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Aliases for DENND4C Gene

Aliases for DENND4C Gene

  • DENN/MADD Domain Containing 4C 2 3
  • C9orf55B 3 4
  • C9orf55 3 4
  • DENN/MADD Domain Containing 4A Pseudogene 3
  • Chromosome 9 Open Reading Frame 55B 2
  • Chromosome 9 Open Reading Frame 55 2
  • DENN Domain-Containing Protein 4C 3
  • BA513M16.3 3

External Ids for DENND4C Gene

Previous HGNC Symbols for DENND4C Gene

  • C9orf55B
  • C9orf55

Previous GeneCards Identifiers for DENND4C Gene

  • GC09P019281
  • GC09P019252

Summaries for DENND4C Gene

GeneCards Summary for DENND4C Gene

DENND4C (DENN/MADD Domain Containing 4C) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2C.

UniProtKB/Swiss-Prot for DENND4C Gene

  • Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND4C Gene

Genomics for DENND4C Gene

Regulatory Elements for DENND4C Gene

Genomic Location for DENND4C Gene

Start:
19,230,435 bp from pter
End:
19,374,266 bp from pter
Size:
143,832 bases
Orientation:
Plus strand

Genomic View for DENND4C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENND4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND4C Gene

Proteins for DENND4C Gene

  • Protein details for DENND4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ89-DEN4C_HUMAN
    Recommended name:
    DENN domain-containing protein 4C
    Protein Accession:
    Q5VZ89
    Secondary Accessions:
    • A2A3R1
    • A2A3R2
    • A2A3R3
    • A2A3R9
    • Q6AI48
    • Q6ZUB3
    • Q8NCY7
    • Q9H6N4
    • Q9NUT1
    • Q9NWA5
    • Q9NWT3

    Protein attributes for DENND4C Gene

    Size:
    1673 amino acids
    Molecular mass:
    186857 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91478.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10466.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAM21141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND4C Gene

neXtProt entry for DENND4C Gene

Proteomics data for DENND4C Gene at MOPED

Post-translational modifications for DENND4C Gene

Other Protein References for DENND4C Gene

No data available for DME Specific Peptides for DENND4C Gene

Domains for DENND4C Gene

Gene Families for DENND4C Gene

HGNC:
  • DENND :DENN/MADD domain containing

Protein Domains for DENND4C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DENND4C Gene

Graphical View of Domain Structure for InterPro Entry

Q5VZ89

UniProtKB/Swiss-Prot:

DEN4C_HUMAN :
  • Q5VZ89
Domain:
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
Similarity:
  • Contains 1 PPR (pentatricopeptide) repeat.
genes like me logo Genes that share domains with DENND4C: view

Function for DENND4C Gene

Molecular function for DENND4C Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.

Gene Ontology (GO) - Molecular Function for DENND4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with DENND4C: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DENND4C Gene

Localization for DENND4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND4C Gene

Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENND4C Gene COMPARTMENTS Subcellular localization image for DENND4C gene
Compartment Confidence
cytosol 5
plasma membrane 5
golgi apparatus 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DENND4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane ISS --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0030904 retromer complex --
GO:0032593 insulin-responsive compartment ISS --
genes like me logo Genes that share ontologies with DENND4C: view

Pathways for DENND4C Gene

SuperPathways for DENND4C Gene

No Data Available

Interacting Proteins for DENND4C Gene

Selected Interacting proteins: Q5VZ89-DEN4C_HUMAN for DENND4C Gene via I2D

Symbol External ID(s) Details
MAP1LC3C

Gene Ontology (GO) - Biological Process for DENND4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0032869 cellular response to insulin stimulus ISS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0072659 protein localization to plasma membrane ISS --
genes like me logo Genes that share ontologies with DENND4C: view

No data available for Pathways by source for DENND4C Gene

Transcripts for DENND4C Gene

mRNA/cDNA for DENND4C Gene

(14) Additional mRNA sequences :
(6) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DENND4C Gene

DENN/MADD domain containing 4C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND4C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ·
SP1: - -
SP2: - - - - - - - - - - - - - - - - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: -
SP9:

ExUns: 18c ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1: - -
SP2: - - - - - - - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for DENND4C Gene

GeneLoc Exon Structure for
DENND4C
ECgene alternative splicing isoforms for
DENND4C

Expression for DENND4C Gene

mRNA expression in normal human tissues for DENND4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DENND4C Gene

SOURCE GeneReport for Unigene cluster for DENND4C Gene Hs.249591

genes like me logo Genes that share expressions with DENND4C: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DENND4C Gene

Orthologs for DENND4C Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND4C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENND4C 35
  • 99.72 (n)
  • 99.7 (a)
DENND4C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DENND4C 35
  • 91.8 (n)
  • 91.89 (a)
DENND4C 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DENND4C 35
  • 92.26 (n)
  • 92.45 (a)
DENND4C 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dennd4c 35
  • 86.3 (n)
  • 87.19 (a)
Dennd4c 16
Dennd4c 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DENND4C 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1308489 35
  • 85.07 (n)
  • 85.84 (a)
chicken
(Gallus gallus)
Aves DENND4C 35
  • 74.74 (n)
  • 77.42 (a)
DENND4C 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DENND4C 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd4c 35
  • 67.73 (n)
  • 70.21 (a)
Str.16012 35
zebrafish
(Danio rerio)
Actinopterygii dennd4c 35
  • 63.43 (n)
  • 65.98 (a)
dennd4c 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Crag 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea denn-4 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1014 36
  • 37 (a)
OneToMany
Species with no ortholog for DENND4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND4C Gene

ENSEMBL:
Gene Tree for DENND4C (if available)
TreeFam:
Gene Tree for DENND4C (if available)

Paralogs for DENND4C Gene

Selected SIMAP similar genes for DENND4C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DENND4C: view

Variants for DENND4C Gene

Sequence variations from dbSNP and Humsavar for DENND4C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs928128 -- 19,341,047(+) GATGC(A/G)GAAAT reference, synonymous-codon, nc-transcript-variant
rs928129 -- 19,341,207(+) ATTAT(G/T)TTCAC intron-variant
rs958208 -- 19,313,405(-) GTTAC(A/T)CAATT intron-variant
rs976383 -- 19,317,024(-) CAGGA(A/G)AAAAA intron-variant
rs1121663 -- 19,248,072(-) agctg(C/T)tgtga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND4C Gene

Variant ID Type Subtype PubMed ID
nsv892702 CNV Gain 21882294
nsv466286 CNV Gain 19166990
esv2677622 CNV Deletion 23128226
esv2665168 CNV Deletion 23128226
esv24621 CNV Loss 19812545
nsv824872 CNV Loss 20364138

Relevant External Links for DENND4C Gene

HapMap Linkage Disequilibrium report
DENND4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND4C Gene

Disorders for DENND4C Gene

No disorders were found for DENND4C Gene.

No data available for UniProtKB/Swiss-Prot for DENND4C Gene

Publications for DENND4C Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4
  3. Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. (PMID: 12906859) Semova N. … Semov A. (Genomics 2003) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for DENND4C Gene

Sources for DENND4C Gene

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