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DENND4C Gene

protein-coding   GIFtS: 43
GCID: GC09P019289

DENN/MADD Domain Containing 4C

(Previous names: chromosome 9 open reading frame 55B, chromosome 9 open reading...)
(Previous symbols: C9orf55B, C9orf55)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DENN/MADD Domain Containing 4C1 2     Chromosome 9 Open Reading Frame 55B1
C9orf551 2 3     bA513M16.32
C9orf55B1 2 3     DENN Domain-Containing Protein 4C2
Chromosome 9 Open Reading Frame 551     DENN/MADD Domain Containing 4A Pseudogene2

External Ids:    HGNC: 260791   Entrez Gene: 556672   Ensembl: ENSG000001371457   UniProtKB: Q5VZ893   

Export aliases for DENND4C gene to outside databases

Previous GC identifers: GC09P019281 GC09P019252


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DENND4C Gene:
DENND4C (DENN/MADD domain containing 4C) is a protein-coding gene. Diseases associated with DENND4C include stomatitis. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot: DEN4C_HUMAN, Q5VZ89
Function: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP,
converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose
transporter-enriched vesicles delivery to the plasma membrane in response to insulin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DENND4C gene promoter:
         AREB6   ISGF-3   AML1a   GATA-6   FOXF2   FOXJ2 (long isoform)   HFH-1   FOXJ2   Ik-3   c-Ets-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DENND4C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENND4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.1   Ensembl cytogenetic band:  9p22.1   HGNC cytogenetic band: 9p22.1

DENND4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENND4C gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P019289:  view genomic region     (about GC identifiers)

Start:
19,230,433 bp from pter      End:
19,374,139 bp from pter
Size:
143,707 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DEN4C_HUMAN, Q5VZ89 (See protein sequence)
Recommended Name: DENN domain-containing protein 4C  
Size: 1673 amino acids; 186857 Da
Sequence caution: Sequence=BAA91294.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91478.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA92039.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15221.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAH10466.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAM21141.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Secondary accessions: A2A3R1 A2A3R2 A2A3R3 A2A3R9 Q6AI48 Q6ZUB3 Q8NCY7 Q9H6N4 Q9NUT1 Q9NWA5
Q9NWT3
Alternative splicing: 6 isoforms:  Q5VZ89-1   Q5VZ89-2   Q5VZ89-3   Q5VZ89-4   Q5VZ89-5   Q5VZ89-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DENND4C: NX_Q5VZ89

Explore proteomics data for DENND4C at MOPED

Post-translational modifications: 

  • Phosphorylated in response to insulin (By similarity)1
  • Ubiquitination2 at Lys51
  • Modification sites at PhosphoSitePlus

  • See DENND4C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060395.5  
    ENSEMBL proteins: 
     ENSP00000473469   ENSP00000473565   ENSP00000473273   ENSP00000369792   ENSP00000354301  
     ENSP00000369789   ENSP00000369797  

    DENND4C Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DENND: DENN/MADD domain containing

    3 InterPro protein domains:
     IPR005112 dDENN_dom
     IPR005113 uDENN_dom
     IPR001194 DENN_dom

    Graphical View of Domain Structure for InterPro Entry Q5VZ89

    ProtoNet protein and cluster: Q5VZ89

    UniProtKB/Swiss-Prot: DEN4C_HUMAN, Q5VZ89
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 PPR (pentatricopeptide) repeat
    Similarity: Contains 1 uDENN domain


    DENND4C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEN4C_HUMAN, Q5VZ89
    Function: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP,
    converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose
    transporter-enriched vesicles delivery to the plasma membrane in response to insulin

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017112Rab guanyl-nucleotide exchange factor activity IDA--
         
    DENND4C for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-miR-624* hsa-miR-301a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidDENND4C 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEN4C_HUMAN, Q5VZ89: Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with
    SLC2A4/GLUT4 storage vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    golgi apparatus3
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane ISS--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0030904retromer complex ----
    GO:0032593insulin-responsive compartment ISS--

    DENND4C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DENND4C
    Interactions:

        Search GeneGlobe Interaction Network for DENND4C

    1 Interacting protein for DENND4C (Q5VZ893) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3CQ9BXW43I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0032313regulation of Rab GTPase activity IDA--
    GO:0032869cellular response to insulin stimulus ISS--
    GO:0072659protein localization to plasma membrane ISS--

    DENND4C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DENND4C (DEN4C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DENND4C gene: 
    NM_017925.5  

    Unigene Cluster for DENND4C:

    DENN/MADD domain containing 4C
    Hs.249591  [show with all ESTs]
    Unigene Representative Sequence: NM_017925
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434457 ENST00000602925 ENST00000602708 ENST00000380437 ENST00000494124
    ENST00000602442 ENST00000380427(uc003znt.3) ENST00000361024 ENST00000380424
    ENST00000380432
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DENND4C (see all 38):
    hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-miR-624* hsa-miR-301a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidDENND4C 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DENND4C
      QuantiTect SYBR Green Assays in human, mouse, rat DENND4C
      QuantiFast Probe-based Assays in human, mouse, rat DENND4C

