External Ids for DENND3 Gene
Previous GeneCards Identifiers for DENND3 Gene
GeneCards Summary for DENND3 Gene
DENND3 (DENN Domain Containing 3) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND4A.
UniProtKB/Swiss-Prot for DENND3 Gene
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.