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Aliases for DENND2C Gene

Aliases for DENND2C Gene

  • DENN/MADD Domain Containing 2C 2 3
  • DENN Domain-Containing Protein 2C 3
  • RP5-1156J9.1 3
  • DJ1156J9.1 3

External Ids for DENND2C Gene

Previous GeneCards Identifiers for DENND2C Gene

  • GC01M114838
  • GC01M115125
  • GC01M112985

Summaries for DENND2C Gene

GeneCards Summary for DENND2C Gene

DENND2C (DENN/MADD Domain Containing 2C) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND5B.

UniProtKB/Swiss-Prot for DENND2C Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND2C Gene

Genomics for DENND2C Gene

Regulatory Elements for DENND2C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DENND2C Gene

114,582,848 bp from pter
114,670,422 bp from pter
87,575 bases
Minus strand

Genomic View for DENND2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DENND2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND2C Gene

Proteins for DENND2C Gene

  • Protein details for DENND2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 2C
    Protein Accession:
    Secondary Accessions:
    • B1AL26
    • Q5TCX6
    • Q6P3R3

    Protein attributes for DENND2C Gene

    928 amino acids
    Molecular mass:
    106865 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DENND2C Gene


neXtProt entry for DENND2C Gene

Proteomics data for DENND2C Gene at MOPED

Post-translational modifications for DENND2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DENND2C Gene

No data available for DME Specific Peptides for DENND2C Gene

Domains for DENND2C Gene

Gene Families for DENND2C Gene

Protein Domains for DENND2C Gene


Suggested Antigen Peptide Sequences for DENND2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 dDENN domain.
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
genes like me logo Genes that share domains with DENND2C: view

Function for DENND2C Gene

Molecular function for DENND2C Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene Ontology (GO) - Molecular Function for DENND2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with DENND2C: view

Animal Model Products

CRISPR Products

miRNA for DENND2C Gene

miRTarBase miRNAs that target DENND2C

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND2C Gene

Localization for DENND2C Gene

Subcellular locations from

Jensen Localization Image for DENND2C Gene COMPARTMENTS Subcellular localization image for DENND2C gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DENND2C Gene

Pathways for DENND2C Gene

SuperPathways for DENND2C Gene

No Data Available

Interacting Proteins for DENND2C Gene

Gene Ontology (GO) - Biological Process for DENND2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DENND2C: view

No data available for Pathways by source for DENND2C Gene

Transcripts for DENND2C Gene

Unigene Clusters for DENND2C Gene

DENN/MADD domain containing 2C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DENND2C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND2C Gene

No ASD Table

Relevant External Links for DENND2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND2C Gene

mRNA expression in normal human tissues for DENND2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DENND2C Gene

This gene is overexpressed in Muscle - Skeletal (8.2), Esophagus - Mucosa (7.9), Skin - Sun Exposed (Lower leg) (5.7), and Skin - Not Sun Exposed (Suprapubic) (5.0).

Protein differential expression in normal tissues for DENND2C Gene

This gene is overexpressed in Serum (41.8) and Plasma (17.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND2C Gene

SOURCE GeneReport for Unigene cluster for DENND2C Gene Hs.654928

genes like me logo Genes that share expressions with DENND2C: view

Expression partners for DENND2C Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DENND2C Gene

Orthologs for DENND2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for DENND2C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DENND2C 35
  • 91.49 (n)
  • 91.15 (a)
  • 91 (a)
(Canis familiaris)
Mammalia DENND2C 35
  • 90.77 (n)
  • 91.06 (a)
  • 92 (a)
(Mus musculus)
Mammalia Dennd2c 35
  • 84.03 (n)
  • 84.35 (a)
Dennd2c 16
Dennd2c 36
  • 84 (a)
(Pan troglodytes)
Mammalia DENND2C 35
  • 99.53 (n)
  • 99.68 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dennd2c 35
  • 83.99 (n)
  • 83.84 (a)
(Monodelphis domestica)
Mammalia DENND2C 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia DENND2C 36
  • 81 (a)
(Gallus gallus)
Aves DENND2C 35
  • 68.21 (n)
  • 70.75 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia DENND2C 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd2c 35
  • 65.76 (n)
  • 65.03 (a)
(Danio rerio)
Actinopterygii dennd2c 35
  • 56.8 (n)
  • 54.76 (a)
dennd2c 36
  • 47 (a)
Species with no ortholog for DENND2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DENND2C Gene

Gene Tree for DENND2C (if available)
Gene Tree for DENND2C (if available)

Paralogs for DENND2C Gene

(4) SIMAP similar genes for DENND2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DENND2C: view

Variants for DENND2C Gene

Sequence variations from dbSNP and Humsavar for DENND2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs76693244 -- 114,596,838(+) ACACA(A/G)ACGGT intron-variant
rs76654043 -- 114,659,916(+) CTCCC(A/G)GATAG intron-variant
rs76598445 -- 114,615,014(+) GTCTC(A/C)AAAAA intron-variant
rs76526786 -- 114,595,482(+) CATCT(A/C)AAAAA intron-variant
rs76496773 -- 114,611,881(+) AAATA(C/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND2C Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV Loss 19812545
nsv831104 CNV Loss 17160897
nsv2498 CNV Insertion 18451855

Relevant External Links for DENND2C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND2C Gene

Disorders for DENND2C Gene

No disorders were found for DENND2C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DENND2C Gene

Publications for DENND2C Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DENND2C Gene

Sources for DENND2C Gene

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