DEFB4B Gene
protein-coding GIFtS: 32
GCID: GC08M007272
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defensin, beta 4B(Previous names: defensin, beta 4, pseudogene )
(Previous symbol: DEFB4P)
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Aliases
for DEFB4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Defensin, Beta 4B1 2 | | DEFB43 | | DEFB4P1 2 | | SAP13 | | Defensin, Beta 4, Pseudogene1 2 | | Beta-Defensin 23 | | Beta-Defensin 4B2 | | Defensin, Beta 23 | | BD-23 | | HBD-21 | | DEFB1023 | | Skin-Antimicrobial Peptide 13 | | DEFB23 | | |
Export aliases for DEFB4B gene to outside databases |
Summaries
for DEFB4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DFB4A_HUMAN, O15263Function: Has antibacterial activity (Potential)
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Genomic Views
for DEFB4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_023736.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DEFB4B
Other transcription factors
Search SABiosciences Chromatin IP Primers for DEFB4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEFB4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1DEFB4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M007272: view genomic region
(about GC identifiers)
Start:
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7,272,382 bp from pter |
End:
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7,274,385 bp from pter |
Size:
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2,004 bases |
Orientation:
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minus strand |
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Proteins
for DEFB4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DFB4A_HUMAN, O15263 (See
protein sequence)Recommended Name: Beta-defensin 4A precursor Size: 64 amino acids; 7038 Da
Subcellular location: Secreted
4 PDB 3D structures from  and Proteopedia  for DEFB4B:1E4Q (3D)
1FD3 (3D)
1FD4 (3D)
1FQQ (3D)
Secondary accessions: Q52LC0Explore the universe of human proteins at neXtProt for DEFB4B: NX_O15263
DEFB4B Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001192195.1
ENSEMBL proteins: ENSP00000424598 Reactome Protein details: O15263
Human Recombinant Protein Products for DEFB4B:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
-- | -- | | GO:0005796 | Golgi lumen |
-- | -- |
DEFB4B for ontologies About GeneDecksing
DEFB4B Antibody Products:
Assay Products for DEFB4B: |
Protein
Domains /
Families
for DEFB4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DEFB4B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15263ProtoNet protein and cluster: O15263 1 Blocks protein family: IPB001855 Beta defensin
UniProtKB/Swiss-Prot: DFB4A_HUMAN, O15263Similarity: Belongs to the beta-defensin family. LAP/TAP subfamily |
Function
for DEFB4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/Swiss-Prot Summary: DFB4A_HUMAN, O15263Function: Has antibacterial activity (Potential)Induction: By inflammationAnimal Models:
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Pathways & Interactions
for DEFB4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 
Reactome Pathways for DEFB4B (see all 6)
DEFB4B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEFB4B
5 Interacting proteins for DEFB4B (O152633) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
DEFB4B for ontologies About GeneDecksing
|
Drugs & Compounds
for DEFB4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DEFB4B
Search CenterWatch for drugs/clinical trials and news about DEFB4B / DFB4A 
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Transcripts
for DEFB4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DEFB4B gene: NM_001205266.1 Unigene Cluster for DEFB4B: Defensin, beta 4B Hs.740237 Unigene Representative Sequence: NM_0012052661 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000318157(uc022arf.1)
GeneLoc Exon Structure
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Expression
for DEFB4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DEFB4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.740237
UniProtKB/Swiss-Prot: DFB4A_HUMAN, O15263Tissue specificity: Expressed in the skin and respiratory tract
SABiosciences Custom PCR Arrays for DEFB4B
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DEFB4B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEFB4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEFB4B |
Orthologs
for DEFB4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DEFB4B (if available)
TreeFam Gene Tree for DEFB4B (if available) |
Paralogs
for DEFB4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DEFB4B gene
- DEFB4A1 2
2 SIMAP similar genes for DEFB4B using alignment to 1 protein entry: DFB4A_HUMAN:DEFB103A DEFB103B
DEFB4B for paralogs About GeneDecksing
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Genomic Variants
for DEFB4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DEFB4B (7272382 - 7274385 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DEFB4B: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for DEFB4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DEFB4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DEFB4B gene integrated from 9 sources:
(articles sorted by number of sources associating them with DEFB4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Chemical synthesis of beta-defensins and LEAP-1/hepcidin. (PubMed id 12010514)2 Kluever E.... Adermann K. (2002)
- Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. (PubMed id 11714914)2 Bauer F.... Sticht H. (2001)
- The structure of human beta-defensin-2 shows evidence of higher order oligomerization. (PubMed id 10906336)2 Hoover D.M.... Lubkowski J. (2000)
- Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. (PubMed id 10603376)2 Diamond G.... Bevins C.L. (2000)
- Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. (PubMed id 10837369)2 Harder J.... Schroeder J.-M. (2000)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
- Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. (PubMed id 9831658)2 Liu L.... Ganz T. (1998)
- A peptide antibiotic from human skin. (PubMed id 9202117)2 Harder J.... Schroeder J.-M. (1997)
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External Searches for DEFB4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DEFB4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DEFB4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEFB4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DEFB4B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DEFB4B gene:
Search GeneIP for patents involving DEFB4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DEFB4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DEFB4B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEFB4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEFB4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEFB4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEFB4B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEFB4B |
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| | | | Search Tocris compounds for DEFB4B |
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 | | | DEFB4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for DEFB4B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DEFB4B |
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