Aliases for DEFB114 Gene
External Ids for DEFB114 Gene
Previous GeneCards Identifiers for DEFB114 Gene
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. The protein encoded by this gene is a beta-defensin with antimicrobial activity against E. coli, S. aureus, and C. albicans. The encoded protein also binds and neutralizes lipopolysaccharide (LPS), a factor involved in inflammatory diseases and male reproductive issues. [provided by RefSeq, Nov 2014]
GeneCards Summary for DEFB114 Gene
DEFB114 (Defensin Beta 114) is a Protein Coding gene. Diseases associated with DEFB114 include Autosomal Recessive Congenital Ichthyosis. Among its related pathways are Defensins and Innate Immune System. GO annotations related to this gene include lipopolysaccharide binding.
UniProtKB/Swiss-Prot for DEFB114 Gene
Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality.