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DENND1A Gene

protein-coding   GIFtS: 50
GCID: GC09M126141

DENN/MADD Domain Containing 1A

(Previous name: KIAA1608)
(Previous symbol: KIAA1608)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DENN/MADD Domain Containing 1A1 2     DENN Domain-Containing Protein 1A2
KIAA16081 2 3 5     Connecdenn3
Connecdenn 12 3     Protein FAM31A3
FAM31A2 3     

External Ids:    HGNC: 293241   Entrez Gene: 577062   Ensembl: ENSG000001195227   OMIM: 6136335   UniProtKB: Q8TEH33   

Export aliases for DENND1A gene to outside databases

Previous GC identifers: GC09M123222 GC09M125181 GC09M095756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DENND1A Gene:
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids.
Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the
early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM
601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed
20154091)).(supplied by OMIM, Nov 2010)

GeneCards Summary for DENND1A Gene:
DENND1A (DENN/MADD domain containing 1A) is a protein-coding gene. Diseases associated with DENND1A include polycystic ovary syndrome, and myopia. GO annotations related to this gene include SH3 domain binding and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.

UniProtKB/Swiss-Prot: DEN1A_HUMAN, Q8TEH3
Function: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35
activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound
form. Regulates clathrin-mediated endocytosis of synaptic vesicles

Gene Wiki entry for DENND1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DENND1A gene promoter:
         Elk-1   SRF (504 AA)   Brachyury   CREB   AREB6   POU2F1   deltaCREB   POU2F1a   Chx10   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDENND1A promoter sequence
   Search Chromatin IP Primers for DENND1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DENND1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q34.11

DENND1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DENND1A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M126141:  view genomic region     (about GC identifiers)

Start:
126,141,933 bp from pter      End:
126,692,431 bp from pter
Size:
550,499 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DEN1A_HUMAN, Q8TEH3 (See protein sequence)
Recommended Name: DENN domain-containing protein 1A  
Size: 1009 amino acids; 110577 Da
Subunit: Interacts with ITSN1 AND SH3GL2 (By similarity). Interacts with RAB35. Interacts with clathrin and with
the adapter protein complex 2, AP-2
Sequence caution: Sequence=AAH09616.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH28061.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAH13155.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MZA3 B1AM80 B7Z3C8 B7Z669 D3PFD3 Q05C88 Q5VWF0 Q6PJZ5 Q8IVD6 Q9H796
Alternative splicing: 7 isoforms:  Q8TEH3-1   Q8TEH3-2   Q8TEH3-3   Q8TEH3-4   Q8TEH3-5   Q8TEH3-6   Q8TEH3-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DENND1A: NX_Q8TEH3

Explore proteomics data for DENND1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DENND1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_065997.1  NP_079096.2  

    ENSEMBL proteins: 
     ENSP00000362727   ENSP00000362722   ENSP00000362720   ENSP00000377766   ENSP00000437457  
     ENSP00000377763  

    DENND1A Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DENND: DENN/MADD domain containing

    3 InterPro protein domains:
     IPR005112 dDENN_dom
     IPR005113 uDENN_dom
     IPR001194 DENN_dom

    Graphical View of Domain Structure for InterPro Entry Q8TEH3

    ProtoNet protein and cluster: Q8TEH3

    UniProtKB/Swiss-Prot: DEN1A_HUMAN, Q8TEH3
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 uDENN domain


    DENND1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEN1A_HUMAN, Q8TEH3
    Function: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35
    activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound
    form. Regulates clathrin-mediated endocytosis of synaptic vesicles

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017112Rab guanyl-nucleotide exchange factor activity IDA--
    GO:0017124SH3 domain binding IEA--
         
