Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DEFB105B Gene

Aliases for DEFB105B Gene

  • Defensin Beta 105B 2 3 5
  • Defensin, Beta 105 3 4
  • Beta-Defensin 5 3 4
  • DEFB-5 3 4
  • BD-5 3 4
  • Defensin, Beta 105B 2
  • Beta-Defensin 105 3
  • DEFB105A DEFB105B 4
  • DEFB105 4
  • DEFB5 4
  • BD5 4

External Ids for DEFB105B Gene

Previous GeneCards Identifiers for DEFB105B Gene

  • GC08U900546
  • GC08P007334

Summaries for DEFB105B Gene

Entrez Gene Summary for DEFB105B Gene

  • Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]

GeneCards Summary for DEFB105B Gene

DEFB105B (Defensin Beta 105B) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is DEFB105A.

UniProtKB/Swiss-Prot for DEFB105B Gene

  • Has antibacterial activity.

Additional gene information for DEFB105B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEFB105B Gene

Genomics for DEFB105B Gene

Regulatory Elements for DEFB105B Gene

Genomic Locations for DEFB105B Gene

Genomic Locations for DEFB105B Gene
3,112 bases
Plus strand

Genomic View for DEFB105B Gene

Genes around DEFB105B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEFB105B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEFB105B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEFB105B Gene

Proteins for DEFB105B Gene

  • Protein details for DEFB105B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-defensin 105
    Protein Accession:
    Secondary Accessions:
    • A1A581
    • Q8IZN8

    Protein attributes for DEFB105B Gene

    78 amino acids
    Molecular mass:
    8923 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEFB105B Gene

Post-translational modifications for DEFB105B Gene

No Post-translational modifications

Other Protein References for DEFB105B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEFB105B Gene

Domains & Families for DEFB105B Gene

Gene Families for DEFB105B Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DEFB105B Gene


Suggested Antigen Peptide Sequences for DEFB105B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta-defensin family.
  • Belongs to the beta-defensin family.
genes like me logo Genes that share domains with DEFB105B: view

Function for DEFB105B Gene

Molecular function for DEFB105B Gene

UniProtKB/Swiss-Prot Function:
Has antibacterial activity.

Phenotypes for DEFB105B Gene

GenomeRNAi human phenotypes for DEFB105B:
genes like me logo Genes that share phenotypes with DEFB105B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEFB105B Gene

Localization for DEFB105B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEFB105B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEFB105B gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for DEFB105B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IBA --
genes like me logo Genes that share ontologies with DEFB105B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DEFB105B Gene

Pathways & Interactions for DEFB105B Gene

genes like me logo Genes that share pathways with DEFB105B: view

Pathways by source for DEFB105B Gene

Interacting Proteins for DEFB105B Gene

Gene Ontology (GO) - Biological Process for DEFB105B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IEA --
GO:0042742 defense response to bacterium IEA,IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with DEFB105B: view

No data available for SIGNOR curated interactions for DEFB105B Gene

Drugs & Compounds for DEFB105B Gene

No Compound Related Data Available

Transcripts for DEFB105B Gene

mRNA/cDNA for DEFB105B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEFB105B Gene

No ASD Table

Relevant External Links for DEFB105B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEFB105B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEFB105B Gene

NURSA nuclear receptor signaling pathways regulating expression of DEFB105B Gene:


SOURCE GeneReport for Unigene cluster for DEFB105B Gene:


mRNA Expression by UniProt/SwissProt for DEFB105B Gene:

Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expression patterns with DEFB105B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEFB105B Gene

Orthologs for DEFB105B Gene

This gene was present in the common ancestor of mammals.

Orthologs for DEFB105B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEFB105A 33 34
  • 98.72 (n)
(Canis familiaris)
Mammalia DEFB105A 33
  • 79.91 (n)
CBD105 34
  • 67 (a)
-- 34
  • 62 (a)
-- 34
  • 62 (a)
(Rattus norvegicus)
Mammalia Defb12 33
  • 77.35 (n)
(Bos Taurus)
Mammalia LOC100296624 33
  • 76.92 (n)
(Mus musculus)
Mammalia Defb12 33 16 34
  • 76.07 (n)
Defb35 34
  • 59 (a)
Species where no ortholog for DEFB105B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEFB105B Gene

Gene Tree for DEFB105B (if available)
Gene Tree for DEFB105B (if available)

Paralogs for DEFB105B Gene

Paralogs for DEFB105B Gene

(1) SIMAP similar genes for DEFB105B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DEFB105B: view

Variants for DEFB105B Gene

Sequence variations from dbSNP and Humsavar for DEFB105B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1004007523 -- 7,486,741(+) TAATT(A/T)TACAA upstream-variant-2KB
rs1016606954 -- 7,486,762(+) CTTCA(G/T)TTAAG upstream-variant-2KB
rs1021627976 -- 7,489,958(+) TCAGG(A/T)GATCT downstream-variant-500B
rs1028016386 -- 7,488,046(+) TTATG(C/T)TATGT intron-variant, upstream-variant-2KB
rs1045969933 -- 7,486,712(+) CTTTG(G/T)TTTAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DEFB105B Gene

