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Aliases for DENND4B Gene

Aliases for DENND4B Gene

  • DENN Domain Containing 4B 2 3
  • DENN/MADD Domain Containing 4B 2 3 5
  • KIAA0476 2 3 4

External Ids for DENND4B Gene

Previous HGNC Symbols for DENND4B Gene

  • KIAA0476

Previous GeneCards Identifiers for DENND4B Gene

  • GC01M150716
  • GC01M152168
  • GC01M125264

Summaries for DENND4B Gene

GeneCards Summary for DENND4B Gene

DENND4B (DENN Domain Containing 4B) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is SBF1.

UniProtKB/Swiss-Prot for DENND4B Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND4B Gene

Genomics for DENND4B Gene

Regulatory Elements for DENND4B Gene

Enhancers for DENND4B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DENND4B on UCSC Golden Path with GeneCards custom track

Promoters for DENND4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DENND4B on UCSC Golden Path with GeneCards custom track

Genomic Location for DENND4B Gene

Chromosome:
1
Start:
153,929,501 bp from pter
End:
153,946,696 bp from pter
Size:
17,196 bases
Orientation:
Minus strand

Genomic View for DENND4B Gene

Genes around DENND4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND4B Gene

Proteins for DENND4B Gene

  • Protein details for DENND4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75064-DEN4B_HUMAN
    Recommended name:
    DENN domain-containing protein 4B
    Protein Accession:
    O75064
    Secondary Accessions:
    • Q5T4K0

    Protein attributes for DENND4B Gene

    Size:
    1496 amino acids
    Molecular mass:
    163847 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32321.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14016.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW53268.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DENND4B Gene

Proteomics data for DENND4B Gene at MOPED

Post-translational modifications for DENND4B Gene

  • Ubiquitination at Lys 610
  • Modification sites at PhosphoSitePlus

Other Protein References for DENND4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DENND4B Gene

Domains & Families for DENND4B Gene

Gene Families for DENND4B Gene

Protein Domains for DENND4B Gene

Suggested Antigen Peptide Sequences for DENND4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75064

UniProtKB/Swiss-Prot:

DEN4B_HUMAN :
  • Contains 1 dDENN domain.
  • Contains 2 PPR (pentatricopeptide) repeats.
Domain:
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 MABP domain.
  • Contains 1 uDENN domain.
Similarity:
  • Contains 2 PPR (pentatricopeptide) repeats.
genes like me logo Genes that share domains with DENND4B: view

Function for DENND4B Gene

Molecular function for DENND4B Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
genes like me logo Genes that share phenotypes with DENND4B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND4B Gene

Localization for DENND4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND4B Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENND4B Gene COMPARTMENTS Subcellular localization image for DENND4B gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 3
extracellular 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for DENND4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with DENND4B: view

Pathways & Interactions for DENND4B Gene

SuperPathways for DENND4B Gene

No Data Available

Interacting Proteins for DENND4B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354597%0d%0a9606.ENSP00000391723%0d%0a
Selected Interacting proteins: ENSP00000354597 O75064-DEN4B_HUMAN for DENND4B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DENND4B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DENND4B Gene

Drugs & Compounds for DENND4B Gene

No Compound Related Data Available

Transcripts for DENND4B Gene

Unigene Clusters for DENND4B Gene

DENN/MADD domain containing 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND4B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15:
SP16:
SP17:
SP18:

ExUns: 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b · 22c · 22d ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b · 28c · 28d
SP1: - -
SP2:
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for DENND4B Gene

GeneLoc Exon Structure for
DENND4B
ECgene alternative splicing isoforms for
DENND4B

Expression for DENND4B Gene

mRNA expression in normal human tissues for DENND4B Gene

Protein differential expression in normal tissues from HIPED for DENND4B Gene

This gene is overexpressed in Cervix (19.3), Peripheral blood mononuclear cells (14.2), CD8 Tcells (7.1), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DENND4B Gene



SOURCE GeneReport for Unigene cluster for DENND4B Gene Hs.744878

genes like me logo Genes that share expression patterns with DENND4B: view

Protein tissue co-expression partners for DENND4B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DENND4B Gene

Orthologs for DENND4B Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DENND4B 35
  • 89.96 (n)
  • 93.6 (a)
DENND4B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DENND4B 35
  • 89.06 (n)
  • 94.5 (a)
DENND4B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dennd4b 35
  • 88.71 (n)
  • 94.11 (a)
Dennd4b 16
Dennd4b 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DENND4B 35
  • 99.69 (n)
  • 99.8 (a)
DENND4B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dennd4b 35
  • 88.61 (n)
  • 94.05 (a)
oppossum
(Monodelphis domestica)
Mammalia DENND4B 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia DENND4B 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC798528 35
  • 61.12 (n)
  • 57.94 (a)
DENND4B 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Crag 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea denn-4 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1014 36
  • 31 (a)
OneToMany
Species with no ortholog for DENND4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DENND4B Gene

ENSEMBL:
Gene Tree for DENND4B (if available)
TreeFam:
Gene Tree for DENND4B (if available)

Paralogs for DENND4B Gene

(2) SIMAP similar genes for DENND4B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DENND4B: view

Variants for DENND4B Gene

Sequence variations from dbSNP and Humsavar for DENND4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1110165 -- 153,941,223(+) TCTGA(G/T)CACAT intron-variant
rs1043608 -- 153,936,593(-) ACAGC(A/C/G)TACCA nc-transcript-variant, reference, synonymous-codon
rs946683 -- 153,943,316(-) CAAAG(C/G)CCAAA intron-variant
rs2297895 -- 153,941,208(-) GGGGA(G/T)GGGAG intron-variant
rs2297896 -- 153,937,726(-) CAGTA(C/T)TGGTG nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DENND4B Gene

Variant ID Type Subtype PubMed ID
nsv872450 CNV Loss 21882294

Variation tolerance for DENND4B Gene

Residual Variation Intolerance Score: 2.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.11; 87.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DENND4B Gene

Disorders for DENND4B Gene

Relevant External Links for DENND4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DENND4B

No disorders were found for DENND4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND4B Gene

Publications for DENND4B Gene

  1. Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. (PMID: 12906859) Semova N. … Semov A. (Genomics 2003) 2 3 4 67
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3
  3. Genome-wide association identifies genetic variants associated with lentiform nucleus volume in Na88=a881345 young and elderly subjects. (PMID: 22903471) Hibar D.P. … Thompson P.M. (Brain Imaging Behav 2013) 3
  4. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for DENND4B Gene

Sources for DENND4B Gene

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