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Aliases for DENND1C Gene

Aliases for DENND1C Gene

  • DENN Domain Containing 1C 2 3 5
  • Connecdenn 3 2 3 4
  • Family With Sequence Similarity 31, Member C 2 3
  • DENN/MADD Domain Containing 1C 2 3
  • FAM31C 3 4
  • DENN Domain-Containing Protein 1C 3
  • Protein FAM31C 4

External Ids for DENND1C Gene

Previous HGNC Symbols for DENND1C Gene

  • FAM31C

Previous GeneCards Identifiers for DENND1C Gene

  • GC19M006419
  • GC19M006230

Summaries for DENND1C Gene

Entrez Gene Summary for DENND1C Gene

  • Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

GeneCards Summary for DENND1C Gene

DENND1C (DENN Domain Containing 1C) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND1A.

UniProtKB/Swiss-Prot for DENND1C Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND1C Gene

Genomics for DENND1C Gene

Regulatory Elements for DENND1C Gene

Enhancers for DENND1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G006771 1.5 FANTOM5 ENCODE dbSUPER 8.9 -290.5 -290450 2.3 ATF1 PKNOX1 ZNF143 KDM4B ZNF263 ZNF623 TBX21 NBN KDM1A CTCF SH2D3A DENND1C VAV1 ZNF557 ADGRE1 GPR108 GC19P006821
GH19G006652 1.1 ENCODE dbSUPER 12 -170.3 -170300 0.6 HDAC1 PKNOX1 TBL1XR1 TCF12 GATA2 CREM NCOA1 ZEB2 NFIC MTA1 DENND1C GC19P006639 GC19M006661
GH19G006667 1.6 FANTOM5 ENCODE dbSUPER 6.8 -186.4 -186433 3.9 HDGF ZFP64 ZNF48 ELK1 ZNF143 PAF1 JUNB ZNF623 TBX21 ZNF518A VAV1 TNFSF14 DENND1C ADGRE1 ZNF557 GPR108 GC19M006661
GH19G006587 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.4 -105.2 -105211 1.5 HDGF PKNOX1 ARNT WRNIP1 YBX1 ZNF48 ZNF207 MCM3 NCOA1 JUNB CD70 TNFSF9 DENND1C ZNF557 RPL7P50 GC19P006581
GH19G006055 2 FANTOM5 Ensembl ENCODE dbSUPER 3.7 +420.1 420077 13.8 FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 FOS RFX2 ACSBG2 PRR22 SAFB SNRPEP4 SLC25A41 CATSPERD DENND1C SAFB2 TNFSF9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DENND1C on UCSC Golden Path with GeneCards custom track

Promoters for DENND1C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106523 957 401 HDGF BACH1 MAX ZNF48 ZIC2 EGR1 POLR2A EED ZNF143 ETV6

Genomic Location for DENND1C Gene

Chromosome:
19
Start:
6,467,204 bp from pter
End:
6,482,557 bp from pter
Size:
15,354 bases
Orientation:
Minus strand

Genomic View for DENND1C Gene

Genes around DENND1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND1C Gene

Proteins for DENND1C Gene

  • Protein details for DENND1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV53-DEN1C_HUMAN
    Recommended name:
    DENN domain-containing protein 1C
    Protein Accession:
    Q8IV53
    Secondary Accessions:
    • B4E051
    • D3PFD4
    • Q8NDB1
    • Q9H5Z2

    Protein attributes for DENND1C Gene

    Size:
    801 amino acids
    Molecular mass:
    87065 Da
    Quaternary structure:
    • Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1.
    SequenceCaution:
    • Sequence=BAB15475.1; Type=Frameshift; Positions=788; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DENND1C Gene

Post-translational modifications for DENND1C Gene

  • Ubiquitination at Lys385, isoforms=2460, and isoforms=2469
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DENND1C Gene

Domains & Families for DENND1C Gene

Gene Families for DENND1C Gene

Protein Domains for DENND1C Gene

Suggested Antigen Peptide Sequences for DENND1C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DENND1C: view

No data available for UniProtKB/Swiss-Prot for DENND1C Gene

Function for DENND1C Gene

Molecular function for DENND1C Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene Ontology (GO) - Molecular Function for DENND1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with DENND1C: view

