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Aliases for DEFB131 Gene

Aliases for DEFB131 Gene

  • Defensin, Beta 131 2 3 4
  • Beta-Defensin 31 3 4
  • DEFB-31 3 4
  • Beta-Defensin 131 3
  • Defensin, Beta 31 3
  • DEFB31 4

External Ids for DEFB131 Gene

Previous GeneCards Identifiers for DEFB131 Gene

  • GC00U991213
  • GC04P009055
  • GC04P008801

Summaries for DEFB131 Gene

Entrez Gene Summary for DEFB131 Gene

  • Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 4p16. [provided by RefSeq, Nov 2014]

GeneCards Summary for DEFB131 Gene

DEFB131 (Defensin, Beta 131) is a Protein Coding gene. Among its related pathways are Defensins and Defensins. An important paralog of this gene is LOC100129216.

UniProtKB/Swiss-Prot for DEFB131 Gene

  • Has antibacterial activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB131 Gene

Genomics for DEFB131 Gene

Regulatory Elements for DEFB131 Gene

Genomic Location for DEFB131 Gene

Start:
9,444,534 bp from pter
End:
9,450,514 bp from pter
Size:
5,981 bases
Orientation:
Plus strand

Genomic View for DEFB131 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB131 Gene

Proteins for DEFB131 Gene

  • Protein details for DEFB131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59861-DB131_HUMAN
    Recommended name:
    Beta-defensin 131
    Protein Accession:
    P59861
    Secondary Accessions:

    Protein attributes for DEFB131 Gene

    Size:
    70 amino acids
    Molecular mass:
    8199 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB131 Gene

Proteomics data for DEFB131 Gene at MOPED

Post-translational modifications for DEFB131 Gene

No Post-translational modifications

Other Protein References for DEFB131 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB131 Gene

Domains for DEFB131 Gene

Gene Families for DEFB131 Gene

HGNC:
  • DEFB :Defensins, beta

Protein Domains for DEFB131 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEFB131 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59861

UniProtKB/Swiss-Prot:

DB131_HUMAN :
  • P59861
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB131: view

Function for DEFB131 Gene

Molecular function for DEFB131 Gene

UniProtKB/Swiss-Prot Function: Has antibacterial activity.

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB131

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DEFB131 Gene

Localization for DEFB131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB131 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEFB131 Gene COMPARTMENTS Subcellular localization image for DEFB131 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for DEFB131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB131: view

Pathways for DEFB131 Gene

SuperPathways for DEFB131 Gene

Superpath Contained pathways
1 Defensins
.80
genes like me logo Genes that share pathways with DEFB131: view

Pathways by source for DEFB131 Gene

2 Reactome pathways for DEFB131 Gene

Interacting Proteins for DEFB131 Gene

Gene Ontology (GO) - Biological Process for DEFB131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB131: view

Transcripts for DEFB131 Gene

mRNA/cDNA for DEFB131 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB131

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB131 Gene

No ASD Table

Relevant External Links for DEFB131 Gene

GeneLoc Exon Structure for
DEFB131
ECgene alternative splicing isoforms for
DEFB131

Expression for DEFB131 Gene

mRNA expression in normal human tissues for DEFB131 Gene

mRNA differential expression in normal tissues according to GTEx for DEFB131 Gene

This gene is overexpressed in Thyroid (35.1) and Small Intestine - Terminal Ileum (17.9).

SOURCE GeneReport for Unigene cluster for DEFB131 Gene Hs.590200

mRNA Expression by UniProt/SwissProt for DEFB131 Gene

P59861-DB131_HUMAN
Tissue specificity: Highly expressed in testis. Is moderately expressed in the prostate and small intestine.
genes like me logo Genes that share expressions with DEFB131: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for DEFB131 Gene

Orthologs for DEFB131 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DEFB131 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
DEFB131 35
  • 98.57 (n)
  • 98.57 (a)
DEFB131 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DEFB131 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Defb43 16
Defb43 36
  • 52 (a)
OneToOne
Species with no ortholog for DEFB131:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB131 Gene

ENSEMBL:
Gene Tree for DEFB131 (if available)
TreeFam:
Gene Tree for DEFB131 (if available)

Paralogs for DEFB131 Gene

Paralogs for DEFB131 Gene

Selected SIMAP similar genes for DEFB131 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DEFB131 Gene

genes like me logo Genes that share paralogs with DEFB131: view

Variants for DEFB131 Gene

Sequence variations from dbSNP and Humsavar for DEFB131 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2865004 -- 9,448,447(+) tgggt(C/T)caagc intron-variant
rs4246697 -- 9,450,197(+) GCTTG(C/T)CTTTA intron-variant
rs4246698 -- 9,443,765(+) CCCTA(C/T)GGCAC upstream-variant-2KB
rs4395502 -- 9,442,782(+) TTTCA(A/G)TTATT upstream-variant-2KB
rs4472138 -- 9,446,171(+) ATGAT(A/G)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB131 Gene

Variant ID Type Subtype PubMed ID
dgv1569e1 CNV Complex 17122850
nsv428437 CNV Gain 18775914
dgv1570e1 CNV Complex 17122850
dgv922e199 CNV Deletion 23128226
esv2678198 CNV Deletion 23128226
nsv471623 CNV Gain+Loss 15918152
dgv1573e1 CNV Complex 17122850
dgv1574e1 CNV Complex 17122850
esv22777 CNV Gain+Loss 19812545
nsv878640 CNV Loss 21882294
dgv5467n71 CNV Gain 21882294
nsv878643 CNV Gain+Loss 21882294
nsv829856 CNV Gain+Loss 17160897
dgv49n64 CNV Gain 17921354
nsv819708 CNV Gain 19587683
nsv470016 CNV Gain 18288195
dgv5468n71 CNV Gain 21882294
dgv644n27 CNV Gain 19166990
nsv818212 CNV Gain 17921354
nsv878632 CNV Loss 21882294
dgv645n27 CNV Gain 19166990
nsv818213 CNV Gain 17921354
dgv1575e1 CNV Complex 17122850
dgv1576e1 CNV Complex 17122850
dgv1577e1 CNV Complex 17122850
dgv5469n71 CNV Gain 21882294
essv7894 CNV CNV 17122850
nsv878655 CNV Gain 21882294
nsv469529 CNV Loss 16826518
nsv878657 CNV Gain+Loss 21882294
nsv878660 CNV Loss 21882294
dgv5470n71 CNV Gain 21882294
nsv469611 CNV Complex 16826518
nsv442891 CNV CNV 18776908
nsv878662 CNV Gain 21882294
nsv4228 CNV Loss 18451855
nsv10445 CNV Gain 18304495
nsv508273 CNV Loss 20534489
esv1163601 CNV Insertion 17803354
dgv5471n71 CNV Gain 21882294
nsv525830 CNV Loss 19592680

Relevant External Links for DEFB131 Gene

HapMap Linkage Disequilibrium report
DEFB131

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB131 Gene

Disorders for DEFB131 Gene

No disorders were found for DEFB131 Gene.

No data available for UniProtKB/Swiss-Prot for DEFB131 Gene

Publications for DEFB131 Gene

  1. ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes. (PMID: 12600824) Kao C.Y. … Wu R. (Am. J. Respir. Cell Mol. Biol. 2003) 2 3 4
  2. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil A.A. … Zhang G. (Physiol. Genomics 2005) 2 3
  3. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte B.C. … McCray P.B. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for DEFB131 Gene

Sources for DEFB131 Gene

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