Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DEFB115 Gene

Aliases for DEFB115 Gene

  • Defensin, Beta 115 2 3 4
  • Beta-Defensin 15 3 4
  • DEFB-15 3 4
  • Beta-Defensin 115 3
  • Defensin, Beta 15 3
  • DEFB15 4

External Ids for DEFB115 Gene

Previous GeneCards Identifiers for DEFB115 Gene

  • GC20U990231
  • GC20P029309
  • GC20P029845
  • GC20P026634

Summaries for DEFB115 Gene

Entrez Gene Summary for DEFB115 Gene

  • Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]

GeneCards Summary for DEFB115 Gene

DEFB115 (Defensin, Beta 115) is a Protein Coding gene. Among its related pathways are Defensins and Defensins.

UniProtKB/Swiss-Prot for DEFB115 Gene

  • Has antibacterial activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB115 Gene

Genomics for DEFB115 Gene

Regulatory Elements for DEFB115 Gene

Genomic Location for DEFB115 Gene

Start:
31,257,664 bp from pter
End:
31,259,632 bp from pter
Size:
1,969 bases
Orientation:
Plus strand

Genomic View for DEFB115 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB115 Gene

Proteins for DEFB115 Gene

  • Protein details for DEFB115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q30KQ5-DB115_HUMAN
    Recommended name:
    Beta-defensin 115
    Protein Accession:
    Q30KQ5
    Secondary Accessions:

    Protein attributes for DEFB115 Gene

    Size:
    88 amino acids
    Molecular mass:
    10071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB115 Gene

Proteomics data for DEFB115 Gene at MOPED

Post-translational modifications for DEFB115 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEFB115 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB115 Gene

Domains for DEFB115 Gene

Gene Families for DEFB115 Gene

HGNC:
  • DEFB :Defensins, beta

Protein Domains for DEFB115 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DEFB115 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q30KQ5

UniProtKB/Swiss-Prot:

DB115_HUMAN :
  • Q30KQ5
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB115: view

Function for DEFB115 Gene

Molecular function for DEFB115 Gene

UniProtKB/Swiss-Prot Function: Has antibacterial activity.

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB115

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DEFB115 Gene

Localization for DEFB115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB115 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEFB115 Gene COMPARTMENTS Subcellular localization image for DEFB115 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for DEFB115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB115: view

Pathways for DEFB115 Gene

SuperPathways for DEFB115 Gene

Superpath Contained pathways
1 Defensins
.80
genes like me logo Genes that share pathways with DEFB115: view

Pathways by source for DEFB115 Gene

2 Reactome pathways for DEFB115 Gene

Interacting Proteins for DEFB115 Gene

Gene Ontology (GO) - Biological Process for DEFB115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB115: view

Transcripts for DEFB115 Gene

mRNA/cDNA for DEFB115 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB115

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DEFB115
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB115 Gene

No ASD Table

Relevant External Links for DEFB115 Gene

GeneLoc Exon Structure for
DEFB115
ECgene alternative splicing isoforms for
DEFB115

Expression for DEFB115 Gene

mRNA expression in normal human tissues for DEFB115 Gene

SOURCE GeneReport for Unigene cluster for DEFB115 Gene Hs.580793

genes like me logo Genes that share expressions with DEFB115: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for DEFB115 Gene

Orthologs for DEFB115 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for DEFB115 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEFB115 35
  • 98.86 (n)
  • 98.86 (a)
DEFB115 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Defb28 16
Defb28 36
  • 48 (a)
OneToOne
Species with no ortholog for DEFB115:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB115 Gene

ENSEMBL:
Gene Tree for DEFB115 (if available)
TreeFam:
Gene Tree for DEFB115 (if available)

Paralogs for DEFB115 Gene

Selected SIMAP similar genes for DEFB115 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB115: view

No data available for Paralogs for DEFB115 Gene

Variants for DEFB115 Gene

Sequence variations from dbSNP and Humsavar for DEFB115 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1474945 -- 31,258,599(+) CTTAT(A/G)TTCCA intron-variant
rs2376540 -- 31,258,601(+) TATGT(G/T)CCAGC intron-variant
rs4911481 -- 31,255,906(+) TGTGT(C/G)CCTTT upstream-variant-2KB
rs4911482 -- 31,255,925(+) CACCC(A/G)CACAC upstream-variant-2KB
rs6060436 -- 31,258,500(+) GGAGC(A/G)GCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB115 Gene

Variant ID Type Subtype PubMed ID
nsv833951 CNV Gain+Loss 17160897
nsv458960 CNV Gain 19166990
nsv470546 CNV Gain 18288195

Relevant External Links for DEFB115 Gene

HapMap Linkage Disequilibrium report
DEFB115

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB115 Gene

Disorders for DEFB115 Gene

No disorders were found for DEFB115 Gene.

No data available for UniProtKB/Swiss-Prot for DEFB115 Gene

Publications for DEFB115 Gene

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil A.A. … Zhang G. (Physiol. Genomics 2005) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte B.C. … McCray P.B. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for DEFB115 Gene

Sources for DEFB115 Gene

Back to Top

Content