Aliases for DENND4C Gene
Aliases for DENND4C Gene
External Ids for DENND4C Gene
- HGNC: 26079
- Entrez Gene: 55667
- Ensembl: ENSG00000137145
- UniProtKB: Q5VZ89
Previous HGNC Symbols for DENND4C Gene
- C9orf55B
- C9orf55
Previous GeneCards Identifiers for DENND4C Gene
- GC09P019281
- GC09P019252
Summaries for DENND4C Gene
GeneCards Summary for DENND4C Gene
DENND4C (DENN Domain Containing 4C) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND4A.
UniProtKB/Swiss-Prot for DENND4C Gene
-
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND4C Gene
Genomics for DENND4C Gene
Regulatory Elements for DENND4C Gene
Enhancers for DENND4C Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09G019180 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 22 | -46.6 | -46621 | 6.0 | HDGF FOXA2 MLX SIN3A ARID4B GATA2 FOS SP5 JUNB TBX21 | DENND4C PLIN2 HAUS6 ENSG00000232978 RPS6P10 |
| GH09G019201 | 1 | ENCODE | 11.5 | -27.9 | -27937 | 1.7 | FOXA2 PKNOX1 ATF1 MLX ARID4B DMAP1 FEZF1 ZNF48 YY1 KLF7 | DENND4C HAUS6 RPS6P10 |
| GH09G019173 | 1.5 | Ensembl ENCODE dbSUPER | 5.8 | -56.2 | -56168 | 1.3 | HDGF FOXA2 ARNT ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 ZNF143 | ENSG00000272842 HAUS6 PLIN2 ENSG00000273226 SAXO1 PSMC3P1 DENND4C RPS6P10 |
| GH09G019250 | 0.5 | ENCODE | 12.6 | +20.3 | 20306 | 1.2 | TEAD4 PRDM10 HNF4A | DENND4C ENSG00000273226 RPS6 GC09P019231 ENSG00000232978 |
| GH09G019192 | 0.5 | ENCODE | 6.6 | -37.6 | -37606 | 0.7 | GATA2 ZFP3 REST NR3C1 | DENND4C RPS6P10 PLIN2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around DENND4C on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the DENND4C gene promoter:
Regulatory Element Products
Genomic Location for DENND4C Gene
- Chromosome:
- 9
- Start:
- 19,230,435 bp from pter
- End:
- 19,374,268 bp from pter
- Size:
- 143,834 bases
- Orientation:
- Plus strand
Genomic View for DENND4C Gene
Genes around DENND4C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p22.1 by Ensembl
- 9p22.1 by Entrez Gene
- 9p22.1 by HGNC
DENND4C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DENND4C Gene
Proteins for DENND4C Gene
-
Protein details for DENND4C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VZ89-DEN4C_HUMAN
- Recommended name:
- DENN domain-containing protein 4C
- Protein Accession:
- Q5VZ89
- A2A3R1
- A2A3R2
- A2A3R3
- A2A3R9
- Q6AI48
- Q6ZUB3
- Q8NCY7
- Q9H6N4
- Q9NUT1
- Q9NWA5
- Q9NWT3
Protein attributes for DENND4C Gene
- Size:
- 1673 amino acids
- Molecular mass:
- 186857 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA91294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91478.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10466.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAM21141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for DENND4C Gene
Post-translational modifications for DENND4C Gene
- Phosphorylated in response to insulin.
