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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DEK Gene

protein-coding   GIFtS: 62
GCID: GC06M018224

DEK Oncogene

(Previous name: DEK oncogene (DNA binding))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEK Oncogene1 2
DEK Oncogene (DNA Binding)1 2
D6S231E2 5
Protein DEK2

External Ids:    HGNC: 27681   Entrez Gene: 79132   Ensembl: ENSG000001247957   OMIM: 1252645   UniProtKB: P356593   

Export aliases for DEK gene to outside databases

Previous GC identifers: GC06M018280 GC06M018332


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DEK Gene:
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces
positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA
processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of
antibodies against this protein are all associated with various diseases. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for DEK Gene: 
DEK (DEK oncogene) is a protein-coding gene. Diseases associated with DEK include iridocyclitis, and acute undifferentiated leukemia. GO annotations related to this gene include histone binding and DNA binding.

UniProtKB/Swiss-Prot: DEK_HUMAN, P35659
Function: Involved in chromatin organization

Gene Wiki entry for DEK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DEK gene promoter:
         AML1a   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEK promoter sequence
   Search SABiosciences Chromatin IP Primers for DEK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p23

DEK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M018224:  view genomic region     (about GC identifiers)

Start:
18,224,099 bp from pter      End:
18,265,054 bp from pter
Size:
40,956 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DEK_HUMAN, P35659 (See protein sequence)
Recommended Name: Protein DEK  
Size: 375 amino acids; 42674 Da
Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and
ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2.
Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6,
MYBBP1A and DDX21. Binds DNA
Subcellular location: Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase
nuclei
2 PDB 3D structures from and Proteopedia for DEK:
1Q1V (3D)        2JX3 (3D)    
Secondary accessions: B2R6K6 B4DN37 Q5TGV4 Q5TGV5
Alternative splicing: 2 isoforms:  P35659-1   P35659-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DEK: NX_P35659

Explore proteomics data for DEK at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase,
    and weakens the binding of DEK to DNA
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35659

  • DEK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DEK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001128181.1  NP_003463.1  

    ENSEMBL proteins: 
     ENSP00000380414   ENSP00000421165   ENSP00000244776   ENSP00000423427   ENSP00000422380  
     ENSP00000425399   ENSP00000423553  

    Human Recombinant Protein Products for DEK: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DEK
    OriGene Protein Over-expression Lysate for DEK
    OriGene MassSpec for DEK 
    OriGene Custom Protein Services for DEK
    GenScript Custom Purified and Recombinant Proteins Services for DEK
    Novus Biologicals DEK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DEK 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    DEK for ontologies           About GeneDecksing



    DEK Antibody Products: 
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    Cloud-Clone Corp. Antibodies for DEK 
    ThermoFisher Antibody for DEK
    LSBio Antibodies in human, mouse, rat for DEK 

    Assay Products for DEK: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DEK 
    Cloud-Clone Corp. CLIAs for DEK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR014876 DEK_C
     IPR003034 SAP_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P35659

    ProtoNet protein and cluster: P35659

    1 Blocks protein domain: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: DEK_HUMAN, P35659
    Similarity: Contains 1 SAP domain


    DEK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEK_HUMAN, P35659
    Function: Involved in chromatin organization

         Genatlas biochemistry entry for DEK:
    nuclear protein of unknown function,likely associated to chromatin

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0042393histone binding IDA12140263
         
    DEK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DEK:
     Decreased Salmonella enterica  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dek):
     homeostasis/metabolism  tumorigenesis 

    DEK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DEK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DEK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DEK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DEK 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DEK
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate DEK (see all 28):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-300 hsa-miR-181c hsa-miR-4272 hsa-miR-200a hsa-miR-340 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDEK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DEK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEK

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DEK
    Sirion Biotech Customized adenovirus for overexpression of DEK

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DEK (see all 13)
    OriGene ORF clones in mouse, rat for DEK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DEK (NM_003472)
    Sino Biological Human cDNA Clone for DEK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEK
    Sirion Biotech Customized lentivirus for stable overexpression of DEK 
                         Customized lentivirus expression plasmids for stable overexpression of DEK 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DEK
    Search LifeMap BioReagents cell lines for DEK
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DEK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for DEK (P356592, 3 ENSP000003804144) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=5 STRING: ENSP00000352980
    HIST1H4LP628053, ENSP000003482584I2D: score=5 STRING: ENSP00000348258
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    HIST1H4DP628053I2D: score=5 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9050861
    GO:0006366transcription from RNA polymerase II promoter TAS9050861
    GO:0007165signal transduction TAS9050861
    GO:0016568chromatin modification IEA--
    GO:0019079viral genome replication TAS9050861

    DEK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DEK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DEK

    1 Novoseek inferred chemical compound relationship for DEK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mnda 79 2 11681413 (1), 12199786 (1)

    Search CenterWatch for drugs/clinical trials and news about DEK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DEK gene (2 alternative transcripts): 
    NM_001134709.1  NM_003472.3  

    Unigene Cluster for DEK:

    DEK oncogene
    Hs.484813  [show with all ESTs]
    Unigene Representative Sequence: BX641063
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397239(uc003ncr.1 uc011djf.1 uc011djg.1) ENST00000505224
    ENST00000244776 ENST00000507591 ENST00000515770 ENST00000512145 ENST00000503715
    ENST00000515742
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DEK
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate DEK (see all 28):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-300 hsa-miR-181c hsa-miR-4272 hsa-miR-200a hsa-miR-340 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDEK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DEK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEK
    Clone
    Products:
         
    OriGene clones in human, mouse for DEK (see all 13)
    OriGene ORF clones in mouse, rat for DEK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DEK (NM_003472)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEK
    Sirion Biotech Customized lentivirus for stable overexpression of DEK 
                         Customized lentivirus expression plasmids for stable overexpression of DEK 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DEK
    OriGene qSTAR qPCR primer pairs in human, mouse for DEK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DEK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEK

    Additional mRNA sequence: 

    AJ270688.1 AJ420539.1 AK294079.1 AK297749.1 AK298089.1 AK312616.1 BC012442.1 BC035259.1 
    BX641063.1 X64229.1 

    19 DOTS entries:

    DT.100842094  DT.100880233  DT.85104704  DT.100880239  DT.92455733  DT.95175179  DT.100880243  DT.87017073 
    DT.121308951  DT.121309020  DT.121308914  DT.92063534  DT.92455719  DT.92455727  DT.100880237  DT.100880238 
    DT.121308919  DT.95307425  DT.97864783 

    24/550 AceView cDNA sequences (see all 550):

    BI259837 BG776813 AI357927 AI924222 CR599640 BG287544 BU622704 AU119103 
    AI928944 BQ226135 BQ008789 AA594258 AI355517 BQ477341 AV756365 BQ574048 
    BG250970 CR623348 BP351575 CB159267 BQ220913 AW029614 AI951595 AA187833 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DEK    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                                                        -               
    SP2:                                                                        
    SP3:                                      -     -           -               


    ECgene alternative splicing isoforms for DEK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DEK expression in normal human tissues (normalized intensities)      DEK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTTATGA
    DEK Expression
    About this image


    DEK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See DEK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DEK

    SOURCE GeneReport for Unigene cluster: Hs.484813

    UniProtKB/Swiss-Prot: DEK_HUMAN, P35659
    Tissue specificity: Ubiquitous. Expressed at relatively high levels

        SABiosciences Custom PCR Arrays for DEK
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DEK gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dek1 , 5 DEK oncogene (DNA binding)1, 5 88.77(n)1
    91.71(a)1
      13 (24.50 cM)5
    1100521  NM_025900.21  NP_080176.21 
     470847755 
    chicken
    (Gallus gallus)
    Aves DEK1 DEK oncogene 77.54(n)
    82.61(a)
      420828  NM_001012560.1  NP_001012578.1 
    lizard
    (Anolis carolinensis)
    Reptilia DEK6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    4(56863232-56877686)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985432 similar to DEK oncogene (DNA binding) 77.41(n)    BC041538.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1363461 zgc:136346 51.03(n)
    42.18(a)
      692304  NM_001045276.1  NP_001038741.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dek6
    Dek
    19(a)
    1 ↔ 1
    2R(12743725-12749243)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G487101 DEK domain-containing chromatin associated protein 45.74(n)
    35.83(a)
      824032  NM_114730.2  NP_190440.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g09249001 hypothetical protein 48.49(n)
    38.01(a)
      4327229  NM_001051786.1  NP_001045251.1 


    ENSEMBL Gene Tree for DEK (if available)
    TreeFam Gene Tree for DEK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DEK gene
    1 SIMAP similar gene for DEK using alignment to 7 protein entries:     DEK_HUMAN (see all proteins):
    DKFZp686A24118