    DENND1A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DENND1A
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    miRTarBase miRNAs that target DENND1A:
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    Block miRNA regulation of human, mouse, rat DENND1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DENND1A (see all 24):
    hsa-miR-498 hsa-miR-185* hsa-miR-137 hsa-miR-449c* hsa-miR-522 hsa-miR-1260b hsa-miR-301a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDENND1A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEN1A_HUMAN, Q8TEH3: Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Cell
    junction, synapse, presynaptic cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    endosome2
    nucleus2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030054cell junction IEA--
    GO:0030136clathrin-coated vesicle IDA--
    GO:0030425dendrite IEA--
    GO:0030665clathrin-coated vesicle membrane IEA--
    GO:0042734presynaptic membrane IEA--

    DENND1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DENND1A
    Interactions:

        Search GeneGlobe Interaction Network for DENND1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for DENND1A (ENSP000003627274) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITSN1ENSP000003707194STRING: ENSP00000370719
    SH3GL2ENSP000003699814STRING: ENSP00000369981
    ITSN2ENSP000003472444STRING: ENSP00000347244
    SH3D19ENSP000003029134STRING: ENSP00000302913
    AP2A1ENSP000003519264STRING: ENSP00000351926
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IMP--
    GO:0015031protein transport IEA--
    GO:0032313regulation of Rab GTPase activity IDA--
    GO:0032483regulation of Rab protein signal transduction IDA--
    GO:0048488synaptic vesicle endocytosis IEA--

    DENND1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DENND1A (DEN1A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DENND1A gene (2 alternative transcripts): 
    NM_020946.1  NM_024820.2  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473039(uc010mwh.1 uc004bny.1) ENST00000373624(uc011lzl.1 uc004bnz.1 uc011lzm.1)
    ENST00000373620(uc004boa.1) ENST00000475421 ENST00000491650 ENST00000497135
    ENST00000373618(uc004boc.3) ENST00000479305 ENST00000462245 ENST00000474676
    ENST00000475615 ENST00000394219 ENST00000542603 ENST00000394215(uc004bob.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DENND1A (see all 24):
    hsa-miR-498 hsa-miR-185* hsa-miR-137 hsa-miR-449c* hsa-miR-522 hsa-miR-1260b hsa-miR-301a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDENND1A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DENND1A
      QuantiFast Probe-based Assays in human, mouse, rat DENND1A

    Selected AceView cDNA sequences (see all 119):

    BX105722 AI563890 BM055398 AL157682 BF992984 BU931225 BM717450 BQ938996 
    CR626287 AL048921 AK074151 AI671592 AA428881 BI768439 AB046828 BC009616 
    BG823215 AA428972 BQ446270 CB132973 BM457864 CD365540 BU754152 AI146851 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DENND1A (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
    SP1:        -                 -                                                                                                                                 
    SP2:        -     -           -                                                                                                                                 
    SP3:                                                                                                  -     -     -     -     -     -     -     -     -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b
    SP1:  -                                                         
    SP2:  -                                                         
    SP3:  -           -     -     -                                 
    SP4:  -           -     -     -                                 
    SP5:  -           -     -     -                                 


    ECgene alternative splicing isoforms for DENND1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DENND1A expression in normal human tissues (normalized intensities)      DENND1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCACTGCTG
    DENND1A Expression
    About this image


    DENND1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Eye (Sensory Organs)
             Retina
    DENND1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DENND1A Protein Expression

    Genevestigator expression for DENND1A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DENND1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DENND1A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dennd1a1 , 5 DENN/MADD domain containing 1A1, 5 86.49(n)1
    89.2(a)1
      2 (24.19 cM)5
    2278011  NM_146122.31  NP_666234.31 
     377989915 
    chicken
    (Gallus gallus)
    Aves DENND1A1 DENN/MADD domain containing 1A 70.01(n)
    72.01(a)
      417102  XM_004946022.1  XP_004946079.1 
    lizard
    (Anolis carolinensis)
    Reptilia DENND1A6
    DENN/MADD domain containing 1A
    53(a)
    1 ↔ 1
    GL344112.1(17882-67755)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dennd1a1 DENN/MADD domain containing 1A 63.74(n)
    66.12(a)
      100487210  XM_002938752.2  XP_002938798.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dennd1a1 DENN/MADD domain containing 1A 61.52(n)
    62.49(a)
      556150  XM_678885.3  XP_683977.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG186596
    --
    29(a)
    1 → many
    2R(5010809-5019486)
    worm
    (Caenorhabditis elegans)
    Secernentea rme-46
    Protein RME-4, isoform a (rme-4) mRNA, complete cd...
    29(a)
    1 → many
    X(10373230-10377752) WBGene00004375


