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Aliases for DENND2C Gene

Aliases for DENND2C Gene

  • DENN Domain Containing 2C 2 3
  • DENN/MADD Domain Containing 2C 2 3 5
  • RP5-1156J9.1 3
  • DJ1156J9.1 3

External Ids for DENND2C Gene

Previous GeneCards Identifiers for DENND2C Gene

  • GC01M114838
  • GC01M115125
  • GC01M112985

Summaries for DENND2C Gene

GeneCards Summary for DENND2C Gene

DENND2C (DENN Domain Containing 2C) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is SBF1.

UniProtKB/Swiss-Prot for DENND2C Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND2C Gene

Genomics for DENND2C Gene

Regulatory Elements for DENND2C Gene

Enhancers for DENND2C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DENND2C on UCSC Golden Path with GeneCards custom track

Promoters for DENND2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DENND2C on UCSC Golden Path with GeneCards custom track

Genomic Location for DENND2C Gene

114,582,848 bp from pter
114,670,422 bp from pter
87,575 bases
Minus strand

Genomic View for DENND2C Gene

Genes around DENND2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND2C Gene

Proteins for DENND2C Gene

  • Protein details for DENND2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 2C
    Protein Accession:
    Secondary Accessions:
    • B1AL26
    • Q5TCX6
    • Q6P3R3

    Protein attributes for DENND2C Gene

    928 amino acids
    Molecular mass:
    106865 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DENND2C Gene


neXtProt entry for DENND2C Gene

Proteomics data for DENND2C Gene at MOPED

Post-translational modifications for DENND2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DENND2C Gene

No data available for DME Specific Peptides for DENND2C Gene

Domains & Families for DENND2C Gene

Gene Families for DENND2C Gene

Protein Domains for DENND2C Gene


Suggested Antigen Peptide Sequences for DENND2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 dDENN domain.
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
genes like me logo Genes that share domains with DENND2C: view

Function for DENND2C Gene

Molecular function for DENND2C Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
genes like me logo Genes that share phenotypes with DENND2C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND2C Gene

Localization for DENND2C Gene

Subcellular locations from

Jensen Localization Image for DENND2C Gene COMPARTMENTS Subcellular localization image for DENND2C gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DENND2C Gene

Pathways & Interactions for DENND2C Gene

SuperPathways for DENND2C Gene

No Data Available

Interacting Proteins for DENND2C Gene

Gene Ontology (GO) - Biological Process for DENND2C Gene


No data available for Pathways by source and SIGNOR curated interactions for DENND2C Gene

Drugs & Compounds for DENND2C Gene

No Compound Related Data Available

Transcripts for DENND2C Gene

Unigene Clusters for DENND2C Gene

DENN/MADD domain containing 2C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND2C Gene

No ASD Table

Relevant External Links for DENND2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND2C Gene

mRNA expression in normal human tissues for DENND2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DENND2C Gene

This gene is overexpressed in Muscle - Skeletal (x8.2), Esophagus - Mucosa (x7.9), Skin - Sun Exposed (Lower leg) (x5.7), and Skin - Not Sun Exposed (Suprapubic) (x5.0).

Protein differential expression in normal tissues from HIPED for DENND2C Gene

This gene is overexpressed in Serum (41.8) and Plasma (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND2C Gene

SOURCE GeneReport for Unigene cluster for DENND2C Gene Hs.654928

genes like me logo Genes that share expression patterns with DENND2C: view

Protein tissue co-expression partners for DENND2C Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DENND2C Gene

Orthologs for DENND2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for DENND2C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DENND2C 35
  • 91.49 (n)
  • 91.15 (a)
  • 91 (a)
(Canis familiaris)
Mammalia DENND2C 35
  • 90.77 (n)
  • 91.06 (a)
  • 92 (a)
(Mus musculus)
Mammalia Dennd2c 35
  • 84.03 (n)
  • 84.35 (a)
Dennd2c 16
Dennd2c 36
  • 84 (a)
(Pan troglodytes)
Mammalia DENND2C 35
  • 99.53 (n)
  • 99.68 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dennd2c 35
  • 83.99 (n)
  • 83.84 (a)
(Monodelphis domestica)
Mammalia DENND2C 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia DENND2C 36
  • 81 (a)
(Gallus gallus)
Aves DENND2C 35
  • 68.21 (n)
  • 70.75 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia DENND2C 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd2c 35
  • 65.76 (n)
  • 65.03 (a)
(Danio rerio)
Actinopterygii dennd2c 35
  • 56.8 (n)
  • 54.76 (a)
dennd2c 36
  • 47 (a)
Species with no ortholog for DENND2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DENND2C Gene

Gene Tree for DENND2C (if available)
Gene Tree for DENND2C (if available)

Paralogs for DENND2C Gene

(4) SIMAP similar genes for DENND2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DENND2C: view

Variants for DENND2C Gene

Sequence variations from dbSNP and Humsavar for DENND2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7541738 - 114,625,979(+) CCAAC(A/C/T)TCCAT reference, missense
rs12136548 - 114,625,476(+) AAGAG(C/T)CACAA reference, missense
rs28398 -- 114,602,082(+) CAATT(A/G)TTCCT intron-variant
rs79867 -- 114,622,489(+) TATTT(A/C)ATTTA intron-variant
rs170307 -- 114,590,706(+) cccgg(A/C/G)gggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND2C Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV Loss 19812545
nsv831104 CNV Loss 17160897
nsv2498 CNV Insertion 18451855

Variation tolerance for DENND2C Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.55; 86.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DENND2C Gene

Disorders for DENND2C Gene

Relevant External Links for DENND2C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DENND2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND2C Gene

Publications for DENND2C Gene

  1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4 67
  2. Common genetic variants on 1p13.2 associate with risk of autism. (PMID: 24189344) Xia K. … Zhang F. (Mol. Psychiatry 2014) 3
  3. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for DENND2C Gene

Sources for DENND2C Gene