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DEK Gene

protein-coding   GIFtS: 63
GCID: GC06M018224

DEK Oncogene

(Previous name: DEK oncogene (DNA binding))
  See DEK-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEK Oncogene1 2
DEK Oncogene (DNA Binding)1 2
D6S231E2 5
Protein DEK2

External Ids:    HGNC: 27681   Entrez Gene: 79132   Ensembl: ENSG000001247957   OMIM: 1252645   UniProtKB: P356593   

Export aliases for DEK gene to outside databases

Previous GC identifers: GC06M018280 GC06M018332


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DEK Gene:
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces
positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA
processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of
antibodies against this protein are all associated with various diseases. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for DEK Gene:
DEK (DEK oncogene) is a protein-coding gene. Diseases associated with DEK include leukemia, acute nonlymphocytic, and iridocyclitis. GO annotations related to this gene include histone binding.

UniProtKB/Swiss-Prot: DEK_HUMAN, P35659
Function: Involved in chromatin organization

Gene Wiki entry for DEK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DEK gene promoter:
         AML1a   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEK promoter sequence
   Search Chromatin IP Primers for DEK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p23

DEK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M018224:  view genomic region     (about GC identifiers)

Start:
18,224,099 bp from pter      End:
18,265,054 bp from pter
Size:
40,956 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DEK_HUMAN, P35659 (See protein sequence)
Recommended Name: Protein DEK  
Size: 375 amino acids; 42674 Da
Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and
ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2.
Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6,
MYBBP1A and DDX21. Binds DNA
2 PDB 3D structures from and Proteopedia for DEK:
1Q1V (3D)        2JX3 (3D)    
Secondary accessions: B2R6K6 B4DN37 Q5TGV4 Q5TGV5
Alternative splicing: 2 isoforms:  P35659-1   P35659-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DEK: NX_P35659

Explore proteomics data for DEK at MOPED

Post-translational modifications: 

  • Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase,
    and weakens the binding of DEK to DNA1
  • Ubiquitination2 at Lys111, Lys125, Lys137, Lys331, Lys349
  • Modification sites at PhosphoSitePlus

  • See DEK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128181.1  NP_003463.1  

    ENSEMBL proteins: 
     ENSP00000380414   ENSP00000421165   ENSP00000244776   ENSP00000423427   ENSP00000422380  
     ENSP00000425399   ENSP00000423553  

    DEK Human Recombinant Protein Products:

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    Novus Biologicals DEK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DEK

     
    Search eBioscience for Proteins for DEK 

    DEK Antibody Products:

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    DEK Assay Products:

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    Cloud-Clone Corp. CLIAs for DEK
    Search eBioscience for ELISAs for DEK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014876 DEK_C
     IPR003034 SAP_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P35659

    ProtoNet protein and cluster: P35659

    1 Blocks protein domain: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: DEK_HUMAN, P35659
    Similarity: Contains 1 SAP domain


    Find genes that share domains with DEK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEK_HUMAN, P35659
    Function: Involved in chromatin organization

         Genatlas biochemistry entry for DEK:
    nuclear protein of unknown function,likely associated to chromatin

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0042393histone binding IDA12140263
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with DEK           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DEK:
     Decreased Salmonella enterica  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dek):
     homeostasis/metabolism  tumorigenesis 

    Find genes that share phenotypes with DEK           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DEK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DEK

    miRNA
    Products:
        
    miRTarBase miRNAs that target DEK:
    hsa-mir-96-5p (MIRT048732), hsa-mir-374b-5p (MIRT016065), hsa-mir-192-5p (MIRT026606), hsa-mir-215-5p (MIRT024668), hsa-mir-186-5p (MIRT044904), hsa-mir-155-5p (MIRT020832)

    Block miRNA regulation of human, mouse, rat DEK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEK (see all 28):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-300 hsa-miR-181c hsa-miR-4272 hsa-miR-200a hsa-miR-340 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDEK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DEK
    Predesigned siRNA for gene silencing in human, mouse, rat DEK

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for DEK (see all 12)
    OriGene ORF clones in mouse, rat for DEK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DEK (NM_003472)
    Sino Biological Human cDNA Clone for DEK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEK

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DEK 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEK_HUMAN, P35659: Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase
    nuclei
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    Find genes that share ontologies with DEK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DEK
    Interactions:

