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Aliases for DENND3 Gene

Aliases for DENND3 Gene

  • DENN/MADD Domain Containing 3 2 3
  • KIAA0870 4

External Ids for DENND3 Gene

Summaries for DENND3 Gene

GeneCards Summary for DENND3 Gene

DENND3 (DENN/MADD Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2C.

UniProtKB/Swiss-Prot for DENND3 Gene

  • Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND3 Gene

Genomics for DENND3 Gene

Genomic Location for DENND3 Gene

Start:
141,117,278 bp from pter
End:
141,195,808 bp from pter
Size:
78,531 bases
Orientation:
Plus strand

Genomic View for DENND3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND3 Gene

Regulatory Elements for DENND3 Gene

Proteins for DENND3 Gene

  • Protein details for DENND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUS2-DEND3_HUMAN
    Recommended name:
    DENN domain-containing protein 3
    Protein Accession:
    A2RUS2
    Secondary Accessions:
    • B7ZM28
    • O94947
    • Q2TAM7
    • Q6ZMS6
    • Q96DK3

    Protein attributes for DENND3 Gene

    Size:
    1198 amino acids
    Molecular mass:
    135890 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DENND3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DENND3 Gene

Proteomics data for DENND3 Gene at MOPED

Post-translational modifications for DENND3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys391, Lys511, and Lys517

No data available for DME Specific Peptides for DENND3 Gene

Domains for DENND3 Gene

Gene Families for DENND3 Gene

HGNC:
  • WDR :WD repeat domain containing
  • DENND :DENN/MADD domain containing

UniProtKB/Swiss-Prot:

DEND3_HUMAN
Domain:
  • Contains 1 dDENN domain.:
    • A2RUS2
  • Contains 1 DENN domain.:
    • A2RUS2
  • Contains 1 uDENN domain.:
    • A2RUS2
Similarity:
  • Contains 11 WD repeats.:
    • A2RUS2
genes like me logo Genes that share domains with DENND3: view

Function for DENND3 Gene

Molecular function for DENND3 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.

Gene Ontology (GO) - Molecular Function for DENND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with DENND3: view

Phenotypes for DENND3 Gene

GenomeRNAi human phenotypes for DENND3:
genes like me logo Genes that share phenotypes with DENND3: view

miRNA for DENND3 Gene

miRTarBase miRNAs that target DENND3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DENND3 Gene

Localization for DENND3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENND3 Gene COMPARTMENTS Subcellular localization image for DENND3 gene
Compartment Confidence
cytosol 2
nucleus 2
endosome 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DENND3 Gene

Pathways for DENND3 Gene

SuperPathways for DENND3 Gene

No Data Available

Interacting Proteins for DENND3 Gene

Gene Ontology (GO) - Biological Process for DENND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008333 endosome to lysosome transport ISS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0044257 cellular protein catabolic process ISS --
genes like me logo Genes that share ontologies with DENND3: view

No data available for Pathways by source for DENND3 Gene

Transcripts for DENND3 Gene

Unigene Clusters for DENND3 Gene

DENN/MADD domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ·
SP1:
SP2: - -
SP3: -
SP4:
SP5: - - - - -
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b ^ 24
SP1: - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: - - - - -
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for DENND3 Gene

GeneLoc Exon Structure for
DENND3
ECgene alternative splicing isoforms for
DENND3

Expression for DENND3 Gene

mRNA expression in normal human tissues for DENND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DENND3 Gene

This gene is overexpressed in Whole Blood (12.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND3 Gene

SOURCE GeneReport for Unigene cluster for DENND3 Gene Hs.18166

genes like me logo Genes that share expressions with DENND3: view

Orthologs for DENND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DENND3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENND3 36
  • 98.33 (n)
  • 97.5 (a)
DENND3 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DENND3 36
  • 81.62 (n)
  • 80.75 (a)
DENND3 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DENND3 36
  • 81.7 (n)
  • 80.78 (a)
DENND3 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dennd3 36
  • 79.26 (n)
  • 79.6 (a)
Dennd3 16
Dennd3 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 61 (a)
OneToMany
-- 37
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DENND3 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dennd3 36
  • 78.8 (n)
  • 78.58 (a)
chicken
(Gallus gallus)
Aves DENND3 36
  • 66.69 (n)
  • 66.72 (a)
DENND3 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DENND3 37
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd3 36
  • 64.95 (n)
  • 61.99 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5903 36
zebrafish
(Danio rerio)
Actinopterygii dennd3a 36
  • 60.69 (n)
  • 53.13 (a)
dennd3a 37
  • 49 (a)
OneToMany
dennd3b 37
  • 48 (a)
OneToMany
Species with no ortholog for DENND3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DENND3 Gene

ENSEMBL:
Gene Tree for DENND3 (if available)
TreeFam:
Gene Tree for DENND3 (if available)

Paralogs for DENND3 Gene

Pseudogenes.org Pseudogenes for DENND3 Gene

genes like me logo Genes that share paralogs with DENND3: view

Variants for DENND3 Gene

Sequence variations from dbSNP and Humsavar for DENND3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs9792 -- 141,195,138(+) ATGCT(A/G)TACTG utr-variant-3-prime
rs11579 -- 141,195,033(+) GTGCC(A/G)CTCAG utr-variant-3-prime
rs170088 -- 141,150,777(-) CTGAC(A/G)TGCAC intron-variant
rs170089 -- 141,151,858(-) TCCAA(A/G)TCAAA intron-variant
rs186287 -- 141,155,544(-) tgcct(A/G)tggtc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DENND3 Gene

Variant ID Type Subtype PubMed ID
esv2737756 CNV Deletion 23290073
nsv891537 CNV Loss 21882294
nsv509284 CNV Insertion 20534489
nsv891538 CNV Loss 21882294
nsv831483 CNV Gain 17160897
nsv824750 CNV Loss 20364138
dgv7890n71 CNV Loss 21882294
nsv891540 CNV Loss 21882294
nsv470239 CNV Loss 18288195
dgv7891n71 CNV Loss 21882294

Relevant External Links for DENND3 Gene

HapMap Linkage Disequilibrium report
DENND3

Disorders for DENND3 Gene

Relevant External Links for DENND3

Genetic Association Database (GAD)
DENND3
Human Genome Epidemiology (HuGE) Navigator
DENND3
genes like me logo Genes that share disorders with DENND3: view

No data available for UniProtKB/Swiss-Prot for DENND3 Gene

Publications for DENND3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4
  5. Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-I^ therapy in multiple sclerosis patients. (PMID: 21502966) Weber F. … Hemmer B. (Pharmacogenomics J. 2012) 3

Products for DENND3 Gene

Sources for DENND3 Gene

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