--	--
GO:0032593	insulin-responsive compartment	ISS	--

Find genes that share ontologies with DENND4C About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for DENND4C
Interactions:

Search GeneGlobe Interaction Network for DENND4C

1 Interacting protein for DENND4C (Q5VZ89³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP1LC3C	Q9BXW4³	I2D: score=1

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Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015031	protein transport	IEA	--
GO:0032313	regulation of Rab GTPase activity	IDA	--
GO:0032869	cellular response to insulin stimulus	ISS	--
GO:0072659	protein localization to plasma membrane	ISS	--

Find genes that share ontologies with DENND4C About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DENND4C (DEN4C)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DENND4C gene:

NM_017925.5

Unigene Cluster for DENND4C:

DENN/MADD domain containing 4C

Hs.249591 [show with all ESTs]

Unigene Representative Sequence: NM_017925

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000434457 ENST00000602925 ENST00000602708 ENST00000380437 ENST00000494124

ENST00000602442 ENST00000380427(uc003znt.3) ENST00000361024 ENST00000380424

ENST00000380432

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Additional mRNA sequence:

AK000627.1 AK000693.1 AK001046.1 AK002020.1 AK025705.1 AK125842.1 AK127734.1 AK299842.1

AK302901.1 AL834521.1 BC144484.1 BC144485.1 CR627367.1 NR_073201.2

15 DOTS entries:

DT.97838739 DT.214521 DT.410018 DT.121149839 DT.100784968 DT.40217577 DT.70101132 DT.121149867

DT.121149910 DT.121149931 DT.439289 DT.91972220 DT.92014101 DT.99999363 DT.92047754

2 AceView cDNA sequences:

N28227 BG197754

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DENND4C (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b	^	18a	·	18b	·
SP1:																																																	-		-
SP2:																	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:
SP4:																																																	-
SP5:

ExUns:	18c	^	19a	·	19b	^	20a	·	20b	^	21	^	22	^	23a	·	23b	^	24	^	25	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32
SP1:	-																								-
SP2:	-		-		-		-		-		-		-		-										-
SP3:																									-										-
SP4:
SP5:

ECgene alternative splicing isoforms for DENND4C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DENND4C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

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DENND4C expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Ovary (Reproductive System)
Oviduct

Pancreas (Endocrine System)
Islets of Langerhans

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Bone (Muscoskeletal System)
Bone Marrow

DENND4C Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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DENND4C Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.249591

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DENND4C gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dennd4c^{1 , 5}	DENN/MADD domain containing 4C^{1, 5}	86.3(n)¹ 87.19(a)¹		4 (40.69 cM)⁵ 329877¹ NM_184088.1¹ NP_908976.1¹ 86748555⁵
chicken (Gallus gallus)	Aves	DENND4C¹	DENN/MADD domain containing 4C	74.74(n) 77.42(a)		427236 XM_004949126.1 XP_004949183.1
lizard (Anolis carolinensis)	Reptilia	DENND4C⁶	DENN/MADD domain containing 4C	74(a)	1 ↔ 1	2(62476030-62579985)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.16012²	Transcribed sequence with weak similarity to protein more	74.18(n)		142033743
zebrafish (Danio rerio)	Actinopterygii	dennd4c¹	DENN/MADD domain containing 4C	63.43(n) 65.98(a)		558626 XM_005166553.1 XP_005166610.1
fruit fly (Drosophila melanogaster)	Insecta	Crag⁶	Calmodulin-binding protein related to a Rab3 GDP/G...	36(a)	1 → many	X(8486086-8495264)
worm (Caenorhabditis elegans)	Secernentea	denn-4⁶	--	35(a)	1 → many	IV(1924008-1948040) WBGene00018681

ENSEMBL Gene Tree for DENND4C (if available)
TreeFam Gene Tree for DENND4C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DENND4C gene

ST5² DENND5A² DENND2D² DENND2A² DENND3² DENND1C² DENND4A² DENND4B²

DENND1B² DENND1A² DENND5B² DENND2C²

2 SIMAP similar genes for DENND4C using alignment to 4 protein entries: DEN4C_HUMAN (see all proteins):

DENND4A DENND4B

Find genes that share paralogs with DENND4C About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184180164^1,2		--	19228909(+)	`TTTTTC/TTTTTT`	2	--	us2k¹		0	--	--	--	--
rs186117722^1,2		--	19229211(+)	`GCTAAA/GTTTTG`	2	--	us2k¹		0	--	--	--	--
rs189728693^1,2		--	19229229(+)	`AGATCC/TTTTCT`	2	--	us2k¹		0	--	--	--	--
rs12340797^1,2	C,F	--	19229240(+)	`TAAACT/CTTTGC`	2	--	us2k¹		1		WA	118
rs182073110^1,2		--	19229242(+)	`AACTTC/TTGCTC`	2	--	us2k¹		0	--	--	--	--
rs186624688^1,2		--	19229290(+)	`CCAAAC/TTGGCC`	2	--	us2k¹		0	--	--	--	--
rs10964051^1,2	F	--	19229472(+)	`CCCAGG/CTATAA`	2	--	us2k¹		1		NA	120
rs72698371^1,2	C,F	--	19229504(+)	`TACAGA/GTTAAA`	2	--	us2k¹		3		WA NA EA	358
rs144751647^1,2		--	19229556(+)	`ATACTC/TACCAG`	2	--	us2k¹		0	--	--	--	--
rs148531834^1,2	C	--	19229630(+)	`TTTTCA/CCCCCA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DENND4C (19230433 - 19374139 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for DENND4C: About this table

Variant ID	Type	Subtype	PubMed ID
esv2677622	CNV	Deletion	23128226
esv2665168	CNV	Deletion	23128226
esv24621	CNV	Loss	19812545
nsv824872	CNV	Loss	20364138
nsv466286	CNV	Gain	19166990
nsv892702	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing DENND4C

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DENND4C gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with DENND4C)

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (Nature 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. (PubMed id 12906859)^{1, 3} Semova N....Semov A. (Genomics 2003)
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)¹ Couzens A.L....Gingras A.C. (Sci Signal 2013)
Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. (PubMed id 21454697)¹ Sano H....Lienhard G.E. (J. Biol. Chem. 2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55667	HGNC: 26079	AceView: C9orf55.1	Ensembl:ENSG00000137145	euGenes: HUgn55667
ECgene: DENND4C	H-InvDB: DENND4C

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DENND4C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DENND4C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DENND4C gene:
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DENN/MADD Domain Containing 4C

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DENN/MADD Domain Containing 4C

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