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DENND1C Gene

protein-coding   GIFtS: 45
GCID: GC19M006467

DENN/MADD Domain Containing 1C

(Previous names: family with sequence similarity 31, member C)
(Previous symbol: FAM31C)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DENN/MADD Domain Containing 1C1 2
FAM31C1 2 3
Family With Sequence Similarity 31, Member C1 2
Connecdenn 32 3
DENN Domain-Containing Protein 1C2
Protein FAM31C3

External Ids:    HGNC: 262251   Entrez Gene: 799582   Ensembl: ENSG000002057447   OMIM: 6136345   UniProtKB: Q8IV533   

Export aliases for DENND1C gene to outside databases

Previous GC identifers: GC19M006419 GC19M006230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DENND1C Gene:
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids.
Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the
early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM
601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed
20154091)).(supplied by OMIM, Nov 2010)

GeneCards Summary for DENND1C Gene:
DENND1C (DENN/MADD domain containing 1C) is a protein-coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot: DEN1C_HUMAN, Q8IV53
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the
exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DENND1C gene promoter:
         Sp1   Pax-6   AP-4   Tal-1beta   NF-E2 p45   E47   YY1   Zic1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDENND1C promoter sequence
   Search Chromatin IP Primers for DENND1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENND1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

DENND1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENND1C gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006467:  view genomic region     (about GC identifiers)

Start:
6,467,218 bp from pter      End:
6,482,568 bp from pter
Size:
15,351 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DEN1C_HUMAN, Q8IV53 (See protein sequence)
Recommended Name: DENN domain-containing protein 1C  
Size: 801 amino acids; 87065 Da
Subunit: Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and
with AP2A2, but not with AP2B1
Sequence caution: Sequence=BAB15475.1; Type=Frameshift; Positions=788;
Secondary accessions: B4E051 D3PFD4 Q8NDB1 Q9H5Z2
Alternative splicing: 2 isoforms:  Q8IV53-1   Q8IV53-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DENND1C: NX_Q8IV53

Explore proteomics data for DENND1C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys385, Lys460, Lys469
  • Modification sites at PhosphoSitePlus

  • See DENND1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001277260.1  NP_079174.2  

    ENSEMBL proteins: 
     ENSP00000370889   ENSP00000465675   ENSP00000437805   ENSP00000467008   ENSP00000466334  
     ENSP00000466583   ENSP00000466394  

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    Cloud-Clone Corp. Proteins for DENND1C

     
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    Search eBioscience for ELISAs for DENND1C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DENND: DENN/MADD domain containing

    3 InterPro protein domains:
     IPR005112 dDENN_dom
     IPR005113 uDENN_dom
     IPR001194 DENN_dom

    Graphical View of Domain Structure for InterPro Entry Q8IV53

    ProtoNet protein and cluster: Q8IV53

    UniProtKB/Swiss-Prot: DEN1C_HUMAN, Q8IV53
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 uDENN domain


    Find genes that share domains with DENND1C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEN1C_HUMAN, Q8IV53
    Function: Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the
    exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017112Rab guanyl-nucleotide exchange factor activity IDA--
         
    Find genes that share ontologies with DENND1C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DENND1C:
     Large cells 

         1 MGI phenotypic allele for Dennd1c (no phenotypes)

    Find genes that share phenotypes with DENND1C           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DENND1C
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    2 qRT-PCR Assays for microRNAs that regulate DENND1C:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidDENND1C 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEN1C_HUMAN, Q8IV53: Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0030136clathrin-coated vesicle IEA--

    Find genes that share ontologies with DENND1C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DENND1C
    Interactions:

        Search GeneGlobe Interaction Network for DENND1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for DENND1C (ENSP000003708894) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3D19ENSP000003029134STRING: ENSP00000302913
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    AP2A1ENSP000003519264STRING: ENSP00000351926
    AP2A2ENSP000004132344STRING: ENSP00000413234
    CLTCENSP000002691224STRING: ENSP00000269122
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity IDA--

    Find genes that share ontologies with DENND1C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DENND1C (DEN1C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DENND1C gene (2 alternative transcripts): 
    NM_001290331.1  NM_024898.3  

    Unigene Cluster for DENND1C:

    DENN/MADD domain containing 1C
    Hs.236449  [show with all ESTs]
    Unigene Representative Sequence: AL713770
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590444 ENST00000381480(uc002mfb.3 uc002mfc.3 uc002mfd.3 uc002mfe.3 uc010xje.2)
    ENST00000590818 ENST00000590867 ENST00000543576 ENST00000591795 ENST00000588988
    ENST00000592543 ENST00000589491 ENST00000590173 ENST00000586046 ENST00000591030
    ENST00000590473 ENST00000588421
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate DENND1C:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidDENND1C 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DENND1C
      QuantiFast Probe-based Assays in human, mouse, rat DENND1C

    Additional mRNA sequence: 

