Aliases for DENND4C Gene
Aliases for DENND4C Gene
External Ids for DENND4C Gene
- HGNC: 26079
- Entrez Gene: 55667
- Ensembl: ENSG00000137145
- UniProtKB: Q5VZ89
Previous HGNC Symbols for DENND4C Gene
- C9orf55B
- C9orf55
Previous GeneCards Identifiers for DENND4C Gene
- GC09P019281
- GC09P019252
Summaries for DENND4C Gene
GeneCards Summary for DENND4C Gene
DENND4C (DENN Domain Containing 4C) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is SBF1.
UniProtKB/Swiss-Prot for DENND4C Gene
-
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND4C Gene
Genomics for DENND4C Gene
Regulatory Elements for DENND4C Gene
Enhancers for DENND4C Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around DENND4C on UCSC Golden Path with GeneCards custom track
Promoters for DENND4C Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around DENND4C on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the DENND4C gene promoter:
Regulatory Element Products
Genomic Location for DENND4C Gene
- Chromosome:
- 9
- Start:
- 19,230,435 bp from pter
- End:
- 19,374,268 bp from pter
- Size:
- 143,834 bases
- Orientation:
- Plus strand
Genomic View for DENND4C Gene
Genes around DENND4C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p22.1 by Ensembl
- 9p22.1 by Entrez Gene
- 9p22.1 by HGNC
DENND4C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DENND4C Gene
Proteins for DENND4C Gene
-
Protein details for DENND4C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VZ89-DEN4C_HUMAN
- Recommended name:
- DENN domain-containing protein 4C
- Protein Accession:
- Q5VZ89
- A2A3R1
- A2A3R2
- A2A3R3
- A2A3R9
- Q6AI48
- Q6ZUB3
- Q8NCY7
- Q9H6N4
- Q9NUT1
- Q9NWA5
- Q9NWT3
Protein attributes for DENND4C Gene
- Size:
- 1673 amino acids
- Molecular mass:
- 186857 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA91294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91478.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10466.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAM21141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for DENND4C Gene
Post-translational modifications for DENND4C Gene
- Phosphorylated in response to insulin.
- Ubiquitination at Lys 51
- Modification sites at PhosphoSitePlus
Other Protein References for DENND4C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DENND4C
- Invitrogen Antibodies for DENND4C
- Search GeneTex for Antibodies for DENND4C
-
Santa Cruz Biotechnology (SCBT) Antibodies for DENND4C
Protein Products
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- Novus Biologicals proteins for DENND4C
- Search GeneTex for Proteins for DENND4C
Assay Products
No data available for DME Specific Peptides for DENND4C Gene
Domains & Families for DENND4C Gene
Gene Families for DENND4C Gene
Suggested Antigen Peptide Sequences for DENND4C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5VZ89UniProtKB/Swiss-Prot:
DEN4C_HUMAN :- Contains 1 dDENN domain.
- Contains 1 PPR (pentatricopeptide) repeat.
- Domain:
-
- Contains 1 dDENN domain.
- Contains 1 DENN domain.
- Contains 1 uDENN domain.
- Similarity:
-
- Contains 1 PPR (pentatricopeptide) repeat.
Function for DENND4C Gene
Molecular function for DENND4C Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
Phenotypes for DENND4C Gene
- MGI mutant phenotypes for DENND4C:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DENND4C:
Animal Models for DENND4C Gene
- MGI Knock Outs for DENND4C:
-
- Dennd4c tm1b(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for DENND4C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
- Search ViGene Biosciences for DENND4C
CRISPR Products
-
OriGene CRISPR knockouts for DENND4C
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND4C
- GenScript: Design CRISPR guide RNA sequences for DENND4C
miRNA for DENND4C Gene
- miRTarBase miRNAs that target DENND4C
-
- hsa-mir-5010-3p (MIRT443175)
- hsa-mir-2113 (MIRT443176)
- hsa-mir-4775 (MIRT443177)
- hsa-mir-550b-2-5p (MIRT443178)
- hsa-mir-1227-3p (MIRT443179)
- hsa-mir-5189-3p (MIRT443180)
- hsa-mir-4714-3p (MIRT443181)
- hsa-mir-7849-3p (MIRT443182)
- hsa-mir-590-3p (MIRT443183)
- hsa-mir-3978 (MIRT448880)
- hsa-mir-6124 (MIRT448881)
- hsa-mir-3148 (MIRT448882)
- hsa-mir-33a-3p (MIRT448883)
- hsa-mir-5582-3p (MIRT448884)
- hsa-mir-548x-3p (MIRT448885)
- hsa-mir-548j-3p (MIRT448886)
- hsa-mir-548aq-3p (MIRT448887)
- hsa-mir-548am-3p (MIRT448888)
- hsa-mir-548aj-3p (MIRT448889)
- hsa-mir-548ah-3p (MIRT448890)
- hsa-mir-548ae-3p (MIRT448891)
- hsa-mir-129-5p (MIRT499092)
- hsa-mir-4776-3p (MIRT499093)
- hsa-mir-1263 (MIRT499094)
- hsa-mir-150-3p (MIRT499095)
- hsa-mir-4659b-5p (MIRT499096)
- hsa-mir-4659a-5p (MIRT499097)
- hsa-mir-5590-5p (MIRT499098)
- hsa-mir-302f (MIRT499099)
- hsa-mir-5692a (MIRT499100)
- hsa-mir-633 (MIRT524189)
- hsa-mir-223-5p (MIRT524190)
- hsa-mir-496 (MIRT524191)
- hsa-mir-4781-3p (MIRT524192)
miRNA Products
- Search ViGene Biosciences for DENND4C
Inhibitory RNA Products
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-
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Clone Products
- OriGene clones in human for DENND4C
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for DENND4C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DENND4C gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DENND4C Gene
