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DENND2A Gene

protein-coding   GIFtS: 49
GCID: GC07M140218

DENN/MADD Domain Containing 2A

(Previous name: KIAA1277)
(Previous symbol: KIAA1277)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DENN/MADD Domain Containing 2A1 2
KIAA12771 2 3
FAM31D2
DENN Domain-Containing Protein 2A2

External Ids:    HGNC: 222121   Entrez Gene: 271472   Ensembl: ENSG000001469667   UniProtKB: Q9ULE33   

Export aliases for DENND2A gene to outside databases

Previous GC identifers: GC07M139670 GC07M139864 GC07M134513


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DENND2A Gene:
DENND2A (DENN/MADD domain containing 2A) is a protein-coding gene. Diseases associated with DENND2A include endotheliitis. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot: DEN2A_HUMAN, Q9ULE3
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of
GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late
endosomes back to trans-Golgi network/TGN transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DENND2A gene promoter:
         GR   SRY   AML1a   GCNF-1   GCNF   GR-alpha   POU6F1 (c2)   GCNF-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDENND2A promoter sequence
   Search Chromatin IP Primers for DENND2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENND2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

DENND2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENND2A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M140218:  view genomic region     (about GC identifiers)

Start:
140,218,220 bp from pter      End:
140,373,793 bp from pter
Size:
155,574 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 139,556,410-139,640,521     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DEN2A_HUMAN, Q9ULE3 (See protein sequence)
Recommended Name: DENN domain-containing protein 2A  
Size: 1009 amino acids; 113853 Da
Sequence caution: Sequence=BAA86591.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JUI3 Q1RMD5 Q86XY0
Alternative splicing: 2 isoforms:  Q9ULE3-1   Q9ULE3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DENND2A: NX_Q9ULE3

Explore proteomics data for DENND2A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DENND2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056504.3  
    ENSEMBL proteins: 
     ENSP00000275884   ENSP00000417673   ENSP00000419654   ENSP00000420145   ENSP00000419464  
     ENSP00000420605   ENSP00000418844   ENSP00000418088   ENSP00000418760   ENSP00000442245  

    DENND2A Human Recombinant Protein Products:

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    Novus Biologicals DENND2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DENND2A

    DENND2A Antibody Products:

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    ThermoFisher Antibodies for DENND2A
    LSBio Antibodies in human, mouse, rat for DENND2A

    DENND2A Assay Products:

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    Cloud-Clone Corp. CLIAs for DENND2A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DENND: DENN/MADD domain containing

    3 InterPro protein domains:
     IPR005112 dDENN_dom
     IPR005113 uDENN_dom
     IPR001194 DENN_dom

    Graphical View of Domain Structure for InterPro Entry Q9ULE3

    ProtoNet protein and cluster: Q9ULE3

    UniProtKB/Swiss-Prot: DEN2A_HUMAN, Q9ULE3
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 uDENN domain


    DENND2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEN2A_HUMAN, Q9ULE3
    Function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of
    GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late
    endosomes back to trans-Golgi network/TGN transport

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017112Rab guanyl-nucleotide exchange factor activity IDA--
         
    DENND2A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DENND2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DENND2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DENND2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DENND2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target DENND2A:
    hsa-mir-185-5p (MIRT045332)

    Block miRNA regulation of human, mouse, rat DENND2A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DENND2A:
    hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidDENND2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DENND2A
    Predesigned siRNA for gene silencing in human, mouse, rat DENND2A

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    GenScript: all cDNA clones in your preferred vector: DENND2A (NM_015689)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENND2A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEN2A_HUMAN, Q9ULE3: Cytoplasm, cytoskeleton. Note=Associated with actin filaments
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0015629actin cytoskeleton IDA--

    DENND2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DENND2A
    Interactions:

        Search GeneGlobe Interaction Network for DENND2A

    1 Interacting protein for DENND2A (Q9ULE32) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --P310162MINT-8107631 MINT-8106357
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0032313regulation of Rab GTPase activity IDA--
    GO:0042147retrograde transport, endosome to Golgi IMP--

    DENND2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DENND2A (DEN2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DENND2A gene: 
    NM_015689.3  

    Unigene Cluster for DENND2A:

    DENN/MADD domain containing 2A
    Hs.6385  [show with all ESTs]
    Unigene Representative Sequence: BC115004
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275884(uc010lnj.3 uc011kre.2 uc010lnk.3 uc003vvw.3)
    ENST00000461883 ENST00000496613 ENST00000469373 ENST00000492720(uc003vvx.3)
    ENST00000475837 ENST00000491728 ENST00000489552 ENST00000477488 ENST00000537639

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DENND2A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DENND2A:
    hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidDENND2A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DENND2A
    Predesigned siRNA for gene silencing in human, mouse, rat DENND2A
    Clone
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    GenScript: all cDNA clones in your preferred vector: DENND2A (NM_015689)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DENND2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DENND2A
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DENND2A
      QuantiTect SYBR Green Assays in human, mouse, rat DENND2A
      QuantiFast Probe-based Assays in human, mouse, rat DENND2A

