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Aliases for DENND2D Gene

Aliases for DENND2D Gene

  • DENN/MADD Domain Containing 2D 2 3
  • DENN Domain-Containing Protein 2D 3
  • RP5-1180E21.2 3

External Ids for DENND2D Gene

Previous GeneCards Identifiers for DENND2D Gene

  • GC01M111442
  • GC01M111531
  • GC01M111729
  • GC01M109601

Summaries for DENND2D Gene

GeneCards Summary for DENND2D Gene

DENND2D (DENN/MADD Domain Containing 2D) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2C.

UniProtKB/Swiss-Prot for DENND2D Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND2D Gene

Genomics for DENND2D Gene

Regulatory Elements for DENND2D Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DENND2D Gene

Start:
111,185,969 bp from pter
End:
111,204,538 bp from pter
Size:
18,570 bases
Orientation:
Minus strand

Genomic View for DENND2D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENND2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND2D Gene

Proteins for DENND2D Gene

  • Protein details for DENND2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6A0-DEN2D_HUMAN
    Recommended name:
    DENN domain-containing protein 2D
    Protein Accession:
    Q9H6A0
    Secondary Accessions:
    • Q5T5V6
    • Q9BSU0

    Protein attributes for DENND2D Gene

    Size:
    471 amino acids
    Molecular mass:
    53672 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DENND2D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DENND2D Gene

Proteomics data for DENND2D Gene at MOPED

Post-translational modifications for DENND2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DENND2D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DENND2D Gene

Domains for DENND2D Gene

Gene Families for DENND2D Gene

HGNC:
  • DENND :DENN/MADD domain containing

Protein Domains for DENND2D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DENND2D Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6A0

UniProtKB/Swiss-Prot:

DEN2D_HUMAN :
  • Q9H6A0
Domain:
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
genes like me logo Genes that share domains with DENND2D: view

Function for DENND2D Gene

Molecular function for DENND2D Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene Ontology (GO) - Molecular Function for DENND2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with DENND2D: view

Phenotypes for DENND2D Gene

GenomeRNAi human phenotypes for DENND2D:
genes like me logo Genes that share phenotypes with DENND2D: view

Animal Model Products

CRISPR Products

miRNA for DENND2D Gene

miRTarBase miRNAs that target DENND2D

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DENND2D Gene

Localization for DENND2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND2D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DENND2D Gene COMPARTMENTS Subcellular localization image for DENND2D gene
Compartment Confidence
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DENND2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DENND2D: view

Pathways for DENND2D Gene

SuperPathways for DENND2D Gene

No Data Available

Gene Ontology (GO) - Biological Process for DENND2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DENND2D: view

No data available for Pathways by source for DENND2D Gene

Transcripts for DENND2D Gene

Unigene Clusters for DENND2D Gene

DENN/MADD domain containing 2D:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DENND2D

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND2D Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: -
SP13:
SP14: -

ExUns: 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for DENND2D Gene

GeneLoc Exon Structure for
DENND2D
ECgene alternative splicing isoforms for
DENND2D

Expression for DENND2D Gene

mRNA expression in normal human tissues for DENND2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DENND2D Gene

This gene is overexpressed in Whole Blood (8.7) and Spleen (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND2D Gene

SOURCE GeneReport for Unigene cluster for DENND2D Gene Hs.557850

mRNA Expression by UniProt/SwissProt for DENND2D Gene

Q9H6A0-DEN2D_HUMAN
Tissue specificity: In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions.
genes like me logo Genes that share expressions with DENND2D: view

In Situ Assay Products

Orthologs for DENND2D Gene

This gene was present in the common ancestor of chordates.

Orthologs for DENND2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENND2D 35
  • 99.65 (n)
  • 99.79 (a)
DENND2D 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DENND2D 35
  • 88.82 (n)
  • 87.69 (a)
DENND2D 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DENND2D 35
  • 90.48 (n)
  • 91.9 (a)
DENND2D 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dennd2d 35
  • 86.16 (n)
  • 90.54 (a)
Dennd2d 16
Dennd2d 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DENND2D 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DENND2D 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dennd2d 35
  • 86.02 (n)
  • 90.54 (a)
chicken
(Gallus gallus)
Aves DENND2D 35
  • 70.58 (n)
  • 71.13 (a)
DENND2D 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DENND2D 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd2d 35
  • 62.18 (n)
  • 60.99 (a)
zebrafish
(Danio rerio)
Actinopterygii dennd2da 35
  • 59.27 (n)
  • 55.6 (a)
dennd2da 36
  • 46 (a)
OneToMany
dennd2db 36
  • 42 (a)
OneToMany
Species with no ortholog for DENND2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DENND2D Gene

ENSEMBL:
Gene Tree for DENND2D (if available)
TreeFam:
Gene Tree for DENND2D (if available)

Paralogs for DENND2D Gene

Selected SIMAP similar genes for DENND2D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DENND2D: view

Variants for DENND2D Gene

Sequence variations from dbSNP and Humsavar for DENND2D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs599134 -- 111,197,723(-) CTCCC(A/C/G)CTGCT intron-variant, missense, reference
rs600430 -- 111,197,460(+) CACCT(G/T)CAGTG intron-variant
rs608881 -- 111,188,279(-) CGGGA(A/G)GCAAA synonymous-codon, reference
rs610261 -- 111,198,320(+) GCTAC(A/G)TCGCC intron-variant
rs622499 -- 111,205,221(+) CGCTC(C/G)CTCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DENND2D Gene

Variant ID Type Subtype PubMed ID
nsv10639 CNV Gain 18304495
nsv463250 CNV Loss 19166990

Relevant External Links for DENND2D Gene

HapMap Linkage Disequilibrium report
DENND2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND2D Gene

Disorders for DENND2D Gene

(1) University of Copenhagen DISEASES for DENND2D Gene

Relevant External Links for DENND2D

Genetic Association Database (GAD)
DENND2D
genes like me logo Genes that share disorders with DENND2D: view

No data available for UniProtKB/Swiss-Prot for DENND2D Gene

Publications for DENND2D Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4

Products for DENND2D Gene

  • antibodies-online proteins for DENND2D
  • antibodies-online antibodies for DENND2D
  • antibodies-online kits for DENND2D

Sources for DENND2D Gene

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