Localization for DENND4C Gene
Subcellular locations from UniProtKB/Swiss-Prot for DENND4C Gene
- Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 5 |
| golgi apparatus | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA,ISS | -- |
| GO:0030659 | cytoplasmic vesicle membrane | IEA | -- |
Pathways & Interactions for DENND4C Gene
More details on SuperPathways for DENND4C
No Data Available
Interacting Proteins for DENND4C Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| MAP1LC3C |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015031 | protein transport | IEA | -- |
| GO:0032869 | cellular response to insulin stimulus | IEA,ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for DENND4C Gene
Transcripts for DENND4C Gene
mRNA/cDNA for DENND4C Gene
- (6) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DENND4C Gene
CRISPR Products
-
OriGene CRISPR knockouts for DENND4C
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND4C
- GenScript: Design CRISPR guide RNA sequences for DENND4C
miRNA Products
- Search ViGene Biosciences for DENND4C
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for DENND4C
- Browse OriGene Inhibitory RNA Products For DENND4C
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
Clone Products
- OriGene clones in human for DENND4C
- OriGene ORF clones in human,mouse for DENND4C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 18c | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for DENND4C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (17.0) and CD8 Tcells (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DENND4C Gene
SOURCE GeneReport for Unigene cluster for DENND4C Gene Hs.249591
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for DENND4C
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DENND4C Gene
Orthologs for DENND4C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | DENND4C 35 |
|
||
| DENND4C 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | DENND4C 35 |
|
||
| DENND4C 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Dennd4c 35 |
|
||
| Dennd4c 16 |
|
||||
| Dennd4c 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | DENND4C 35 |
|
||
| DENND4C 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | RGD1308489 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DENND4C 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | DENND4C 35 |
|
||
| DENND4C 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | DENND4C 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dennd4c 35 |
|
||
| Str.16012 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | dennd4c 35 |
|
||
| dennd4c 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Crag 36 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | denn-4 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1014 36 |
|
OneToMany |
- Species with no ortholog for DENND4C:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DENND4C Gene
Paralogs for DENND4C Gene
(2) SIMAP similar genes for DENND4C Gene using alignment to 4 proteins:
Variants for DENND4C Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17818730 | - | 19,346,712(+) | GCATG(A/G/T)CTACT | nc-transcript-variant, reference, missense | |
| rs6475322 | - | 19,346,943(+) | TAGTA(A/C)ATTCT | nc-transcript-variant, reference, missense | |
| rs34267952 | - | 19,346,596(-) | CAATA(A/C)CTGGA | nc-transcript-variant, reference, missense | |
| rs928128 | -- | 19,341,047(+) | GATGC(A/G)GAAAT | nc-transcript-variant, reference, synonymous-codon | |
| rs928129 | -- | 19,341,207(+) | ATTAT(G/T)TTCAC | intron-variant |
Residual Variation Intolerance Score:
11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.86;
83.63% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DENND4C Gene
Disorders for DENND4C Gene
Relevant External Links for DENND4C
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- DENND4C
No disorders were found for DENND4C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND4C Gene
Publications for DENND4C Gene
- Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4 67
- Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. (PMID: 12906859) Semova N. … Semov A. (Genomics 2003) 2 3
- Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
- Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
Products for DENND4C Gene
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- OriGene qPCR primer pairs for DENND4C
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- ViGene Biosciences adenoviral particle packaged cDNA for DENND4C gene
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- ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
- ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
- ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
- Search ViGene Biosciences for DENND4C
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- Santa Cruz Biotechnology (SCBT) Antibodies for DENND4C
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- Santa Cruz Biotechnology (SCBT) CRISPR for DENND4C
Sources for DENND4C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
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