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Aliases for DENND2A Gene

Aliases for DENND2A Gene

  • DENN Domain Containing 2A 2 3
  • DENN/MADD Domain Containing 2A 2 3 5
  • KIAA1277 2 3 4
  • FAM31D 3

External Ids for DENND2A Gene

Previous HGNC Symbols for DENND2A Gene

  • KIAA1277

Previous GeneCards Identifiers for DENND2A Gene

  • GC07M139670
  • GC07M139864
  • GC07M140218
  • GC07M134513

Summaries for DENND2A Gene

GeneCards Summary for DENND2A Gene

DENND2A (DENN Domain Containing 2A) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is SBF1.

UniProtKB/Swiss-Prot for DENND2A Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND2A Gene

Genomics for DENND2A Gene

Regulatory Elements for DENND2A Gene

Enhancers for DENND2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DENND2A on UCSC Golden Path with GeneCards custom track

Promoters for DENND2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DENND2A on UCSC Golden Path with GeneCards custom track

Genomic Location for DENND2A Gene

140,518,418 bp from pter
140,673,993 bp from pter
155,576 bases
Minus strand

Genomic View for DENND2A Gene

Genes around DENND2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND2A Gene

Proteins for DENND2A Gene

  • Protein details for DENND2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 2A
    Protein Accession:
    Secondary Accessions:
    • C9JUI3
    • Q1RMD5
    • Q86XY0

    Protein attributes for DENND2A Gene

    1009 amino acids
    Molecular mass:
    113853 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA86591.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND2A Gene


neXtProt entry for DENND2A Gene

Proteomics data for DENND2A Gene at MOPED

Post-translational modifications for DENND2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DENND2A Gene

Domains & Families for DENND2A Gene

Gene Families for DENND2A Gene

Protein Domains for DENND2A Gene


Suggested Antigen Peptide Sequences for DENND2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 dDENN domain.
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
genes like me logo Genes that share domains with DENND2A: view

Function for DENND2A Gene

Molecular function for DENND2A Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport.

Phenotypes for DENND2A Gene

genes like me logo Genes that share phenotypes with DENND2A: view

Animal Model Products

CRISPR Products

miRNA for DENND2A Gene

miRTarBase miRNAs that target DENND2A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND2A Gene

Localization for DENND2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND2A Gene

Cytoplasm, cytoskeleton. Note=Associated with actin filaments.

Subcellular locations from

Jensen Localization Image for DENND2A Gene COMPARTMENTS Subcellular localization image for DENND2A gene
Compartment Confidence
cytoskeleton 5
nucleus 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DENND2A Gene

Pathways & Interactions for DENND2A Gene

SuperPathways for DENND2A Gene

No Data Available

Interacting Proteins for DENND2A Gene

Gene Ontology (GO) - Biological Process for DENND2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with DENND2A: view

No data available for Pathways by source and SIGNOR curated interactions for DENND2A Gene

Drugs & Compounds for DENND2A Gene

No Compound Related Data Available

Transcripts for DENND2A Gene

Unigene Clusters for DENND2A Gene

DENN/MADD domain containing 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DENND2A Gene

No ASD Table

Relevant External Links for DENND2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND2A Gene

mRNA expression in normal human tissues for DENND2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DENND2A Gene

This gene is overexpressed in Adipocyte (52.5) and Fetal ovary (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DENND2A Gene

SOURCE GeneReport for Unigene cluster for DENND2A Gene Hs.6385

genes like me logo Genes that share expression patterns with DENND2A: view

Protein tissue co-expression partners for DENND2A Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DENND2A Gene

Orthologs for DENND2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for DENND2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DENND2A 35
  • 87.85 (n)
  • 88.45 (a)
  • 87 (a)
(Canis familiaris)
Mammalia DENND2A 35
  • 87.87 (n)
  • 87.97 (a)
  • 87 (a)
(Mus musculus)
Mammalia Dennd2a 35
  • 83.35 (n)
  • 84.09 (a)
Dennd2a 16
Dennd2a 36
  • 83 (a)
(Pan troglodytes)
Mammalia DENND2A 35
  • 99.41 (n)
  • 99.5 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dennd2a 35
  • 83.2 (n)
  • 84.69 (a)
(Monodelphis domestica)
Mammalia DENND2A 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia DENND2A 36
  • 61 (a)
(Gallus gallus)
Aves DENND2A 35
  • 73.99 (n)
  • 75.33 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia DENND2A 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd2a 35
  • 67.74 (n)
  • 68.75 (a)
(Danio rerio)
Actinopterygii si:dkey-82f1.1 35
  • 65.13 (n)
  • 66.52 (a)
Species with no ortholog for DENND2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DENND2A Gene

Gene Tree for DENND2A (if available)
Gene Tree for DENND2A (if available)

Paralogs for DENND2A Gene

(4) SIMAP similar genes for DENND2A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with DENND2A: view

Variants for DENND2A Gene

Sequence variations from dbSNP and Humsavar for DENND2A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs269243 - 140,601,931(+) AGAGG(G/T)GATCG nc-transcript-variant, reference, missense
rs2293177 - 140,544,760(-) TGATC(A/G)AACTG downstream-variant-500B, reference, missense
rs6464833 - 140,527,493(+) ACAGG(A/G)TGCTG reference, missense
rs766690 -- 140,560,988(+) AAAGT(C/T)GTGAG intron-variant
rs870216 -- 140,532,813(-) TCCAG(A/G)GATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND2A Gene

Variant ID Type Subtype PubMed ID
nsv464735 CNV Gain 19166990
esv2659341 CNV Deletion 23128226
esv2673558 CNV Deletion 23128226
nsv831157 CNV Gain 17160897
esv2735244 CNV Deletion 23290073
esv2675359 CNV Deletion 23128226
nsv366001 CNV Loss 16902084

Variation tolerance for DENND2A Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.00; 93.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DENND2A Gene

Disorders for DENND2A Gene

Relevant External Links for DENND2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DENND2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND2A Gene

Publications for DENND2A Gene

  1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4 67
  2. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. (PMID: 20395239) Macgregor S. … Mackey D.A. (Hum. Mol. Genet. 2010) 3
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for DENND2A Gene

Sources for DENND2A Gene