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DEGS2 Gene

protein-coding   GIFtS: 52
GCID: GC14M100612

Delta(4)-Desaturase, Sphingolipid 2

(Previous names: chromosome 14 open reading frame 66, degenerative spermatocyte...)
(Previous symbol: C14orf66)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Delta(4)-Desaturase, Sphingolipid 21 2     Degenerative Spermatocyte Homolog 2, Lipid Desaturase2
C14orf661 2 3     Sphingolipid C4-Hydroxylase/Delta 4-Desaturase2
Dihydroceramide Desaturase 21 2     Sphingolipid Delta 4 Desaturase/C-4 Hydroxylase2
Sphingolipid Delta(4)-Desaturase 21 2     Sphingolipid Delta(4)-Desaturase/C4-Hydroxylase DES22
DES22 5     EC 1.-.-.-3
Chromosome 14 Open Reading Frame 661     EC 1.14.-.-3
Degenerative Spermatocyte Homolog 2, Lipid Desaturase (Drosophila)1     Degenerative Spermatocyte Homolog 23
FADS82     

External Ids:    HGNC: 201131   Entrez Gene: 1230992   Ensembl: ENSG000001683507   OMIM: 6108625   UniProtKB: Q6QHC53   

Export aliases for DEGS2 gene to outside databases

Previous GC identifers: GC14M099683 GC14M080795


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DEGS2 Gene:
This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin
and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and
also as a sphingolipid C4-hydroxylase. (provided by RefSeq, Oct 2008)

GeneCards Summary for DEGS2 Gene:
DEGS2 (delta(4)-desaturase, sphingolipid 2) is a protein-coding gene. GO annotations related to this gene include sphingosine hydroxylase activity and sphingolipid delta-4 desaturase activity. An important paralog of this gene is DEGS1.

UniProtKB/Swiss-Prot: DEGS2_HUMAN, Q6QHC5
Function: Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid
C4-hydroxylase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DEGS2 gene promoter:
         HFH-3   Brachyury   NCX/Ncx   Pax-2   AP-4   Pax-2a   GATA-1   FOXI1   Pax-2b   FOXJ2 (long isoform)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEGS2 promoter sequence
   Search Chromatin IP Primers for DEGS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEGS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

DEGS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEGS2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M100612:  view genomic region     (about GC identifiers)

Start:
100,612,753 bp from pter      End:
100,626,500 bp from pter
Size:
13,748 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DEGS2_HUMAN, Q6QHC5 (See protein sequence)
Recommended Name: Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2  
Size: 323 amino acids; 37197 Da
Secondary accessions: Q6P492

Explore the universe of human proteins at neXtProt for DEGS2: NX_Q6QHC5

Explore proteomics data for DEGS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DEGS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_996801.2  
    ENSEMBL proteins: 
     ENSP00000307126   ENSP00000450637  
    Reactome Protein details: Q6QHC5

    DEGS2 Human Recombinant Protein Products:

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    antibodies-online proteins for DEGS2 (2 products) 

     
    antibodies-online peptides for DEGS2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FADS: Fatty acid desaturases

    3 InterPro protein domains:
     IPR013866 Sphingolipid_d4-desaturase_N
     IPR011388 Sphingolipid_d4-desaturase
     IPR005804 Fatty_acid_desaturase-1

    Graphical View of Domain Structure for InterPro Entry Q6QHC5

    ProtoNet protein and cluster: Q6QHC5

    UniProtKB/Swiss-Prot: DEGS2_HUMAN, Q6QHC5
    Similarity: Belongs to the fatty acid desaturase family. DEGS subfamily


    Find genes that share domains with DEGS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEGS2_HUMAN, Q6QHC5
    Function: Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid
    C4-hydroxylase (By similarity)
    Induction: Up-regulated during keratinocyte differentiation. Not expressed at day 0 or day 3 after
    differentiation, detected on day 6 and increases by day 9

         Enzyme Numbers (IUBMB): EC 1.14.-.-1 EC 1.-.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000170sphingosine hydroxylase activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0042284sphingolipid delta-4 desaturase activity IEA--
         
    Find genes that share ontologies with DEGS2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DEGS2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEGS2_HUMAN, Q6QHC5: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    extracellular2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DEGS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DEGS2 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    Sphingolipid metabolism0.61
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3ceramide de novo biosynthesis
    ceramide de novo biosynthesis


    Find genes that share SuperPaths with DEGS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DEGS2
        ceramide de novo biosynthesis

    1 Reactome Pathway for DEGS2
        Sphingolipid de novo biosynthesis


    2 Kegg Pathways  (Kegg details for DEGS2):
        Sphingolipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: DEGS2_HUMAN, Q6QHC5
    Pathway: Membrane lipid metabolism; sphingolipid biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DEGS2
    Interactions:

        Search GeneGlobe Interaction Network for DEGS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for DEGS2 (ENSP000003071264) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACER1ENSP000003014524STRING: ENSP00000301452
    ASAH1ENSP000003711524STRING: ENSP00000371152
    ASAH2ENSP000003788974STRING: ENSP00000378897
    CERKENSP000002162644STRING: ENSP00000216264
    ENPP7ENSP000003326564STRING: ENSP00000332656
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006667sphinganine metabolic process IEA--
    GO:0030148sphingolipid biosynthetic process TAS--

    Find genes that share ontologies with DEGS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DEGS2

    1 HMDB Compound for DEGS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    DihydroceramideN-Acylsphinganine (see all 2)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DEGS2 gene: 
    NM_206918.2  

