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Aliases for DEFB125 Gene

Aliases for DEFB125 Gene

  • Defensin, Beta 125 2 3 4
  • Beta Defensin 25 2 3
  • Beta-Defensin 25 3 4
  • DEFB-25 3 4
  • Beta-Defensin 125 3
  • DEFB25 4

External Ids for DEFB125 Gene

Previous GeneCards Identifiers for DEFB125 Gene

  • GC20U990240

Summaries for DEFB125 Gene

Entrez Gene Summary for DEFB125 Gene

  • Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]

GeneCards Summary for DEFB125 Gene

DEFB125 (Defensin, Beta 125) is a Protein Coding gene. Among its related pathways are Defensins and Defensins.

UniProtKB/Swiss-Prot for DEFB125 Gene

  • Has antibacterial activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB125 Gene

Genomics for DEFB125 Gene

Regulatory Elements for DEFB125 Gene

Genomic Location for DEFB125 Gene

87,250 bp from pter
97,094 bp from pter
9,845 bases
Plus strand

Genomic View for DEFB125 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB125 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB125 Gene

Proteins for DEFB125 Gene

  • Protein details for DEFB125 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-defensin 125
    Protein Accession:
    Secondary Accessions:
    • A1A502
    • Q7Z7B9

    Protein attributes for DEFB125 Gene

    156 amino acids
    Molecular mass:
    17537 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB125 Gene

Proteomics data for DEFB125 Gene at MOPED

Post-translational modifications for DEFB125 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEFB125 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB125 Gene

Domains for DEFB125 Gene

Gene Families for DEFB125 Gene

Protein Domains for DEFB125 Gene


Suggested Antigen Peptide Sequences for DEFB125 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta-defensin family.
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB125: view

Function for DEFB125 Gene

Molecular function for DEFB125 Gene

UniProtKB/Swiss-Prot Function:
Has antibacterial activity.

Phenotypes for DEFB125 Gene

GenomeRNAi human phenotypes for DEFB125:
genes like me logo Genes that share phenotypes with DEFB125: view

miRNA for DEFB125 Gene

miRTarBase miRNAs that target DEFB125

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB125

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DEFB125 Gene

Localization for DEFB125 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB125 Gene


Subcellular locations from

Jensen Localization Image for DEFB125 Gene COMPARTMENTS Subcellular localization image for DEFB125 gene
Compartment Confidence
extracellular 3
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DEFB125 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB125: view

Pathways for DEFB125 Gene

SuperPathways for DEFB125 Gene

Superpath Contained pathways
1 Defensins
genes like me logo Genes that share pathways with DEFB125: view

Pathways by source for DEFB125 Gene

2 Reactome pathways for DEFB125 Gene

Interacting Proteins for DEFB125 Gene

Gene Ontology (GO) - Biological Process for DEFB125 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB125: view

Transcripts for DEFB125 Gene

mRNA/cDNA for DEFB125 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEFB125 Gene

Defensin, beta 125:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB125

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB125 Gene

No ASD Table

Relevant External Links for DEFB125 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEFB125 Gene

mRNA expression in normal human tissues for DEFB125 Gene

mRNA differential expression in normal tissues according to GTEx for DEFB125 Gene

This gene is overexpressed in Testis (38.6), Bladder (7.5), and Cervix - Endocervix (6.9).

Protein differential expression in normal tissues for DEFB125 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DEFB125 Gene

SOURCE GeneReport for Unigene cluster for DEFB125 Gene Hs.380220

genes like me logo Genes that share expressions with DEFB125: view

Expression partners for DEFB125 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DEFB125 Gene

Orthologs for DEFB125 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DEFB125 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia DEFB125 35
  • 69.57 (n)
  • 52.17 (a)
CBD125 36
  • 50 (a)
(Pan troglodytes)
Mammalia DEFB125 35
  • 98.08 (n)
  • 95.51 (a)
DEFB125 36
  • 93 (a)
(Mus musculus)
Mammalia Defb26 16
Defb26 36
  • 27 (a)
Species with no ortholog for DEFB125:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB125 Gene

Gene Tree for DEFB125 (if available)
Gene Tree for DEFB125 (if available)

Paralogs for DEFB125 Gene

(2) SIMAP similar genes for DEFB125 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB125: view

No data available for Paralogs for DEFB125 Gene

Variants for DEFB125 Gene

Sequence variations from dbSNP and Humsavar for DEFB125 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs892665 -- 94,613(+) gttca(A/C)ctttt intron-variant
rs6033515 -- 92,053(+) TGAGC(C/T)TAata intron-variant
rs6033543 -- 92,180(+) AGAGC(C/T)TTATC intron-variant
rs6040382 -- 90,438(+) TCTCG(C/T)CACCT intron-variant
rs6041286 -- 91,639(+) ATAGC(C/T)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB125 Gene

Variant ID Type Subtype PubMed ID
nsv912549 CNV Loss 21882294
dgv4505n71 CNV Gain 21882294
dgv4506n71 CNV Gain 21882294
esv2751910 CNV Loss 17911159

Relevant External Links for DEFB125 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB125 Gene

Disorders for DEFB125 Gene

Relevant External Links for DEFB125

Genetic Association Database (GAD)

No disorders were found for DEFB125 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DEFB125 Gene

Publications for DEFB125 Gene

  1. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte B.C. … McCray P.B. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis. (PMID: 12620395) Rodriguez-Jimenez F.-J. … Motzkus D. (Genomics 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DEFB125 Gene

Sources for DEFB125 Gene

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