Phenotypes for DENND1C Gene

genes like me logo Genes that share phenotypes with DENND1C: view

Animal Models for DENND1C Gene

MGI Knock Outs for DENND1C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DENND1C Gene

Localization for DENND1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND1C Gene

Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENND1C gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for DENND1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030136 clathrin-coated vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with DENND1C: view

Pathways & Interactions for DENND1C Gene

genes like me logo Genes that share pathways with DENND1C: view

Pathways by source for DENND1C Gene

Interacting Proteins for DENND1C Gene

Gene Ontology (GO) - Biological Process for DENND1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with DENND1C: view

No data available for SIGNOR curated interactions for DENND1C Gene

Drugs & Compounds for DENND1C Gene

No Compound Related Data Available

Transcripts for DENND1C Gene

Unigene Clusters for DENND1C Gene

DENN/MADD domain containing 1C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND1C Gene

No ASD Table

Relevant External Links for DENND1C Gene

GeneLoc Exon Structure for
DENND1C
ECgene alternative splicing isoforms for
DENND1C

Expression for DENND1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DENND1C Gene

mRNA differential expression in normal tissues according to GTEx for DENND1C Gene

This gene is overexpressed in Whole Blood (x19.3) and Spleen (x7.1).

Protein differential expression in normal tissues from HIPED for DENND1C Gene

This gene is overexpressed in Lymph node (16.0), NK cells (13.8), CD8 Tcells (10.7), Blymphocyte (10.2), and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DENND1C Gene



Protein tissue co-expression partners for DENND1C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DENND1C Gene:

DENND1C

SOURCE GeneReport for Unigene cluster for DENND1C Gene:

Hs.236449

Evidence on tissue expression from TISSUES for DENND1C Gene

  • Lymph node(4.4)
  • Intestine(4.3)
  • Liver(4.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with DENND1C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND1C Gene

Orthologs for DENND1C Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DENND1C 34 35
  • 95.53 (n)
dog
(Canis familiaris)
Mammalia DENND1C 34 35
  • 84.47 (n)
cow
(Bos Taurus)
Mammalia DENND1C 34 35
  • 82.47 (n)
mouse
(Mus musculus)
Mammalia Dennd1c 34 16 35
  • 75.69 (n)
rat
(Rattus norvegicus)
Mammalia Dennd1c 34
  • 73.11 (n)
oppossum
(Monodelphis domestica)
Mammalia DENND1C 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 10 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia DENND1C 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd1c 34
  • 59.38 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-76b14.2 34
  • 55.9 (n)
DENND1C 35
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18659 35
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rme-4 35
  • 27 (a)
OneToMany
Species where no ortholog for DENND1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND1C Gene

ENSEMBL:
Gene Tree for DENND1C (if available)
TreeFam:
Gene Tree for DENND1C (if available)

Paralogs for DENND1C Gene

(2) SIMAP similar genes for DENND1C Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for DENND1C Gene

genes like me logo Genes that share paralogs with DENND1C: view

Variants for DENND1C Gene

Sequence variations from dbSNP and Humsavar for DENND1C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs751257354 Uncertain significance 6,477,249(+) GGGGG(A/G)TACCC reference, missense
rs1000017818 -- 6,470,674(+) TGGAA(C/T)GTAGT intron-variant
rs1000244407 -- 6,473,064(+) ATTTA(C/T)GTAGC intron-variant
rs1000418310 -- 6,468,643(+) GGCCG(A/G)TTCTG reference, synonymous-codon
rs1000468877 -- 6,478,460(+) CATGT(C/G)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND1C Gene

Variant ID Type Subtype PubMed ID
esv2161777 CNV deletion 18987734
nsv1149440 CNV deletion 26484159
nsv833727 CNV loss 17160897

Variation tolerance for DENND1C Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DENND1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DENND1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND1C Gene

Disorders for DENND1C Gene

Relevant External Links for DENND1C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DENND1C

No disorders were found for DENND1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND1C Gene

Publications for DENND1C Gene

  1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3 4 64
  2. The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. (PMID: 20154091) Marat A.L. … McPherson P.S. (J. Biol. Chem. 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for DENND1C Gene

Sources for DENND1C Gene

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