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Aliases for DEFB133 Gene

Aliases for DEFB133 Gene

  • Defensin Beta 133 2 3 5
  • Defensin, Beta 133 2 4

External Ids for DEFB133 Gene

Previous GeneCards Identifiers for DEFB133 Gene

  • GC12U900425
  • GC06M049645

Summaries for DEFB133 Gene

GeneCards Summary for DEFB133 Gene

DEFB133 (Defensin Beta 133) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System.

UniProtKB/Swiss-Prot for DEFB133 Gene

  • Has antibacterial activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB133 Gene

Genomics for DEFB133 Gene

Regulatory Elements for DEFB133 Gene

Enhancers for DEFB133 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G049939 1 ENCODE 0.4 +10.2 10225 1.2 PKNOX1 FOXA2 ATF1 ARNT SIN3A YY1 ZNF766 GATA2 ELK1 NCOA1 DEFB113 DEFB133 GC06P049919
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DEFB133 on UCSC Golden Path with GeneCards custom track

Genomic Location for DEFB133 Gene

Chromosome:
6
Start:
49,946,021 bp from pter
End:
49,950,265 bp from pter
Size:
4,245 bases
Orientation:
Minus strand

Genomic View for DEFB133 Gene

Genes around DEFB133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEFB133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEFB133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB133 Gene

Proteins for DEFB133 Gene

  • Protein details for DEFB133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q30KQ1-DB133_HUMAN
    Recommended name:
    Beta-defensin 133
    Protein Accession:
    Q30KQ1
    Secondary Accessions:
    • Q4QY39

    Protein attributes for DEFB133 Gene

    Size:
    61 amino acids
    Molecular mass:
    7213 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB133 Gene

Post-translational modifications for DEFB133 Gene

No Post-translational modifications

Other Protein References for DEFB133 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB133 Gene

Domains & Families for DEFB133 Gene

Gene Families for DEFB133 Gene

Protein Domains for DEFB133 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEFB133 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q30KQ1

UniProtKB/Swiss-Prot:

DB133_HUMAN :
  • Belongs to the beta-defensin family.
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB133: view

Function for DEFB133 Gene

Molecular function for DEFB133 Gene

UniProtKB/Swiss-Prot Function:
Has antibacterial activity.

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DEFB133 Gene

Localization for DEFB133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB133 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEFB133 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for DEFB133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DEFB133: view

Pathways & Interactions for DEFB133 Gene

genes like me logo Genes that share pathways with DEFB133: view

Pathways by source for DEFB133 Gene

Interacting Proteins for DEFB133 Gene

Gene Ontology (GO) - Biological Process for DEFB133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IEA --
GO:0042742 defense response to bacterium IEA,IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB133: view

No data available for SIGNOR curated interactions for DEFB133 Gene

Drugs & Compounds for DEFB133 Gene

No Compound Related Data Available

Transcripts for DEFB133 Gene

mRNA/cDNA for DEFB133 Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB133 Gene

No ASD Table

Relevant External Links for DEFB133 Gene

GeneLoc Exon Structure for
DEFB133
ECgene alternative splicing isoforms for
DEFB133

Expression for DEFB133 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEFB133 Gene

NURSA nuclear receptor signaling pathways regulating expression of DEFB133 Gene:

DEFB133

SOURCE GeneReport for Unigene cluster for DEFB133 Gene:

Hs.558270
genes like me logo Genes that share expression patterns with DEFB133: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEFB133 Gene

Orthologs for DEFB133 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DEFB133 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEFB133 35
  • 95 (a)
OneToOne
Species where no ortholog for DEFB133 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB133 Gene

ENSEMBL:
Gene Tree for DEFB133 (if available)
TreeFam:
Gene Tree for DEFB133 (if available)

Paralogs for DEFB133 Gene

(1) SIMAP similar genes for DEFB133 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB133: view

No data available for Paralogs for DEFB133 Gene

Variants for DEFB133 Gene

Sequence variations from dbSNP and Humsavar for DEFB133 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000213368 -- 49,951,382(+) TGTAA(A/C)ATTGT upstream-variant-2KB
rs1000306827 -- 49,947,260(+) TCCAA(A/C)TGAGA intron-variant
rs1000540632 -- 49,949,768(+) TTTTG(A/G)TTTAG upstream-variant-2KB
rs1000640284 -- 49,948,679(+) TACTA(C/T)TTAAG intron-variant
rs1000702055 -- 49,948,915(+) ATCTG(A/G)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB133 Gene

Variant ID Type Subtype PubMed ID
nsv603091 CNV loss 21841781

Variation tolerance for DEFB133 Gene

Gene Damage Index Score: 2.12; 38.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEFB133 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEFB133

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB133 Gene

Disorders for DEFB133 Gene

Relevant External Links for DEFB133

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEFB133

No disorders were found for DEFB133 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEFB133 Gene

Publications for DEFB133 Gene

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil A.A. … Zhang G. (Physiol. Genomics 2005) 3 4 64

Products for DEFB133 Gene

Sources for DEFB133 Gene

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