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Aliases for DEK Gene

Aliases for DEK Gene

  • DEK Proto-Oncogene 2 3 5
  • DEK Oncogene (DNA Binding) 2 3
  • DEK Oncogene 2
  • Protein DEK 3
  • D6S231E 3

External Ids for DEK Gene

Previous GeneCards Identifiers for DEK Gene

  • GC06M018280
  • GC06M018332

Summaries for DEK Gene

Entrez Gene Summary for DEK Gene

  • This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for DEK Gene

DEK (DEK Proto-Oncogene) is a Protein Coding gene. Diseases associated with DEK include Acute Myeloid Leukemia With T(6;9)(P23;Q34) and Iridocyclitis. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. GO annotations related to this gene include nucleic acid binding and histone binding.

UniProtKB/Swiss-Prot for DEK Gene

  • Involved in chromatin organization.

Gene Wiki entry for DEK Gene

Additional gene information for DEK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEK Gene

Genomics for DEK Gene

Regulatory Elements for DEK Gene

Enhancers for DEK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H017583 1.1 Ensembl ENCODE 13.9 +680.6 680572 1.4 ATF1 TBL1XR1 ARNT RAD21 ZNF143 ATF7 ZNF548 MIXL1 ZNF654 ZC3H11A NUP153 DEK LOC105374952 RNU6-190P SUMO2P13 LOC102724591
GH06H018214 0.7 ENCODE 20.3 +48.7 48693 2.5 NR2F1 CEBPG JUND EED IKZF1 ZNF548 ATF7 PRDM10 ZBTB33 RUNX3 DEK NUP153 LOC105374952 RNU6-263P IMPDH1P9 KDM1B
GH06H018584 1.3 Ensembl ENCODE 9.8 -320.4 -320403 1.2 PKNOX1 FOXA2 ATF1 ARNT ZNF493 FEZF1 ZNF2 TCF12 ZNF766 GLIS2 NUP153 DEK MIR548A1 LOC105374957
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DEK on UCSC Golden Path with GeneCards custom track

Promoters for DEK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for DEK Gene

Genomic Locations for DEK Gene
40,956 bases
Minus strand

Genomic View for DEK Gene

Genes around DEK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEK Gene

Proteins for DEK Gene

  • Protein details for DEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DEK
    Protein Accession:
    Secondary Accessions:
    • B2R6K6
    • B4DN37
    • Q5TGV4
    • Q5TGV5

    Protein attributes for DEK Gene

    375 amino acids
    Molecular mass:
    42674 Da
    Quaternary structure:
    • Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.

    Three dimensional structures from OCA and Proteopedia for DEK Gene

    Alternative splice isoforms for DEK Gene


neXtProt entry for DEK Gene

Post-translational modifications for DEK Gene

  • Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
  • Ubiquitination at isoforms=2111, isoforms=2125, isoforms=2137, posLast=331331, and posLast=349349
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DEK (DEK)
  • Abcam antibodies for DEK
  • Santa Cruz Biotechnology (SCBT) Antibodies for DEK

No data available for DME Specific Peptides for DEK Gene

Domains & Families for DEK Gene

Gene Families for DEK Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DEK Gene


Suggested Antigen Peptide Sequences for DEK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DEK: view

No data available for UniProtKB/Swiss-Prot for DEK Gene

Function for DEK Gene

Molecular function for DEK Gene

GENATLAS Biochemistry:
nuclear protein of unknown function,likely associated to chromatin
UniProtKB/Swiss-Prot Function:
Involved in chromatin organization.

Phenotypes From GWAS Catalog for DEK Gene

Gene Ontology (GO) - Molecular Function for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
GO:0003723 RNA binding IDA 22658674
GO:0042393 histone binding IDA 12140263
genes like me logo Genes that share ontologies with DEK: view
genes like me logo Genes that share phenotypes with DEK: view

Animal Models for DEK Gene

MGI Knock Outs for DEK:

miRNA for DEK Gene

miRTarBase miRNAs that target DEK

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DEK Gene

Localization for DEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEK Gene

Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEK gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 21653549
GO:0005654 nucleoplasm TAS --
GO:0043292 contractile fiber IEA --
genes like me logo Genes that share ontologies with DEK: view

Pathways & Interactions for DEK Gene

genes like me logo Genes that share pathways with DEK: view

SIGNOR curated interactions for DEK Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS 9050861
GO:0007165 signal transduction TAS 9050861
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with DEK: view

Drugs & Compounds for DEK Gene

(1) Additional Compounds for DEK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DEK: view

Transcripts for DEK Gene

Unigene Clusters for DEK Gene

DEK oncogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP3: - - -

Relevant External Links for DEK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEK Gene

Protein differential expression in normal tissues from HIPED for DEK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.7) and Tlymphocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DEK Gene

Protein tissue co-expression partners for DEK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DEK Gene:


SOURCE GeneReport for Unigene cluster for DEK Gene:


mRNA Expression by UniProt/SwissProt for DEK Gene:

Tissue specificity: Ubiquitous. Expressed at relatively high levels.

