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Aliases for DEFB134 Gene

Aliases for DEFB134 Gene

  • Defensin, Beta 134 2 3 4

External Ids for DEFB134 Gene

Previous GeneCards Identifiers for DEFB134 Gene

  • GC00U921672
  • GC08M011888
  • GC08M011851
  • GC08M010782

Summaries for DEFB134 Gene

Entrez Gene Summary for DEFB134 Gene

  • Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]

GeneCards Summary for DEFB134 Gene

DEFB134 (Defensin, Beta 134) is a Protein Coding gene. Among its related pathways are Defensins and Defensins.

UniProtKB/Swiss-Prot for DEFB134 Gene

  • Has antibacterial activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB134 Gene

Genomics for DEFB134 Gene

Genomic Location for DEFB134 Gene

Start:
11,993,174 bp from pter
End:
11,996,312 bp from pter
Size:
3,139 bases
Orientation:
Minus strand

Genomic View for DEFB134 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB134 Gene

Proteins for DEFB134 Gene

  • Protein details for DEFB134 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4QY38-DB134_HUMAN
    Recommended name:
    Beta-defensin 134
    Protein Accession:
    Q4QY38
    Secondary Accessions:
    • A1L4A4

    Protein attributes for DEFB134 Gene

    Size:
    66 amino acids
    Molecular mass:
    7552 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB134 Gene

Proteomics data for DEFB134 Gene at MOPED

Post-translational modifications for DEFB134 Gene

No Post-translational modifications

Other Protein References for DEFB134 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB134 Gene

Domains for DEFB134 Gene

Gene Families for DEFB134 Gene

HGNC:
  • DEFB :Defensins, beta

Protein Domains for DEFB134 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEFB134 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4QY38

UniProtKB/Swiss-Prot:

DB134_HUMAN :
  • Q4QY38
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB134: view

Function for DEFB134 Gene

Molecular function for DEFB134 Gene

UniProtKB/Swiss-Prot Function: Has antibacterial activity.

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB134

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DEFB134 Gene

Localization for DEFB134 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB134 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEFB134 Gene COMPARTMENTS Subcellular localization image for DEFB134 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for DEFB134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB134: view

Pathways for DEFB134 Gene

SuperPathways for DEFB134 Gene

Superpath Contained pathways
1 Defensins
.80
genes like me logo Genes that share pathways with DEFB134: view

Pathways by source for DEFB134 Gene

2 Reactome pathways for DEFB134 Gene

Interacting Proteins for DEFB134 Gene

Gene Ontology (GO) - Biological Process for DEFB134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB134: view

Transcripts for DEFB134 Gene

mRNA/cDNA for DEFB134 Gene

(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEFB134 Gene

Defensin, beta 134:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB134

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB134 Gene

No ASD Table

Relevant External Links for DEFB134 Gene

GeneLoc Exon Structure for
DEFB134
ECgene alternative splicing isoforms for
DEFB134

Expression for DEFB134 Gene

mRNA expression in normal human tissues for DEFB134 Gene

mRNA differential expression in normal tissues according to GTEx for DEFB134 Gene

This gene is overexpressed in Testis (20.7), Pancreas (5.2), Brain - Cerebellum (4.7), and Brain - Cerebellar Hemisphere (4.1).

SOURCE GeneReport for Unigene cluster for DEFB134 Gene Hs.631852

genes like me logo Genes that share expressions with DEFB134: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for DEFB134 Gene

Orthologs for DEFB134 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DEFB134 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEFB134 36
  • 100 (a)
OneToOne
Species with no ortholog for DEFB134:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB134 Gene

ENSEMBL:
Gene Tree for DEFB134 (if available)
TreeFam:
Gene Tree for DEFB134 (if available)

Paralogs for DEFB134 Gene

Selected SIMAP similar genes for DEFB134 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB134: view

No data available for Paralogs for DEFB134 Gene

Variants for DEFB134 Gene

Sequence variations from dbSNP and Humsavar for DEFB134 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1132195 -- 11,993,486(-) GTCTG(C/G)ACTGA downstream-variant-500B
rs4131536 -- 11,997,779(+) agaca(C/T)tgaca upstream-variant-2KB
rs4604485 -- 11,993,647(-) TTTTG(A/G)CACCT downstream-variant-500B
rs6601646 -- 11,994,708(+) TTATT(G/T)TTTAA intron-variant
rs6601647 -- 11,995,360(+) GATGT(A/G)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB134 Gene

Variant ID Type Subtype PubMed ID
nsv890366 CNV Gain 21882294
nsv516685 CNV Gain+Loss 19592680
nsv428195 CNV Gain 18775914
dgv2199e1 CNV Complex 17122850
dgv2200e1 CNV Complex 17122850
dgv7704n71 CNV Gain 21882294
esv2736614 CNV Deletion 23290073
essv15113 CNV CNV 17122850
dgv1269e199 CNV Deletion 23128226
esv3862 CNV Duplication 18987735
nsv465468 CNV Gain 19166990
nsv890372 CNV Gain 21882294
nsv6080 CNV Insertion 18451855
esv33396 CNV Loss 17666407

Relevant External Links for DEFB134 Gene

HapMap Linkage Disequilibrium report
DEFB134

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB134 Gene

Disorders for DEFB134 Gene

No disorders were found for DEFB134 Gene.

No data available for UniProtKB/Swiss-Prot for DEFB134 Gene

Publications for DEFB134 Gene

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil A.A. … Zhang G. (Physiol. Genomics 2005) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DEFB134 Gene

Sources for DEFB134 Gene

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