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Aliases for DENND4A Gene

Aliases for DENND4A Gene

  • DENN/MADD Domain Containing 4A 2 3
  • DENN Domain-Containing Protein 4A 3 4
  • C-Myc Promoter Binding Protein 2 3
  • MYCPBP 3 4
  • IRLB 3 4
  • C-Myc Promoter-Binding Protein 3

External Ids for DENND4A Gene

Previous Symbols for DENND4A Gene

  • MYCPBP

Summaries for DENND4A Gene

GeneCards Summary for DENND4A Gene

DENND4A (DENN/MADD Domain Containing 4A) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2C.

UniProtKB/Swiss-Prot for DENND4A Gene

  • Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.

Gene Wiki entry for DENND4A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND4A Gene

Genomics for DENND4A Gene

Genomic Location for DENND4A Gene

Start:
65,658,046 bp from pter
End:
65,792,293 bp from pter
Size:
134,248 bases
Orientation:
Minus strand

Genomic View for DENND4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENND4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND4A Gene

Regulatory Elements for DENND4A Gene

Proteins for DENND4A Gene

  • Protein details for DENND4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z401-MYCPP_HUMAN
    Recommended name:
    C-myc promoter-binding protein
    Protein Accession:
    Q7Z401
    Secondary Accessions:
    • E7EPL3
    • Q14655
    • Q86T77
    • Q8IVX2
    • Q8NB93

    Protein attributes for DENND4A Gene

    Size:
    1863 amino acids
    Molecular mass:
    209244 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AL833317; Type=Frameshift; Positions=1774; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DENND4A Gene

Proteomics data for DENND4A Gene at MOPED

Post-translational modifications for DENND4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DENND4A Gene

No data available for DME Specific Peptides for DENND4A Gene

Domains for DENND4A Gene

Gene Families for DENND4A Gene

HGNC:
  • DENND :DENN/MADD domain containing

Protein Domains for DENND4A Gene

Suggested Antigen Peptide Sequences for DENND4A Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z401

UniProtKB/Swiss-Prot:

MYCPP_HUMAN
Domain:
  • Contains 1 dDENN domain.:
    • Q7Z401
  • Contains 1 DENN domain.:
    • Q7Z401
  • Contains 1 MABP domain.:
    • Q7Z401
  • Contains 1 uDENN domain.:
    • Q7Z401
Similarity:
  • Contains 2 PPR (pentatricopeptide) repeats.:
    • Q7Z401
genes like me logo Genes that share domains with DENND4A: view

Function for DENND4A Gene

Molecular function for DENND4A Gene

UniProtKB/Swiss-Prot Function: Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.
UniProtKB/Swiss-Prot Induction: By serum in low-passage fibroblasts.

Gene Ontology (GO) - Molecular Function for DENND4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 8056341
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with DENND4A: view

Phenotypes for DENND4A Gene

genes like me logo Genes that share phenotypes with DENND4A: view

miRNA for DENND4A Gene

miRTarBase miRNAs that target DENND4A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DENND4A Gene

Localization for DENND4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND4A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENND4A Gene COMPARTMENTS Subcellular localization image for DENND4A gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DENND4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DENND4A: view

Pathways for DENND4A Gene

SuperPathways for DENND4A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DENND4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8056341
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DENND4A: view

No data available for Pathways by source for DENND4A Gene

Transcripts for DENND4A Gene

Unigene Clusters for DENND4A Gene

DENN/MADD domain containing 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND4A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:

ExUns: 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b · 34c
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for DENND4A Gene

GeneLoc Exon Structure for
DENND4A
ECgene alternative splicing isoforms for
DENND4A

Expression for DENND4A Gene

mRNA expression in normal human tissues for DENND4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND4A Gene

SOURCE GeneReport for Unigene cluster for DENND4A Gene Hs.654567

mRNA Expression by UniProt/SwissProt for DENND4A Gene

Q7Z401-MYCPP_HUMAN
Tissue specificity: Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner.
genes like me logo Genes that share expressions with DENND4A: view

No data available for mRNA differential expression in normal tissues for DENND4A Gene

Orthologs for DENND4A Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENND4A 35
  • 99.83 (n)
  • 99.74 (a)
DENND4A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DENND4A 35
  • 92.42 (n)
  • 93.54 (a)
DENND4A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DENND4A 35
  • 93.32 (n)
  • 94.7 (a)
DENND4A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dennd4a 35
  • 89.13 (n)
  • 92.84 (a)
Dennd4a 16
Dennd4a 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DENND4A 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DENND4A 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dennd4a 35
  • 89.33 (n)
  • 92.98 (a)
chicken
(Gallus gallus)
Aves DENND4A 35
  • 77.06 (n)
  • 80.65 (a)
DENND4A 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DENND4A 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd4a 35
  • 67.87 (n)
  • 71.13 (a)
Str.19491 35
zebrafish
(Danio rerio)
Actinopterygii dennd4a 35
  • 61.84 (n)
  • 64.55 (a)
dennd4a 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001102 35
  • 52.84 (n)
  • 47.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Crag 35
  • 48.73 (n)
  • 46.53 (a)
Crag 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea denn-4 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1014 36
  • 40 (a)
OneToMany
Species with no ortholog for DENND4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND4A Gene

ENSEMBL:
Gene Tree for DENND4A (if available)
TreeFam:
Gene Tree for DENND4A (if available)

Paralogs for DENND4A Gene

Selected SIMAP similar genes for DENND4A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DENND4A Gene

genes like me logo Genes that share paralogs with DENND4A: view

Variants for DENND4A Gene

Sequence variations from dbSNP and Humsavar for DENND4A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs721151 -- 65,771,222(-) GCATG(G/T)ACAAC intron-variant
rs934542 -- 65,723,838(-) aacta(C/T)agtct intron-variant
rs996381 -- 65,680,422(+) GGGAA(A/T)ACAGA intron-variant
rs1055737 -- 65,661,581(-) CTAAA(A/C)AAAAT utr-variant-3-prime
rs1061554 -- 65,792,085(+) AGCGG(A/G)ACACG utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DENND4A Gene

Variant ID Type Subtype PubMed ID
nsv904314 CNV Loss 21882294
dgv2400n71 CNV Loss 21882294
nsv833043 CNV Loss 17160897
esv2749787 CNV Deletion 23290073
nsv904318 CNV Loss 21882294
nsv819095 CNV Loss 19587683
dgv2401n71 CNV Loss 21882294
nsv904322 CNV Loss 21882294
nsv833044 CNV Loss 17160897
esv5701 OTHER Inversion 19470904

Relevant External Links for DENND4A Gene

HapMap Linkage Disequilibrium report
DENND4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND4A Gene

Disorders for DENND4A Gene

Relevant External Links for DENND4A

Genetic Association Database (GAD)
DENND4A
genes like me logo Genes that share disorders with DENND4A: view

No data available for UniProtKB/Swiss-Prot for DENND4A Gene

Publications for DENND4A Gene

  1. Cloning of a cDNA encoding a human protein which binds a sequence in the c-myc gene similar to the interferon-stimulated response element. (PMID: 8056341) Stasiv Y.Z. … Kisselev L.L. (Gene 1994) 2 3 4 23
  2. Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. (PMID: 12906859) Semova N. … Semov A. (Genomics 2003) 2 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 48

Products for DENND4A Gene

  • antibodies-online proteins for DENND4A
  • antibodies-online antibodies for DENND4A
  • antibodies-online kits for DENND4A

Sources for DENND4A Gene

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