        GeneGlobe Interaction Network for DEK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DEK (P356592, 3 ENSP000003804144) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=5 STRING: ENSP00000352980
    HIST1H4LP628053, ENSP000003482584I2D: score=5 STRING: ENSP00000348258
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    HIST1H4DP628053I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9050861
    GO:0006366transcription from RNA polymerase II promoter TAS9050861
    GO:0007165signal transduction TAS9050861
    GO:0016568chromatin modification IEA--
    GO:0019079viral genome replication TAS9050861

    Find genes that share ontologies with DEK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DEK

    1 Novoseek inferred chemical compound relationship for DEK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mnda 79 2 11681413 (1), 12199786 (1)



    Find genes that share compounds with DEK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DEK gene (2 alternative transcripts): 
    NM_001134709.1  NM_003472.3  

    Unigene Cluster for DEK:

    DEK oncogene
    Hs.484813  [show with all ESTs]
    Unigene Representative Sequence: BX641063
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397239(uc003ncr.1 uc011djf.1 uc011djg.1) ENST00000505224
    ENST00000244776 ENST00000507591 ENST00000515770 ENST00000512145 ENST00000503715
    ENST00000515742
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DEK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEK (see all 28):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-300 hsa-miR-181c hsa-miR-4272 hsa-miR-200a hsa-miR-340 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDEK 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DEK
    Predesigned siRNA for gene silencing in human, mouse, rat DEK
    Clone
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    OriGene clones in human, mouse for DEK (see all 12)
    OriGene ORF clones in mouse, rat for DEK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DEK (NM_003472)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEK
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DEK
    OriGene qSTAR qPCR primer pairs in human, mouse for DEK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEK
      QuantiTect SYBR Green Assays in human, mouse, rat DEK
      QuantiFast Probe-based Assays in human, mouse, rat DEK

    Additional mRNA sequence: 

    AJ270688.1 AJ420539.1 AK294079.1 AK297749.1 AK298089.1 AK312616.1 BC012442.1 BC035259.1 
    BX641063.1 X64229.1 

    19 DOTS entries:

    DT.100842094  DT.100880233  DT.85104704  DT.100880239  DT.92455733  DT.95175179  DT.100880243  DT.87017073 
    DT.121308951  DT.121309020  DT.121308914  DT.92063534  DT.92455719  DT.92455727  DT.100880237  DT.100880238 
    DT.121308919  DT.95307425  DT.97864783 

    Selected AceView cDNA sequences (see all 550):

    BG287544 BQ008789 AW029614 AA279225 AI951595 BM853230 CK826160 AA187833 
    BC035259 BQ774258 BM453178 AA594258 AW028455 BU622704 BF933280 BQ477754 
    BQ436240 AI630647 BU751980 CA416541 AU119103 AI355517 BQ477341 AV756365 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DEK    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                                                        -               
    SP2:                                                                        
    SP3:                                      -     -           -               


    ECgene alternative splicing isoforms for DEK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DEK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTTATGA
    DEK Expression
    About this image


    DEK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    DEK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DEK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484813

    UniProtKB/Swiss-Prot: DEK_HUMAN, P35659
    Tissue specificity: Ubiquitous. Expressed at relatively high levels

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    QuantiFast Probe-based Assays in human, mouse, rat DEK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DEK gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dek1 , 5 DEK oncogene (DNA binding)1, 5 86.36(n)1
    88.24(a)1
      13 (24.50 cM)5
    1100521  NM_025900.21  NP_080176.21 
     470847755 
    chicken
    (Gallus gallus)
    Aves DEK1 DEK oncogene 79.44(n)
    86.6(a)
      420828  NM_001012560.1  NP_001012578.1 
    lizard
    (Anolis carolinensis)
    Reptilia DEK6
    DEK oncogene
    78(a)
    1 ↔ 1
    4(56863232-56877686)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985432 similar to DEK oncogene (DNA binding) 77.41(n)    BC041538.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dek6
    DEK oncogene
    29(a)
    1 ↔ 1
    16(43680738-43696209) ENSDARG00000070108
    fruit fly
    (Drosophila melanogaster)
    Insecta Dek6
    Dek
    17(a)
    1 ↔ 1
    2R(12743725-12749243)


    ENSEMBL Gene Tree for DEK (if available)
    TreeFam Gene Tree for DEK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DEK gene
    1 SIMAP similar gene for DEK using alignment to 7 protein entries:     DEK_HUMAN (see all proteins):
    DKFZp686A24118

