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Aliases for DEFB108B Gene

Aliases for DEFB108B Gene

  • Defensin, Beta 108B 2 3 4
  • Beta-Defensin 8 3 4
  • DEFB-8 3 4
  • HBD-8 3 4
  • Beta-Defensin 108B 3
  • Defensin, Beta 108 4
  • Defensin, Beta 8 3
  • DEFB108 4
  • DEFB8 4
  • BD-8 4

External Ids for DEFB108B Gene

Summaries for DEFB108B Gene

Entrez Gene Summary for DEFB108B Gene

  • Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. A pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Oct 2014]

GeneCards Summary for DEFB108B Gene

DEFB108B (Defensin, Beta 108B) is a Protein Coding gene. Among its related pathways are Defensins and Defensins.

UniProtKB/Swiss-Prot for DEFB108B Gene

  • Has antibacterial activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB108B Gene

Genomics for DEFB108B Gene

Genomic Location for DEFB108B Gene

Start:
71,833,200 bp from pter
End:
71,837,710 bp from pter
Size:
4,511 bases
Orientation:
Plus strand

Genomic View for DEFB108B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB108B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB108B Gene

Regulatory Elements for DEFB108B Gene

Proteins for DEFB108B Gene

  • Protein details for DEFB108B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NET1-D108B_HUMAN
    Recommended name:
    Beta-defensin 108B
    Protein Accession:
    Q8NET1
    Secondary Accessions:

    Protein attributes for DEFB108B Gene

    Size:
    73 amino acids
    Molecular mass:
    8326 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB108B Gene

Proteomics data for DEFB108B Gene at MOPED

Post-translational modifications for DEFB108B Gene

No Post-translational modifications

Other Protein References for DEFB108B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB108B Gene

Domains for DEFB108B Gene

Gene Families for DEFB108B Gene

HGNC:
  • DEFB :Defensins, beta

Protein Domains for DEFB108B Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

D108B_HUMAN
Family:
  • Belongs to the beta-defensin family.:
    • Q8NET1
genes like me logo Genes that share domains with DEFB108B: view

Function for DEFB108B Gene

Molecular function for DEFB108B Gene

UniProtKB/Swiss-Prot Function: Has antibacterial activity.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DEFB108B Gene

Localization for DEFB108B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB108B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEFB108B Gene COMPARTMENTS Subcellular localization image for DEFB108B gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DEFB108B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB108B: view

Pathways for DEFB108B Gene

SuperPathways for DEFB108B Gene

Superpath Contained pathways
1 Defensins
.80
genes like me logo Genes that share pathways with DEFB108B: view

Pathways by source for DEFB108B Gene

2 Reactome pathways for DEFB108B Gene

Interacting Proteins for DEFB108B Gene

Gene Ontology (GO) - Biological Process for DEFB108B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB108B: view

Transcripts for DEFB108B Gene

mRNA/cDNA for DEFB108B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEFB108B Gene

Defensin, beta 108B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB108B Gene

No ASD Table

Relevant External Links for DEFB108B Gene

GeneLoc Exon Structure for
DEFB108B
ECgene alternative splicing isoforms for
DEFB108B

Expression for DEFB108B Gene

mRNA expression in normal human tissues for DEFB108B Gene

SOURCE GeneReport for Unigene cluster for DEFB108B Gene Hs.555032

mRNA Expression by UniProt/SwissProt for DEFB108B Gene

Q8NET1-D108B_HUMAN
Tissue specificity: Specifically expressed in testis. Low expression is detected also in liver.
genes like me logo Genes that share expressions with DEFB108B: view

Orthologs for DEFB108B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DEFB108B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEFB108B 36
  • 84.8 (n)
  • 79.41 (a)
DEFB108B 37
  • 96 (a)
OneToOne
Species with no ortholog for DEFB108B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB108B Gene

ENSEMBL:
Gene Tree for DEFB108B (if available)
TreeFam:
Gene Tree for DEFB108B (if available)

Paralogs for DEFB108B Gene

Selected SIMAP similar genes for DEFB108B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB108B: view

No data available for Paralogs for DEFB108B Gene

Variants for DEFB108B Gene

Sequence variations from dbSNP and Humsavar for DEFB108B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1945051 -- 71,835,300(+) gcact(C/T)attgc intron-variant
rs1945052 -- 71,835,409(+) AAAAA(A/G)ACACA intron-variant
rs1945054 -- 71,836,719(+) AAAAT(G/T)GCAAC intron-variant
rs1955061 -- 71,833,984(+) CCAAA(A/G)TAGAT intron-variant
rs4122047 -- 71,834,040(+) TAAGC(A/C)ACTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB108B Gene

Variant ID Type Subtype PubMed ID
dgv223e199 CNV Deletion 23128226
esv2744758 CNV Deletion 23290073
dgv1219n71 CNV Gain 21882294
dgv396e1 CNV Complex 17122850
nsv428262 CNV Gain+Loss 18775914
dgv1220n71 CNV Loss 21882294
esv25167 CNV Gain 19812545
nsv8837 CNV Gain+Loss 18304495

Relevant External Links for DEFB108B Gene

HapMap Linkage Disequilibrium report
DEFB108B

Disorders for DEFB108B Gene

Relevant External Links for DEFB108B

Genetic Association Database (GAD)
DEFB108B
Human Genome Epidemiology (HuGE) Navigator
DEFB108B
genes like me logo Genes that share disorders with DEFB108B: view

No data available for UniProtKB/Swiss-Prot for DEFB108B Gene

Publications for DEFB108B Gene

  1. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte B.C. … McCray P.B. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  2. ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes. (PMID: 12600824) Kao C.Y. … Wu R. (Am. J. Respir. Cell Mol. Biol. 2003) 3 4
  3. Duplication and selection in the evolution of primate beta-defensin genes. (PMID: 12734011) Semple C.A.M. … Dorin J.R. (Genome Biol. 2003) 3 4
  4. Copy number variation of defensin genes and HIV infection in Brazilian children. (PMID: 19194307) Milanese M. … Crovella S. (J. Acquir. Immune Defic. Syndr. 2009) 3 49

Products for DEFB108B Gene

Sources for DEFB108B Gene

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