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Aliases for DEFB115 Gene

Aliases for DEFB115 Gene

  • Defensin Beta 115 2 3 5
  • Defensin, Beta 115 2 4
  • Beta-Defensin 15 3 4
  • DEFB-15 3 4
  • Beta-Defensin 115 3
  • Defensin, Beta 15 3
  • DEFB15 4

External Ids for DEFB115 Gene

Previous GeneCards Identifiers for DEFB115 Gene

  • GC20U990231
  • GC20P029309
  • GC20P029845
  • GC20P026634

Summaries for DEFB115 Gene

Entrez Gene Summary for DEFB115 Gene

  • Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]

GeneCards Summary for DEFB115 Gene

DEFB115 (Defensin Beta 115) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System.

UniProtKB/Swiss-Prot for DEFB115 Gene

  • Has antibacterial activity.

Additional gene information for DEFB115 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB115 Gene

Genomics for DEFB115 Gene

Regulatory Elements for DEFB115 Gene

Enhancers for DEFB115 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H031245 0.4 FANTOM5 0.4 -11.8 -11817 0 SREBF1 LINC01597 DEFB116 DEFB121 GC20M031241 DEFB115
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DEFB115 on UCSC Golden Path with GeneCards custom track

Genomic Location for DEFB115 Gene

31,257,664 bp from pter
31,259,632 bp from pter
1,969 bases
Plus strand

Genomic View for DEFB115 Gene

Genes around DEFB115 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEFB115 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEFB115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB115 Gene

Proteins for DEFB115 Gene

  • Protein details for DEFB115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-defensin 115
    Protein Accession:

    Protein attributes for DEFB115 Gene

    88 amino acids
    Molecular mass:
    10071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB115 Gene

Post-translational modifications for DEFB115 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEFB115 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB115 Gene

Domains & Families for DEFB115 Gene

Gene Families for DEFB115 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DEFB115 Gene


Suggested Antigen Peptide Sequences for DEFB115 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta-defensin family.
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB115: view

Function for DEFB115 Gene

Molecular function for DEFB115 Gene

UniProtKB/Swiss-Prot Function:
Has antibacterial activity.
genes like me logo Genes that share phenotypes with DEFB115: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DEFB115
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DEFB115 Gene

Localization for DEFB115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB115 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEFB115 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for DEFB115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB115: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DEFB115 Gene

Pathways & Interactions for DEFB115 Gene

genes like me logo Genes that share pathways with DEFB115: view

Pathways by source for DEFB115 Gene

Interacting Proteins for DEFB115 Gene

Gene Ontology (GO) - Biological Process for DEFB115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IEA --
GO:0042742 defense response to bacterium IBA,IEA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB115: view

No data available for SIGNOR curated interactions for DEFB115 Gene

Drugs & Compounds for DEFB115 Gene

No Compound Related Data Available

Transcripts for DEFB115 Gene

mRNA/cDNA for DEFB115 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DEFB115
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB115 Gene

No ASD Table

Relevant External Links for DEFB115 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEFB115 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEFB115 Gene

NURSA nuclear receptor signaling pathways regulating expression of DEFB115 Gene:


SOURCE GeneReport for Unigene cluster for DEFB115 Gene:

genes like me logo Genes that share expression patterns with DEFB115: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEFB115 Gene

Orthologs for DEFB115 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for DEFB115 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEFB115 33 34
  • 98.86 (n)
(Mus musculus)
Mammalia Defb28 34
  • 48 (a)
Species where no ortholog for DEFB115 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB115 Gene

Gene Tree for DEFB115 (if available)
Gene Tree for DEFB115 (if available)

Paralogs for DEFB115 Gene

(8) SIMAP similar genes for DEFB115 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB115: view

No data available for Paralogs for DEFB115 Gene

Variants for DEFB115 Gene

Sequence variations from dbSNP and Humsavar for DEFB115 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000107068 -- 31,255,823(+) TCAAT(C/T)CTATG upstream-variant-2KB
rs1000209091 -- 31,259,437(+) ATATT(C/T)ATGTG intron-variant
rs1001513599 -- 31,257,860(+) CCACA(G/T)GGATG intron-variant
rs1002055837 -- 31,258,036(+) TCTAG(C/T)ATCCT intron-variant
rs1002303902 -- 31,258,859(+) GTGCT(C/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB115 Gene

Variant ID Type Subtype PubMed ID
dgv4298n100 CNV gain 25217958
dgv4299n100 CNV gain 25217958
dgv4300n100 CNV gain 25217958
esv2763228 CNV gain 21179565
esv3645643 CNV gain 21293372
esv3645644 CNV loss 21293372
esv3645645 CNV gain 21293372
nsv458960 CNV gain 19166990
nsv470546 CNV gain 18288195
nsv585909 CNV gain 21841781
nsv833951 CNV gain+loss 17160897
nsv964448 CNV duplication 23825009

Variation tolerance for DEFB115 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEFB115 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB115 Gene

Disorders for DEFB115 Gene

Relevant External Links for DEFB115

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DEFB115 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEFB115 Gene

Publications for DEFB115 Gene

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil AA … Zhang G (Physiological genomics 2005) 2 3 4 60
  2. Discovery of five conserved beta -defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte BC … McCray PB (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60

Products for DEFB115 Gene

Sources for DEFB115 Gene

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