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Aliases for DEFB105B Gene

Aliases for DEFB105B Gene

  • Defensin, Beta 105B 2 3
  • Defensin, Beta 105 3 4
  • Beta-Defensin 5 3 4
  • DEFB-5 3 4
  • BD-5 3 4
  • Beta-Defensin 105 3
  • DEFB105A DEFB105B 4
  • DEFB105 4
  • DEFB5 4
  • BD5 4

External Ids for DEFB105B Gene

Previous GeneCards Identifiers for DEFB105B Gene

  • GC08U900546
  • GC08P007334

Summaries for DEFB105B Gene

Entrez Gene Summary for DEFB105B Gene

  • Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]

GeneCards Summary for DEFB105B Gene

DEFB105B (Defensin, Beta 105B) is a Protein Coding gene. Among its related pathways are Defensins and Defensins. An important paralog of this gene is DEFB105A.

UniProtKB/Swiss-Prot for DEFB105B Gene

  • Has antibacterial activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB105B Gene

Genomics for DEFB105B Gene

Regulatory Elements for DEFB105B Gene

Genomic Location for DEFB105B Gene

Start:
7,487,669 bp from pter
End:
7,489,593 bp from pter
Size:
1,925 bases
Orientation:
Plus strand

Genomic View for DEFB105B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEFB105B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB105B Gene

Proteins for DEFB105B Gene

  • Protein details for DEFB105B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG35-D105A_HUMAN
    Recommended name:
    Beta-defensin 105
    Protein Accession:
    Q8NG35
    Secondary Accessions:
    • A1A581
    • Q8IZN8

    Protein attributes for DEFB105B Gene

    Size:
    78 amino acids
    Molecular mass:
    8923 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB105B Gene

Proteomics data for DEFB105B Gene at MOPED

Post-translational modifications for DEFB105B Gene

No Post-translational modifications

Other Protein References for DEFB105B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB105B Gene

Domains for DEFB105B Gene

Gene Families for DEFB105B Gene

HGNC:
  • DEFB :Defensins, beta

Protein Domains for DEFB105B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DEFB105B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG35

UniProtKB/Swiss-Prot:

D105A_HUMAN :
  • Q8NG35
Family:
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB105B: view

Function for DEFB105B Gene

Molecular function for DEFB105B Gene

UniProtKB/Swiss-Prot Function: Has antibacterial activity.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DEFB105B Gene

Localization for DEFB105B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB105B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEFB105B Gene COMPARTMENTS Subcellular localization image for DEFB105B gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for DEFB105B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DEFB105B: view

Pathways for DEFB105B Gene

SuperPathways for DEFB105B Gene

Superpath Contained pathways
1 Defensins
.80
genes like me logo Genes that share pathways with DEFB105B: view

Pathways by source for DEFB105B Gene

2 Reactome pathways for DEFB105B Gene

Interacting Proteins for DEFB105B Gene

Gene Ontology (GO) - Biological Process for DEFB105B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with DEFB105B: view

Transcripts for DEFB105B Gene

mRNA/cDNA for DEFB105B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEFB105B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DEFB105B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB105B Gene

No ASD Table

Relevant External Links for DEFB105B Gene

GeneLoc Exon Structure for
DEFB105B
ECgene alternative splicing isoforms for
DEFB105B

Expression for DEFB105B Gene

mRNA expression in normal human tissues for DEFB105B Gene

SOURCE GeneReport for Unigene cluster for DEFB105B Gene Hs.381378

mRNA Expression by UniProt/SwissProt for DEFB105B Gene

Q8NG35-D105A_HUMAN
Tissue specificity: Specifically expressed in testis
genes like me logo Genes that share expressions with DEFB105B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for DEFB105B Gene

Orthologs for DEFB105B Gene

This gene was present in the common ancestor of mammals.

Orthologs for DEFB105B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEFB105A 35
  • 98.72 (n)
  • 96.15 (a)
DEFB105A 36
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LOC100296624 35
  • 76.92 (n)
  • 64.1 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
CBD105 36
  • 67 (a)
ManyToMany
DEFB105A 35
  • 79.91 (n)
  • 67.95 (a)
mouse
(Mus musculus)
Mammalia Defb12 35
  • 76.07 (n)
  • 66.67 (a)
Defb12 36
  • 61 (a)
ManyToMany
Defb35 36
  • 59 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Defb12 35
  • 77.35 (n)
  • 67.95 (a)
Species with no ortholog for DEFB105B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB105B Gene

ENSEMBL:
Gene Tree for DEFB105B (if available)
TreeFam:
Gene Tree for DEFB105B (if available)

Paralogs for DEFB105B Gene

Paralogs for DEFB105B Gene

Selected SIMAP similar genes for DEFB105B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DEFB105B: view

