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Aliases for DEFB108B Gene

Aliases for DEFB108B Gene

  • Defensin Beta 108B 2 3 5
  • Defensin, Beta 108B 2 3 4
  • Beta-Defensin 8 3 4
  • DEFB-8 3 4
  • HBD-8 3 4
  • Defensin, Beta 108 4
  • Defensin, Beta 8 3
  • DEFB108 4
  • DEFB8 4
  • BD-8 4

External Ids for DEFB108B Gene

Previous GeneCards Identifiers for DEFB108B Gene

  • GC11P071222
  • GC11U900687
  • GC11P071545
  • GC11P067838

Summaries for DEFB108B Gene

Entrez Gene Summary for DEFB108B Gene

  • Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. A pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Oct 2014]

GeneCards Summary for DEFB108B Gene

DEFB108B (Defensin Beta 108B) is a Protein Coding gene. Among its related pathways are Immune System and Defensins.

UniProtKB/Swiss-Prot for DEFB108B Gene

  • Has antibacterial activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB108B Gene

Genomics for DEFB108B Gene

Regulatory Elements for DEFB108B Gene


Genomic Location for DEFB108B Gene

Chromosome:
11
Start:
71,833,200 bp from pter
End:
71,837,710 bp from pter
Size:
4,511 bases
Orientation:
Plus strand

Genomic View for DEFB108B Gene

Genes around DEFB108B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEFB108B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEFB108B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB108B Gene

Proteins for DEFB108B Gene

  • Protein details for DEFB108B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NET1-D108B_HUMAN
    Recommended name:
    Beta-defensin 108B
    Protein Accession:
    Q8NET1

    Protein attributes for DEFB108B Gene

    Size:
    73 amino acids
    Molecular mass:
    8326 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB108B Gene

Proteomics data for DEFB108B Gene at MOPED

Post-translational modifications for DEFB108B Gene

No Post-translational modifications

Other Protein References for DEFB108B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB108B Gene

Domains & Families for DEFB108B Gene

Gene Families for DEFB108B Gene

Protein Domains for DEFB108B Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEFB108B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NET1

UniProtKB/Swiss-Prot:

D108B_HUMAN :
  • Belongs to the beta-defensin family.
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB108B: view

Function for DEFB108B Gene

Molecular function for DEFB108B Gene

UniProtKB/Swiss-Prot Function:
Has antibacterial activity.

Phenotypes for DEFB108B Gene

GenomeRNAi human phenotypes for DEFB108B:
genes like me logo Genes that share phenotypes with DEFB108B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DEFB108B Gene

Localization for DEFB108B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB108B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEFB108B Gene COMPARTMENTS Subcellular localization image for DEFB108B gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for DEFB108B Gene

Pathways & Interactions for DEFB108B Gene

SuperPathways for DEFB108B Gene

Superpath Contained pathways
1 Defensins
.82
2 Immune System
genes like me logo Genes that share pathways with DEFB108B: view

Pathways by source for DEFB108B Gene

4 Reactome pathways for DEFB108B Gene

Interacting Proteins for DEFB108B Gene

Gene Ontology (GO) - Biological Process for DEFB108B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB108B: view

No data available for SIGNOR curated interactions for DEFB108B Gene

Drugs & Compounds for DEFB108B Gene

No Compound Related Data Available

Transcripts for DEFB108B Gene

mRNA/cDNA for DEFB108B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEFB108B Gene

Defensin, beta 108B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB108B Gene

No ASD Table

Relevant External Links for DEFB108B Gene

GeneLoc Exon Structure for
DEFB108B
ECgene alternative splicing isoforms for
DEFB108B

Expression for DEFB108B Gene

mRNA expression in normal human tissues for DEFB108B Gene

SOURCE GeneReport for Unigene cluster for DEFB108B Gene Hs.555032

mRNA Expression by UniProt/SwissProt for DEFB108B Gene

Q8NET1-D108B_HUMAN
Tissue specificity: Specifically expressed in testis. Low expression is detected also in liver.
genes like me logo Genes that share expression patterns with DEFB108B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DEFB108B Gene

Orthologs for DEFB108B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DEFB108B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEFB108B 35
  • 84.8 (n)
  • 79.41 (a)
DEFB108B 36
  • 96 (a)
OneToOne
Species with no ortholog for DEFB108B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB108B Gene

ENSEMBL:
Gene Tree for DEFB108B (if available)
TreeFam:
Gene Tree for DEFB108B (if available)

Paralogs for DEFB108B Gene

(8) SIMAP similar genes for DEFB108B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DEFB108B: view

No data available for Paralogs for DEFB108B Gene

Variants for DEFB108B Gene

Sequence variations from dbSNP and Humsavar for DEFB108B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12793731 - 71,837,446(+) CCTGT(A/C/G/T)GGGAC reference, missense
rs12285436 - 71,837,419(+) AGGAG(A/G)TCTGT reference, missense
rs12285495 - 71,837,474(+) AATCC(A/T)TGTTG reference, missense
rs7120658 - 71,837,498(+) TAGCC(A/G)ACCCT reference, missense
rs1945051 -- 71,835,300(+) gcact(C/T)attgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEFB108B Gene

Variant ID Type Subtype PubMed ID
dgv223e199 CNV Deletion 23128226
esv2744758 CNV Deletion 23290073
dgv1219n71 CNV Gain 21882294
dgv396e1 CNV Complex 17122850
nsv428262 CNV Gain+Loss 18775914
dgv1220n71 CNV Loss 21882294
esv25167 CNV Gain 19812545
nsv8837 CNV Gain+Loss 18304495

Variation tolerance for DEFB108B Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.76; 89.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DEFB108B Gene

Disorders for DEFB108B Gene

Relevant External Links for DEFB108B

Genetic Association Database (GAD)
DEFB108B
Human Genome Epidemiology (HuGE) Navigator
DEFB108B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEFB108B

No disorders were found for DEFB108B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEFB108B Gene

Publications for DEFB108B Gene

  1. Copy number variation of defensin genes and HIV infection in Brazilian children. (PMID: 19194307) Milanese M. … Crovella S. (J. Acquir. Immune Defic. Syndr. 2009) 3 48 67
  2. ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes. (PMID: 12600824) Kao C.Y. … Wu R. (Am. J. Respir. Cell Mol. Biol. 2003) 3
  3. Duplication and selection in the evolution of primate beta-defensin genes. (PMID: 12734011) Semple C.A.M. … Dorin J.R. (Genome Biol. 2003) 3
  4. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte B.C. … McCray P.B. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DEFB108B Gene

Sources for DEFB108B Gene

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