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Aliases for DEFB110 Gene

Aliases for DEFB110 Gene

  • Defensin, Beta 110 2 3 4
  • Defensin, Beta 110 Locus 2 3
  • Beta-Defensin 111 3 4
  • Beta-Defensin 10 3 4
  • Beta-Defensin 11 3 4
  • DEFB-10 3 4
  • DEFB-11 3 4
  • DEFB111 3 4
  • Defensin, Beta 111 4
  • Beta-Defensin 110 3
  • Defensin, Beta 10 3
  • DEFB10 4
  • DEFB11 4

External Ids for DEFB110 Gene

Previous GeneCards Identifiers for DEFB110 Gene

  • GC06U990313
  • GC06M050084
  • GC06M049708

Summaries for DEFB110 Gene

Entrez Gene Summary for DEFB110 Gene

  • Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

GeneCards Summary for DEFB110 Gene

DEFB110 (Defensin, Beta 110) is a Protein Coding gene. Among its related pathways are Defensins and Defensins.

UniProtKB/Swiss-Prot for DEFB110 Gene

  • Has antibacterial activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB110 Gene

Genomics for DEFB110 Gene

Regulatory Elements for DEFB110 Gene

Genomic Location for DEFB110 Gene

Start:
50,009,138 bp from pter
End:
50,021,981 bp from pter
Size:
12,844 bases
Orientation:
Minus strand

Genomic View for DEFB110 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB110 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB110 Gene

Proteins for DEFB110 Gene

  • Protein details for DEFB110 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q30KQ9-DB110_HUMAN
    Recommended name:
    Beta-defensin 110
    Protein Accession:
    Q30KQ9
    Secondary Accessions:
    • Q30KR0

    Protein attributes for DEFB110 Gene

    Size:
    67 amino acids
    Molecular mass:
    8001 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DEFB110 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEFB110 Gene

Proteomics data for DEFB110 Gene at MOPED

Post-translational modifications for DEFB110 Gene

No Post-translational modifications

Other Protein References for DEFB110 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB110 Gene

Domains for DEFB110 Gene

Gene Families for DEFB110 Gene

HGNC:
  • DEFB :Defensins, beta

Protein Domains for DEFB110 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DEFB110 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q30KQ9

UniProtKB/Swiss-Prot:

DB110_HUMAN :
  • Q30KQ9
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB110: view

Function for DEFB110 Gene

Molecular function for DEFB110 Gene

UniProtKB/Swiss-Prot Function: Has antibacterial activity.

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB110

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DEFB110 Gene

Localization for DEFB110 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB110 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEFB110 Gene COMPARTMENTS Subcellular localization image for DEFB110 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for DEFB110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DEFB110: view

Pathways for DEFB110 Gene

SuperPathways for DEFB110 Gene

Superpath Contained pathways
1 Defensins
.80
genes like me logo Genes that share pathways with DEFB110: view

Pathways by source for DEFB110 Gene

2 Reactome pathways for DEFB110 Gene

Interacting Proteins for DEFB110 Gene

Gene Ontology (GO) - Biological Process for DEFB110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with DEFB110: view

Transcripts for DEFB110 Gene

mRNA/cDNA for DEFB110 Gene

(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEFB110 Gene

Defensin, beta 110 locus:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB110

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB110 Gene

No ASD Table

Relevant External Links for DEFB110 Gene

GeneLoc Exon Structure for
DEFB110
ECgene alternative splicing isoforms for
DEFB110

Expression for DEFB110 Gene

mRNA expression in normal human tissues for DEFB110 Gene

SOURCE GeneReport for Unigene cluster for DEFB110 Gene Hs.571093

genes like me logo Genes that share expressions with DEFB110: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for DEFB110 Gene

Orthologs for DEFB110 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DEFB110 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEFB110 35
  • 98.01 (n)
  • 94.03 (a)
DEFB110 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DEFB110 35
  • 83.08 (n)
  • 70.15 (a)
dog
(Canis familiaris)
Mammalia CBD111 36
  • 78 (a)
OneToOne
DEFB110 35
  • 87.56 (n)
  • 77.61 (a)
mouse
(Mus musculus)
Mammalia Gm15386 16
Gm15386 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Defb17 35
  • 83.59 (n)
  • 70.77 (a)
Species with no ortholog for DEFB110:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB110 Gene

ENSEMBL:
Gene Tree for DEFB110 (if available)
TreeFam:
Gene Tree for DEFB110 (if available)

Paralogs for DEFB110 Gene

Selected SIMAP similar genes for DEFB110 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB110: view

No data available for Paralogs for DEFB110 Gene

Variants for DEFB110 Gene

Sequence variations from dbSNP and Humsavar for DEFB110 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs594927 -- 50,019,568(+) AGAGC(A/T)AGGCA intron-variant
rs596450 -- 50,019,908(+) GCAGA(A/C)ACACC intron-variant
rs600168 -- 50,014,245(-) TGTTA(C/T)ATATG intron-variant
rs614058 -- 50,013,522(+) GATGA(G/T)ATTTT intron-variant
rs627990 -- 50,014,335(+) TATGG(A/G)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB110 Gene

Variant ID Type Subtype PubMed ID
nsv5295 CNV Loss 18451855

Relevant External Links for DEFB110 Gene

HapMap Linkage Disequilibrium report
DEFB110

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB110 Gene

Disorders for DEFB110 Gene

Relevant External Links for DEFB110

Genetic Association Database (GAD)
DEFB110
genes like me logo Genes that share disorders with DEFB110: view

No data available for UniProtKB/Swiss-Prot for DEFB110 Gene

Publications for DEFB110 Gene

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil A.A. … Zhang G. (Physiol. Genomics 2005) 2 3 4
  2. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte B.C. … McCray P.B. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4

Products for DEFB110 Gene

Sources for DEFB110 Gene

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