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DENND4A Gene

protein-coding   GIFtS: 50
GCID: GC15M065952

DENN/MADD Domain Containing 4A

(Previous name: c-myc promoter binding protein)
(Previous symbol: MYCPBP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DENN/MADD Domain Containing 4A1 2
MYCPBP1 2 3
C-Myc Promoter Binding Protein1 2
IRLB2 3
DENN Domain-Containing Protein 4A2 3
C-Myc Promoter-Binding Protein2

External Ids:    HGNC: 243211   Entrez Gene: 102602   Ensembl: ENSG000001744857   OMIM: 6003825   UniProtKB: Q7Z4013   

Export aliases for DENND4A gene to outside databases

Previous GC identifers: GC15M063741 GC15M042779


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DENND4A Gene:
DENND4A (DENN/MADD domain containing 4A) is a protein-coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot: MYCPP_HUMAN, Q7Z401
Function: Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP
to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341,
it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter

Gene Wiki entry for DENND4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DENND4A gene promoter:
         AML1a   HOXA3   Sp1   MEF-2   RORalpha2   AREB6   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDENND4A promoter sequence
   Search Chromatin IP Primers for DENND4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENND4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

DENND4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENND4A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M065952:  view genomic region     (about GC identifiers)

Start:
65,950,384 bp from pter      End:
66,084,631 bp from pter
Size:
134,248 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYCPP_HUMAN, Q7Z401 (See protein sequence)
Recommended Name: C-myc promoter-binding protein  
Size: 1863 amino acids; 209244 Da
Developmental stage: Highly expressed in fetal liver
Sequence caution: Sequence=AL833317; Type=Frameshift; Positions=1774;
Secondary accessions: E7EPL3 Q14655 Q86T77 Q8IVX2 Q8NB93
Alternative splicing: 2 isoforms:  Q7Z401-1   Q7Z401-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DENND4A: NX_Q7Z401

Explore proteomics data for DENND4A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DENND4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138295.1  NP_005839.3  

    ENSEMBL proteins: 
     ENSP00000456605   ENSP00000391167   ENSP00000396830   ENSP00000457358  

    DENND4A Human Recombinant Protein Products:

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    Novus Biologicals DENND4A Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DENND4A 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DENND: DENN/MADD domain containing

    5 InterPro protein domains:
     IPR005112 dDENN_dom
     IPR023341 MABP
     IPR005113 uDENN_dom
     IPR001194 DENN_dom
     IPR002885 Pentatricopeptide_repeat

    Graphical View of Domain Structure for InterPro Entry Q7Z401

    ProtoNet protein and cluster: Q7Z401

    UniProtKB/Swiss-Prot: MYCPP_HUMAN, Q7Z401
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 MABP domain
    Similarity: Contains 2 PPR (pentatricopeptide) repeats
    Similarity: Contains 1 uDENN domain


    Find genes that share domains with DENND4A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYCPP_HUMAN, Q7Z401
    Function: Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP
    to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341,
    it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter
    Induction: By serum in low-passage fibroblasts

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS8056341
    GO:0017112Rab guanyl-nucleotide exchange factor activity IDA--
         
    Find genes that share ontologies with DENND4A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DENND4A:
     Actin fiber cells  Increased S DNA content  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DENND4A
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    Selected qRT-PCR Assays for microRNAs that regulate DENND4A (see all 28):
    hsa-miR-579 hsa-miR-520d-5p hsa-miR-15a hsa-miR-503 hsa-miR-374a hsa-miR-10b* hsa-miR-374c hsa-miR-1184
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYCPP_HUMAN, Q7Z401: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with DENND4A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including DENND4A: 
              Necrosis in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DENND4A

    Selected Interacting proteins for DENND4A (Q7Z4012, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3MINT-50898 I2D: score=4 
    YWHABP319462, 3MINT-50997 I2D: score=3 
    YWHAZP631042, 3MINT-3320063 I2D: score=1 
    YWHAQP273483I2D: score=2 
    CEBPEQ157443I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS8056341
    GO:0032313regulation of Rab GTPase activity IDA--

    Find genes that share ontologies with DENND4A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DENND4A (MYCPP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DENND4A gene (2 alternative transcripts): 
    NM_001144823.1  NM_005848.3  

    Unigene Cluster for DENND4A:

    DENN/MADD domain containing 4A
    Hs.654567  [show with all ESTs]
    Unigene Representative Sequence: NM_001144823
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561863 ENST00000443035(uc002api.3 uc002aph.3 uc002apj.3)
    ENST00000431932 ENST00000562540 ENST00000567323 ENST00000564674 ENST00000562028
    ENST00000568515(uc010ujj.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DENND4A (see all 28):
    hsa-miR-579 hsa-miR-520d-5p hsa-miR-15a hsa-miR-503 hsa-miR-374a hsa-miR-10b* hsa-miR-374c hsa-miR-1184
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 2): DENND4A (NM_005848)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENND4A
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DENND4A
      QuantiTect SYBR Green Assays in human, mouse, rat DENND4A
      QuantiFast Probe-based Assays in human, mouse, rat DENND4A

    Additional mRNA sequence: 

    AF534403.1 AK091268.1 AK091368.1 AK290292.1 AK299570.1 AK307411.1 AL832602.2 AL833317.1 
    AL833384.1 BC028057.1 BC041706.1 X63417.1 

    6 DOTS entries:

    DT.422698  DT.97838411  DT.92061312  DT.92061311  DT.100024571  DT.91805594 

    Selected AceView cDNA sequences (see all 104):

