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Aliases for DENND1C Gene

Aliases for DENND1C Gene

  • DENN Domain Containing 1C 2 3 5
  • Connecdenn 3 2 3 4
  • Family With Sequence Similarity 31, Member C 2 3
  • DENN/MADD Domain Containing 1C 2 3
  • FAM31C 3 4
  • DENN Domain-Containing Protein 1C 3
  • Protein FAM31C 4

External Ids for DENND1C Gene

Previous HGNC Symbols for DENND1C Gene

  • FAM31C

Previous GeneCards Identifiers for DENND1C Gene

  • GC19M006419
  • GC19M006230

Summaries for DENND1C Gene

Entrez Gene Summary for DENND1C Gene

  • The protein encoded by this gene functions as a guanine nucleotide exchange factor for the early endosomal small GTPase RAB35, which regulates endosomal membrane trafficking and is involved in actin polymerization. The encoded protein activates RAB35 by promoting the exchange of RAB35-bound GDP for GTP. This gene may play a role in linking RAB35 activation with the clathrin machinery. [provided by RefSeq, May 2017]

GeneCards Summary for DENND1C Gene

DENND1C (DENN Domain Containing 1C) is a Protein Coding gene. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Vesicle-mediated transport. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND1A.

UniProtKB/Swiss-Prot for DENND1C Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Additional gene information for DENND1C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND1C Gene

Genomics for DENND1C Gene

Regulatory Elements for DENND1C Gene

Enhancers for DENND1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H006587 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.1 -105.2 -105211 1.5 HDGF PKNOX1 ARNT YBX1 ZBTB40 ZNF366 SIRT6 ZNF143 ZNF207 ATF7 DENND1C LOC390877 FLJ25758 MBD3L5 MBD3L3 ACSBG2 ZNF557 ARHGEF18 DUS3L VMAC
GH19H006674 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15 -192.6 -192550 1.1 HDGF PKNOX1 YBX1 ZNF143 ZNF207 FOS ZNF548 ATF7 RUNX3 NCOA1 TNFSF14 DENND1C C3 TRIP10 GPR108 XAB2 ZNF557 DUS3L KHSRP STXBP2
GH19H007177 1.5 Ensembl ENCODE dbSUPER 15.4 -698.5 -698518 7.1 HDGF PKNOX1 FEZF1 ZNF121 ZNF302 ZNF143 ZNF207 ATF7 RUNX3 ZNF202 ELAVL1 XAB2 KHSRP ZNF557 MAP2K7 GTF2F1 DENND1C ARHGEF18 GPR108 EVI5L
GH19H007191 1.3 Ensembl ENCODE dbSUPER 15.4 -709.9 -709875 0.9 HDGF PKNOX1 YBX1 BATF ZNF366 ATF7 ETV6 RUNX3 CREM IKZF2 KHSRP ELAVL1 DENND1C XAB2 ARHGEF18 GTF2F1 MAP2K7 STXBP2 GC19P007214 GC19P007151
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DENND1C on UCSC Golden Path with GeneCards custom track

Promoters for DENND1C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for DENND1C Gene

Genomic Locations for DENND1C Gene
15,354 bases
Minus strand

Genomic View for DENND1C Gene

Genes around DENND1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND1C Gene

Proteins for DENND1C Gene

  • Protein details for DENND1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 1C
    Protein Accession:
    Secondary Accessions:
    • B4E051
    • D3PFD4
    • Q8NDB1
    • Q9H5Z2

    Protein attributes for DENND1C Gene

    801 amino acids
    Molecular mass:
    87065 Da
    Quaternary structure:
    • Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1.
    • Sequence=BAB15475.1; Type=Frameshift; Positions=788; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND1C Gene


neXtProt entry for DENND1C Gene

Post-translational modifications for DENND1C Gene

  • Ubiquitination at isoforms=2385, isoforms=2460, and isoforms=2469
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DENND1C Gene

Domains & Families for DENND1C Gene

Gene Families for DENND1C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DENND1C Gene

Suggested Antigen Peptide Sequences for DENND1C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DENND1C: view

No data available for UniProtKB/Swiss-Prot for DENND1C Gene

Function for DENND1C Gene

Molecular function for DENND1C Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Phenotypes From GWAS Catalog for DENND1C Gene