    Additional mRNA sequence: 

    AK000627.1 AK000693.1 AK001046.1 AK002020.1 AK025705.1 AK125842.1 AK127734.1 AK299842.1 
    AK302901.1 AL834521.1 BC144484.1 BC144485.1 CR627367.1 NR_073201.2 

    15 DOTS entries:

    DT.97838739  DT.214521  DT.410018  DT.121149839  DT.100784968  DT.40217577  DT.70101132  DT.121149867 
    DT.121149910  DT.121149931  DT.439289  DT.91972220  DT.92014101  DT.99999363  DT.92047754 

    2 AceView cDNA sequences:

    N28227 BG197754 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DENND4C (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ·
    SP1:                                                                                                                                                  -     -   
    SP2:                                                  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                  -         
    SP5:                                                                                                                                                            

    ExUns: 18c ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:  -                                                                       -                                       
    SP2:  -     -     -     -     -     -     -     -                             -                                       
    SP3:                                                                          -                             -         
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for DENND4C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DENND4C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DENND4C Expression
    About this image


    DENND4C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    DENND4C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DENND4C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249591
        Custom PCR Arrays for DENND4C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND4C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DENND4C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dennd4c1 , 5 DENN/MADD domain containing 4C1, 5 86.3(n)1
    87.19(a)1
      4 (40.69 cM)5
    3298771  NM_184088.11  NP_908976.11 
     867485555 
    chicken
    (Gallus gallus)
    Aves DENND4C1 DENN/MADD domain containing 4C 74.74(n)
    77.42(a)
      427236  XM_004949126.1  XP_004949183.1 
    lizard
    (Anolis carolinensis)
    Reptilia DENND4C6
    DENN/MADD domain containing 4C
    74(a)
    1 ↔ 1
    2(62476030-62579985)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.160122 Transcribed sequence with weak similarity to protein more 74.18(n)    142033743 
    zebrafish
    (Danio rerio)
    Actinopterygii dennd4c1 DENN/MADD domain containing 4C 63.43(n)
    65.98(a)
      558626  XM_005166553.1  XP_005166610.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Crag6
    Calmodulin-binding protein related to a Rab3 GDP/G...
    36(a)
    1 → many
    X(8486086-8495264)
    worm
    (Caenorhabditis elegans)
    Secernentea denn-46
    --
    35(a)
    1 → many
    IV(1924008-1948040) WBGene00018681


    ENSEMBL Gene Tree for DENND4C (if available)
    TreeFam Gene Tree for DENND4C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DENND4C gene
    ST52  DENND5A2  DENND2D2  DENND2A2  DENND32  DENND1C2  DENND4A2  DENND4B2  
    DENND1B2  DENND1A2  DENND5B2  DENND2C2  
    2 SIMAP similar genes for DENND4C using alignment to 4 protein entries:     DEN4C_HUMAN (see all proteins):
    DENND4A    DENND4B

    DENND4C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DENND4C (see all 3807)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841801641,2
    --19228909(+) TTTTTC/TTTTTT 2 -- us2k10--------
    rs1861177221,2
    --19229211(+) GCTAAA/GTTTTG 2 -- us2k10--------
    rs1897286931,2
    --19229229(+) AGATCC/TTTTCT 2 -- us2k10--------
    rs123407971,2
    C,F--19229240(+) TAAACT/CTTTGC 2 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1820731101,2
    --19229242(+) AACTTC/TTGCTC 2 -- us2k10--------
    rs1866246881,2
    --19229290(+) CCAAAC/TTGGCC 2 -- us2k10--------
    rs109640511,2
    F--19229472(+) CCCAGG/CTATAA 2 -- us2k11Minor allele frequency- C:0.05NA 120
    rs726983711,2
    C,F--19229504(+) TACAGA/GTTAAA 2 -- us2k13Minor allele frequency- G:0.06WA NA EA 358
    rs1447516471,2
    --19229556(+) ATACTC/TACCAG 2 -- us2k10--------
    rs1485318341,2
    C--19229630(+) TTTTCA/CCCCCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DENND4C (19230433 - 19374139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DENND4C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677622CNV Deletion23128226
    esv2665168CNV Deletion23128226
    esv24621CNV Loss19812545
    nsv824872CNV Loss20364138
    nsv466286CNV Gain19166990
    nsv892702CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for DENND4C:    
    About MalaCards
    stomatitis


    DENND4C for disorders           About GeneDecksing


    Export disorders for DENND4C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DENND4C gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with DENND4C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. (PubMed id 12906859)1, 3 Semova N....Semov A. (Genomics 2003)
    5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    6. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. (PubMed id 21454697)1 Sano H....Lienhard G.E. (J. Biol. Chem. 2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55667 HGNC: 26079 AceView: C9orf55.1 Ensembl:ENSG00000137145 euGenes: HUgn55667
    ECgene: DENND4C H-InvDB: DENND4C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DENND4C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DENND4C gene:
    Search GeneIP for patents involving DENND4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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