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DENND1B Gene

protein-coding   GIFtS: 45
GCID: GC01M197473

DENN/MADD Domain Containing 1B

(Previous names: family with sequence similarity 31, member B, chromosome...)
(Previous symbols: FAM31B, C1orf218)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DENN/MADD Domain Containing 1B1 2     Chromosome 1 Open Reading Frame 2181
FAM31B1 2 3 5     C1ORF182
C1orf2181 2 3     DENN Domain-Containing Protein 1B2
Family With Sequence Similarity 31, Member B1 2     Protein FAM31B3
Connecdenn 22 3     C1orf185

External Ids:    HGNC: 284041   Entrez Gene: 1634862   Ensembl: ENSG000002130477   OMIM: 6132925   UniProtKB: Q6P3S13   

Export aliases for DENND1B gene to outside databases

Previous GC identifers: GC01M194253 GC01M195746 GC01M195788 GC01M168677


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DENND1B Gene:
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids.
Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the
early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM
601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed
20154091)).(supplied by OMIM, Nov 2010)

GeneCards Summary for DENND1B Gene:
DENND1B (DENN/MADD domain containing 1B) is a protein-coding gene. Diseases associated with DENND1B include primary biliary cirrhosis, and crohn's disease. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot: DEN1B_HUMAN, Q6P3S1
Function: Guanine nucleotide exchange factor (GEF) for RAB35. Promotes the exchange of GDP to GTP, converting
inactive GDP-bound RAB35 into its active GTP-bound form. May play a role in clathrin-mediated endocytosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DENND1B gene promoter:
         STAT1   STAT4   Nkx2-2   STAT1beta   NF-kappaB   STAT1alpha   C/EBPalpha   STAT2   STAT3   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DENND1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENND1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.3   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q31.3

DENND1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENND1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M197473:  view genomic region     (about GC identifiers)

Start:
197,473,878 bp from pter      End:
197,744,826 bp from pter
Size:
270,949 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DEN1B_HUMAN, Q6P3S1 (See protein sequence)
Recommended Name: DENN domain-containing protein 1B  
Size: 426 amino acids; 48260 Da
Subunit: Interacts with RAB35. Interacts with clathrin heavy chain/CLTC and with AP2A2. Isoform 5 interacts with
AP2B1
Sequence caution: Sequence=AAH74735.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA90918.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15024.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW91280.1; Type=Erroneous gene model
prediction;
1 PDB 3D structure from and Proteopedia for DENND1B:
3TW8 (3D)    
Secondary accessions: B5MD89 D3PFD5 Q5T3B8 Q5T3B9 Q5T3C1 Q5TAI8 Q6B0I8 Q8NDT1 Q8TBE6 Q9H774
Q9NXU2
Alternative splicing: 5 isoforms:  Q6P3S1-1   Q6P3S1-2   Q6P3S1-3   Q6P3S1-4   Q6P3S1-5   (Mutations at Lys-502 almost completely abolishes AP2B1-binding, mutations at Lys-500 and Lys-509 greatly reduce AP2B1-binding. Mutations at Lys-489 causes only a slight reduction in AP2B1-binding, while mutations at Arg-501 or Arg-507 have no effect. Ref.9 (DAA12502) sequence is in conflict in position: 664:K->R. Contains a phosphoserine at position 652)

Explore the universe of human proteins at neXtProt for DENND1B: NX_Q6P3S1

Explore proteomics data for DENND1B at MOPED

Post-translational modifications: 

  • Isoform 5: Phosphorylated on Ser-6521
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DENND1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001182144.1  NP_001182145.1  NP_659414.2  

    ENSEMBL proteins: 
     ENSP00000375839   ENSP00000294737   ENSP00000235453   ENSP00000356366   ENSP00000410025  
     ENSP00000383751  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DENND: DENN/MADD domain containing