    Unigene Cluster for DEGS2:

    Delta(4)-desaturase, sphingolipid 2
    Hs.159643  [show with all ESTs]
    Unigene Representative Sequence: BC063598
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305631(uc001ygx.2) ENST00000553834 ENST00000557117
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DEGS2
      QuantiFast Probe-based Assays in human, mouse, rat DEGS2

    Additional mRNA sequence: 

    AY541700.1 BC063598.1 

    2 DOTS entries:

    DT.97836458  DT.91746859 

    19 AceView cDNA sequences:

    BM817460 BE562826 BG698427 CB306252 BM789564 CA488047 BQ129385 BG739820 
    BC063598 CA488627 BM790771 AY541700 CA314430 NM_206918 CB242859 BE378727 
    BM821335 AA282457 BG742605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DEGS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGGGTGC
    DEGS2 Expression
    About this image


    DEGS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
    DEGS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DEGS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159643

    UniProtKB/Swiss-Prot: DEGS2_HUMAN, Q6QHC5
    Tissue specificity: Highly expressed in skin, intestine and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DEGS2 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Degs21 , 5 degenerative spermatocyte homolog 2 (Drosophila), lipid more1, 5 82.46(n)1
    86.38(a)1
      12 (59.46 cM)5
    700591  NM_027299.51  NP_081575.21 
     1086867925 
    chicken
    (Gallus gallus)
    Aves DEGS21 degenerative spermatocyte homolog 2, lipid desaturase more 68.32(n)
    74.53(a)
      423454  XM_421364.4  XP_421364.2 
    lizard
    (Anolis carolinensis)
    Reptilia DEGS26
    delta(4)-desaturase, sphingolipid 2
    68(a)
    1 ↔ 1
    GL343270.1(1046905-1058899)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC757912 hypothetical protein MGC75791 72.17(n)    BC061313.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.173142 Danio rerio, Similar to RIKEN cDNA 2210008A03 gene, more 75(n)    BC045962.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ifc1 infertile crescent 63.3(n)
    57.73(a)
      33836  NM_057246.5  NP_476594.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ttm-51 ttm-5 53.58(n)
    54.21(a)
      173327  NM_061148.3  NP_493549.1 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AGR025W1 AGOS_AGR025W 56.75(n)
    46.41(a)
      4622989  NM_211752.2  NP_986690.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DES-1-LIKE1 DES-1-LIKE 51.18(n)
    46.45(a)
      825832  NM_116731.3  NP_192402.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06396001 Os02g0639600 54.97(n)
    48.52(a)
      4330104  NM_001054075.1  NP_001047540.1 


    ENSEMBL Gene Tree for DEGS2 (if available)
    TreeFam Gene Tree for DEGS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DEGS2 gene
    DEGS12  
    1 SIMAP similar gene for DEGS2 using alignment to 2 protein entries:     DEGS2_HUMAN (see all proteins):
    DEGS1

    Find genes that share paralogs with DEGS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DEGS2 (see all 362)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573249001,2
    C--80802744(+) AAAAA-/A/AA  
            
    GAAAG
    1 -- int11NA 2
    rs1818136381,2
    --100612306(+) GTGGGA/GGATAG 1 -- ds50010--------
    rs1167240271,2
    F--100612332(+) AGGGAC/TGCTCC 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1507145031,2
    C--100612652(+) CGAAGC/TGGCAC 1 -- ds50010--------
    rs2014123531,2
    --100612673(+) AGCTC-/CACTCAT 1 -- ds50010--------
    rs1863306881,2
    C--100612746(+) GCACAA/GTCCAT 1 -- ds50010--------
    rs1380410571,2
    --100612798(+) ACCCCA/GGAGAA 1 -- ut310--------
    rs1114442261,2
    F--100612806(+) GAAGTG/CAGCTC 1 -- ut311Minor allele frequency- C:0.50CSA 4
    rs1164845201,2
    C,F--100612970(+) GCTGCG/ACGGGA 1 -- ut311Minor allele frequency- A:0.13WA 118
    rs1154422411,2
    C,F--100613058(+) GGGGCC/TGATGG 1 -- ut311Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for DEGS2 (100612753 - 100626500 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DEGS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000926CNV Deletion20482838
    nsv902226CNV Loss21882294
    nsv524413CNV Loss19592680
    nsv526793CNV Loss19592680
    nsv527130CNV Loss19592680
    nsv902225CNV Loss21882294
    nsv832874CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DEGS2
    DNA2.0 Custom Variant and Variant Library Synthesis for DEGS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610862    OMIM disorders: --


    Find genes that share disorders with DEGS2           About GenesLikeMe

    Genetic Association Database (GAD): DEGS2
    Human Genome Epidemiology (HuGE) Navigator: DEGS2 (1 document)

    Export disorders for DEGS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DEGS2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DEGS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation. (PubMed id 15063729)1, 2, 9 Mizutani Y.... Igarashi Y. (FEBS Lett. 2004)
    2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    4. Dihydroceramide-based response to hypoxia. (PubMed id 21914808)1 Devlin C.M....Petrache I. (J. Biol. Chem. 2011)
    5. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 123099 HGNC: 20113 AceView: C14orf66 Ensembl:ENSG00000168350 euGenes: HUgn123099
    ECgene: DEGS2 Kegg: 123099 H-InvDB: DEGS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DEGS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DEGS2 gene:
    Search GeneIP for patents involving DEGS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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