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DENND3 Gene

protein-coding   GIFtS: 51
GCID: GC08P142127

DENN/MADD Domain Containing 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DENN/MADD Domain Containing 31 2
DENN Domain-Containing Protein 32
KIAA08703

External Ids:    HGNC: 291341   Entrez Gene: 228982   Ensembl: ENSG000001053397   UniProtKB: A2RUS23   

Export aliases for DENND3 gene to outside databases

Previous GC identifers: GC08P142156 GC08P137450


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DENND3 Gene:
DENND3 (DENN/MADD domain containing 3) is a protein-coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot: DEND3_HUMAN, A2RUS2
Function: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP,
converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport
from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DENND3 gene promoter:
         RP58   AML1a   AP-4   GATA-1   AREB6   POU2F1   POU2F1a   STAT3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDENND3 promoter sequence
   Search Chromatin IP Primers for DENND3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENND3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

DENND3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENND3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P142127:  view genomic region     (about GC identifiers)

Start:
142,127,377 bp from pter      End:
142,205,907 bp from pter
Size:
78,531 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DEND3_HUMAN, A2RUS2 (See protein sequence)
Recommended Name: DENN domain-containing protein 3  
Size: 1198 amino acids; 135890 Da
Secondary accessions: B7ZM28 O94947 Q2TAM7 Q6ZMS6 Q96DK3
Alternative splicing: 4 isoforms:  A2RUS2-1   A2RUS2-2   A2RUS2-3   A2RUS2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DENND3: NX_A2RUS2

Explore proteomics data for DENND3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys391, Lys511, Lys517
  • Modification sites at PhosphoSitePlus

  • See DENND3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055772.2  
    ENSEMBL proteins: 
     ENSP00000430625   ENSP00000430695   ENSP00000428641   ENSP00000428714   ENSP00000429780  
     ENSP00000430786   ENSP00000428276   ENSP00000428155   ENSP00000429533   ENSP00000430912  
     ENSP00000429725   ENSP00000262585   ENSP00000410594  

    DENND3 Human Recombinant Protein Products:

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    Novus Biologicals DENND3 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DENND3

     
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    Search antibodies-online for antibodies for DENND3 

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    Cloud-Clone Corp. ELISAs for DENND3
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    Search eBioscience for ELISAs for DENND3 
    antibodies-online kits for DENND3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing
    DENND: DENN/MADD domain containing

    Selected InterPro protein domains (see all 7):
     IPR005112 dDENN_dom
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005113 uDENN_dom
     IPR001194 DENN_dom

    Graphical View of Domain Structure for InterPro Entry A2RUS2

    ProtoNet protein and cluster: A2RUS2

    UniProtKB/Swiss-Prot: DEND3_HUMAN, A2RUS2
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 uDENN domain
    Similarity: Contains 3 WD repeats


    Find genes that share domains with DENND3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEND3_HUMAN, A2RUS2
    Function: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP,
    converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport
    from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017112Rab guanyl-nucleotide exchange factor activity IDA--
         
    Find genes that share ontologies with DENND3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DENND3:
     Decreased Wnt reporter activit  Increased cell number in G1, s 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DENND3

    miRNA
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    miRTarBase miRNAs that target DENND3:
    hsa-mir-335-5p (MIRT019167)

    Block miRNA regulation of human, mouse, rat DENND3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DENND3:
    hsa-miR-149 hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidDENND3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DENND3

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    GenScript: all cDNA clones in your preferred vector: DENND3 (NM_014957)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DENND3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENND3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endosome1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DENND3
    Interactions:

        Search GeneGlobe Interaction Network for DENND3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DENND3 (A2RUS23 ENSP000002625854) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    YAP1P469373, ENSP000002824414I2D: score=1 STRING: ENSP00000282441
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008333endosome to lysosome transport ISS--
    GO:0032313regulation of Rab GTPase activity IDA--
    GO:0044257cellular protein catabolic process ISS--

    Find genes that share ontologies with DENND3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DENND3 (DEND3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DENND3 gene: 
    NM_014957.2  

    Unigene Cluster for DENND3:

    DENN/MADD domain containing 3
    Hs.18166  [show with all ESTs]
    Unigene Representative Sequence: NM_014957
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000519291 ENST00000518347 ENST00000518198(uc003yvw.1 uc003yvx.3)
    ENST00000519811 ENST00000520986 ENST00000523058 ENST00000518668(uc010mep.3)
    ENST00000518249 ENST00000523015 ENST00000521477 ENST00000520482(uc003yvz.1)
    ENST00000523066 ENST00000518806 ENST00000517985 ENST00000517813(uc003ywa.1)
    ENST00000523308(uc003ywb.3) ENST00000520571 ENST00000523530
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate DENND3:
    hsa-miR-149 hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidDENND3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DENND3
    Predesigned siRNA for gene silencing in human, mouse, rat DENND3
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    GenScript: all cDNA clones in your preferred vector: DENND3 (NM_014957)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DENND3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENND3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DENND3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DENND3
      QuantiTect SYBR Green Assays in human, mouse, rat DENND3
      QuantiFast Probe-based Assays in human, mouse, rat DENND3

    Additional mRNA sequence: 