    3 InterPro protein domains:
     IPR005112 dDENN_dom
     IPR005113 uDENN_dom
     IPR001194 DENN_dom

    Graphical View of Domain Structure for InterPro Entry Q6P3S1

    ProtoNet protein and cluster: Q6P3S1

    UniProtKB/Swiss-Prot: DEN1B_HUMAN, Q6P3S1
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 uDENN domain


    DENND1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEN1B_HUMAN, Q6P3S1
    Function: Guanine nucleotide exchange factor (GEF) for RAB35. Promotes the exchange of GDP to GTP, converting
    inactive GDP-bound RAB35 into its active GTP-bound form. May play a role in clathrin-mediated endocytosis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017112Rab guanyl-nucleotide exchange factor activity IDA--
         
    DENND1B for ontologies           About GeneDecksing


    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate DENND1B (see all 113):
    hsa-miR-548j hsa-miR-579 hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-374a hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): DENND1B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEN1B_HUMAN, Q6P3S1: Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0030136clathrin-coated vesicle IEA--

    DENND1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DENND1B
    Interactions:

        Search GeneGlobe Interaction Network for DENND1B

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0032313regulation of Rab GTPase activity IDA--

    DENND1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DENND1B (DEN1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DENND1B gene (5 alternative transcripts): 
    NM_001142795.1  NM_019049.1  NM_001195215.1  NM_001195216.1  NM_144977.4  

    Unigene Cluster for DENND1B:

    DENN/MADD domain containing 1B
    Hs.125056  [show with all ESTs]
    Unigene Representative Sequence: AK024832
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391979(uc021pgu.1 uc010ppf.2) ENST00000294737 ENST00000463124
    ENST00000235453(uc001gue.3) ENST00000367396(uc001guf.3) ENST00000496935(uc001gug.4)
    ENST00000422998 ENST00000294738 ENST00000468589(uc021pgv.1) ENST00000495550
    ENST00000477581 ENST00000400967
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DENND1B (see all 113):
    hsa-miR-548j hsa-miR-579 hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-374a hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): DENND1B 3' UTR sequence
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    Additional mRNA sequence: 

    AK024832.1 BC074735.2 

    3 DOTS entries:

    DT.309530  DT.100016665  DT.102826067 

    Selected AceView cDNA sequences (see all 57):

    BC016588 AX746849 CR622563 BC074735 AL831839 BC063877 AK091207 BC063456 
    AA809946 AI948992 AI480253 CD243988 BG610917 AI636062 AK024832 BU663451 
    AW328012 BX091956 BI759326 AA171951 AA824385 BG391716 BE242664 AW957524 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DENND1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGTCACC
    DENND1B Expression
    About this image

    DENND1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DENND1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125056

    UniProtKB/Swiss-Prot: DEN1B_HUMAN, Q6P3S1
    Tissue specificity: Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid
    lineage cells and in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive
    T-cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DENND1B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dennd1b1 , 5 DENN/MADD domain containing 1B1, 5 85.72(n)1
    86.21(a)1
      1 (60.84 cM)5
    3292601  NM_001166501.11  NP_001159973.11 
     1389634365 
    chicken
    (Gallus gallus)
    Aves DENND1B1 DENN/MADD domain containing 1B 75.66(n)
    76.66(a)
      424351  XM_422194.4  XP_422194.4 
    lizard
    (Anolis carolinensis)
    Reptilia DENND1B6
    DENN/MADD domain containing 1B
    46(a)
    1 ↔ 1
    GL343432.1(504020-712642)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dennd1b1 DENN/MADD domain containing 1B 70.27(n)
    71.45(a)
      101735275  XM_004913749.1  XP_004913806.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dennd1b1 DENN/MADD domain containing 1B 61.01(n)
    59.35(a)
      560720  XM_684120.6  XP_689212.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG186596
    --
    17(a)
    1 → many
    2R(5010809-5019486)
    worm
    (Caenorhabditis elegans)
    Secernentea rme-46
    Protein RME-4, isoform a (rme-4) mRNA, complete cd...
    21(a)
    1 → many
    X(10373230-10377752) WBGene00004375


