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Aliases for DENND4B Gene

Aliases for DENND4B Gene

  • DENN/MADD Domain Containing 4B 2 3
  • KIAA0476 2 3 4
  • DENN Domain-Containing Protein 4B 3

External Ids for DENND4B Gene

Previous HGNC Symbols for DENND4B Gene

  • KIAA0476

Previous GeneCards Identifiers for DENND4B Gene

  • GC01M150716
  • GC01M152168
  • GC01M125264

Summaries for DENND4B Gene

GeneCards Summary for DENND4B Gene

DENND4B (DENN/MADD Domain Containing 4B) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2C.

UniProtKB/Swiss-Prot for DENND4B Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND4B Gene

Genomics for DENND4B Gene

Regulatory Elements for DENND4B Gene

Genomic Location for DENND4B Gene

Start:
153,929,501 bp from pter
End:
153,946,696 bp from pter
Size:
17,196 bases
Orientation:
Minus strand

Genomic View for DENND4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENND4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND4B Gene

Proteins for DENND4B Gene

  • Protein details for DENND4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75064-DEN4B_HUMAN
    Recommended name:
    DENN domain-containing protein 4B
    Protein Accession:
    O75064
    Secondary Accessions:
    • Q5T4K0

    Protein attributes for DENND4B Gene

    Size:
    1496 amino acids
    Molecular mass:
    163847 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32321.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14016.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW53268.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DENND4B Gene

Proteomics data for DENND4B Gene at MOPED

Post-translational modifications for DENND4B Gene

  • Ubiquitination at Lys610
  • Modification sites at PhosphoSitePlus

Other Protein References for DENND4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DENND4B Gene

Domains for DENND4B Gene

Gene Families for DENND4B Gene

HGNC:
  • DENND :DENN/MADD domain containing

Protein Domains for DENND4B Gene

Suggested Antigen Peptide Sequences for DENND4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75064

UniProtKB/Swiss-Prot:

DEN4B_HUMAN :
  • O75064
Domain:
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 MABP domain.
  • Contains 1 uDENN domain.
Similarity:
  • Contains 2 PPR (pentatricopeptide) repeats.
genes like me logo Genes that share domains with DENND4B: view

Function for DENND4B Gene

Molecular function for DENND4B Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene Ontology (GO) - Molecular Function for DENND4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with DENND4B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DENND4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DENND4B Gene

Localization for DENND4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND4B Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENND4B Gene COMPARTMENTS Subcellular localization image for DENND4B gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
extracellular 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for DENND4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with DENND4B: view

Pathways for DENND4B Gene

SuperPathways for DENND4B Gene

No Data Available

Interacting Proteins for DENND4B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354597%0d%0a9606.ENSP00000391723%0d%0a
Selected Interacting proteins: ENSP00000354597 O75064-DEN4B_HUMAN for DENND4B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DENND4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032483 regulation of Rab protein signal transduction IDA 20937701
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DENND4B: view

No data available for Pathways by source for DENND4B Gene

Transcripts for DENND4B Gene

Unigene Clusters for DENND4B Gene

DENN/MADD domain containing 4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DENND4B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DENND4B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND4B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15:
SP16:
SP17:
SP18:

ExUns: 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b · 22c · 22d ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b · 28c · 28d
SP1: - -
SP2:
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for DENND4B Gene

GeneLoc Exon Structure for
DENND4B
ECgene alternative splicing isoforms for
DENND4B

Expression for DENND4B Gene

mRNA expression in normal human tissues for DENND4B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND4B Gene

SOURCE GeneReport for Unigene cluster for DENND4B Gene Hs.744878

genes like me logo Genes that share expressions with DENND4B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DENND4B Gene

Orthologs for DENND4B Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENND4B 35
  • 99.69 (n)
  • 99.8 (a)
DENND4B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DENND4B 35
  • 89.96 (n)
  • 93.6 (a)
DENND4B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DENND4B 35
  • 89.06 (n)
  • 94.5 (a)
DENND4B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dennd4b 35
  • 88.71 (n)
  • 94.11 (a)
Dennd4b 16
Dennd4b 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DENND4B 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Dennd4b 35
  • 88.61 (n)
  • 94.05 (a)
lizard
(Anolis carolinensis)
Reptilia DENND4B 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DENND4B 36
  • 56 (a)
OneToOne
LOC798528 35
  • 61.12 (n)
  • 57.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta Crag 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea denn-4 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1014 36
  • 31 (a)
OneToMany
Species with no ortholog for DENND4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DENND4B Gene

ENSEMBL:
Gene Tree for DENND4B (if available)
TreeFam:
Gene Tree for DENND4B (if available)

Paralogs for DENND4B Gene

Selected SIMAP similar genes for DENND4B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DENND4B: view

Variants for DENND4B Gene

Sequence variations from dbSNP and Humsavar for DENND4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs946683 -- 153,943,316(-) CAAAG(C/G)CCAAA intron-variant, upstream-variant-2KB
rs1043608 -- 153,936,593(-) ACAGC(C/G)TACCA reference, synonymous-codon, nc-transcript-variant
rs1110165 -- 153,941,223(+) TCTGA(G/T)CACAT intron-variant
rs2252508 -- 153,941,294(-) TCCCT(C/T)CCAGA intron-variant
rs2297895 -- 153,941,208(-) GGGGA(G/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND4B Gene

Variant ID Type Subtype PubMed ID
nsv872450 CNV Loss 21882294

Relevant External Links for DENND4B Gene

HapMap Linkage Disequilibrium report
DENND4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND4B Gene

Disorders for DENND4B Gene

No disorders were found for DENND4B Gene.

No data available for UniProtKB/Swiss-Prot for DENND4B Gene

Publications for DENND4B Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. (PMID: 12906859) Semova N. … Semov A. (Genomics 2003) 2 3 4
  3. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4
  4. Genome-wide association identifies genetic variants associated with lentiform nucleus volume in Na88=a881345 young and elderly subjects. (PMID: 22903471) Hibar D.P. … Thompson P.M. (Brain Imaging Behav 2013) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for DENND4B Gene

Sources for DENND4B Gene

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