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Aliases for DENND3 Gene

Aliases for DENND3 Gene

  • DENN Domain Containing 3 2 3 5
  • DENN/MADD Domain Containing 3 2
  • KIAA0870 4

External Ids for DENND3 Gene

Previous GeneCards Identifiers for DENND3 Gene

  • GC08P142156
  • GC08P137450
  • GC08P142127

Summaries for DENND3 Gene

GeneCards Summary for DENND3 Gene

DENND3 (DENN Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is SBF1.

UniProtKB/Swiss-Prot for DENND3 Gene

  • Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND3 Gene

Genomics for DENND3 Gene

Regulatory Elements for DENND3 Gene

Enhancers for DENND3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DENND3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DENND3 Gene

Chromosome:
8
Start:
141,117,278 bp from pter
End:
141,195,808 bp from pter
Size:
78,531 bases
Orientation:
Plus strand

Genomic View for DENND3 Gene

Genes around DENND3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND3 Gene

Proteins for DENND3 Gene

  • Protein details for DENND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUS2-DEND3_HUMAN
    Recommended name:
    DENN domain-containing protein 3
    Protein Accession:
    A2RUS2
    Secondary Accessions:
    • B7ZM28
    • O94947
    • Q2TAM7
    • Q6ZMS6
    • Q96DK3

    Protein attributes for DENND3 Gene

    Size:
    1198 amino acids
    Molecular mass:
    135890 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DENND3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DENND3 Gene

Post-translational modifications for DENND3 Gene

  • Ubiquitination at Lys 391, Lys 511, and Lys 517
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DENND3 Gene

Domains & Families for DENND3 Gene

Suggested Antigen Peptide Sequences for DENND3 Gene

Graphical View of Domain Structure for InterPro Entry

A2RUS2

UniProtKB/Swiss-Prot:

DEND3_HUMAN :
  • Contains 1 dDENN domain.
  • Contains 11 WD repeats.
Domain:
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
Similarity:
  • Contains 11 WD repeats.
genes like me logo Genes that share domains with DENND3: view

Function for DENND3 Gene

Molecular function for DENND3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.

Gene Ontology (GO) - Molecular Function for DENND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with DENND3: view
genes like me logo Genes that share phenotypes with DENND3: view

Animal Model Products

CRISPR Products

miRNA for DENND3 Gene

miRTarBase miRNAs that target DENND3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND3 Gene

Localization for DENND3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENND3 Gene COMPARTMENTS Subcellular localization image for DENND3 gene
Compartment Confidence
cytosol 2
nucleus 2
endosome 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DENND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with DENND3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DENND3 Gene

Pathways & Interactions for DENND3 Gene

SuperPathways for DENND3 Gene

No Data Available

Interacting Proteins for DENND3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262585%0d%0a9606.ENSP00000363970%0d%0a9606.ENSP00000282441%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000262585 A2RUS2-DEND3_HUMAN for DENND3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DENND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008333 endosome to lysosome transport ISS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0044257 cellular protein catabolic process ISS --
genes like me logo Genes that share ontologies with DENND3: view

No data available for Pathways by source and SIGNOR curated interactions for DENND3 Gene

Drugs & Compounds for DENND3 Gene

No Compound Related Data Available

Transcripts for DENND3 Gene

Unigene Clusters for DENND3 Gene

DENN/MADD domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ·
SP1:
SP2: - -
SP3: -
SP4:
SP5: - - - - -
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b ^ 24
SP1: - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: - - - - -
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for DENND3 Gene

GeneLoc Exon Structure for
DENND3
ECgene alternative splicing isoforms for
DENND3

Expression for DENND3 Gene

mRNA expression in normal human tissues for DENND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DENND3 Gene

This gene is overexpressed in Whole Blood (x12.4).

Protein differential expression in normal tissues from HIPED for DENND3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (52.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DENND3 Gene



Protein tissue co-expression partners for DENND3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DENND3 Gene:

DENND3

SOURCE GeneReport for Unigene cluster for DENND3 Gene:

Hs.18166
genes like me logo Genes that share expression patterns with DENND3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DENND3 Gene

Orthologs for DENND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DENND3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DENND3 34
  • 81.62 (n)
  • 80.75 (a)
DENND3 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DENND3 34
  • 81.7 (n)
  • 80.78 (a)
DENND3 35
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dennd3 34
  • 79.26 (n)
  • 79.6 (a)
Dennd3 16
Dennd3 35
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DENND3 34
  • 98.33 (n)
  • 97.5 (a)
DENND3 35
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dennd3 34
  • 78.8 (n)
  • 78.58 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DENND3 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves DENND3 34
  • 66.69 (n)
  • 66.72 (a)
DENND3 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DENND3 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd3 34
  • 64.95 (n)
  • 61.99 (a)
zebrafish
(Danio rerio)
Actinopterygii dennd3a 34
  • 60.69 (n)
  • 53.13 (a)
dennd3a 35
  • 49 (a)
OneToMany
dennd3b 35
  • 48 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5903 34
Species where no ortholog for DENND3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DENND3 Gene

ENSEMBL:
Gene Tree for DENND3 (if available)
TreeFam:
Gene Tree for DENND3 (if available)

Paralogs for DENND3 Gene

Pseudogenes.org Pseudogenes for DENND3 Gene

genes like me logo Genes that share paralogs with DENND3: view

Variants for DENND3 Gene

Sequence variations from dbSNP and Humsavar for DENND3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs307761 - 141,144,192(-) TATGA(C/G/T)TGTCC intron-variant, nc-transcript-variant, reference, missense
rs11997191 - 141,160,766(+) CCTGC(A/G)GCTGC intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1045248 -- 141,194,227(+) AAAGG(C/G)GAATA nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs1045303 -- 141,190,368(+) CTGCC(A/C/G)CGAGG intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1808701 -- 141,180,150(-) tctcc(A/G)cagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND3 Gene

Variant ID Type Subtype PubMed ID
dgv1426e214 CNV loss 21293372
esv2737756 CNV deletion 23290073
esv3415271 CNV duplication 20981092
esv3619054 CNV loss 21293372
esv3619055 CNV loss 21293372
nsv1126125 CNV deletion 24896259
nsv470239 CNV loss 18288195
nsv473858 CNV novel sequence insertion 20440878
nsv509284 CNV insertion 20534489
nsv612568 CNV gain 21841781
nsv824750 CNV loss 20364138
nsv831483 CNV gain 17160897

Variation tolerance for DENND3 Gene

Residual Variation Intolerance Score: 8.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DENND3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DENND3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND3 Gene

Disorders for DENND3 Gene

Relevant External Links for DENND3

Genetic Association Database (GAD)
DENND3
Human Genome Epidemiology (HuGE) Navigator
DENND3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DENND3

No disorders were found for DENND3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND3 Gene

Publications for DENND3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy. (PMID: 25925668) Xu J. … McPherson P.S. (EMBO Rep. 2015) 3 65

Products for DENND3 Gene

Sources for DENND3 Gene

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