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Aliases for DEFB129 Gene

Aliases for DEFB129 Gene

  • Defensin, Beta 129 2 3 4
  • Beta-Defensin 29 3 4
  • C20orf87 3 4
  • DEFB-29 3 4
  • DEFB29 3 4
  • Chromosome 20 Open Reading Frame 87 2
  • Beta-Defensin 129 3
  • Beta Defensin 29 3
  • BA530N10.3 3
  • HBD-29 3

External Ids for DEFB129 Gene

Previous HGNC Symbols for DEFB129 Gene

  • C20orf87

Previous GeneCards Identifiers for DEFB129 Gene

  • GC20P000195
  • GC20P000202
  • GC20P000155
  • GC20P000215

Summaries for DEFB129 Gene

Entrez Gene Summary for DEFB129 Gene

  • Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]

GeneCards Summary for DEFB129 Gene

DEFB129 (Defensin, Beta 129) is a Protein Coding gene. Among its related pathways are Defensins and Defensins.

UniProtKB/Swiss-Prot for DEFB129 Gene

  • Has antibacterial activity.

Gene Wiki entry for DEFB129 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB129 Gene

Genomics for DEFB129 Gene

Regulatory Elements for DEFB129 Gene

Genomic Location for DEFB129 Gene

227,258 bp from pter
229,886 bp from pter
2,629 bases
Plus strand

Genomic View for DEFB129 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB129 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB129 Gene

Proteins for DEFB129 Gene

  • Protein details for DEFB129 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-defensin 129
    Protein Accession:
    Secondary Accessions:
    • Q8NES7

    Protein attributes for DEFB129 Gene

    183 amino acids
    Molecular mass:
    20299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB129 Gene

Proteomics data for DEFB129 Gene at MOPED

Post-translational modifications for DEFB129 Gene

No Post-translational modifications

Other Protein References for DEFB129 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB129 Gene

Domains for DEFB129 Gene

Gene Families for DEFB129 Gene

  • DEFB :Defensins, beta

Protein Domains for DEFB129 Gene


Suggested Antigen Peptide Sequences for DEFB129 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H1M3
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB129: view

Function for DEFB129 Gene

Molecular function for DEFB129 Gene

UniProtKB/Swiss-Prot Function:
Has antibacterial activity.

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB129

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DEFB129 Gene

Localization for DEFB129 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB129 Gene


Subcellular locations from

Jensen Localization Image for DEFB129 Gene COMPARTMENTS Subcellular localization image for DEFB129 gene
Compartment Confidence
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for DEFB129 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB129: view

Pathways for DEFB129 Gene

SuperPathways for DEFB129 Gene

Superpath Contained pathways
1 Defensins
genes like me logo Genes that share pathways with DEFB129: view

Pathways by source for DEFB129 Gene

2 Reactome pathways for DEFB129 Gene

Interacting Proteins for DEFB129 Gene

Gene Ontology (GO) - Biological Process for DEFB129 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB129: view

Transcripts for DEFB129 Gene

mRNA/cDNA for DEFB129 Gene

(13) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEFB129 Gene

Defensin, beta 129:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB129

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB129 Gene

No ASD Table

Relevant External Links for DEFB129 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEFB129 Gene

mRNA expression in normal human tissues for DEFB129 Gene

SOURCE GeneReport for Unigene cluster for DEFB129 Gene Hs.112087

mRNA Expression by UniProt/SwissProt for DEFB129 Gene

Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expressions with DEFB129: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for DEFB129 Gene

Orthologs for DEFB129 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DEFB129 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BBD129 35
  • 79.05 (n)
  • 64 (a)
DEFB129 36
  • 64 (a)
(Canis familiaris)
Mammalia DEFB129 35
  • 78.64 (n)
  • 63.54 (a)
CBD129 36
  • 63 (a)
(Mus musculus)
Mammalia Defb23 35
  • 67.09 (n)
  • 47.77 (a)
Defb23 16
Defb23 36
  • 46 (a)
(Pan troglodytes)
Mammalia DEFB129 35
  • 100 (n)
  • 100 (a)
DEFB129 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Defb23 35
  • 66.23 (n)
  • 46.75 (a)
Species with no ortholog for DEFB129:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB129 Gene

Gene Tree for DEFB129 (if available)
Gene Tree for DEFB129 (if available)

Paralogs for DEFB129 Gene

No data available for Paralogs for DEFB129 Gene

Variants for DEFB129 Gene

Sequence variations from dbSNP and Humsavar for DEFB129 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1053783 - 229,665(+) TAACA(C/G)CAAAG reference, missense
rs2164169 -- 225,761(-) TGGTC(A/G)TAGCT upstream-variant-2KB
rs2298148 -- 227,262(-) CCTTG(A/G)ATCTG utr-variant-5-prime
rs2298149 -- 227,248(-) TGATG(C/T)TCCTG upstream-variant-2KB
rs4813167 -- 226,775(+) GGCGG(A/T)TCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DEFB129 Gene

Variant ID Type Subtype PubMed ID
esv2751910 CNV Loss 17911159
nsv912554 CNV Gain 21882294
dgv65n68 CNV Loss 17160897
nsv469544 CNV Loss 16826518
nsv458837 CNV Gain 19166990

Relevant External Links for DEFB129 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB129 Gene

Disorders for DEFB129 Gene

Relevant External Links for DEFB129

Genetic Association Database (GAD)

No disorders were found for DEFB129 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DEFB129 Gene

Publications for DEFB129 Gene

  1. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte B.C. … McCray P.B. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes. (PMID: 12600824) Kao C.Y. … Wu R. (Am. J. Respir. Cell Mol. Biol. 2003) 3 4
  4. Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis. (PMID: 12620395) Rodriguez-Jimenez F.-J. … Motzkus D. (Genomics 2003) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for DEFB129 Gene

Sources for DEFB129 Gene

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