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Aliases for DEK Gene

Aliases for DEK Gene

  • DEK Proto-Oncogene 2 3
  • DEK Oncogene (DNA Binding) 2 3
  • D6S231E 3 6
  • DEK Oncogene 2
  • Protein DEK 3

External Ids for DEK Gene

Previous GeneCards Identifiers for DEK Gene

  • GC06M018280
  • GC06M018332

Summaries for DEK Gene

Entrez Gene Summary for DEK Gene

  • This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for DEK Gene

DEK (DEK Proto-Oncogene) is a Protein Coding gene. Diseases associated with DEK include 'acute myeloid leukemia with t(6;9)(p23;q34)' and iridocyclitis. GO annotations related to this gene include histone binding.

UniProtKB/Swiss-Prot for DEK Gene

  • Involved in chromatin organization.

Gene Wiki entry for DEK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEK Gene

Genomics for DEK Gene

Regulatory Elements for DEK Gene

Genomic Location for DEK Gene

18,223,868 bp from pter
18,264,823 bp from pter
40,956 bases
Minus strand

Genomic View for DEK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEK Gene

Proteins for DEK Gene

  • Protein details for DEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DEK
    Protein Accession:
    Secondary Accessions:
    • B2R6K6
    • B4DN37
    • Q5TGV4
    • Q5TGV5

    Protein attributes for DEK Gene

    375 amino acids
    Molecular mass:
    42674 Da
    Quaternary structure:
    • Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.

    Three dimensional structures from OCA and Proteopedia for DEK Gene

    Alternative splice isoforms for DEK Gene


neXtProt entry for DEK Gene

Proteomics data for DEK Gene at MOPED

Post-translational modifications for DEK Gene

  • Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
  • Ubiquitination at Lys111, Lys125, Lys137, Lys331, and Lys349
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DEK (DEK)

No data available for DME Specific Peptides for DEK Gene

Domains for DEK Gene

Protein Domains for DEK Gene


Suggested Antigen Peptide Sequences for DEK Gene

Graphical View of Domain Structure for InterPro Entry



  • P35659
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with DEK: view

No data available for Gene Families for DEK Gene

Function for DEK Gene

Molecular function for DEK Gene

GENATLAS Biochemistry:
nuclear protein of unknown function,likely associated to chromatin
UniProtKB/Swiss-Prot Function:
Involved in chromatin organization.

Gene Ontology (GO) - Molecular Function for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0042393 histone binding IDA 12140263
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DEK: view

Phenotypes for DEK Gene

genes like me logo Genes that share phenotypes with DEK: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEK

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DEK Gene

Localization for DEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEK Gene

Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.

Subcellular locations from

Jensen Localization Image for DEK Gene COMPARTMENTS Subcellular localization image for DEK gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21653549
GO:0043292 contractile fiber IEA --
genes like me logo Genes that share ontologies with DEK: view

Pathways for DEK Gene

SuperPathways for DEK Gene

No Data Available

Gene Ontology (GO) - Biological Process for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9050861
GO:0006366 transcription from RNA polymerase II promoter TAS 9050861
GO:0007165 signal transduction TAS 9050861
GO:0016568 chromatin modification IEA --
GO:0019079 viral genome replication TAS 9050861
genes like me logo Genes that share ontologies with DEK: view

No data available for Pathways by source for DEK Gene

Compounds for DEK Gene

(1) Novoseek inferred chemical compound relationships for DEK Gene

Compound -log(P) Hits PubMed IDs
mnda 79 2
genes like me logo Genes that share compounds with DEK: view

Transcripts for DEK Gene

Unigene Clusters for DEK Gene

DEK oncogene:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP3: - - -

Relevant External Links for DEK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEK Gene

mRNA expression in normal human tissues for DEK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DEK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.7) and Tlymphocyte (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DEK Gene

SOURCE GeneReport for Unigene cluster for DEK Gene Hs.484813

mRNA Expression by UniProt/SwissProt for DEK Gene

Tissue specificity: Ubiquitous. Expressed at relatively high levels
genes like me logo Genes that share expressions with DEK: view

Expression partners for DEK Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DEK Gene

Orthologs for DEK Gene

This gene was present in the common ancestor of animals.

Orthologs for DEK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DEK 35
  • 92.27 (n)
  • 94.13 (a)
DEK 36
  • 94 (a)
(Canis familiaris)
Mammalia DEK 35
  • 94.05 (n)
  • 97.23 (a)
DEK 36
  • 88 (a)
(Mus musculus)
Mammalia Dek 35
  • 86.36 (n)
  • 88.24 (a)
Dek 16
Dek 36
  • 89 (a)
(Pan troglodytes)
Mammalia DEK 35
  • 98.84 (n)
  • 98.66 (a)
DEK 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dek 35
  • 87.08 (n)
  • 89.84 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
-- 36
  • 72 (a)
-- 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia DEK 36
  • 84 (a)
(Gallus gallus)
Aves DEK 35
  • 79.44 (n)
  • 86.6 (a)
DEK 36
  • 83 (a)
(Anolis carolinensis)
Reptilia DEK 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dek 35
  • 66.56 (n)
  • 64.71 (a)
Str.6224 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398543 35
(Danio rerio)
Actinopterygii dek 36
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dek 36
  • 17 (a)
Species with no ortholog for DEK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEK Gene

Gene Tree for DEK (if available)
Gene Tree for DEK (if available)

Paralogs for DEK Gene

Selected SIMAP similar genes for DEK Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DEK: view

No data available for Paralogs for DEK Gene

Variants for DEK Gene

Sequence variations from dbSNP and Humsavar for DEK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3476 -- 18,224,942(-) GCCTC(A/G)AAAGT utr-variant-3-prime
rs140821 -- 18,249,011(+) GTACC(-/CA)CTCTC intron-variant
rs172520 -- 18,258,285(-) AGCTT(C/T)CTTTC intron-variant
rs188533 -- 18,238,179(-) tgaac(A/C)caaGA intron-variant
rs214497 -- 18,230,780(-) agtct(A/C)ccatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEK Gene

Variant ID Type Subtype PubMed ID
esv271692 CNV Insertion 20981092

Relevant External Links for DEK Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEK Gene

Disorders for DEK Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DEK Gene in MalaCards »

(2) Diseases for DEK Gene including...


  • Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.

(2) University of Copenhagen DISEASES for DEK Gene

(17) Novoseek inferred disease relationships for DEK Gene

Disease -log(P) Hits PubMed IDs
arthritis juvenile rheumatoid 73.9 6
iridocyclitis 66.5 1
retinoblastoma 56.6 7
ataxia telangiectasia 44.2 2
leukemogenesis 34.3 1

Genatlas disease for DEK Gene

myelodysplastic syndrome,refractory anemia with excess of blasts in transformation (MDS/RAEBT),acute myeloid leukemia of poor prognosis (AML),with t(6;9)(p23;q34) translocation

Relevant External Links for DEK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DEK: view

No data available for OMIM for DEK Gene

Publications for DEK Gene

  1. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (PMID: 1549122) Von Lindern M. … Grosveld G. (Mol. Cell. Biol. 1992) 2 3 4 23
  2. Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene. (PMID: 9058666) Murray K.J. … Szer I.S. (J. Rheumatol. 1997) 3 23 48
  3. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. (PMID: 12140263) Hollenbach A.D. … Grosveld G. (J. Cell Sci. 2002) 3 4 23
  4. Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. (PMID: 15199154) Kappes F. … Gruss C. (Mol. Cell. Biol. 2004) 3 4 23
  5. Solution NMR structure of the C-terminal domain of the human protein DEK. (PMID: 15238633) Devany M. … Matsuo H. (Protein Sci. 2004) 3 4 23

Products for DEK Gene

Sources for DEK Gene

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