    AB020677.2 AK057136.1 AK091556.1 AK123283.1 AL110264.1 BC133023.1 BC144226.1 

    18 DOTS entries:

    DT.413808  DT.101975817  DT.95128848  DT.100784582  DT.100784581  DT.100696221  DT.100784584  DT.91908517 
    DT.95268196  DT.97769162  DT.101978452  DT.40213983  DT.65284073  DT.75111851  DT.95268197  DT.91913278 
    DT.436504  DT.86838601 

    Selected AceView cDNA sequences (see all 222):

    AI081777 AW292418 BQ086294 CA440718 AI810683 BU679734 BM767431 AI472065 
    BF434278 AI523725 BQ073138 BM767091 AW575401 AI950328 BM767110 AI818018 
    AL110264 CB529011 CD515145 BF060969 AK057136 BM767415 AI380753 BM749480 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DENND3 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                          -     -                           
    SP3:                                                              -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                  -     -     -     -     -                                                                                 

    ExUns: 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b ^ 24
    SP1:                    -                       -                       -                 -     -                 -     -     -                           
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for DENND3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DENND3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACCTCAGG
    DENND3 Expression
    About this image


    DENND3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Lung (Respiratory System)
    DENND3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DENND3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18166
        Custom PCR Arrays for DENND3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DENND3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DENND3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dennd31 , 5 DENN/MADD domain containing 31, 5 79.26(n)1
    79.6(a)1
      15 (34.01 cM)5
    1058411  NM_001081066.11  NP_001074535.11 
     735125605 
    chicken
    (Gallus gallus)
    Aves DENND31 DENN/MADD domain containing 3 66.69(n)
    66.72(a)
      420309  XM_418419.4  XP_418419.2 
    lizard
    (Anolis carolinensis)
    Reptilia DENND36
    DENN/MADD domain containing 3
    63(a)
    1 ↔ 1
    4(15277414-15324810)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dennd31 DENN/MADD domain containing 3 64.95(n)
    61.99(a)
      100493383  XM_002934475.2  XP_002934521.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dennd3a1 DENN/MADD domain containing 3a 60.69(n)
    53.13(a)
      797970  XM_001338383.4  XP_001338419.4 


    ENSEMBL Gene Tree for DENND3 (if available)
    TreeFam Gene Tree for DENND3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DENND3 gene
    ST52  DENND5A2  DENND2D2  DENND2A2  DENND1C2  DENND4A2  DENND4B2  DENND1B2  
    DENND1A2  DENND5B2  DENND2C2  DENND4C2  
    1 SIMAP similar gene for DENND3 using alignment to 13 protein entries:     DEND3_HUMAN (see all proteins):
    MADD

    Find genes that share paralogs with DENND3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DENND3
    PGOHUM00000257086


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DENND3 (see all 1652)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381571381,2
    C--142136737(+) GGCCTC/TTTGGT 1 -- us2k10--------
    rs1495553931,2
    --142136938(+) TGGCTC/TATGGC 1 -- us2k10--------
    rs2013466331,2
    --142136961(+) TGAGA-/GCGCCTC 1 -- us2k10--------
    rs78154571,2
    C,F,A,H--142136963(+) AGAGCG/CCCTCT 1 -- us2k19Minor allele frequency- C:0.43NS EA WA NA 770
    rs78165011,2
    C,F,A,H--142136964(+) GAGCGC/TCTCTC 1 -- us2k19Minor allele frequency- T:0.44EA NS NA WA 662
    rs1433967881,2
    --142137025(+) GGCTGC/GTAAAA 1 -- us2k10--------
    rs1137060731,2
    C--142137212(+) CAGCTCT/-ACTCT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1483670261,2
    --142137255(+) TGGGAC/GGCAGA 1 -- us2k10--------
    rs1433086551,2
    --142137322(+) ACTCTA/GTCTCA 1 -- us2k10--------
    rs1808281191,2
    --142137474(+) AGGCAA/GCCTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DENND3 (142127377 - 142205907 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for DENND3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737756CNV Deletion23290073
    nsv509284CNV Insertion20534489
    nsv891540CNV Loss21882294
    dgv7891n71CNV Loss21882294
    nsv891538CNV Loss21882294
    nsv824750CNV Loss20364138
    nsv470239CNV Loss18288195
    dgv7890n71CNV Loss21882294
    nsv891537CNV Loss21882294
    nsv831483CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DENND3
    DNA2.0 Custom Variant and Variant Library Synthesis for DENND3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with DENND3           About GenesLikeMe

    Genetic Association Database (GAD): DENND3
    Human Genome Epidemiology (HuGE) Navigator: DENND3 (1 document)

    Export disorders for DENND3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DENND3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DENND3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-I^ therapy in multiple sclerosis patients. (PubMed id 21502966)1 Weber F....Hemmer B. (Pharmacogenomics J. 2012)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PubMed id 20937701)2 Yoshimura S.... Barr F.A. (J. Cell Biol. 2010)
    10. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22898 HGNC: 29134 AceView: KIAA0870 Ensembl:ENSG00000105339 euGenes: HUgn22898
    ECgene: DENND3 H-InvDB: DENND3

    (According to HUGE)
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    HUGE: KIAA0870

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DENND3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DENND3 gene:
    Search GeneIP for patents involving DENND3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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