    ENSEMBL Gene Tree for DENND1B (if available)
    TreeFam Gene Tree for DENND1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DENND1B gene
    ST52  DENND5A2  DENND2D2  DENND2A2  DENND32  DENND1C2  DENND4A2  DENND4B2  
    DENND1A2  DENND5B2  DENND2C2  DENND4C2  
    3 SIMAP similar genes for DENND1B using alignment to 5 protein entries:     DEN1B_HUMAN (see all proteins):
    DENND1A    DENND1C    ST5

    DENND1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DENND1B (see all 4536)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828894541,2
    --197473384(+) AATAAG/TAAAGG 1 -- int10--------
    rs133750981,2
    C,F,H--197473403(+) ATTAAT/ACCCAG 1 -- int17Minor allele frequency- A:0.09NS EA WA CSA 538
    rs1410003981,2
    --197473423(+) ACCCAC/GAGGGA 1 -- int10--------
    rs1861708021,2
    --197473553(+) TTTCAC/TCTCTG 1 -- int10--------
    rs2010757021,2
    --197473963(+) GCATA-/TTTTTT 1 -- ut310--------
    rs10249201,2
    C,F,A,H--197473969(-) TTTTTA/TAAAAA 1 -- ut3112Minor allele frequency- T:0.09NS EA NA WA 786
    rs784947001,2
    C--197474238(+) CTTTAC/TGCATT 1 -- ut310--------
    rs1914132911,2
    --197474381(+) AAGTTA/GCACTG 1 -- ut310--------
    rs75533271,2
    C,F,H--197474565(+) AAAGAG/AGTAAT 1 -- ut3121Minor allele frequency- A:0.10NS EA NA WA CSA 1358
    rs121336591,2
    C,F,A,H--197474654(+) ACATAG/ACATTC 1 -- ut3123Minor allele frequency- A:0.05NA NS EA 2340

    HapMap Linkage Disequilibrium report for DENND1B (197473878 - 197723878 bp, first 250kb of DENND1B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DENND1B (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2053199CNV Deletion18987734
    esv1218085CNV Deletion17803354
    esv2657002CNV Deletion23128226
    esv2721073CNV Deletion23290073
    esv992847CNV Deletion20482838
    esv987539CNV Deletion20482838
    esv2721084CNV Deletion23290073
    esv4662CNV Deletion18987735
    esv2558030CNV Deletion19546169
    esv1439856CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613292    OMIM disorders: --

    5 diseases for DENND1B:    
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    primary biliary cirrhosis    crohn's disease    asthma    inflammatory bowel disease
    obesity


    DENND1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): DENND1B
    Human Genome Epidemiology (HuGE) Navigator: DENND1B (4 documents)

    Export disorders for DENND1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DENND1B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with DENND1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variants of DENND1B associated with asthma in children. (PubMed id 20032318)1, 2, 4 Sleiman P.M....Hakonarson H. (N. Engl. J. Med. 2010)
    2. Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. (PubMed id 22065758)1, 2 Wu X....Reinisch K.M. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    3. The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. (PubMed id 20154091)1, 2 Marat A.L. and McPherson P.S. (J. Biol. Chem. 2010)
    4. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (Nat. Genet. 2010)
    5. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. (PubMed id 22977732)1 Nookala R.K....Blundell T.L. (Open Biol 2012)
    9. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    10. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1 Mells G.F....Anderson C.A. (Nat. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 163486 HGNC: 28404 AceView: FLJ20054 Ensembl:ENSG00000213047 euGenes: HUgn163486
    ECgene: DENND1B H-InvDB: DENND1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DENND1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DENND1B gene:
    Search GeneIP for patents involving DENND1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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