    DEK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/939 SNPs in DEK are shown (see all 939)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420619821,2
    --18224657(+) TGTCAC/TTGTGT 2 -- ut310--------
    rs1908122561,2
    --18224670(+) TAAACA/CGCATG 2 -- ut310--------
    rs1114157711,2
    C,F--18224718(+) TAAATC/TTGAAA 2 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1404006911,2
    --18224799(+) CTCTGA/CAAGCC 2 -- ut310--------
    rs1499498801,2
    C--18225004(+) AATAAA/GAATCA 2 -- ut310--------
    rs1464941161,2
    --18225117(+) AAAACA/GTACCT 2 -- ut310--------
    rs34761,2
    C,F,A,H--18225173(-) GCCTCA/GAAAGT 2 -- ut3138Minor allele frequency- N:0.00NS EA MN NA WA 5154
    rs1409922361,2
    C--18225193(+) TAACTA/GTTCCT 2 -- ut310--------
    rs1839120651,2
    --18225201(+) CCTTCA/GGTGTT 2 -- ut310--------
    rs1457418321,2
    C--18225207(+) GTGTTC/GCCATC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DEK (18224099 - 18265054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DEK:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv271692CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 125264    OMIM disorders: --

    UniProtKB/Swiss-Prot: DEK_HUMAN, P35659
  • Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also
    known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the
    formation of a DEK-CAN fusion gene

  • 20/29 diseases for DEK (see all 29):    About MalaCards
    iridocyclitis    acute undifferentiated leukemia    juvenile rheumatoid arthritis    refractory anemia
    rheumatic disease    ataxia telangiectasia    neuroendocrine carcinoma    merkel cell carcinoma
    retinoblastoma    acute myeloid leukemia    small cell carcinoma    lupus erythematosus
    ataxia    sarcoidosis    kaposi's sarcoma    arthritis
    myelodysplastic syndromes    rheumatoid arthritis    myeloid leukemia    systemic lupus erythematosus

    2 diseases from the University of Copenhagen DISEASES database for DEK:
    Leukemia     Juvenile rheumatoid arthritis

    DEK for disorders           About GeneDecksing

    10/17 Novoseek inferred disease relationships for DEK gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arthritis juvenile rheumatoid 73.9 7 12823858 (2), 17030615 (1), 18332104 (1), 9684994 (1) (see all 5)
    iridocyclitis 66.5 1 9058666 (1)
    retinoblastoma 56.6 10 16180235 (3), 16007192 (2), 16254365 (1), 16894028 (1)
    ataxia telangiectasia 44.2 4 12483538 (1), 15766865 (1)
    leukemogenesis 34.3 1 16696975 (1)
    autoimmune diseases 33.3 7 16829531 (1), 12823858 (1), 15987677 (1), 17001602 (1) (see all 5)
    bladder cancer 29.1 3 16721057 (1), 15987677 (1), 12875971 (1)
    hepatocellular carcinoma 21.2 3 15987677 (1), 12483538 (1), 15991281 (1)
    rheumatic diseases 21.1 2 7869324 (2)
    cancer 20.5 24 19223548 (2), 12483538 (2), 16894028 (2), 19563407 (2) (see all 11)

    Genatlas disease: DEK
    myelodysplastic syndrome,refractory anemia with excess of blasts in transformation (MDS/RAEBT),acute myeloid
    leukemia of poor prognosis (AML),with t(6;9)(p23;q34) translocation

    Genetic Association Database (GAD): DEK
    Human Genome Epidemiology (HuGE) Navigator: DEK (2 documents)

    Export disorders for DEK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DEK gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with DEK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (PubMed id 1549122)1, 2, 3, 9 Von Lindern M.... Grosveld G. (1992)
    2. The distribution of the DEK protein in mammalian chromatin. (PubMed id 17524367)1, 2, 9 Hu H.G....Knippers R. (2007)
    3. Solution NMR structure of the N-terminal domain of the human DEK protein. (PubMed id 18227428)1, 2, 9 Devany M....Matsuo H. (2008)
    4. Solution NMR structure of the C-terminal domain of the human protein DEK. (PubMed id 15238633)1, 2, 9 Devany M.... Matsuo H. (2004)
    5. Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. (PubMed id 15199154)1, 2, 9 Kappes F....Gruss C. (2004)
    6. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. (PubMed id 12140263)1, 2, 9 Hollenbach A.D....Grosveld G. (2002)
    7. Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene. (PubMed id 9058666)1, 4, 9 Murray K.J....Szer I.S. (1997)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. (PubMed id 16603771)1, 2 Cavellan E....Farrants A.K. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7913 HGNC: 2768 AceView: DEK Ensembl:ENSG00000124795 euGenes: HUgn7913
    ECgene: DEK H-InvDB: DEK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DEK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DEK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DEK gene:
    Search GeneIP for patents involving DEK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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