Variants for DEFB105B Gene

Sequence variations from dbSNP and Humsavar for DEFB105B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2737593 -- 7,489,022(+) CTGCT(A/G)GCTAC intron-variant
rs2737595 -- 7,490,064(+) CTAGT(A/G)TCTGC downstream-variant-500B
rs2737994 -- 7,488,575(-) ACCTC(A/G)TGCAT intron-variant
rs6422765 -- 7,489,021(-) TAGCC(A/G)GCAGG intron-variant
rs62639779 -- 7,489,632(+) TTATC(C/G)AAATC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DEFB105B Gene

Variant ID Type Subtype PubMed ID
nsv428194 CNV Gain+Loss 18775914
dgv2191e1 CNV Complex 17122850
nsv515968 CNV Gain+Loss 19592680
nsv821656 CNV Gain 15273396
dgv2192e1 CNV Complex 17122850
esv2736558 CNV Deletion 23290073
nsv510977 CNV Complex 20534489
dgv2193e1 CNV Complex 17122850
dgv7659n71 CNV Gain 21882294
esv21583 CNV Gain+Loss 19812545
nsv890078 CNV Gain 21882294
esv33606 CNV Gain+Loss 17666407
dgv7661n71 CNV Gain 21882294
dgv7662n71 CNV Gain 21882294
nsv8281 CNV Gain+Loss 18304495
dgv7663n71 CNV Loss 21882294
dgv7664n71 CNV Loss 21882294
nsv471650 CNV Gain+Loss 15918152
dgv2195e1 CNV Complex 17122850
dgv7666n71 CNV Gain 21882294
dgv7667n71 CNV Gain+Loss 21882294
dgv7668n71 CNV Gain 21882294
dgv7669n71 CNV Gain 21882294
dgv7670n71 CNV Loss 21882294
dgv7672n71 CNV Gain+Loss 21882294
dgv7673n71 CNV Gain+Loss 21882294
esv996398 CNV Gain 20482838
nsv890110 CNV Gain 21882294
esv2752265 CNV Gain 17911159
nsv824519 CNV Loss 20364138
nsv824521 CNV Gain 20364138
nsv515100 CNV Complex 21397061
dgv31n14 CNV Loss 18776910
dgv7675n71 CNV Loss 21882294
nsv890153 CNV Loss 21882294
nsv442397 CNV CNV 18776908
nsv469521 CNV Complex 16826518
dgv7677n71 CNV Gain+Loss 21882294
dgv7678n71 CNV Gain 21882294
dgv7679n71 CNV Gain 21882294
dgv25n31 CNV Duplication 19718026
dgv7680n71 CNV Loss 21882294
dgv7681n71 CNV Gain 21882294
esv2752266 CNV Loss 17911159
nsv890230 CNV Gain+Loss 21882294
nsv890228 CNV Gain 21882294
nsv508496 CNV Loss 20534489
dgv7682n71 CNV Gain 21882294
esv25631 CNV Gain+Loss 19812545
nsv890256 CNV Gain+Loss 21882294
dgv7683n71 CNV Gain+Loss 21882294
dgv7684n71 CNV Loss 21882294
dgv7685n71 CNV Gain 21882294
nsv890270 CNV Loss 21882294
dgv7686n71 CNV Gain 21882294
dgv7687n71 CNV Gain 21882294
esv992071 CNV Gain 20482838
dgv7688n71 CNV Gain 21882294
dgv7689n71 CNV Gain 21882294
nsv433398 CNV Gain 18776910
dgv7690n71 CNV Gain+Loss 21882294
dgv7691n71 CNV Gain 21882294
dgv26n31 CNV Duplication 19718026
dgv1170n67 CNV Loss 20364138
nsv824524 CNV Gain+Loss 20364138
dgv7692n71 CNV Gain 21882294
dgv7693n71 CNV Gain+Loss 21882294

Relevant External Links for DEFB105B Gene

HapMap Linkage Disequilibrium report
DEFB105B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEFB105B Gene

Disorders for DEFB105B Gene

No disorders were found for DEFB105B Gene.

No data available for UniProtKB/Swiss-Prot for DEFB105B Gene

Publications for DEFB105B Gene

  1. Duplication and selection in the evolution of primate beta-defensin genes. (PMID: 12734011) Semple C.A.M. … Dorin J.R. (Genome Biol. 2003) 3 4
  2. Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. (PMID: 12193721) Yamaguchi Y. … Ouchi Y. (J. Immunol. 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. (PMID: 11854508) Schutte B.C. … McCray P.B. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. (PMID: 12916016) Hollox E.J. … Barber J.C. (Am. J. Hum. Genet. 2003) 3

Products for DEFB105B Gene

Sources for DEFB105B Gene

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