- Ubiquitination at isoforms=5, 651
- Modification sites at PhosphoSitePlus
Other Protein References for DENND4C Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DENND4C
- Novus Biologicals Antibodies for DENND4C
- Invitrogen Antibodies for DENND4C
- Search GeneTex for Antibodies for DENND4C
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DENND4C
- Origene Custom Protein Services for DENND4C
- Novus Biologicals proteins for DENND4C
- Search GeneTex for Proteins for DENND4C
Assay Products
No data available for DME Specific Peptides for DENND4C Gene
Domains & Families for DENND4C Gene
Gene Families for DENND4C Gene
Suggested Antigen Peptide Sequences for DENND4C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DENND4C Gene
Function for DENND4C Gene
Molecular function for DENND4C Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0017112 | Rab guanyl-nucleotide exchange factor activity | TAS,IEA | -- |
Phenotypes for DENND4C Gene
- MGI mutant phenotypes for DENND4C:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DENND4C:
Animal Models for DENND4C Gene
- MGI Knock Outs for DENND4C:
-
- Dennd4c tm1b(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DENND4C
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DENND4C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
- Search ViGene Biosciences for DENND4C
CRISPR Products
-
OriGene CRISPR knockouts for DENND4C
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND4C
- GenScript: Design CRISPR guide RNA sequences for DENND4C
miRNA for DENND4C Gene
- miRTarBase miRNAs that target DENND4C
-
- hsa-mir-5010-3p (MIRT443175)
- hsa-mir-2113 (MIRT443176)
- hsa-mir-4775 (MIRT443177)
- hsa-mir-550b-2-5p (MIRT443178)
- hsa-mir-1227-3p (MIRT443179)
- hsa-mir-5189-3p (MIRT443180)
- hsa-mir-4714-3p (MIRT443181)
- hsa-mir-7849-3p (MIRT443182)
- hsa-mir-590-3p (MIRT443183)
- hsa-mir-3978 (MIRT448880)
- hsa-mir-6124 (MIRT448881)
- hsa-mir-3148 (MIRT448882)
- hsa-mir-33a-3p (MIRT448883)
- hsa-mir-5582-3p (MIRT448884)
- hsa-mir-548x-3p (MIRT448885)
- hsa-mir-548j-3p (MIRT448886)
- hsa-mir-548aq-3p (MIRT448887)
- hsa-mir-548am-3p (MIRT448888)
- hsa-mir-548aj-3p (MIRT448889)
- hsa-mir-548ah-3p (MIRT448890)
- hsa-mir-548ae-3p (MIRT448891)
- hsa-mir-129-5p (MIRT499092)
- hsa-mir-4776-3p (MIRT499093)
- hsa-mir-1263 (MIRT499094)
- hsa-mir-150-3p (MIRT499095)
- hsa-mir-4659b-5p (MIRT499096)
- hsa-mir-4659a-5p (MIRT499097)
- hsa-mir-5590-5p (MIRT499098)
- hsa-mir-302f (MIRT499099)
- hsa-mir-5692a (MIRT499100)
- hsa-mir-633 (MIRT524189)
- hsa-mir-223-5p (MIRT524190)
- hsa-mir-496 (MIRT524191)
- hsa-mir-4781-3p (MIRT524192)
miRNA Products
- Search ViGene Biosciences for DENND4C
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for DENND4C
- Browse OriGene Inhibitory RNA Products For DENND4C
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DENND4C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DENND4C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for DENND4C
-
ViGene Biosciences adenoviral particle packaged cDNA for DENND4C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DENND4C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DENND4C Gene
Localization for DENND4C Gene
Subcellular locations from UniProtKB/Swiss-Prot for DENND4C Gene
- Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| golgi apparatus | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS,IDA | -- |
| GO:0005886 | plasma membrane | IEA,ISS | -- |
| GO:0030659 | cytoplasmic vesicle membrane | IEA | -- |
| GO:0030904 | retromer complex | IEA | -- |
| GO:0032593 | insulin-responsive compartment | IEA,ISS | -- |
Pathways & Interactions for DENND4C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | RAB GEFs exchange GTP for GDP on RABs | ||
Pathways by source for DENND4C Gene
3 Reactome pathways for DENND4C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015031 | protein transport | IEA | -- |
| GO:0032869 | cellular response to insulin stimulus | IEA,ISS | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
| GO:0061024 | membrane organization | TAS | -- |
| GO:0072659 | protein localization to plasma membrane | ISS,IEA | -- |
No data available for SIGNOR curated interactions for DENND4C Gene
Transcripts for DENND4C Gene
mRNA/cDNA for DENND4C Gene
- (10) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DENND4C Gene
CRISPR Products
-
OriGene CRISPR knockouts for DENND4C
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND4C
- GenScript: Design CRISPR guide RNA sequences for DENND4C
miRNA Products
- Search ViGene Biosciences for DENND4C
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for DENND4C
- Browse OriGene Inhibitory RNA Products For DENND4C
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DENND4C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DENND4C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 18c | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for DENND4C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (17.0) and CD8 Tcells (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DENND4C Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DENND4C Gene:
DENND4CSOURCE GeneReport for Unigene cluster for DENND4C Gene:
Hs.249591Evidence on tissue expression from TISSUES for DENND4C Gene
- Lymph node(4.2)
- Nervous system(2.4)
Primer Products
-
OriGene qPCR primer pairs for DENND4C
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND4C Gene
Orthologs for DENND4C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DENND4C 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | DENND4C 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | DENND4C 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Dennd4c 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1308489 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DENND4C 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | DENND4C 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DENND4C 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dennd4c 34 |
|
||
| Str.16012 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | dennd4c 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Crag 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | denn-4 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1014 35 |
|
OneToMany |
- Species where no ortholog for DENND4C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DENND4C Gene
Paralogs for DENND4C Gene
(2) SIMAP similar genes for DENND4C Gene using alignment to 4 proteins:
Variants for DENND4C Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004981 | -- | 19,362,801(+) | AATCT(C/T)TTAGA | intron-variant | |
| rs1000006132 | -- | 19,313,697(+) | TCCTT(A/G)CAGAG | intron-variant | |
| rs1000049000 | -- | 19,235,861(+) | CCAAA(A/G)TGCTG | intron-variant | |
| rs1000065884 | -- | 19,285,548(+) | TAAAA(A/C)CTGAA | intron-variant | |
| rs1000071821 | -- | 19,273,975(+) | TTTAT(C/T)TGTGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1060561 | CNV | insertion | 17803354 |
| esv1745994 | CNV | deletion | 17803354 |
| esv2302206 | CNV | deletion | 18987734 |
| esv24621 | CNV | loss | 19812545 |
| esv2665168 | CNV | deletion | 23128226 |
| esv2668263 | CNV | deletion | 23128226 |
| esv2677622 | CNV | deletion | 23128226 |
| esv2738259 | CNV | deletion | 23290073 |
| esv28580 | CNV | loss | 19812545 |
| esv3544632 | CNV | deletion | 23714750 |
| esv3544634 | CNV | deletion | 23714750 |
| esv3573165 | CNV | loss | 25503493 |
| esv3619900 | CNV | loss | 21293372 |
| esv3619901 | CNV | gain | 21293372 |
| esv3619902 | CNV | loss | 21293372 |
| esv3619903 | CNV | loss | 21293372 |
| esv3619904 | CNV | loss | 21293372 |
| esv3619905 | CNV | gain | 21293372 |
| esv3619906 | CNV | loss | 21293372 |
| esv3619907 | CNV | gain | 21293372 |
| esv3619908 | CNV | loss | 21293372 |
| esv3619909 | CNV | loss | 21293372 |
| nsv1024948 | CNV | loss | 25217958 |
| nsv1029922 | CNV | gain | 25217958 |
| nsv1030736 | CNV | gain | 25217958 |
| nsv1074852 | CNV | deletion | 25765185 |
| nsv466286 | CNV | gain | 19166990 |
| nsv613729 | CNV | gain | 21841781 |
| nsv613730 | CNV | gain | 21841781 |
| nsv824872 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.86;
83.63% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for DENND4C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DENND4C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND4C Gene
Disorders for DENND4C Gene
Relevant External Links for DENND4C
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- DENND4C
No disorders were found for DENND4C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND4C Gene
Publications for DENND4C Gene
- Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. (PMID: 21454697) Sano H. … Lienhard G.E. (J. Biol. Chem. 2011) 2 3 64
- Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
Products for DENND4C Gene
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for DENND4C
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- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DENND4C
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- OriGene qPCR primer pairs for DENND4C
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- GenScript: Next-day shipping cDNA ORF clone for DENND4C in any vector
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- GenScript: Design CRISPR guide RNA sequences for DENND4C
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- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DENND4C
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for DENND4C
- Novus Biologicals proteins for DENND4C
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for DENND4C
- ViGene Biosciences adenoviral particle packaged cDNA for DENND4C gene
- ViGene Biosciences lentiviral particle packaged cDNA for DENND4C gene
- ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
- Search ViGene Biosciences for DENND4C
- Horizon Cell Lines for DENND4C
- Cyagen custom Knockout/knockin (KOKI) mouse models for DENND4C
- VectorBuilder custom plasmid, inducible vectors for DENND4C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DENND4C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for DENND4C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer