Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DENND4C Gene

Aliases for DENND4C Gene

  • DENN Domain Containing 4C 2 3 5
  • DENN/MADD Domain Containing 4C 2 3
  • C9orf55B 3 4
  • C9orf55 3 4
  • DENN/MADD Domain Containing 4A Pseudogene 3
  • Chromosome 9 Open Reading Frame 55B 2
  • Chromosome 9 Open Reading Frame 55 2
  • DENN Domain-Containing Protein 4C 3
  • BA513M16.3 3
  • RAB10GEF 3

External Ids for DENND4C Gene

Previous HGNC Symbols for DENND4C Gene

  • C9orf55B
  • C9orf55

Previous GeneCards Identifiers for DENND4C Gene

  • GC09P019281
  • GC09P019252

Summaries for DENND4C Gene

GeneCards Summary for DENND4C Gene

DENND4C (DENN Domain Containing 4C) is a Protein Coding gene. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Vesicle-mediated transport. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND4A.

UniProtKB/Swiss-Prot for DENND4C Gene

  • Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.

Additional gene information for DENND4C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND4C Gene

Genomics for DENND4C Gene

Regulatory Elements for DENND4C Gene

Enhancers for DENND4C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H018975 1.3 Ensembl ENCODE 86.6 -253.8 -253784 1 PKNOX1 ARNT FEZF1 GLI4 ZNF2 GLIS2 ZNF302 KLF7 SP3 YY2 DENND4C ENSG00000273226 RPS6P10 RPS6 HAUS6 ENSG00000272842 ENSG00000227167 ENSG00000270712 SCARNA8 RRAGA
GH09H019173 1.5 Ensembl ENCODE dbSUPER 32.3 -56.2 -56168 1 HDGF FOXA2 ARNT ARID4B YBX1 GLI4 ZNF2 ZBTB7B ZNF207 ZNF143 DENND4C HAUS6 SCARNA8 ENSG00000272842 PLIN2 RPS6 ENSG00000273226 SAXO1 PSMC3P1 RPS6P10
GH09H019180 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22 -46.6 -46621 5 HDGF FOXA2 ARID4B SIN3A ZNF143 FOS ATF7 RUNX3 JUNB ZNF592 DENND4C PLIN2 HAUS6 ENSG00000232978 RPS6P10
GH09H019158 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -68.8 -68803 5 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS DENND4C SCARNA8 PLIN2 ACER2 RPS6P10
GH09H018392 1.2 Ensembl ENCODE 18.4 -836.8 -836822 2 ZNF133 FEZF1 BRCA1 ZNF2 GLIS2 ZNF548 FOS SP3 REST TSHZ1 ENSG00000273226 DENND4C ENSG00000227167 LOC105369293
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DENND4C on UCSC Golden Path with GeneCards custom track

Promoters for DENND4C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000233729 965 3601 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for DENND4C Gene

Chromosome:
9
Start:
19,230,435 bp from pter
End:
19,374,268 bp from pter
Size:
143,834 bases
Orientation:
Plus strand

Genomic View for DENND4C Gene

Genes around DENND4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND4C Gene

Proteins for DENND4C Gene

  • Protein details for DENND4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ89-DEN4C_HUMAN
    Recommended name:
    DENN domain-containing protein 4C
    Protein Accession:
    Q5VZ89
    Secondary Accessions:
    • A2A3R1
    • A2A3R2
    • A2A3R3
    • A2A3R9
    • Q6AI48
    • Q6ZUB3
    • Q8NCY7
    • Q9H6N4
    • Q9NUT1
    • Q9NWA5
    • Q9NWT3
    • R4GN35
    • R4GNB2

    Protein attributes for DENND4C Gene

    Size:
    1909 amino acids
    Molecular mass:
    212711 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91478.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86313.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10466.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND4C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DENND4C Gene

Post-translational modifications for DENND4C Gene

No data available for DME Specific Peptides for DENND4C Gene

Domains & Families for DENND4C Gene

Gene Families for DENND4C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DENND4C Gene

Suggested Antigen Peptide Sequences for DENND4C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DENND4C: view

No data available for UniProtKB/Swiss-Prot for DENND4C Gene

Function for DENND4C Gene

Molecular function for DENND4C Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.