Gene Ontology (GO) - Molecular Function for DENND1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with DENND1C: view

Phenotypes for DENND1C Gene

genes like me logo Genes that share phenotypes with DENND1C: view

Animal Models for DENND1C Gene

MGI Knock Outs for DENND1C:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DENND1C Gene

Localization for DENND1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND1C Gene

Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENND1C gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for DENND1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030136 clathrin-coated vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with DENND1C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DENND1C Gene

Pathways & Interactions for DENND1C Gene

genes like me logo Genes that share pathways with DENND1C: view

Pathways by source for DENND1C Gene

Interacting Proteins for DENND1C Gene

Gene Ontology (GO) - Biological Process for DENND1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with DENND1C: view

No data available for SIGNOR curated interactions for DENND1C Gene

Drugs & Compounds for DENND1C Gene

No Compound Related Data Available

Transcripts for DENND1C Gene

Unigene Clusters for DENND1C Gene

DENN/MADD domain containing 1C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND1C Gene

No ASD Table

Relevant External Links for DENND1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DENND1C Gene

mRNA differential expression in normal tissues according to GTEx for DENND1C Gene

This gene is overexpressed in Whole Blood (x19.3) and Spleen (x7.1).

Protein differential expression in normal tissues from HIPED for DENND1C Gene

This gene is overexpressed in Lymph node (16.0), NK cells (13.8), CD8 Tcells (10.7), Blymphocyte (10.2), and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DENND1C Gene

Protein tissue co-expression partners for DENND1C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DENND1C Gene:


SOURCE GeneReport for Unigene cluster for DENND1C Gene:


Evidence on tissue expression from TISSUES for DENND1C Gene

  • Lymph node(4.4)
  • Intestine(4.3)
  • Liver(4.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with DENND1C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND1C Gene

Orthologs for DENND1C Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND1C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DENND1C 33 34
  • 95.53 (n)
(Canis familiaris)
Mammalia DENND1C 33 34
  • 84.47 (n)
(Bos Taurus)
Mammalia DENND1C 33 34
  • 82.47 (n)
(Mus musculus)
Mammalia Dennd1c 33 16 34
  • 75.69 (n)
(Rattus norvegicus)
Mammalia Dennd1c 33
  • 73.11 (n)
(Monodelphis domestica)
Mammalia DENND1C 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 10 (a)
(Anolis carolinensis)
Reptilia DENND1C 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd1c 33
  • 59.38 (n)
(Danio rerio)
Actinopterygii si:dkey-76b14.2 33
  • 55.9 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18659 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea rme-4 34
  • 27 (a)
Species where no ortholog for DENND1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND1C Gene

Gene Tree for DENND1C (if available)
Gene Tree for DENND1C (if available)

Paralogs for DENND1C Gene

(2) SIMAP similar genes for DENND1C Gene using alignment to 7 proteins: Pseudogenes for DENND1C Gene

genes like me logo Genes that share paralogs with DENND1C: view

Variants for DENND1C Gene

Sequence variations from dbSNP and Humsavar for DENND1C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs751257354 Uncertain significance 6,477,249(+) GGGGG(A/G)TACCC reference, missense
rs1000017818 -- 6,470,674(+) TGGAA(C/T)GTAGT intron-variant
rs1000244407 -- 6,473,064(+) ATTTA(C/T)GTAGC intron-variant
rs1000418310 -- 6,468,643(+) GGCCG(A/G)TTCTG reference, synonymous-codon
rs1000468877 -- 6,478,460(+) CATGT(C/G)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DENND1C Gene

Variant ID Type Subtype PubMed ID
esv2161777 CNV deletion 18987734
nsv1149440 CNV deletion 26484159
nsv833727 CNV loss 17160897

Variation tolerance for DENND1C Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DENND1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND1C Gene

Disorders for DENND1C Gene

Relevant External Links for DENND1C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DENND1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND1C Gene

Publications for DENND1C Gene

  1. The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. (PMID: 20154091) Marat AL … McPherson PS (The Journal of biological chemistry 2010) 3 4 60
  2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S … Barr FA (The Journal of cell biology 2010) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60

Products for DENND1C Gene

Sources for DENND1C Gene

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