    BU633382 AI923987 BC028057 BU431382 NM_005848 CK904099 BU845366 BQ721664 
    AW500927 AI628351 BE268538 AA669492 AW501527 BC041706 AL832602 BX495425 
    CK300924 AW501229 AL833384 CK904100 N50598 BM718270 CB069125 AF534403 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DENND4A (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
    SP1:                                                                                                  -                                                         
    SP2:                    -                                                                             -                                   -                     
    SP3:                                                                                                  -                                   -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b · 34c
    SP1:              -                                               -                                 
    SP2:              -                                               -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for DENND4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DENND4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTGTATT
    DENND4A Expression
    About this image


    DENND4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    DENND4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DENND4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654567

    UniProtKB/Swiss-Prot: MYCPP_HUMAN, Q7Z401
    Tissue specificity: Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood
    lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than
    in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DENND4A: 
              Necrosis in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DENND4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DENND4A
    QuantiTect SYBR Green Assays in human, mouse, rat DENND4A
    QuantiFast Probe-based Assays in human, mouse, rat DENND4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DENND4A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dennd4a1 , 5 DENN/MADD domain containing 4A1, 5 89.13(n)1
    92.84(a)1
      9 (34.93 cM)5
    1024421  NM_001162917.11  NP_001156389.11 
     648113405 
    chicken
    (Gallus gallus)
    Aves DENND4A1 DENN/MADD domain containing 4A 77.06(n)
    80.65(a)
      415541  XM_413911.4  XP_413911.4 
    lizard
    (Anolis carolinensis)
    Reptilia DENND4A6
    DENN/MADD domain containing 4A
    76(a)
    1 ↔ 1
    GL343503.1(294838-366170)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.194912 Transcribed sequence with weak similarity to protein more 72.67(n)    AL867989.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dennd4a1 DENN/MADD domain containing 4A 61.84(n)
    64.55(a)
      558211  NM_001080989.2  NP_001074458.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Crag1 Calmodulin-binding protein related to a Rab3 GDP/GTP more 48.73(n)
    46.53(a)
      31800  NM_167164.3  NP_727281.2 
    worm
    (Caenorhabditis elegans)
    Secernentea denn-46
    --
    33(a)
    1 → many
    IV(1924008-1948040) WBGene00018681


    ENSEMBL Gene Tree for DENND4A (if available)
    TreeFam Gene Tree for DENND4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DENND4A gene
    ST52  DENND5A2  DENND2D2  DENND2A2  DENND32  DENND1C2  DENND4B2  DENND1B2  
    DENND1A2  DENND5B2  DENND2C2  DENND4C2  
    2 SIMAP similar genes for DENND4A using alignment to 4 protein entries:     MYCPP_HUMAN (see all proteins):
    DENND4C    DENND4B

    Find genes that share paralogs with DENND4A           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for DENND4A
    PGOHUM00000262226 PGOHUM00000249559 PGOHUM00000236399


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DENND4A (see all 2344)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711394301,2
    C--42869373(-) ACATC-/TTTT  
      
    /TTTTT
    TTTTT
    2 -- int11NA 2
    rs572497021,2
    C--42911146(+) AAGGCA/GTGAAG 2 -- us2k10--------
    rs1384041551,2
    C--42911221(+) CGCAGA/CATTTG 2 -- us2k10--------
    rs1427956411,2
    --42911227(+) ATTTGA/GCTGTG 2 -- us2k10--------
    rs1474117861,2
    C--42911237(+) GTACCC/TAGGAA 2 -- us2k10--------
    rs1932686641,2
    --42911248(+) GTATCA/GTACCT 2 -- us2k10--------
    rs1836700411,2
    --42911375(+) TAGACA/TTGAGC 2 -- us2k10--------
    rs1397624531,2
    --42911387(+) AAATAG/TAATTT 2 -- us2k10--------
    rs1410948521,2
    --65952560(+) GCAAGG/TTCAGC 2 -- ds50010--------
    rs1928667941,2
    --65952742(+) AGTGTC/TGTGGA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DENND4A (65950384 - 66084631 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for DENND4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749787CNV Deletion23290073
    nsv904314CNV Loss21882294
    nsv819095CNV Loss19587683
    nsv833044CNV Loss17160897
    dgv2401n71CNV Loss21882294
    nsv904318CNV Loss21882294
    nsv904322CNV Loss21882294
    dgv2400n71CNV Loss21882294
    nsv833043CNV Loss17160897
    esv5701OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DENND4A
    DNA2.0 Custom Variant and Variant Library Synthesis for DENND4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600382    OMIM disorders: --


    Find genes that share disorders with DENND4A           About GenesLikeMe

    Genetic Association Database (GAD): DENND4A

    Export disorders for DENND4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DENND4A gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with DENND4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. (PubMed id 12906859)1, 2, 3, 9 Semova N....Semov A. (Genomics 2003)
    2. Cloning of a cDNA encoding a human protein which binds a sequence in the c-myc gene similar to the interferon-stimulated response element. (PubMed id 8056341)1, 2, 3, 9 Stasiv Y.Z....Kisselev L.L. (Gene 1994)
    3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. Seventy-five genetic loci influencing the human red blood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (Nature 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10260 HGNC: 24321 AceView: MYCPBP Ensembl:ENSG00000174485 euGenes: HUgn10260
    ECgene: DENND4A H-InvDB: DENND4A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DENND4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DENND4A gene:
    Search GeneIP for patents involving DENND4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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