Evidence on tissue expression from TISSUES for DEK Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Bone marrow(2.8)
  • Skin(2.3)
  • Blood(2.2)
  • Spleen(2.2)
  • Heart(2.1)
  • Lung(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with DEK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEK Gene

Orthologs for DEK Gene

This gene was present in the common ancestor of animals.

Orthologs for DEK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEK 33 34
  • 98.84 (n)
(Canis familiaris)
Mammalia DEK 33 34
  • 94.05 (n)
(Bos Taurus)
Mammalia DEK 33 34
  • 92.27 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 88 (a)
-- 34
  • 72 (a)
-- 34
  • 52 (a)
(Rattus norvegicus)
Mammalia Dek 33
  • 87.08 (n)
(Mus musculus)
Mammalia Dek 33 16 34
  • 86.36 (n)
(Ornithorhynchus anatinus)
Mammalia DEK 34
  • 84 (a)
(Gallus gallus)
Aves DEK 33 34
  • 79.44 (n)
(Anolis carolinensis)
Reptilia DEK 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dek 33
  • 66.56 (n)
Str.6224 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398543 33
(Danio rerio)
Actinopterygii dek 34
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dek 34
  • 17 (a)
Species where no ortholog for DEK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEK Gene

Gene Tree for DEK (if available)
Gene Tree for DEK (if available)

Paralogs for DEK Gene

(1) SIMAP similar genes for DEK Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DEK: view

No data available for Paralogs for DEK Gene

Variants for DEK Gene

Sequence variations from dbSNP and Humsavar for DEK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000016996 -- 18,243,732(+) CTTCT(A/G)TAACC intron-variant
rs1000036179 -- 18,224,186(+) TGATT(C/T)AGATT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000097076 -- 18,228,898(+) GCCCA(C/G)CACAG intron-variant
rs1000190947 -- 18,264,721(+) TCCCC(A/G/T)GCTGC upstream-variant-2KB
rs1000205166 -- 18,259,061(+) CGCGG(C/T)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEK Gene

Variant ID Type Subtype PubMed ID
nsv1144134 CNV deletion 24896259
esv3567345 CNV deletion 23714750
esv3567344 CNV deletion 23714750
esv3424290 CNV insertion 20981092
esv3335295 CNV insertion 20981092
esv3307418 CNV mobile element insertion 20981092

Variation tolerance for DEK Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEK Gene

Disorders for DEK Gene

MalaCards: The human disease database

(4) MalaCards diseases for DEK Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myeloid leukemia with t(6;9)(p23;q34)
  • aml with t(6;9)(p23;q34)
  • primary iridocyclitis
rheumatoid arthritis, systemic juvenile
  • juvenile rheumatoid arthritis
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search DEK in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122). {ECO:0000269 PubMed:1549122}.

Genatlas disease for DEK Gene

myelodysplastic syndrome,refractory anemia with excess of blasts in transformation (MDS/RAEBT),acute myeloid leukemia of poor prognosis (AML),with t(6;9)(p23;q34) translocation

Relevant External Links for DEK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DEK: view

Publications for DEK Gene

  1. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (PMID: 1549122) von Lindern M … Grosveld G (Molecular and cellular biology 1992) 2 3 4 22 60
  2. Solution NMR structure of the N-terminal domain of the human DEK protein. (PMID: 18227428) Devany M … Matsuo H (Protein science : a publication of the Protein Society 2008) 3 4 22 60
  3. The distribution of the DEK protein in mammalian chromatin. (PMID: 17524367) Hu HG … Knippers R (Biochemical and biophysical research communications 2007) 3 4 22 60
  4. Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. (PMID: 15199154) Kappes F … Gruss C (Molecular and cellular biology 2004) 3 4 22 60
  5. Solution NMR structure of the C-terminal domain of the human protein DEK. (PMID: 15238633) Devany M … Matsuo H (Protein science : a publication of the Protein Society 2004) 3 4 22 60

Products for DEK Gene

Sources for DEK Gene

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