Phenotypes From GWAS Catalog for DENND4C Gene

Gene Ontology (GO) - Molecular Function for DENND4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with DENND4C: view
genes like me logo Genes that share phenotypes with DENND4C: view

Animal Models for DENND4C Gene

MGI Knock Outs for DENND4C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DENND4C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DENND4C Gene

Localization for DENND4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND4C Gene

Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENND4C gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DENND4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DENND4C: view

Pathways & Interactions for DENND4C Gene

genes like me logo Genes that share pathways with DENND4C: view

Pathways by source for DENND4C Gene

Interacting Proteins for DENND4C Gene

Selected Interacting proteins: Q5VZ89-DEN4C_HUMAN for DENND4C Gene via IID

Gene Ontology (GO) - Biological Process for DENND4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0032869 cellular response to insulin stimulus ISS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with DENND4C: view

No data available for SIGNOR curated interactions for DENND4C Gene

Drugs & Compounds for DENND4C Gene

No Compound Related Data Available

Transcripts for DENND4C Gene

mRNA/cDNA for DENND4C Gene

(10) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DENND4C Gene

DENN/MADD domain containing 4C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DENND4C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DENND4C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ·
SP1: - -
SP2: - - - - - - - - - - - - - - - - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: -
SP9:

ExUns: 18c ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1: - -
SP2: - - - - - - - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for DENND4C Gene

GeneLoc Exon Structure for
DENND4C
ECgene alternative splicing isoforms for
DENND4C

Expression for DENND4C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DENND4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DENND4C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.0) and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DENND4C Gene



Protein tissue co-expression partners for DENND4C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DENND4C Gene:

DENND4C

SOURCE GeneReport for Unigene cluster for DENND4C Gene:

Hs.249591

Evidence on tissue expression from TISSUES for DENND4C Gene

  • Liver(4.2)
  • Lymph node(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with DENND4C: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND4C Gene

Orthologs for DENND4C Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND4C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENND4C 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia DENND4C 33 34
  • 92.26 (n)
cow
(Bos Taurus)
Mammalia DENND4C 33 34
  • 91.8 (n)
mouse
(Mus musculus)
Mammalia Dennd4c 33 16 34
  • 86.3 (n)
rat
(Rattus norvegicus)
Mammalia RGD1308489 33
  • 85.07 (n)
oppossum
(Monodelphis domestica)
Mammalia DENND4C 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves DENND4C 33 34
  • 74.74 (n)
lizard
(Anolis carolinensis)
Reptilia DENND4C 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd4c 33
  • 67.73 (n)
Str.16012 33
zebrafish
(Danio rerio)
Actinopterygii dennd4c 33 34
  • 63.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta Crag 34
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea denn-4 34
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1014 34
  • 37 (a)
OneToMany
Species where no ortholog for DENND4C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND4C Gene

ENSEMBL:
Gene Tree for DENND4C (if available)
TreeFam:
Gene Tree for DENND4C (if available)

Paralogs for DENND4C Gene

(2) SIMAP similar genes for DENND4C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DENND4C: view

Variants for DENND4C Gene

Sequence variations from dbSNP and Humsavar for DENND4C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000004981 -- 19,362,801(+) AATCT(C/T)TTAGA intron-variant
rs1000006132 -- 19,313,697(+) TCCTT(A/G)CAGAG intron-variant
rs1000049000 -- 19,235,861(+) CCAAA(A/G)TGCTG intron-variant
rs1000065884 -- 19,285,548(+) TAAAA(A/C)CTGAA intron-variant
rs1000071821 -- 19,273,975(+) TTTAT(C/T)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND4C Gene

Variant ID Type Subtype PubMed ID
esv1060561 CNV insertion 17803354
esv1745994 CNV deletion 17803354
esv2302206 CNV deletion 18987734
esv24621 CNV loss 19812545
esv2665168 CNV deletion 23128226
esv2668263 CNV deletion 23128226
esv2677622 CNV deletion 23128226
esv2738259 CNV deletion 23290073
esv28580 CNV loss 19812545
esv3544632 CNV deletion 23714750
esv3544634 CNV deletion 23714750
esv3573165 CNV loss 25503493
esv3619900 CNV loss 21293372
esv3619901 CNV gain 21293372
esv3619902 CNV loss 21293372
esv3619903 CNV loss 21293372
esv3619904 CNV loss 21293372
esv3619905 CNV gain 21293372
esv3619906 CNV loss 21293372
esv3619907 CNV gain 21293372
esv3619908 CNV loss 21293372
esv3619909 CNV loss 21293372
nsv1024948 CNV loss 25217958
nsv1029922 CNV gain 25217958
nsv1030736 CNV gain 25217958
nsv1074852 CNV deletion 25765185
nsv466286 CNV gain 19166990
nsv613729 CNV gain 21841781
nsv613730 CNV gain 21841781
nsv824872 CNV loss 20364138

Variation tolerance for DENND4C Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DENND4C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DENND4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND4C Gene

Disorders for DENND4C Gene

Relevant External Links for DENND4C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DENND4C

No disorders were found for DENND4C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND4C Gene

Publications for DENND4C Gene

  1. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. (PMID: 21454697) Sano H … Lienhard GE (The Journal of biological chemistry 2011) 2 3 60
  2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S … Barr FA (The Journal of cell biology 2010) 3 4 60
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60

Products for DENND4C Gene

Sources for DENND4C Gene

Content
Loading form....