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Aliases for DENND2D Gene

Aliases for DENND2D Gene

  • DENN Domain Containing 2D 2 3
  • DENN/MADD Domain Containing 2D 2 3 5
  • RP5-1180E21.2 3

External Ids for DENND2D Gene

Previous GeneCards Identifiers for DENND2D Gene

  • GC01M111442
  • GC01M111531
  • GC01M111729
  • GC01M109601

Summaries for DENND2D Gene

GeneCards Summary for DENND2D Gene

DENND2D (DENN Domain Containing 2D) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is SBF1.

UniProtKB/Swiss-Prot for DENND2D Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND2D Gene

Genomics for DENND2D Gene

Regulatory Elements for DENND2D Gene

Enhancers for DENND2D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DENND2D on UCSC Golden Path with GeneCards custom track

Promoters for DENND2D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DENND2D on UCSC Golden Path with GeneCards custom track

Genomic Location for DENND2D Gene

111,185,969 bp from pter
111,204,791 bp from pter
18,823 bases
Minus strand

Genomic View for DENND2D Gene

Genes around DENND2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND2D Gene

Proteins for DENND2D Gene

  • Protein details for DENND2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 2D
    Protein Accession:
    Secondary Accessions:
    • Q5T5V6
    • Q9BSU0

    Protein attributes for DENND2D Gene

    471 amino acids
    Molecular mass:
    53672 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DENND2D Gene


neXtProt entry for DENND2D Gene

Proteomics data for DENND2D Gene at MOPED

Post-translational modifications for DENND2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DENND2D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DENND2D Gene

Domains & Families for DENND2D Gene

Gene Families for DENND2D Gene

Protein Domains for DENND2D Gene


Suggested Antigen Peptide Sequences for DENND2D Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 dDENN domain.
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
genes like me logo Genes that share domains with DENND2D: view

Function for DENND2D Gene

Molecular function for DENND2D Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Phenotypes for DENND2D Gene

genes like me logo Genes that share phenotypes with DENND2D: view

Animal Model Products

CRISPR Products

miRNA for DENND2D Gene

miRTarBase miRNAs that target DENND2D

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND2D Gene

Localization for DENND2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND2D Gene


Subcellular locations from

Jensen Localization Image for DENND2D Gene COMPARTMENTS Subcellular localization image for DENND2D gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DENND2D Gene

Pathways & Interactions for DENND2D Gene

SuperPathways for DENND2D Gene

No Data Available

Gene Ontology (GO) - Biological Process for DENND2D Gene


No data available for Pathways by source and SIGNOR curated interactions for DENND2D Gene

Drugs & Compounds for DENND2D Gene

No Compound Related Data Available

Transcripts for DENND2D Gene

Unigene Clusters for DENND2D Gene

DENN/MADD domain containing 2D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND2D Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP9: - - - - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: -
SP14: -

ExUns: 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2: -

Relevant External Links for DENND2D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND2D Gene

mRNA expression in normal human tissues for DENND2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DENND2D Gene

This gene is overexpressed in Whole Blood (x8.7) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for DENND2D Gene

This gene is overexpressed in CD8 Tcells (17.0), Peripheral blood mononuclear cells (15.6), and NK cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND2D Gene

SOURCE GeneReport for Unigene cluster for DENND2D Gene Hs.557850

mRNA Expression by UniProt/SwissProt for DENND2D Gene

Tissue specificity: In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions.
genes like me logo Genes that share expression patterns with DENND2D: view

Protein tissue co-expression partners for DENND2D Gene

- Elite partner

Primer Products

Orthologs for DENND2D Gene

This gene was present in the common ancestor of chordates.

Orthologs for DENND2D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DENND2D 35
  • 88.82 (n)
  • 87.69 (a)
  • 88 (a)
(Canis familiaris)
Mammalia DENND2D 35
  • 90.48 (n)
  • 91.9 (a)
  • 91 (a)
(Mus musculus)
Mammalia Dennd2d 35
  • 86.16 (n)
  • 90.54 (a)
Dennd2d 16
Dennd2d 36
  • 90 (a)
(Pan troglodytes)
Mammalia DENND2D 35
  • 99.65 (n)
  • 99.79 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dennd2d 35
  • 86.02 (n)
  • 90.54 (a)
(Monodelphis domestica)
Mammalia DENND2D 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia DENND2D 36
  • 69 (a)
(Gallus gallus)
Aves DENND2D 35
  • 70.58 (n)
  • 71.13 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia DENND2D 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd2d 35
  • 62.18 (n)
  • 60.99 (a)
(Danio rerio)
Actinopterygii dennd2da 35
  • 59.27 (n)
  • 55.6 (a)
dennd2da 36
  • 46 (a)
dennd2db 36
  • 42 (a)
Species with no ortholog for DENND2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DENND2D Gene

Gene Tree for DENND2D (if available)
Gene Tree for DENND2D (if available)

Paralogs for DENND2D Gene

(4) SIMAP similar genes for DENND2D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DENND2D: view

Variants for DENND2D Gene

Sequence variations from dbSNP and Humsavar for DENND2D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35742969 - 111,192,267(+) CCCAG(C/T)TGAAG nc-transcript-variant, reference, missense
rs599134 -- 111,197,723(-) CTCCC(A/C/G)CTGCT intron-variant, reference, missense
rs600430 -- 111,197,460(+) CACCT(G/T)CAGTG intron-variant
rs638825 -- 111,200,092(-) GTCTC(G/T)GTGGT intron-variant
rs639210 -- 111,200,139(-) AGGCC(A/G)TATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND2D Gene

Variant ID Type Subtype PubMed ID
nsv10639 CNV Gain 18304495
nsv463250 CNV Loss 19166990

Variation tolerance for DENND2D Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DENND2D Gene

Disorders for DENND2D Gene

Relevant External Links for DENND2D

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DENND2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND2D Gene

Publications for DENND2D Gene

  1. Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D. (PMID: 23182661) Ling B. … Zhang K. (Lung Cancer 2013) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer. (PMID: 24695972) Kanda M. … Kodera Y. (Gastric Cancer 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Downregulation of DENND2D by promoter hypermethylation is associated with early recurrence of hepatocellular carcinoma. (PMID: 24189587) Kanda M. … Kodera Y. (Int. J. Oncol. 2014) 3

Products for DENND2D Gene

Sources for DENND2D Gene