    Find genes that share paralogs with DEK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DEK (see all 939)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420619821,2
    --18224657(+) TGTCAC/TTGTGT 2 -- ut310--------
    rs1908122561,2
    --18224670(+) TAAACA/CGCATG 2 -- ut310--------
    rs1114157711,2
    C,F--18224718(+) TAAATC/TTGAAA 2 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1404006911,2
    --18224799(+) CTCTGA/CAAGCC 2 -- ut310--------
    rs1499498801,2
    C--18225004(+) AATAAA/GAATCA 2 -- ut310--------
    rs1464941161,2
    --18225117(+) AAAACA/GTACCT 2 -- ut310--------
    rs34761,2
    C,F,A,H--18225173(-) GCCTCA/GAAAGT 2 -- ut3138Minor allele frequency- N:0.00NS EA MN NA WA 5154
    rs1409922361,2
    C--18225193(+) TAACTA/GTTCCT 2 -- ut310--------
    rs1839120651,2
    --18225201(+) CCTTCA/GGTGTT 2 -- ut310--------
    rs1457418321,2
    C--18225207(+) GTGTTC/GCCATC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DEK (18224099 - 18265054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DEK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271692CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DEK
    DNA2.0 Custom Variant and Variant Library Synthesis for DEK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 125264    OMIM disorders: --

    UniProtKB/Swiss-Prot: DEK_HUMAN, P35659
  • Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also
    known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the
    formation of a DEK-CAN fusion gene

  • 2 diseases for DEK:    
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    leukemia, acute nonlymphocytic    iridocyclitis

    2 diseases from the University of Copenhagen DISEASES database for DEK:
    Leukemia     Juvenile rheumatoid arthritis

    Find genes that share disorders with DEK           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DEK gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arthritis juvenile rheumatoid 73.9 7 12823858 (2), 17030615 (1), 18332104 (1), 9684994 (1) (see all 5)
    iridocyclitis 66.5 1 9058666 (1)
    retinoblastoma 56.6 10 16180235 (3), 16007192 (2), 16254365 (1), 16894028 (1)
    ataxia telangiectasia 44.2 4 12483538 (1), 15766865 (1)
    leukemogenesis 34.3 1 16696975 (1)
    autoimmune diseases 33.3 7 16829531 (1), 12823858 (1), 15987677 (1), 17001602 (1) (see all 5)
    bladder cancer 29.1 3 16721057 (1), 15987677 (1), 12875971 (1)
    hepatocellular carcinoma 21.2 3 15987677 (1), 12483538 (1), 15991281 (1)
    rheumatic diseases 21.1 2 7869324 (2)
    cancer 20.5 24 19223548 (2), 12483538 (2), 16894028 (2), 19563407 (2) (see all 11)

    Genatlas disease: DEK
    myelodysplastic syndrome,refractory anemia with excess of blasts in transformation (MDS/RAEBT),acute myeloid
    leukemia of poor prognosis (AML),with t(6;9)(p23;q34) translocation

    Genetic Association Database (GAD): DEK
    Human Genome Epidemiology (HuGE) Navigator: DEK (2 documents)

    Export disorders for DEK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DEK gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with DEK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (PubMed id 1549122)1, 2, 3, 9 Von Lindern M.... Grosveld G. (Mol. Cell. Biol. 1992)
    2. The distribution of the DEK protein in mammalian chromatin. (PubMed id 17524367)1, 2, 9 Hu H.G.... Knippers R. (Biochem. Biophys. Res. Commun. 2007)
    3. Solution NMR structure of the N-terminal domain of the human DEK protein. (PubMed id 18227428)1, 2, 9 Devany M.... Matsuo H. (Protein Sci. 2008)
    4. Solution NMR structure of the C-terminal domain of the human protein DEK. (PubMed id 15238633)1, 2, 9 Devany M.... Matsuo H. (Protein Sci. 2004)
    5. Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. (PubMed id 15199154)1, 2, 9 Kappes F.... Gruss C. (Mol. Cell. Biol. 2004)
    6. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. (PubMed id 12140263)1, 2, 9 Hollenbach A.D....Grosveld G. (J. Cell Sci. 2002)
    7. Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene. (PubMed id 9058666)1, 4, 9 Murray K.J....Szer I.S. (J. Rheumatol. 1997)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. (PubMed id 16603771)1, 2 Cavellan E.... Oestlund Farrants A.-K. (J. Biol. Chem. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7913 HGNC: 2768 AceView: DEK Ensembl:ENSG00000124795 euGenes: HUgn7913
    ECgene: DEK H-InvDB: DEK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DEK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DEK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DEK gene:
    Search GeneIP for patents involving DEK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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