Variant ID Type Subtype PubMed ID
esv21583 CNV gain+loss 19812545
esv25631 CNV gain+loss 19812545
esv2752265 CNV gain 17911159
esv2752266 CNV loss 17911159
esv2759589 CNV gain+loss 17122850
esv2761169 CNV gain+loss 21179565
dgv6964n100 CNV gain 25217958
dgv6963n100 CNV loss 25217958
dgv6962n100 CNV gain 25217958
dgv6961n100 CNV gain+loss 25217958
dgv6960n100 CNV loss 25217958
dgv6959n100 CNV loss 25217958
dgv6958n100 CNV gain+loss 25217958
dgv6955n100 CNV gain 25217958
dgv6950n100 CNV loss 25217958
dgv6949n100 CNV gain 25217958
dgv6948n100 CNV gain+loss 25217958
dgv6947n100 CNV gain+loss 25217958
dgv6946n100 CNV gain 25217958
dgv6945n100 CNV loss 25217958
dgv6944n100 CNV gain 25217958
dgv6943n100 CNV gain 25217958
dgv6942n100 CNV loss 25217958
dgv6941n100 CNV gain+loss 25217958
dgv6940n100 CNV loss 25217958
dgv6939n100 CNV gain 25217958
dgv6937n100 CNV loss 25217958
dgv6936n100 CNV gain+loss 25217958
dgv6935n100 CNV gain 25217958
dgv6934n100 CNV gain+loss 25217958
dgv6933n100 CNV loss 25217958
dgv6932n100 CNV gain+loss 25217958
dgv6931n100 CNV gain+loss 25217958
dgv6928n100 CNV gain 25217958
dgv6927n100 CNV gain+loss 25217958
dgv6926n100 CNV loss 25217958
dgv6925n100 CNV gain 25217958
dgv6924n100 CNV loss 25217958
dgv6923n100 CNV gain+loss 25217958
dgv6915n100 CNV gain 25217958
dgv6912n100 CNV loss 25217958
dgv6911n100 CNV loss 25217958
dgv6910n100 CNV gain+loss 25217958
dgv6909n100 CNV gain 25217958
dgv6908n100 CNV gain 25217958
dgv6907n100 CNV loss 25217958
dgv6906n100 CNV gain 25217958
dgv6898n100 CNV loss 25217958
dgv6896n100 CNV gain+loss 25217958
dgv6895n100 CNV loss 25217958
dgv6894n100 CNV gain+loss 25217958
dgv6890n100 CNV gain 25217958
dgv6887n100 CNV loss 25217958
dgv6885n100 CNV gain 25217958
dgv6882n100 CNV gain 25217958
dgv31n14 CNV loss 18776910
dgv26n31 CNV gain 19718026
dgv25n31 CNV gain 19718026
dgv2035e212 CNV gain 25503493
dgv11932n54 CNV loss 21841781
dgv11931n54 CNV loss 21841781
dgv11930n54 CNV gain 21841781
dgv11929n54 CNV loss 21841781
dgv11928n54 CNV gain 21841781
dgv11923n54 CNV loss 21841781
dgv11922n54 CNV loss 21841781
dgv11921n54 CNV loss 21841781
dgv11919n54 CNV loss 21841781
dgv11918n54 CNV loss 21841781
dgv11917n54 CNV gain 21841781
dgv11916n54 CNV loss 21841781
dgv11915n54 CNV loss 21841781
dgv11914n54 CNV gain 21841781
dgv11913n54 CNV gain 21841781
dgv11912n54 CNV loss 21841781
dgv11911n54 CNV loss 21841781
dgv1170n67 CNV loss 20364138
nsv967555 CNV duplication 23825009
nsv951093 CNV deletion 24416366
nsv951092 CNV deletion 24416366
nsv8281 CNV gain+loss 18304495
nsv824524 CNV gain+loss 20364138
nsv824521 CNV gain 20364138
nsv824519 CNV loss 20364138
nsv821656 CNV gain 15273396
nsv610102 CNV gain+loss 21841781
nsv610077 CNV gain 21841781
nsv610065 CNV gain+loss 21841781
nsv515968 CNV gain+loss 19592680
nsv515100 CNV gain 21397061
nsv510977 OTHER complex 20534489
nsv508496 CNV deletion 20534489
nsv471650 CNV gain+loss 15918152
nsv469521 CNV gain+loss 16826518
nsv442397 CNV gain 18776908
nsv433398 CNV gain 18776910
nsv428194 CNV gain+loss 18775914
nsv1141572 CNV duplication 24896259
nsv1031948 CNV gain+loss 25217958
nsv1031577 CNV gain 25217958
nsv1031322 CNV loss 25217958
nsv1030619 CNV loss 25217958
nsv1029830 CNV gain 25217958
nsv1026778 CNV gain 25217958
esv996398 CNV gain 20482838
esv992071 CNV gain 20482838
esv3891325 CNV gain 25118596
esv3891323 CNV gain+loss 25118596
esv3891321 CNV gain+loss 25118596
esv3891318 CNV gain 25118596
esv3616114 CNV loss 21293372
esv3584577 CNV gain 24956385
esv3584575 CNV gain 24956385
esv3584574 CNV gain 24956385
esv33606 CNV gain+loss 17666407
esv2764098 CNV gain+loss 21179565

Relevant External Links for DEFB105B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DEFB105B Gene

Disorders for DEFB105B Gene

Relevant External Links for DEFB105B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DEFB105B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEFB105B Gene

Publications for DEFB105B Gene

  1. Duplication and selection in the evolution of primate beta-defensin genes. (PMID: 12734011) Semple CA … Dorin JR (Genome biology 2003) 3 4 60
  2. Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. (PMID: 12193721) Yamaguchi Y … Ouchi Y (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 60
  3. Human defensin 5 disulfide array mutants: disulfide bond deletion attenuates antibacterial activity against Staphylococcus aureus. (PMID: 21861459) Wanniarachchi YA … Nolan EM (Biochemistry 2011) 3 60
  4. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. (PMID: 16033865) Patil AA … Zhang G (Physiological genomics 2005) 3 60
  5. Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence. (PMID: 15588320) Taudien S … Platzer M (BMC genomics 2004) 3 60

Products for DEFB105B Gene

Sources for DEFB105B Gene

Loading form....