    Additional mRNA sequence: 

    AB033103.2 AK290056.1 AK297959.1 BC049193.1 BC115004.1 BC132875.1 BC144190.1 

    4 DOTS entries:

    DT.113941  DT.40191857  DT.40215461  DT.100035420 

    Selected AceView cDNA sequences (see all 87):

    AL710939 AI223795 AI131051 AA207027 AI298983 BM468484 AA324098 BC049193 
    BM698088 AA035723 AA402260 BX091824 BE859017 BE781192 BU507826 BE669799 
    BM702441 AB033103 AI057416 AI038256 BG057972 AI422088 BG121789 AI424287 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DENND2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATGGGTT
    DENND2A Expression
    About this image


    DENND2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Node Cells Atrioventricular Node
             Atrioventricular Node
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    DENND2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DENND2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6385
        Custom PCR Arrays for DENND2A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DENND2A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dennd2a1 , 5 DENN/MADD domain containing 2A1, 5 83.35(n)1
    84.09(a)1
      6 (18.26 cM)5
    2097731  NM_172477.41  NP_766065.11 
     394623785 
    chicken
    (Gallus gallus)
    Aves DENND2A1 DENN/MADD domain containing 2A 73.99(n)
    75.33(a)
      418115  XM_416349.4  XP_416349.4 
    lizard
    (Anolis carolinensis)
    Reptilia DENND2A6
    DENN/MADD domain containing 2A
    66(a)
    1 ↔ 1
    5(15482953-15558464)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dennd2a1 DENN/MADD domain containing 2A 67.74(n)
    68.75(a)
      100485949  XM_002941613.2  XP_002941659.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-82f1.11 si:dkey-82f1.1 65.13(n)
    66.52(a)
      563917  XM_001920340.4  XP_001920375.4 


    ENSEMBL Gene Tree for DENND2A (if available)
    TreeFam Gene Tree for DENND2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DENND2A gene
    ST52  DENND5A2  DENND2D2  DENND32  DENND1C2  DENND4A2  DENND4B2  DENND1B2  
    DENND1A2  DENND5B2  DENND2C2  DENND4C2  
    4 SIMAP similar genes for DENND2A using alignment to 8 protein entries:     DEN2A_HUMAN (see all proteins):
    DKFZp667I053    ST5    DENND2D    DENND2C

    DENND2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DENND2A (see all 2146)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453437031,2
    C--140217760(+) CTTTT-/TGTGTGT 1 -- ds50010--------
    rs1424782701,2
    --140217822(+) TCTTCC/TAAGAG 1 -- ds50010--------
    rs1475611421,2
    C--140217869(+) AGAGAC/GACGTC 1 -- ds50010--------
    rs1132064061,2
    C--140217872(+) GAGACG/ATCCAT 1 -- ds50012Minor allele frequency- A:0.04CSA WA 120
    rs1403241531,2
    C--140217944(+) CATCCA/GTCTAC 1 -- ds50010--------
    rs734923231,2
    C,F--140217960(+) CCGTTC/TCTCCC 1 -- ds50012Minor allele frequency- T:0.03WA 120
    rs743272541,2
    C,F--140218007(+) TAGGAG/AGCCTC 1 -- ds50011Minor allele frequency- A:0.05NA 120
    rs1908176441,2
    --140218014(+) CCTCAA/CTCCCT 1 -- ds50010--------
    rs1145420451,2
    F--140218039(+) GGCTCC/TGCCTC 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1442876821,2
    --140218054(+) CCTCAC/TAGTCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DENND2A (140218220 - 140373793 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DENND2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659341CNV Deletion23128226
    esv2675359CNV Deletion23128226
    esv2735244CNV Deletion23290073
    esv2673558CNV Deletion23128226
    nsv366001CNV Loss16902084
    nsv831157CNV Gain17160897
    nsv464735CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DENND2A
    DNA2.0 Custom Variant and Variant Library Synthesis for DENND2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for DENND2A:    
    About MalaCards
    endotheliitis


    DENND2A for disorders           About GeneDecksing

    Genetic Association Database (GAD): DENND2A
    Human Genome Epidemiology (HuGE) Navigator: DENND2A (1 document)

    Export disorders for DENND2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DENND2A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DENND2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. (PubMed id 20395239)1, 4 Macgregor S....Mackey D.A. (Hum. Mol. Genet. 2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    5. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PubMed id 20937701)2 Yoshimura S.... Barr F.A. (J. Cell Biol. 2010)
    6. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27147 HGNC: 22212 AceView: KIAA1277 Ensembl:ENSG00000146966 euGenes: HUgn27147
    ECgene: DENND2A H-InvDB: DENND2A

    (According to HUGE)
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    HUGE: KIAA1277

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DENND2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DENND2A gene:
    Search GeneIP for patents involving DENND2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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