    ENSEMBL Gene Tree for DENND1A (if available)
    TreeFam Gene Tree for DENND1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DENND1A gene
    ST52  DENND5A2  DENND2D2  DENND2A2  DENND32  DENND1C2  DENND4A2  DENND4B2  
    DENND1B2  DENND5B2  DENND2C2  DENND4C2  
    3 SIMAP similar genes for DENND1A using alignment to 1 protein entry:     DEN1A_HUMAN:
    KIAA1608    DENND1B    DENND1C

    DENND1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DENND1A (see all 9789)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735733041,2
    C,F--95756450(+) ATGGGG/ATGGTC 1 -- ds50012Minor allele frequency- A:0.15WA 120
    rs1401201591,2
    --95756467(+) TCTGCA/GTTCCC 1 -- ds50010--------
    rs1930059801,2
    --95756654(+) CTGAGC/GAGGCC 1 -- ds50010--------
    rs120059211,2
    H--95756656(+) GAGCAC/GGCCTG 1 -- ds50010--------
    rs22757821,2
    C--95756673(+) GCCCAA/GCCCCG 1 -- ds50016Minor allele frequency- G:0.29EA NA WA 1100
    rs794499251,2
    C--95756749(+) GGTGCA/GGGGAG 1 -- ds50010--------
    rs1843161051,2
    --95756750(+) GTGCGC/GGGAGT 1 -- ds50010--------
    rs1867502801,2
    --95756759(+) GTTGAC/TTCCTT 1 -- ds50010--------
    rs1923843191,2
    --95757018(+) GCCTTA/GGGGTA 1 -- ut310--------
    rs1468696711,2
    --95757045(+) GGGGCC/TGCCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DENND1A (126141933 - 126391933 bp, first 250kb of DENND1A)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DENND1A (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739022CNV Deletion23290073
    esv2739027CNV Deletion23290073
    esv2657034CNV Deletion23128226
    esv2739026CNV Deletion23290073
    esv2659343CNV Deletion23128226
    esv2670403CNV Deletion23128226
    esv2739024CNV Deletion23290073
    esv2739030CNV Deletion23290073
    esv1000891CNV Deletion20482838
    esv2739025CNV Deletion23290073

    Human Gene Mutation Database (HGMD): DENND1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DENND1A
    DNA2.0 Custom Variant and Variant Library Synthesis for DENND1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613633    OMIM disorders: --

    6 diseases for DENND1A:    About MalaCards
    polycystic ovary syndrome    myopia    cleft lip    retinitis
    adenocarcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for DENND1A:
    Polycystic ovary syndrome

    DENND1A for disorders           About GeneDecksing

    Genetic Association Database (GAD): DENND1A
    Human Genome Epidemiology (HuGE) Navigator: DENND1A (4 documents)

    Export disorders for DENND1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DENND1A gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with DENND1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. (PubMed id 21151128)1, 4 Chen Z.J....Zhao Y. (Nat. Genet. 2011)
    2. The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. (PubMed id 20154091)1, 2 Marat A.L. and McPherson P.S. (J. Biol. Chem. 2010)
    3. A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. (PubMed id 20691247)1, 4 Verweij K.J....Wray N.R. (Biol Psychol 2010)
    4. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 3 Nagase T.... Ohara O. (DNA Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57706 HGNC: 29324 AceView: KIAA1608 Ensembl:ENSG00000119522 euGenes: HUgn57706
    ECgene: DENND1A H-InvDB: DENND1A

    (According to HUGE)
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    HUGE: KIAA1608

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DENND1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DENND1A gene:
    Search GeneIP for patents involving DENND1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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