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Aliases for DENND2D Gene

Aliases for DENND2D Gene

  • DENN Domain Containing 2D 2 3 5
  • DENN/MADD Domain Containing 2D 2 3
  • DENN Domain-Containing Protein 2D 3
  • RP5-1180E21.2 3

External Ids for DENND2D Gene

Previous GeneCards Identifiers for DENND2D Gene

  • GC01M111442
  • GC01M111531
  • GC01M111729
  • GC01M109601

Summaries for DENND2D Gene

GeneCards Summary for DENND2D Gene

DENND2D (DENN Domain Containing 2D) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot for DENND2D Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND2D Gene

Genomics for DENND2D Gene

Regulatory Elements for DENND2D Gene

Enhancers for DENND2D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F111211 1.4 FANTOM5 Ensembl ENCODE 18.3 -17.6 -17611 21.2 MLX CREB3L1 YBX1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 CHI3L2 DENND2D ENSG00000232240 LOC105378903 PIFO ATP5F1 WDR77 OVGP1 CEPT1 CD53
GH01F111138 1 ENCODE 15.8 +64.1 64066 4.5 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SP3 DRAM2 DENND2D CHI3L2 OVGP1 LOC440600 ENSG00000272982
GH01F111185 1.6 FANTOM5 Ensembl ENCODE 11.4 +9.1 9055 21.3 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DRAM2 KCND3-AS1 CEPT1 HIGD1AP12 NRBF2P3 CHI3L2 ENSG00000243960 DDX20 ENSG00000273373 DENND2D
GH01F111234 0.5 ENCODE 11.2 -31.5 -31516 3.9 ELF3 ARID4B THRB RAD21 DNMT3B RARA GATA4 RCOR1 CREM CEBPB CHI3L2 DENND2D ENSG00000232240 LOC105378903 OVGP1 ATP5F1 WDR77 CHIAP1
GH01F111144 0.7 Ensembl 11.1 +60.3 60291 0.2 CHI3L2 DENND2D OVGP1 DRAM2 ENSG00000272982
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DENND2D on UCSC Golden Path with GeneCards custom track

Promoters for DENND2D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000542612 791 1201 ELF3 HDAC1 TBP ATF1 TBL1XR1 ARID4B ZNF2 ZBTB40 GATA2 EGR1

Genomic Location for DENND2D Gene

Chromosome:
1
Start:
111,185,969 bp from pter
End:
111,204,791 bp from pter
Size:
18,823 bases
Orientation:
Minus strand

Genomic View for DENND2D Gene

Genes around DENND2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND2D Gene

Proteins for DENND2D Gene

  • Protein details for DENND2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6A0-DEN2D_HUMAN
    Recommended name:
    DENN domain-containing protein 2D
    Protein Accession:
    Q9H6A0
    Secondary Accessions:
    • Q5T5V6
    • Q9BSU0

    Protein attributes for DENND2D Gene

    Size:
    471 amino acids
    Molecular mass:
    53672 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DENND2D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DENND2D Gene

Post-translational modifications for DENND2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DENND2D Gene

Domains & Families for DENND2D Gene

Gene Families for DENND2D Gene

Protein Domains for DENND2D Gene

Suggested Antigen Peptide Sequences for DENND2D Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6A0

UniProtKB/Swiss-Prot:

DEN2D_HUMAN :
  • Contains 1 dDENN domain.
Domain:
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
genes like me logo Genes that share domains with DENND2D: view

Function for DENND2D Gene

Molecular function for DENND2D Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene Ontology (GO) - Molecular Function for DENND2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with DENND2D: view
genes like me logo Genes that share phenotypes with DENND2D: view

Animal Models for DENND2D Gene

MGI Knock Outs for DENND2D:

Animal Model Products

miRNA for DENND2D Gene

miRTarBase miRNAs that target DENND2D

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DENND2D Gene

Localization for DENND2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND2D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENND2D Gene COMPARTMENTS Subcellular localization image for DENND2D gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DENND2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DENND2D: view