    AK026410.1 AK055820.1 AK225623.1 AK303226.1 AK303509.1 AL713770.1 AL834293.1 BC033437.1 
    BX647304.1 

    13 DOTS entries:

    DT.92420956  DT.455753  DT.100776748  DT.97840598  DT.99966553  DT.121448523  DT.121448490  DT.121448552 
    DT.95174165  DT.100677014  DT.95174168  DT.95219297  DT.303758 

    Selected AceView cDNA sequences (see all 89):

    BQ053864 BG744050 BC033437 BQ710519 AW024310 AK055820 CB047062 BX647304 
    AI540133 AL713770 AL834293 AA688049 AW024298 BE674790 AA806897 BP338858 
    BI834057 BM562240 BE327580 AI521312 AI355445 AI038101 BE674956 BF511502 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DENND1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCCAAGA
    DENND1C Expression
    About this image

    DENND1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DENND1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.236449
        Custom PCR Arrays for DENND1C
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DENND1C gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dennd1c1 , 5 DENN/MADD domain containing 1C1, 5 75.69(n)1
    74.24(a)1
      17 (29.65 cM)5
    707851  NM_153551.11  NP_705779.11 
     570660565 
    lizard
    (Anolis carolinensis)
    Reptilia DENND1C6
    DENN/MADD domain containing 1C
    41(a)
    1 ↔ 1
    2(76164371-76220090)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dennd1c1 DENN/MADD domain containing 1C 59.38(n)
    56.45(a)
      100498227  XM_002941016.2  XP_002941062.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-76b14.21 si:dkey-76b14.2 55.9(n)
    51.31(a)
      101886409  XM_005168402.1  XP_005168459.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG186596
    --
    23(a)
    1 → many
    2R(5010809-5019486)
    worm
    (Caenorhabditis elegans)
    Secernentea rme-46
    Protein RME-4, isoform a (rme-4) mRNA, complete cd...
    27(a)
    1 → many
    X(10373230-10377752) WBGene00004375


    ENSEMBL Gene Tree for DENND1C (if available)
    TreeFam Gene Tree for DENND1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DENND1C gene
    ST52  DENND5A2  DENND2D2  DENND2A2  DENND32  DENND4A2  DENND4B2  DENND1B2  
    DENND1A2  DENND5B2  DENND2C2  DENND4C2  
    2 SIMAP similar genes for DENND1C using alignment to 7 protein entries:     DEN1C_HUMAN (see all proteins):
    DENND1B    DENND1A

    Find genes that share paralogs with DENND1C           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DENND1C
    PGOHUM00000243228


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DENND1C (see all 541)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681862051,2
    C--6398389(+) CCCTG-/GTT   
      TTTT
    /T
    TTTTT
    1 -- int12NA 4
    rs351735351,2
    C,F--6467910(-) ACCCCA/GAACCC 2 K E mis14Minor allele frequency- G:0.04NA EU 713
    rs2021553971,2
    C--6467966(+) GAGACA/GTGACT 2 T M mis10--------
    rs352902401,2
    C,F--6467980(-) GAGTCC/TGACCA 2 S syn13Minor allele frequency- T:0.06NA WA 194
    rs2006714671,2
    C--6468009(+) CCTGGA/CGTCCT 2 A S mis10--------
    rs1169308311,2
    C,F--6468040(+) AAAGAC/TGAGGC 2 S syn12Minor allele frequency- T:0.01NA EU 683
    rs342229841,2
    C,F--6468061(-) TCCCTG/ACCATC 2 /L syn12Minor allele frequency- A:0.00NA EU 635
    rs2007385981,2
    C--6468081(+) GGGCTC/TCGGCT 2 K E mis11Minor allele frequency- T:0.00EU 559
    rs1903728971,2
    C,F--6468148(+) ATAGGG/AAAGTT 1 -- int11Minor allele frequency- A:0.01EU 567
    rs1426932431,2
    C--6468201(+) ATTAGA/GGGAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for DENND1C (6467218 - 6482568 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DENND1C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2161777CNV Deletion18987734
    nsv910916CNV Loss21882294
    nsv910924CNV Loss21882294
    nsv910923CNV Loss21882294
    nsv833727CNV Loss17160897
    dgv3698n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DENND1C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613634    OMIM disorders: --


    Find genes that share disorders with DENND1C           About GenesLikeMe


    Export disorders for DENND1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DENND1C gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with DENND1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. (PubMed id 20154091)1, 2 Marat A.L. and McPherson P.S. (J. Biol. Chem. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    5. Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton. (PubMed id 22072793)1 Marat A.L....McPherson P.S. (Mol. Biol. Cell 2012)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PubMed id 20937701)2 Yoshimura S.... Barr F.A. (J. Cell Biol. 2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79958 HGNC: 26225 AceView: FAM31C Ensembl:ENSG00000205744 euGenes: HUgn79958
    ECgene: DENND1C H-InvDB: DENND1C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DENND1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DENND1C gene:
    Search GeneIP for patents involving DENND1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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