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Aliases for DEFB133 Gene

Aliases for DEFB133 Gene

  • Defensin, Beta 133 2 3 4

External Ids for DEFB133 Gene

Summaries for DEFB133 Gene

GeneCards Summary for DEFB133 Gene

DEFB133 (Defensin, Beta 133) is a Protein Coding gene. Among its related pathways are Defensins and Defensins.

UniProtKB/Swiss-Prot for DEFB133 Gene

  • Has antibacterial activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB133 Gene

Genomics for DEFB133 Gene

Genomic Location for DEFB133 Gene

Start:
49,946,101 bp from pter
End:
49,949,444 bp from pter
Size:
3,344 bases
Orientation:
Minus strand

Genomic View for DEFB133 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB133 Gene

Regulatory Elements for DEFB133 Gene

Proteins for DEFB133 Gene

  • Protein details for DEFB133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q30KQ1-DB133_HUMAN
    Recommended name:
    Beta-defensin 133
    Protein Accession:
    Q30KQ1
    Secondary Accessions:
    • Q4QY39

    Protein attributes for DEFB133 Gene

    Size:
    61 amino acids
    Molecular mass:
    7213 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB133 Gene

Proteomics data for DEFB133 Gene at MOPED

Post-translational modifications for DEFB133 Gene

No Post-translational modifications

Other Protein References for DEFB133 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB133 Gene

Domains for DEFB133 Gene

Gene Families for DEFB133 Gene

HGNC:
  • DEFB :Defensins, beta

Protein Domains for DEFB133 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DB133_HUMAN
Family:
  • Belongs to the beta-defensin family.:
    • Q30KQ1
genes like me logo Genes that share domains with DEFB133: view

Function for DEFB133 Gene

Molecular function for DEFB133 Gene

UniProtKB/Swiss-Prot Function: Has antibacterial activity.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DEFB133 Gene

Localization for DEFB133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB133 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEFB133 Gene COMPARTMENTS Subcellular localization image for DEFB133 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for DEFB133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DEFB133: view

Pathways for DEFB133 Gene

SuperPathways for DEFB133 Gene

Superpath Contained pathways
1 Defensins
.80
genes like me logo Genes that share pathways with DEFB133: view

Pathways by source for DEFB133 Gene

2 Reactome pathways for DEFB133 Gene

Interacting Proteins for DEFB133 Gene

Gene Ontology (GO) - Biological Process for DEFB133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with DEFB133: view

Transcripts for DEFB133 Gene

mRNA/cDNA for DEFB133 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB133 Gene

No ASD Table

Relevant External Links for DEFB133 Gene

GeneLoc Exon Structure for
DEFB133
ECgene alternative splicing isoforms for
DEFB133

Expression for DEFB133 Gene

mRNA expression in normal human tissues for DEFB133 Gene

SOURCE GeneReport for Unigene cluster for DEFB133 Gene Hs.558270

genes like me logo Genes that share expressions with DEFB133: view

Orthologs for DEFB133 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for DEFB133 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEFB133 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Defb44-ps 16
Species with no ortholog for DEFB133:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB133 Gene

ENSEMBL:
Gene Tree for DEFB133 (if available)
TreeFam:
Gene Tree for DEFB133 (if available)

Paralogs for DEFB133 Gene

Selected SIMAP similar genes for DEFB133 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB133: view

No data available for Paralogs for DEFB133 Gene

Variants for DEFB133 Gene

Sequence variations from dbSNP and Humsavar for DEFB133 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3900863 -- 49,948,746(-) TATGA(C/T)GATTA intron-variant
rs6458719 -- 49,948,625(+) CTAGA(C/T)GTTAC intron-variant
rs7356955 -- 49,945,786(+) TTTGG(A/G)TACCT downstream-variant-500B
rs7760672 -- 49,946,268(+) AGTCA(C/T)TATAA intron-variant
rs9369926 -- 49,949,551(+) TTAGA(A/C)ACTGG upstream-variant-2KB

Relevant External Links for DEFB133 Gene

HapMap Linkage Disequilibrium report
DEFB133

No data available for Structural Variations from Database of Genomic Variants (DGV) for DEFB133 Gene

Disorders for DEFB133 Gene

No disorders were found for DEFB133 Gene.

No data available for UniProtKB/Swiss-Prot for DEFB133 Gene

Publications for DEFB133 Gene

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil A.A. … Zhang G. (Physiol. Genomics 2005) 3 4

Products for DEFB133 Gene

Sources for DEFB133 Gene

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