Pathways & Interactions for DENND2D Gene

SuperPathways for DENND2D Gene

genes like me logo Genes that share pathways with DENND2D: view

Pathways by source for DENND2D Gene

2 Reactome pathways for DENND2D Gene

Gene Ontology (GO) - Biological Process for DENND2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DENND2D: view

No data available for SIGNOR curated interactions for DENND2D Gene

Transcripts for DENND2D Gene

Unigene Clusters for DENND2D Gene

DENN/MADD domain containing 2D:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND2D Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: -
SP13:
SP14: -

ExUns: 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for DENND2D Gene

GeneLoc Exon Structure for
DENND2D
ECgene alternative splicing isoforms for
DENND2D

Expression for DENND2D Gene

mRNA expression in normal human tissues for DENND2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DENND2D Gene

This gene is overexpressed in Whole Blood (x8.7) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for DENND2D Gene

This gene is overexpressed in CD8 Tcells (17.0), Peripheral blood mononuclear cells (15.6), and NK cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DENND2D Gene



Protein tissue co-expression partners for DENND2D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DENND2D Gene:

DENND2D

SOURCE GeneReport for Unigene cluster for DENND2D Gene:

Hs.557850

mRNA Expression by UniProt/SwissProt for DENND2D Gene:

Q9H6A0-DEN2D_HUMAN
Tissue specificity: In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions.
genes like me logo Genes that share expression patterns with DENND2D: view

Primer Products

Orthologs for DENND2D Gene

This gene was present in the common ancestor of chordates.

Orthologs for DENND2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENND2D 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia DENND2D 34 35
  • 90.48 (n)
cow
(Bos Taurus)
Mammalia DENND2D 34 35
  • 88.82 (n)
mouse
(Mus musculus)
Mammalia Dennd2d 34 16 35
  • 86.16 (n)
rat
(Rattus norvegicus)
Mammalia Dennd2d 34
  • 86.02 (n)
oppossum
(Monodelphis domestica)
Mammalia DENND2D 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DENND2D 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DENND2D 34 35
  • 70.58 (n)
lizard
(Anolis carolinensis)
Reptilia DENND2D 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd2d 34
  • 62.18 (n)
zebrafish
(Danio rerio)
Actinopterygii dennd2da 34 35
  • 59.27 (n)
dennd2db 35
  • 42 (a)
OneToMany
Species where no ortholog for DENND2D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DENND2D Gene

ENSEMBL:
Gene Tree for DENND2D (if available)
TreeFam:
Gene Tree for DENND2D (if available)

Paralogs for DENND2D Gene

(4) SIMAP similar genes for DENND2D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DENND2D: view

Variants for DENND2D Gene

Sequence variations from dbSNP and Humsavar for DENND2D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10857859 -- 111,191,102(+) GGTTG(C/G)AACAT intron-variant
rs11102218 -- 111,192,559(+) TTCCC(A/G)GTTAG intron-variant
rs11102219 -- 111,206,320(+) AGAAG(C/T)TAGTT intron-variant, upstream-variant-2KB
rs111300880 -- 111,200,350(+) CTAAG(A/G/T)GGGTC intron-variant, upstream-variant-2KB
rs111378970 -- 111,192,143(+) ACCTC(C/T)TCCAT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DENND2D Gene

Variant ID Type Subtype PubMed ID
nsv1003363 CNV loss 25217958
nsv10639 CNV gain 18304495
nsv463250 CNV loss 19166990
nsv547535 CNV loss 21841781

Variation tolerance for DENND2D Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DENND2D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DENND2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND2D Gene

Disorders for DENND2D Gene

Relevant External Links for DENND2D

Genetic Association Database (GAD)
DENND2D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DENND2D

No disorders were found for DENND2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND2D Gene

Publications for DENND2D Gene

  1. Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D. (PMID: 23182661) Ling B. … Zhang K. (Lung Cancer 2013) 3 4 64
  2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DENND2D Gene

Sources for DENND2D Gene

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