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Aliases for DEFB128 Gene

Aliases for DEFB128 Gene

  • Defensin, Beta 128 2 3 4
  • Beta-Defensin 28 3 4
  • DEFB-28 3 4
  • DEFB28 3 4
  • Beta-Defensin 128 3
  • Defensin, Beta 28 3
  • Defensin 2
  • Beta 28 2
  • HBD-28 3

External Ids for DEFB128 Gene

Previous GeneCards Identifiers for DEFB128 Gene

  • GC20U990241
  • GC20M000117
  • GC20M000168

Summaries for DEFB128 Gene

Entrez Gene Summary for DEFB128 Gene

  • Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]

GeneCards Summary for DEFB128 Gene

DEFB128 (Defensin, Beta 128) is a Protein Coding gene. Among its related pathways are Defensins and Defensins.

UniProtKB/Swiss-Prot for DEFB128 Gene

  • Has antibacterial activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB128 Gene

Genomics for DEFB128 Gene

Regulatory Elements for DEFB128 Gene

Genomic Location for DEFB128 Gene

Start:
187,853 bp from pter
End:
189,681 bp from pter
Size:
1,829 bases
Orientation:
Minus strand

Genomic View for DEFB128 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB128 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB128 Gene

Proteins for DEFB128 Gene

  • Protein details for DEFB128 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7B8-DB128_HUMAN
    Recommended name:
    Beta-defensin 128
    Protein Accession:
    Q7Z7B8
    Secondary Accessions:
    • B2RU29

    Protein attributes for DEFB128 Gene

    Size:
    93 amino acids
    Molecular mass:
    10650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB128 Gene

Proteomics data for DEFB128 Gene at MOPED

Post-translational modifications for DEFB128 Gene

No Post-translational modifications

Other Protein References for DEFB128 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB128 Gene

Domains for DEFB128 Gene

Gene Families for DEFB128 Gene

HGNC:
  • DEFB :Defensins, beta

Protein Domains for DEFB128 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEFB128 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7B8

UniProtKB/Swiss-Prot:

DB128_HUMAN :
  • Q7Z7B8
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB128: view

Function for DEFB128 Gene

Molecular function for DEFB128 Gene

UniProtKB/Swiss-Prot Function: Has antibacterial activity.

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB128

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DEFB128 Gene

Localization for DEFB128 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB128 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEFB128 Gene COMPARTMENTS Subcellular localization image for DEFB128 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for DEFB128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB128: view

Pathways for DEFB128 Gene

SuperPathways for DEFB128 Gene

Superpath Contained pathways
1 Defensins
.80
genes like me logo Genes that share pathways with DEFB128: view

Pathways by source for DEFB128 Gene

2 Reactome pathways for DEFB128 Gene

Interacting Proteins for DEFB128 Gene

Gene Ontology (GO) - Biological Process for DEFB128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB128: view

Transcripts for DEFB128 Gene

mRNA/cDNA for DEFB128 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB128

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DEFB128
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB128 Gene

No ASD Table

Relevant External Links for DEFB128 Gene

GeneLoc Exon Structure for
DEFB128
ECgene alternative splicing isoforms for
DEFB128

Expression for DEFB128 Gene

mRNA expression in normal human tissues for DEFB128 Gene

SOURCE GeneReport for Unigene cluster for DEFB128 Gene Hs.516818

genes like me logo Genes that share expressions with DEFB128: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for DEFB128 Gene

Orthologs for DEFB128 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DEFB128 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CBD128 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Defb20 16
Defb20 36
  • 39 (a)
OneToOne
Species with no ortholog for DEFB128:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB128 Gene

ENSEMBL:
Gene Tree for DEFB128 (if available)
TreeFam:
Gene Tree for DEFB128 (if available)

Paralogs for DEFB128 Gene

Selected SIMAP similar genes for DEFB128 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB128: view

No data available for Paralogs for DEFB128 Gene

Variants for DEFB128 Gene

Sequence variations from dbSNP and Humsavar for DEFB128 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs722829 -- 189,060(-) AAGCA(C/T)GAAGC intron-variant
rs1342136 -- 187,439(+) agagg(A/G)gaaag downstream-variant-500B
rs1469781 -- 190,001(-) GTAGC(C/T)GGATG upstream-variant-2KB
rs1469782 -- 189,948(-) ACCCA(A/G)GGCCC upstream-variant-2KB
rs4813041 -- 187,766(+) TTATT(A/G)TGTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DEFB128 Gene

Variant ID Type Subtype PubMed ID
dgv4506n71 CNV Gain 21882294
esv2751910 CNV Loss 17911159
nsv912554 CNV Gain 21882294
dgv65n68 CNV Loss 17160897
nsv469544 CNV Loss 16826518
dgv4507n71 CNV Gain 21882294
nsv510776 CNV Loss 20534489
nsv912557 CNV Gain 21882294

Relevant External Links for DEFB128 Gene

HapMap Linkage Disequilibrium report
DEFB128

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB128 Gene

Disorders for DEFB128 Gene

No disorders were found for DEFB128 Gene.

No data available for UniProtKB/Swiss-Prot for DEFB128 Gene

Publications for DEFB128 Gene

  1. Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis. (PMID: 12620395) Rodriguez-Jimenez F.-J. … Motzkus D. (Genomics 2003) 3 4
  2. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil A.A. … Zhang G. (Physiol. Genomics 2005) 2 3
  3. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte B.C. … McCray P.B. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for DEFB128 Gene

Sources for DEFB128 Gene

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